73210-73-8,MFCD00661104
Catalog No.:AA005Q3K

73210-73-8 | N-(2-((2-Hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)morpholine-4-carboxamide

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5mg
≥98%
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10mg
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA005Q3K
Chemical Name:
N-(2-((2-Hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)morpholine-4-carboxamide
CAS Number:
73210-73-8
Molecular Formula:
C36H54N6O14
Molecular Weight:
794.8458
MDL Number:
MFCD00661104
SMILES:
OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1.OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1.OC(=O)/C=C/C(=O)O
Properties
Properties
 
Form:
Solid  
MP:
168 - 170°C   
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
358  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.6  

Literature

Title: Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β₁ adrenoceptor.

Journal: Journal of neuroimmunology 20120401

Title: The use of mouse models for understanding the biology of down syndrome and aging.

Journal: Current gerontology and geriatrics research 20120101

Title: Age-related neurodegeneration and memory loss in down syndrome.

Journal: Current gerontology and geriatrics research 20120101

Title: Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities.

Journal: Neural plasticity 20120101

Title: Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111201

Title: The use of mouse models to understand and improve cognitive deficits in Down syndrome.

Journal: Disease models & mechanisms 20110901

Title: Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20110901

Title: Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.

Journal: Neurobiology of disease 20110801

Title: The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110701

Title: Insulin and β-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways.

Journal: Neurochemical research 20110401

Title: Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

Journal: Trends in pharmacological sciences 20110401

Title: Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.

Journal: PloS one 20110101

Title: The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

Journal: American journal of physiology. Endocrinology and metabolism 20100601

Title: Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain.

Journal: Experimental neurology 20100101

Title: A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors.

Journal: PloS one 20100101

Title: Beta-blockers and heart failure.

Journal: Indian heart journal 20100101

Title: Effect of inhibition of extracellular signal-regulated kinase on relaxations to beta-adrenoceptor agonists in porcine isolated blood vessels.

Journal: British journal of pharmacology 20091201

Title: Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

Journal: Science translational medicine 20091118

Title: Maintenance of beta-adrenergic receptor signaling can reduce Fas signaling in human retinal endothelial cells.

Journal: Experimental eye research 20091001

Title: Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301

Title: The adrenergic receptor subtypes present in frog (Rana esculenta) skin.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080801

Title: Beta-adrenergic receptor stimulation modulates iNOS protein levels through p38 and ERK1/2 signaling in human retinal endothelial cells.

Journal: Experimental eye research 20080701

Title: Carvedilol in the treatment of elderly patients with chronic heart failure.

Journal: Clinical interventions in aging 20080301

Title: Understanding cardiac output.

Journal: Critical care (London, England) 20080101

Title: beta(2) and beta(3)-adrenoceptor inhibition of alpha(1)-adrenoceptor-stimulated Ca(2+) elevation in human cultured prostatic stromal cells.

Journal: European journal of pharmacology 20070910

Title: Are we misunderstanding beta-blockers.

Journal: International journal of cardiology 20070809

Title: Advanced-glycation end products (AGEs) derived from glycated albumin suppress early beta1-adrenergic preconditioning.

Journal: Fundamental & clinical pharmacology 20070201

Title: Carvedilol in the treatment of chronic heart failure: lessons from the Carvedilol Or Metoprolol European Trial.

Journal: Vascular health and risk management 20070201

Title: Sympathetic neurotransmission modulates expression of inflammatory markers in the rat retina.

Journal: Experimental eye research 20070101

Title: NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.

Journal: International journal of cancer 20061001

Title: Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes.

Journal: Cardiovascular research 20060701

Title: Beta1-adrenergic receptors maintain fetal heart rate and survival.

Journal: Biology of the neonate 20060101

Title: In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: Site of action of beta-ligands at the human beta1-adrenoceptor.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of beta1-adrenergic preconditioning.

Journal: Cardiovascular research 20050601

Title: Sulfation in dog.

Journal: Current drug metabolism 20050601

Title: A clinical, physiology and pharmacology evaluation of orthostatic hypotension in the elderly.

Journal: International urology and nephrology 20050101

Title: Dobutamine inhibits phorbol-myristate-acetate-induced activation of nuclear factor-kappaB in human T lymphocytes in vitro.

Journal: Anesthesia and analgesia 20041101

Title: Effect of overexpressed adenylyl cyclase VI on beta 1- and beta 2-adrenoceptor responses in adult rat ventricular myocytes.

Journal: British journal of pharmacology 20041001

Title: Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040915

Title: Agonist binding and activation of the rat beta(1)-adrenergic receptor: role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43)).

Journal: Biochemical pharmacology 20040815

Title: Adrenergic regulation of vascular smooth muscle tone in calf digital artery.

Journal: Journal of veterinary pharmacology and therapeutics 20040801

Title: Heme oxygenase-1 gene expression in pericentral hepatocytes through beta1-adrenoceptor stimulation.

Journal: Shock (Augusta, Ga.) 20040401

Title: Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.

Journal: The Journal of pharmacology and experimental therapeutics 20040301

Title: Adenylate cyclase activity in postmortem brain of suicide subjects: reduced response to beta-adrenergic stimulation.

Journal: Biological psychiatry 20031215

Title: Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor.

Journal: Circulation 20030722

Title: Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation.

Journal: The Journal of biological chemistry 20030606

Title: Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Pharmacological characterization of putative beta1-beta2-adrenergic receptor heterodimers.

Journal: Canadian journal of physiology and pharmacology 20030201

Title: Bucindolol displays intrinsic sympathomimetic activity in human myocardium.

Journal: Circulation 20020521

Title: Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways.

Journal: Cardiovascular research 20020201

Title: Neurohormonal activation in heart failure after acute myocardial infarction treated with beta-receptor antagonists.

Journal: European journal of heart failure 20020101

Title: Characterization of beta-adrenoceptor subtype in bladder smooth muscle in cynomolgus monkey.

Journal: Japanese journal of pharmacology 20020101

Title: Cardioselective beta-blockers for reversible airway disease.

Journal: The Cochrane database of systematic reviews 20020101

Title: beta-Adrenergic receptors, transgenic mice, and pharmacological model systems.

Journal: Molecular pharmacology 20011001

Title: Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice.

Journal: Molecular pharmacology 20011001

Title: Beta2-adrenoceptor-mediated prejunctional facilitation and postjunctional inhibition of sympathetic neuroeffector transmission in the guinea pig vas deferens.

Journal: The Journal of pharmacology and experimental therapeutics 20010801

Title: The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure.

Journal: International journal of cardiology 20010801

Title: Cardioselective beta-blocker use in patients with reversible airway disease.

Journal: The Cochrane database of systematic reviews 20010101

Title: Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.

Journal: Molecular pharmacology 19991101

Title: Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers.

Journal: British journal of clinical pharmacology 19990101

Title: Xamoterol improves the control of chronic atrial fibrillation in elderly patients.

Journal: Age and ageing 19950701

Title: Xamoterol, a beta 1-adrenoceptor partial agonist: review of the clinical efficacy in heart failure.

Journal: British journal of clinical pharmacology 19890101

Title: The pharmacology of xamoterol: a basis for modulation of the autonomic control of the heart.

Journal: British journal of clinical pharmacology 19890101

Title: Contrasting effects of single doses of pindolol and xamoterol on left ventricular diastolic function.

Journal: British journal of clinical pharmacology 19890101

Title: Comparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindolol.

Journal: The Journal of pharmacology and experimental therapeutics 19870901

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Tags:73210-73-8 Molecular Formula|73210-73-8 MDL|73210-73-8 SMILES|73210-73-8 N-(2-((2-Hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)morpholine-4-carboxamide
Catalog No.: AA005Q3K
73210-73-8,MFCD00661104
73210-73-8 | N-(2-((2-Hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)morpholine-4-carboxamide
Pack Size: 1mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 5mg
Purity: ≥98%
in stock
$143.00 $100.00
Pack Size: 10mg
Purity: ≥98%
in stock
$263.00 $184.00
Pack Size: 25mg
Purity: ≥98%
in stock
$600.00 $420.00
Quantity
- +
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Technical Information
Catalog Number: AA005Q3K
Chemical Name: N-(2-((2-Hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)morpholine-4-carboxamide
CAS Number: 73210-73-8
Molecular Formula: C36H54N6O14
Molecular Weight: 794.8458
MDL Number: MFCD00661104
SMILES: OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1.OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1.OC(=O)/C=C/C(=O)O
Properties
Form: Solid  
MP: 168 - 170°C   
Storage: -20 ℃;Inert atmosphere;  
Complexity: 358  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.6  
Literature fold

Title: Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β₁ adrenoceptor.

Journal: Journal of neuroimmunology20120401

Title: The use of mouse models for understanding the biology of down syndrome and aging.

Journal: Current gerontology and geriatrics research20120101

Title: Age-related neurodegeneration and memory loss in down syndrome.

Journal: Current gerontology and geriatrics research20120101

Title: Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities.

Journal: Neural plasticity20120101

Title: Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20111201

Title: The use of mouse models to understand and improve cognitive deficits in Down syndrome.

Journal: Disease models & mechanisms20110901

Title: Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20110901

Title: Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.

Journal: Neurobiology of disease20110801

Title: The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20110701

Title: Insulin and β-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways.

Journal: Neurochemical research20110401

Title: Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

Journal: Trends in pharmacological sciences20110401

Title: Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.

Journal: PloS one20110101

Title: The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

Journal: American journal of physiology. Endocrinology and metabolism20100601

Title: Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain.

Journal: Experimental neurology20100101

Title: A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors.

Journal: PloS one20100101

Title: Beta-blockers and heart failure.

Journal: Indian heart journal20100101

Title: Effect of inhibition of extracellular signal-regulated kinase on relaxations to beta-adrenoceptor agonists in porcine isolated blood vessels.

Journal: British journal of pharmacology20091201

Title: Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

Journal: Science translational medicine20091118

Title: Maintenance of beta-adrenergic receptor signaling can reduce Fas signaling in human retinal endothelial cells.

Journal: Experimental eye research20091001

Title: Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20090301

Title: The adrenergic receptor subtypes present in frog (Rana esculenta) skin.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP20080801

Title: Beta-adrenergic receptor stimulation modulates iNOS protein levels through p38 and ERK1/2 signaling in human retinal endothelial cells.

Journal: Experimental eye research20080701

Title: Carvedilol in the treatment of elderly patients with chronic heart failure.

Journal: Clinical interventions in aging20080301

Title: Understanding cardiac output.

Journal: Critical care (London, England)20080101

Title: beta(2) and beta(3)-adrenoceptor inhibition of alpha(1)-adrenoceptor-stimulated Ca(2+) elevation in human cultured prostatic stromal cells.

Journal: European journal of pharmacology20070910

Title: Are we misunderstanding beta-blockers.

Journal: International journal of cardiology20070809

Title: Advanced-glycation end products (AGEs) derived from glycated albumin suppress early beta1-adrenergic preconditioning.

Journal: Fundamental & clinical pharmacology20070201

Title: Carvedilol in the treatment of chronic heart failure: lessons from the Carvedilol Or Metoprolol European Trial.

Journal: Vascular health and risk management20070201

Title: Sympathetic neurotransmission modulates expression of inflammatory markers in the rat retina.

Journal: Experimental eye research20070101

Title: NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.

Journal: International journal of cancer20061001

Title: Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes.

Journal: Cardiovascular research20060701

Title: Beta1-adrenergic receptors maintain fetal heart rate and survival.

Journal: Biology of the neonate20060101

Title: In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol.

Journal: The Journal of pharmacology and experimental therapeutics20051201

Title: Site of action of beta-ligands at the human beta1-adrenoceptor.

Journal: The Journal of pharmacology and experimental therapeutics20050601

Title: PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of beta1-adrenergic preconditioning.

Journal: Cardiovascular research20050601

Title: Sulfation in dog.

Journal: Current drug metabolism20050601

Title: A clinical, physiology and pharmacology evaluation of orthostatic hypotension in the elderly.

Journal: International urology and nephrology20050101

Title: Dobutamine inhibits phorbol-myristate-acetate-induced activation of nuclear factor-kappaB in human T lymphocytes in vitro.

Journal: Anesthesia and analgesia20041101

Title: Effect of overexpressed adenylyl cyclase VI on beta 1- and beta 2-adrenoceptor responses in adult rat ventricular myocytes.

Journal: British journal of pharmacology20041001

Title: Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20040915

Title: Agonist binding and activation of the rat beta(1)-adrenergic receptor: role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43)).

Journal: Biochemical pharmacology20040815

Title: Adrenergic regulation of vascular smooth muscle tone in calf digital artery.

Journal: Journal of veterinary pharmacology and therapeutics20040801

Title: Heme oxygenase-1 gene expression in pericentral hepatocytes through beta1-adrenoceptor stimulation.

Journal: Shock (Augusta, Ga.)20040401

Title: Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.

Journal: The Journal of pharmacology and experimental therapeutics20040301

Title: Adenylate cyclase activity in postmortem brain of suicide subjects: reduced response to beta-adrenergic stimulation.

Journal: Biological psychiatry20031215

Title: Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor.

Journal: Circulation20030722

Title: Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation.

Journal: The Journal of biological chemistry20030606

Title: Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter.

Journal: The Journal of pharmacology and experimental therapeutics20030501

Title: Pharmacological characterization of putative beta1-beta2-adrenergic receptor heterodimers.

Journal: Canadian journal of physiology and pharmacology20030201

Title: Bucindolol displays intrinsic sympathomimetic activity in human myocardium.

Journal: Circulation20020521

Title: Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways.

Journal: Cardiovascular research20020201

Title: Neurohormonal activation in heart failure after acute myocardial infarction treated with beta-receptor antagonists.

Journal: European journal of heart failure20020101

Title: Characterization of beta-adrenoceptor subtype in bladder smooth muscle in cynomolgus monkey.

Journal: Japanese journal of pharmacology20020101

Title: Cardioselective beta-blockers for reversible airway disease.

Journal: The Cochrane database of systematic reviews20020101

Title: beta-Adrenergic receptors, transgenic mice, and pharmacological model systems.

Journal: Molecular pharmacology20011001

Title: Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice.

Journal: Molecular pharmacology20011001

Title: Beta2-adrenoceptor-mediated prejunctional facilitation and postjunctional inhibition of sympathetic neuroeffector transmission in the guinea pig vas deferens.

Journal: The Journal of pharmacology and experimental therapeutics20010801

Title: The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure.

Journal: International journal of cardiology20010801

Title: Cardioselective beta-blocker use in patients with reversible airway disease.

Journal: The Cochrane database of systematic reviews20010101

Title: Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.

Journal: Molecular pharmacology19991101

Title: Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers.

Journal: British journal of clinical pharmacology19990101

Title: Xamoterol improves the control of chronic atrial fibrillation in elderly patients.

Journal: Age and ageing19950701

Title: Xamoterol, a beta 1-adrenoceptor partial agonist: review of the clinical efficacy in heart failure.

Journal: British journal of clinical pharmacology19890101

Title: The pharmacology of xamoterol: a basis for modulation of the autonomic control of the heart.

Journal: British journal of clinical pharmacology19890101

Title: Contrasting effects of single doses of pindolol and xamoterol on left ventricular diastolic function.

Journal: British journal of clinical pharmacology19890101

Title: Comparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindolol.

Journal: The Journal of pharmacology and experimental therapeutics19870901

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