745-62-0,MFCD00077862
Catalog No.:AA005W3G

745-62-0 | Prost-13-en-1-oic acid,9,11,15-trihydroxy-, (9a,11a,13E,15S)-

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Purity
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1mg
≥98%
in stock  
$79.00   $55.00
- +
5mg
≥98%
in stock  
$348.00   $243.00
- +
10mg
≥98%
in stock  
$578.00   $404.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA005W3G
Chemical Name:
Prost-13-en-1-oic acid,9,11,15-trihydroxy-, (9a,11a,13E,15S)-
CAS Number:
745-62-0
Molecular Formula:
C20H36O5
Molecular Weight:
356.4968
MDL Number:
MFCD00077862
SMILES:
CCCCCC(C=C[C@H]1C(O)CC([C@@H]1CCCCCCC(=O)O)O)O
Properties
Computed Properties
 
Complexity:
396  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
13  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.5  

Literature

Title: Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

Journal: Chemico-biological interactions 20150605

Title: Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals' skeletal muscle.

Journal: Molecules (Basel, Switzerland) 20120716

Title: Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production.

Journal: Bioorganic & medicinal chemistry 20120501

Title: Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.

Journal: Journal of lipid research 20120401

Title: Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.

Journal: British journal of pharmacology 20120301

Title: Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat.

Journal: European journal of pharmacology 20110901

Title: Progesterone activates the principal Ca2+ channel of human sperm.

Journal: Nature 20110317

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.

Journal: British journal of pharmacology 20101001

Title: Aspirin inhibits fractalkine expression in atherosclerotic plaques and reduces atherosclerosis in ApoE gene knockout mice.

Journal: Cardiovascular drugs and therapy 20100201

Title: The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts.

Journal: Arthritis research & therapy 20100101

Title: Early inhibition of prostaglandin synthesis by n-3 fatty acids determinates histologic severity of necrotizing pancreatitis.

Journal: Pancreas 20090501

Title: Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors.

Journal: Journal of vascular research 20090101

Title: Activation of the PGI(2)/IP system contributes to the development of circulatory failure in a rat model of endotoxic shock.

Journal: Hypertension (Dallas, Tex. : 1979) 20080801

Title: Lipoproteins inhibit platelet aggregation and arachidonic acid metabolism in experimental hypercholesterolaemia.

Journal: Clinical and experimental pharmacology & physiology 20080501

Title: Effects of bioactive ceramics on the pathogenesis of rat vascular smooth muscle cells treated with phorbol 12-myristate 13-acetate.

Journal: Journal of materials science. Materials in medicine 20080301

Title: Long-term fenofibrate treatment impairs endothelium-dependent dilation to acetylcholine by altering the cyclooxygenase pathway.

Journal: Cardiovascular research 20070715

Title: Role of eicosanoids of the contralateral kidney in maintenance of two-kidney, one-clip renovascular hypertension in rats.

Journal: Scandinavian journal of urology and nephrology 20070101

Title: Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in mice.

Journal: Gastroenterology 20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Plasma levels of nitrites, PGF1alpha, and nitrotyrosine in LPS-treated rats: functional and histochemical implications in aorta.

Journal: Journal of physiology and biochemistry 20060301

Title: Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein.

Journal: Atherosclerosis 20060101

Title: Effect of prostaglandins against alloxan-induced diabetes mellitus.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20060101

Title: Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20050801

Title: Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20041101

Title: Systemic inflammatory response after endoscopic (TEP) vs Shouldice groin hernia repair.

Journal: Hernia : the journal of hernias and abdominal wall surgery 20040801

Title: C-reactive protein decreases prostacyclin release from human aortic endothelial cells.

Journal: Circulation 20031007

Title: Effects of exogenous heme on renal function: role of heme oxygenase and cyclooxygenase.

Journal: Hypertension (Dallas, Tex. : 1979) 20031001

Title: Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20030401

Title: Dietary fish protein lowers blood pressure and alters tissue polyunsaturated fatty acid composition in spontaneously hypertensive rats.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20030401

Title: Nitric oxide, anti-inflammatory drugs on renal prostaglandins and cyclooxygenase-2.

Journal: Hypertension (Dallas, Tex. : 1979) 20020301

Title: Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array.

Journal: Endocrinology 20010901

Title: PGF(2alpha), a prostanoid released by endothelial cells activated by hypoxia, is a chemoattractant candidate for neutrophil recruitment.

Journal: The American journal of pathology 20010701

Title: An efficient synthesis of 3-hetero-13,14-dihydro prostaglandin F1alpha analogues.

Journal: Organic letters 20010308

Title: Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components.

Journal: The British journal of nutrition 20010101

Title: Effect of prostaglandins on morphine-induced catalepsy in mice.

Journal: Acta physiologica Polonica 19830101

Title: Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis.

Journal: Thrombosis research 19820101

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SDS
Historical Records
Tags:745-62-0 Molecular Formula|745-62-0 MDL|745-62-0 SMILES|745-62-0 Prost-13-en-1-oic acid,9,11,15-trihydroxy-, (9a,11a,13E,15S)-
Catalog No.: AA005W3G
745-62-0,MFCD00077862
745-62-0 | Prost-13-en-1-oic acid,9,11,15-trihydroxy-, (9a,11a,13E,15S)-
Pack Size: 1mg
Purity: ≥98%
in stock
$79.00 $55.00
Pack Size: 5mg
Purity: ≥98%
in stock
$348.00 $243.00
Pack Size: 10mg
Purity: ≥98%
in stock
$578.00 $404.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA005W3G
Chemical Name: Prost-13-en-1-oic acid,9,11,15-trihydroxy-, (9a,11a,13E,15S)-
CAS Number: 745-62-0
Molecular Formula: C20H36O5
Molecular Weight: 356.4968
MDL Number: MFCD00077862
SMILES: CCCCCC(C=C[C@H]1C(O)CC([C@@H]1CCCCCCC(=O)O)O)O
Properties
Complexity: 396  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 5  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 25  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 13  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.5  
Literature fold

Title: Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

Journal: Chemico-biological interactions20150605

Title: Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals' skeletal muscle.

Journal: Molecules (Basel, Switzerland)20120716

Title: Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production.

Journal: Bioorganic & medicinal chemistry20120501

Title: Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.

Journal: Journal of lipid research20120401

Title: Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.

Journal: British journal of pharmacology20120301

Title: Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat.

Journal: European journal of pharmacology20110901

Title: Progesterone activates the principal Ca2+ channel of human sperm.

Journal: Nature20110317

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.

Journal: British journal of pharmacology20101001

Title: Aspirin inhibits fractalkine expression in atherosclerotic plaques and reduces atherosclerosis in ApoE gene knockout mice.

Journal: Cardiovascular drugs and therapy20100201

Title: The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts.

Journal: Arthritis research & therapy20100101

Title: Early inhibition of prostaglandin synthesis by n-3 fatty acids determinates histologic severity of necrotizing pancreatitis.

Journal: Pancreas20090501

Title: Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors.

Journal: Journal of vascular research20090101

Title: Activation of the PGI(2)/IP system contributes to the development of circulatory failure in a rat model of endotoxic shock.

Journal: Hypertension (Dallas, Tex. : 1979)20080801

Title: Lipoproteins inhibit platelet aggregation and arachidonic acid metabolism in experimental hypercholesterolaemia.

Journal: Clinical and experimental pharmacology & physiology20080501

Title: Effects of bioactive ceramics on the pathogenesis of rat vascular smooth muscle cells treated with phorbol 12-myristate 13-acetate.

Journal: Journal of materials science. Materials in medicine20080301

Title: Long-term fenofibrate treatment impairs endothelium-dependent dilation to acetylcholine by altering the cyclooxygenase pathway.

Journal: Cardiovascular research20070715

Title: Role of eicosanoids of the contralateral kidney in maintenance of two-kidney, one-clip renovascular hypertension in rats.

Journal: Scandinavian journal of urology and nephrology20070101

Title: Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in mice.

Journal: Gastroenterology20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Plasma levels of nitrites, PGF1alpha, and nitrotyrosine in LPS-treated rats: functional and histochemical implications in aorta.

Journal: Journal of physiology and biochemistry20060301

Title: Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein.

Journal: Atherosclerosis20060101

Title: Effect of prostaglandins against alloxan-induced diabetes mellitus.

Journal: Prostaglandins, leukotrienes, and essential fatty acids20060101

Title: Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster.

Journal: Prostaglandins, leukotrienes, and essential fatty acids20050801

Title: Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro.

Journal: Prostaglandins, leukotrienes, and essential fatty acids20041101

Title: Systemic inflammatory response after endoscopic (TEP) vs Shouldice groin hernia repair.

Journal: Hernia : the journal of hernias and abdominal wall surgery20040801

Title: C-reactive protein decreases prostacyclin release from human aortic endothelial cells.

Journal: Circulation20031007

Title: Effects of exogenous heme on renal function: role of heme oxygenase and cyclooxygenase.

Journal: Hypertension (Dallas, Tex. : 1979)20031001

Title: Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery.

Journal: The Journal of pharmacology and experimental therapeutics20030601

Title: High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries.

Journal: American journal of physiology. Heart and circulatory physiology20030401

Title: Dietary fish protein lowers blood pressure and alters tissue polyunsaturated fatty acid composition in spontaneously hypertensive rats.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20030401

Title: Nitric oxide, anti-inflammatory drugs on renal prostaglandins and cyclooxygenase-2.

Journal: Hypertension (Dallas, Tex. : 1979)20020301

Title: Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.

Journal: Veterinary therapeutics : research in applied veterinary medicine20020101

Title: Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array.

Journal: Endocrinology20010901

Title: PGF(2alpha), a prostanoid released by endothelial cells activated by hypoxia, is a chemoattractant candidate for neutrophil recruitment.

Journal: The American journal of pathology20010701

Title: An efficient synthesis of 3-hetero-13,14-dihydro prostaglandin F1alpha analogues.

Journal: Organic letters20010308

Title: Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components.

Journal: The British journal of nutrition20010101

Title: Effect of prostaglandins on morphine-induced catalepsy in mice.

Journal: Acta physiologica Polonica19830101

Title: Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis.

Journal: Thrombosis research19820101

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