Name: Name:Imidazo[1,2-b]pyridazine
Brand: AABLOCKS
SKU: AA003QWU
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA003QWU

Chemical Name: Imidazo[1,2-b]pyridazine

CAS Number: 766-55-2

Molecular Formula: C6H5N3

Molecular Weight: 119.1240

MDL Number: MFCD07782103

SMILES: c1cnn2c(c1)ncc2

Properties

Form: Solid

MP: 47 - 50 °C

Solubility: Soluble in dimethylformamide.

Storage: Inert atmosphere;Room Temperature;

Complexity: 105

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 9

Hydrogen Bond Acceptor Count: 2

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 0

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 0.3

Literature fold

Title: Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.

Journal: Journal of medicinal chemistry20120412

Title: Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.

Journal: Bioorganic & medicinal chemistry letters20110801

Title: Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.

Journal: Blood20110721

Title: Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism.

Journal: Biochemistry20110208

Title: Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.

Journal: Bioorganic & medicinal chemistry letters20110201

Title: Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference.

Journal: PloS one20110101

Title: Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.

Journal: Bioorganic & medicinal chemistry letters20100901

Title: Inhibitors of PIM-1 kinase: a computational analysis of the binding free energies of a range of imidazo [1,2-b] pyridazines.

Journal: Journal of chemical information and modeling20100322

Title: Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect.

Journal: Neuropharmacology20100301

Title: Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.

Journal: Blood20091105

Title: Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.

Journal: Structure (London, England : 1993)20090311

Title: T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin.

Journal: Neuropharmacology20090301

Title: Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20040503

766-55-2 | Imidazo[1,2-b]pyridazine