Title: Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity?
Journal: Orphanet journal of rare diseases20140101
Title: Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice.
Journal: Experimental neurology20121001
Title: Sigma-1R agonist improves motor function and motoneuron survival in ALS mice.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics20121001
Title: Influence of sigma-1 receptor modulators on ethanol-induced conditioned place preference in the extinction-reinstatement model.
Journal: Behavioural pharmacology20120201
Title: Decreased brain sigma-1 receptor contributes to the relationship between heart failure and depression.
Journal: Cardiovascular research20120101
Title: Identification of a potent and selective σ₁ receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells.
Journal: Bioorganic & medicinal chemistry20111101
Title: Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats.
Journal: Behavioural pharmacology20110901
Title: Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
Journal: British journal of pharmacology20110801
Title: Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats.
Journal: Brain research bulletin20110530
Title: Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury.
Journal: Journal of neurotrauma20110501
Title: Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.
Journal: Biological psychiatry20110201
Title: The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action.
Journal: Neuropharmacology20101101
Title: Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
Journal: The Journal of pharmacology and experimental therapeutics20100201
Title: Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons.
Journal: Neuroscience20090804
Title: Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Journal: Psychopharmacology20090701
Title: Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice.
Journal: Pain20090601
Title: Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice.
Journal: Pharmacological reports : PR20090101
Title: Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathway.
Journal: Journal of neuroscience research20081201
Title: Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
Journal: British journal of pharmacology20080701
Title: Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.
Journal: Journal of neurochemistry20080101
Title: Protective effects of the sigma agonist Pre-084 in the rat retina.
Journal: The British journal of ophthalmology20071001
Title: Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine.
Journal: European journal of pharmacology20070601
Title: Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.
Journal: The Journal of pharmacology and experimental therapeutics20061201
Title: Sigma receptor ligands protect human retinal cells against oxidative stress.
Journal: Neuroreport20060227
Title: Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.
Journal: Neuroreport20050801
Title: Pregnenolone sulfate acts through a G-protein-coupled sigma1-like receptor to enhance short term facilitation in adult hippocampal neurons.
Journal: European journal of pharmacology20050725
Title: Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain.
Journal: Synapse (New York, N.Y.)20050301
Title: Effects of neurosteroids on ischemia-reperfusion injury in the rat retina: role of sigma1 recognition sites.
Journal: European journal of pharmacology20040913
Title: Cocaine modulates cytokine and enhances tumor growth through sigma receptors.
Journal: Journal of neuroimmunology20040201
Title: Preserved sigma1 (sigma1) receptor expression and behavioral efficacy in the aged C57BL/6 mouse.
Journal: Neurobiology of aging20031001
Title: IL-10 mediates sigma 1 receptor-dependent suppression of antitumor immunity.
Journal: Journal of immunology (Baltimore, Md. : 1950)20030401
Title: Enhanced antidepressant effect of sigma(1) (sigma(1)) receptor agonists in beta(25-35)-amyloid peptide-treated mice.
Journal: Behavioural brain research20020821
Title: Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels.
Journal: The European journal of neuroscience20020501
Title: Differential involvement of the sigma(1) (sigma(1)) receptor in the anti-amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse.
Journal: British journal of pharmacology20011201
Title: Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats.
Journal: European journal of pharmacology20011116
Title: Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands.
Journal: British journal of pharmacology20011001
Title: The anti-amnesic effects of sigma1 (sigma1) receptor agonists confirmed by in vivo antisense strategy in the mouse.
Journal: Brain research20010413
Title: Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand.
Journal: The Journal of pharmacology and experimental therapeutics19911101
