Title: Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum.
Journal: The Journal of steroid biochemistry and molecular biology20170701
Title: Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.
Journal: Chemico-biological interactions20130525
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry20121115
Title: Tomatidine promotes the inhibition of 24-alkylated sterol biosynthesis and mitochondrial dysfunction in Leishmania amazonensis promastigotes.
Journal: Parasitology20120901
Title: Structure-activity relationships of α-, β(1)-, γ-, and δ-tomatine and tomatidine against human breast (MDA-MB-231), gastric (KATO-III), and prostate (PC3) cancer cells.
Journal: Journal of agricultural and food chemistry20120418
Title: Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT).
Journal: Journal of agricultural and food chemistry20120314
Title: Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression.
Journal: The Journal of antimicrobial chemotherapy20120301
Title: The side population in human lung cancer cell line NCI-H460 is enriched in stem-like cancer cells.
Journal: PloS one20120101
Title: Footprinting of inhibitor interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite.
Journal: TheScientificWorldJournal20120101
Title: ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma.
Journal: Oncogene20111208
Title: GLYCOALKALOID METABOLISM1 is required for steroidal alkaloid glycosylation and prevention of phytotoxicity in tomato.
Journal: The Plant cell20111201
Title: Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.
Journal: British journal of cancer20110510
Title: Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping.
Journal: PloS one20110101
Title: Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer.
Journal: PloS one20110101
Title: Identification of novel functional inhibitors of acid sphingomyelinase.
Journal: PloS one20110101
Title: Gli2 expression and human bladder transitional carcinoma cell invasiveness.
Journal: The Journal of urology20100701
Title: Distortion of trichome morphology by the hairless mutation of tomato affects leaf surface chemistry.
Journal: Journal of experimental botany20100201
Title: Smoothened as a new therapeutic target for human osteosarcoma.
Journal: Molecular cancer20100101
Title: Resistance of wild Solanum accessions to aphids and other potato pests in Quebec field conditions.
Journal: Journal of insect science (Online)20100101
Title: Chemoprotective Effect of Sobatum against Lithium-Induced Oxidative Damage in Rats.
Journal: Journal of young pharmacists : JYP20100101
Title: Plant antimicrobial agents and their effects on plant and human pathogens.
Journal: International journal of molecular sciences20090801
Title: Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells.
Journal: Journal of agricultural and food chemistry20090708
Title: Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.
Journal: International journal of molecular sciences20090701
Title: Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
Journal: The Journal of pharmacology and experimental therapeutics20090601
Title: Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.
Journal: Nature20090409
Title: Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers.
Journal: British journal of cancer20090127
Title: Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells.
Journal: Biochemical and biophysical research communications20080815
Title: Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages.
Journal: FEBS letters20080709
Title: Simultaneously cycled NMR spectroscopy.
Journal: Journal of the American Chemical Society20080409
Title: Heterologous expression of Fusarium oxysporum tomatinase in Saccharomyces cerevisiae increases its resistance to saponins and improves ethanol production during the fermentation of Agave tequilana Weber var. azul and Agave salmiana must.
Journal: Antonie van Leeuwenhoek20080301
Title: Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy.
Journal: BMC cancer20080101
Title: Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.
Journal: FEBS letters20071222
Title: Hedgehog signaling pathway is inactive in colorectal cancer cell lines.
Journal: International journal of cancer20071215
Title: Efficient conversion of tomatidine into neuritogenic pregnane derivative.
Journal: Chemical & pharmaceutical bulletin20070701
Title: Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer.
Journal: PloS one20060101
Title: Identification of a tomatinase in the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382.
Journal: Molecular plant-microbe interactions : MPMI20051001
Title: Influence of incorporated wild Solanum genomes on potato properties in terms of starch nanostructure and glycoalkaloid content.
Journal: Journal of agricultural and food chemistry20050629
Title: Glycoalkaloid aglycone accumulations associated with infection by Clavibacter michiganensis ssp. sepedonicus in potato species Solanum acaule and Solanum tuberosum and their interspecific somatic hybrids.
Journal: Plant cell reports20050301
Title: A novel glucosyltransferase involved in steroid saponin biosynthesis in Solanum aculeatissimum.
Journal: Plant molecular biology20050101
Title: Tomatidine and lycotetraose, hydrolysis products of alpha-tomatine by Fusarium oxysporum tomatinase, suppress induced defense responses in tomato cells.
Journal: FEBS letters20040730
Title: Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells.
Journal: Journal of agricultural and food chemistry20040519
Title: Dehydrotomatine and alpha-tomatine content in tomato fruits and vegetative plant tissues.
Journal: Journal of agricultural and food chemistry20040407
Title: Activation of the hedgehog pathway in advanced prostate cancer.
Journal: Molecular cancer20040101
Title: Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
Journal: Nature20030320
Title: Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20030101
Title: Determination of glycoalkaloids and relative aglycones by nonaqueous capillary electrophoresis coupled with electrospray ionization-ion trap mass spectrometry.
Journal: Electrophoresis20020901
Title: Non-aqueous capillary electrophoresis with diode array and electrospray mass spectrometric detection for the analysis of selected steroidal alkaloids in plant extracts.
Journal: Journal of chromatography. A20010713
Title: Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells.
Journal: Anticancer research20010101
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Title: Anil Ahsan, et al. Tomatidine Protects Against Ischemic Neuronal Injury by Improving Lysosomal Function. Eur J Pharmacol. 2020 Jun 21;173280.
