74135-04-9,MFCD18814415
Catalog No.:AA00FFI8

74135-04-9 | Deproceptin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
1 week  
$177.00   $124.00
- +
5mg
98%
1 week  
$447.00   $313.00
- +
10mg
98%
1 week  
$685.00   $480.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FFI8
Chemical Name:
Deproceptin
CAS Number:
74135-04-9
Molecular Formula:
C28H35N5O5
Molecular Weight:
521.6080
MDL Number:
MFCD18814415
SMILES:
C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)N
Properties
Computed Properties
 
Complexity:
855  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.3  

Literature

Title: Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases.

Journal: Pharmacological reports : PR 20141001

Title: Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.

Journal: Regulatory peptides 20121110

Title: Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.

Journal: Bioorganic & medicinal chemistry 20111201

Title: Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.

Journal: European journal of medicinal chemistry 20101001

Title: Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4.

Journal: Bioorganic & medicinal chemistry letters 20060715

Title: [(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs.

Journal: Biochemical and biophysical research communications 20060623

Title: Partial and full agonism in endomorphin derivatives: comparison by null and operational model.

Journal: Peptides 20060601

Title: Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.

Journal: The journal of peptide research : official journal of the American Peptide Society 20050901

Title: Synthesis of morphiceptin (Tyr-Pro-Phe-Pro-NH(2)) by dipeptidyl aminopeptidase IV derived from Aspergillus oryzae.

Journal: Journal of agricultural and food chemistry 20050727

Title: Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor.

Journal: Journal of medicinal chemistry 20050505

Title: Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

Journal: Biochemical pharmacology 20050101

Title: Developmental changes in the inhibition of cultured rat uterine cell proliferation by opioid peptides.

Journal: Cell proliferation 20030601

Title: Synthesis and binding affinity of neuropeptide Y at opiate receptors.

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Analgesia induced by local plantar injections of opiates in the formalin test in infant rats.

Journal: Developmental psychobiology 20030301

Title: Effect of cerebral ventricles perfusion with morphiceptin and Met-enkephalin on trigemino-hypoglossal reflex in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201

Title: Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II.

Journal: Journal of pharmaceutical sciences 20021001

Title: Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.

Journal: Journal of medicinal chemistry 20011108

Title: A topochemical approach to explain morphiceptin bioactivity.

Journal: Journal of medicinal chemistry 19930319

Title: Morphine and morphiceptin increase the threshold for epinephrine-induced cardiac arrhythmias in the rat through brain mu opioid receptors.

Journal: Clinical and experimental pharmacology & physiology 19930201

Title: Morphiceptin and beta-casomorphin-5 analogues containing a reduced peptide bond: selective mu-receptor agonists and a novel mu antagonist, H-Tyr-Pro psi (CH2-NH)Phe-Pro-Gly-OH.

Journal: Biopolymers 19920801

Title: Involvement of multiple opiate receptors in opioid kindling.

Journal: Brain research 19900528

Title: Modified oligopeptides designed to interact with the HIV-1 proteinase inhibit viral replication.

Journal: Archives of virology 19900101

Title: Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.

Journal: The Journal of pharmacology and experimental therapeutics 19890401

Title: Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.

Journal: The Journal of pharmacology and experimental therapeutics 19890401

Title: Involvement of the mu-opiate receptor in peripheral analgesia.

Journal: Neuroscience 19890101

Title: Opiate-induced seizures: a study of mu and delta specific mechanisms.

Journal: Experimental neurology 19860801

Title: Receptors for opioid peptides in the guinea-pig ileum.

Journal: The Journal of pharmacology and experimental therapeutics 19851101

Title: Potent morphiceptin analogs: structure activity relationships and morphine-like activities.

Journal: The Journal of pharmacology and experimental therapeutics 19831101

Title: Differential cardiovascular effects of mu, delta and kappa opiate agonists at discrete hypothalamic sites in the anesthetized rat.

Journal: Life sciences 19821101

Title: Opioid pharmacology in the rat hippocampal slice.

Journal: Life sciences 19821101

Title: Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors.

Journal: Science (New York, N.Y.) 19810403

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SDS
Tags:74135-04-9 Molecular Formula|74135-04-9 MDL|74135-04-9 SMILES|74135-04-9 Deproceptin
Catalog No.: AA00FFI8
74135-04-9,MFCD18814415
74135-04-9 | Deproceptin
Pack Size: 1mg
Purity: 98%
1 week
$177.00 $124.00
Pack Size: 5mg
Purity: 98%
1 week
$447.00 $313.00
Pack Size: 10mg
Purity: 98%
1 week
$685.00 $480.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00FFI8
Chemical Name: Deproceptin
CAS Number: 74135-04-9
Molecular Formula: C28H35N5O5
Molecular Weight: 521.6080
MDL Number: MFCD18814415
SMILES: C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)N4CCCC4C(=O)N
Properties
Complexity: 855  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 38  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 9  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.3  
Literature fold

Title: Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases.

Journal: Pharmacological reports : PR20141001

Title: Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.

Journal: Regulatory peptides20121110

Title: Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.

Journal: Bioorganic & medicinal chemistry20111201

Title: Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.

Journal: European journal of medicinal chemistry20101001

Title: Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4.

Journal: Bioorganic & medicinal chemistry letters20060715

Title: [(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs.

Journal: Biochemical and biophysical research communications20060623

Title: Partial and full agonism in endomorphin derivatives: comparison by null and operational model.

Journal: Peptides20060601

Title: Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay.

Journal: The Journal of pharmacology and experimental therapeutics20060601

Title: Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.

Journal: The journal of peptide research : official journal of the American Peptide Society20050901

Title: Synthesis of morphiceptin (Tyr-Pro-Phe-Pro-NH(2)) by dipeptidyl aminopeptidase IV derived from Aspergillus oryzae.

Journal: Journal of agricultural and food chemistry20050727

Title: Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor.

Journal: Journal of medicinal chemistry20050505

Title: Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

Journal: Biochemical pharmacology20050101

Title: Developmental changes in the inhibition of cultured rat uterine cell proliferation by opioid peptides.

Journal: Cell proliferation20030601

Title: Synthesis and binding affinity of neuropeptide Y at opiate receptors.

Journal: Bioorganic & medicinal chemistry letters20030324

Title: Analgesia induced by local plantar injections of opiates in the formalin test in infant rats.

Journal: Developmental psychobiology20030301

Title: Effect of cerebral ventricles perfusion with morphiceptin and Met-enkephalin on trigemino-hypoglossal reflex in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20021201

Title: Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II.

Journal: Journal of pharmaceutical sciences20021001

Title: Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.

Journal: Journal of medicinal chemistry20011108

Title: A topochemical approach to explain morphiceptin bioactivity.

Journal: Journal of medicinal chemistry19930319

Title: Morphine and morphiceptin increase the threshold for epinephrine-induced cardiac arrhythmias in the rat through brain mu opioid receptors.

Journal: Clinical and experimental pharmacology & physiology19930201

Title: Morphiceptin and beta-casomorphin-5 analogues containing a reduced peptide bond: selective mu-receptor agonists and a novel mu antagonist, H-Tyr-Pro psi (CH2-NH)Phe-Pro-Gly-OH.

Journal: Biopolymers19920801

Title: Involvement of multiple opiate receptors in opioid kindling.

Journal: Brain research19900528

Title: Modified oligopeptides designed to interact with the HIV-1 proteinase inhibit viral replication.

Journal: Archives of virology19900101

Title: Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.

Journal: The Journal of pharmacology and experimental therapeutics19890401

Title: Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.

Journal: The Journal of pharmacology and experimental therapeutics19890401

Title: Involvement of the mu-opiate receptor in peripheral analgesia.

Journal: Neuroscience19890101

Title: Opiate-induced seizures: a study of mu and delta specific mechanisms.

Journal: Experimental neurology19860801

Title: Receptors for opioid peptides in the guinea-pig ileum.

Journal: The Journal of pharmacology and experimental therapeutics19851101

Title: Potent morphiceptin analogs: structure activity relationships and morphine-like activities.

Journal: The Journal of pharmacology and experimental therapeutics19831101

Title: Differential cardiovascular effects of mu, delta and kappa opiate agonists at discrete hypothalamic sites in the anesthetized rat.

Journal: Life sciences19821101

Title: Opioid pharmacology in the rat hippocampal slice.

Journal: Life sciences19821101

Title: Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors.

Journal: Science (New York, N.Y.)19810403

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