Name: Name:Bis(methylthio)gliotoxin(FR-49175)
Brand: AABLOCKS
SKU: AA01E53U
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA01E53U

Chemical Name: Bis(methylthio)gliotoxin(FR-49175)

CAS Number: 74149-38-5

Molecular Formula: C15H20N2O4S2

Molecular Weight: 356.4603

MDL Number: MFCD00133146

SMILES: CSC12CC3=CC=CC(C3N2C(=O)C(N(C1=O)C)(SC)CO)O

Properties

Complexity: 623

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 4

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 23

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 0.1

Literature fold

Title: Opposed effects of enzymatic gliotoxin N- and S-methylations.

Journal: Journal of the American Chemical Society20140820

Title: Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus.

Journal: Chemistry & biology20140814

Title: Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis.

Journal: Diagnostic microbiology and infectious disease20120501

Title: Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities.

Journal: Journal of natural products20120127

Title: Glionitrin B, a cancer invasion inhibitory diketopiperazine produced by microbial coculture.

Journal: Journal of natural products20111028

Title: Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.

Journal: Bioorganic & medicinal chemistry20100401

Title: Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit.

Journal: The Journal of biological chemistry20041210

Title: Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors.

Journal: Bioorganic & medicinal chemistry20030220

Title: Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives.

Journal: Chemical & pharmaceutical bulletin19860101

74149-38-5 | Bis(methylthio)gliotoxin(FR-49175)