77-67-8,MFCD00072123
Catalog No.:AA003PW2

77-67-8 | Ethosuximide

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Purity
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1mg
98%
in stock  
$6.00   $4.00
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250mg
98%
in stock  
$20.00   $14.00
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1g
98%
in stock  
$43.00   $30.00
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5g
>98.0%(GC)(T)
in stock  
$52.00   $36.00
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25g
>98.0%(GC)(T)
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$148.00   $104.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA003PW2
Chemical Name:
Ethosuximide
CAS Number:
77-67-8
Molecular Formula:
C7H11NO2
Molecular Weight:
141.1677
MDL Number:
MFCD00072123
SMILES:
CC1(CC)CC(=O)NC1=O
Properties
Properties
 
BP:
150 °C / 12mmHg  
Form:
Solid  
MP:
51 °C  
Refractive Index:
1.5026 (estimate)  
Solubility:
ethanol: 100 mg/mL  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
188  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.4  

Literature

Title: Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway.

Journal: The Journal of biological chemistry 20151120

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20141101

Title: Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20121203

Title: Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring.

Journal: Biomedical chromatography : BMC 20121201

Title: Non-convulsive status epilepticus of frontal origin in mucopolysaccharidosis type II successfully treated with ethosuximide.

Journal: Developmental medicine and child neurology 20121001

Title: Quantum dot nanoparticles affect the reproductive system of Caenorhabditis elegans.

Journal: Environmental toxicology and chemistry 20121001

Title: Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome.

Journal: Neuroscience 20120918

Title: Synthesis and anticonvulsant properties of new mannich bases derived from 3,3-disubstituted pyrrolidine-2,5-diones. Part IV.

Journal: Archiv der Pharmazie 20120901

Title: Randomised controlled monotherapy trials: which comparators to use?

Journal: Epileptic disorders : international epilepsy journal with videotape 20120901

Title: A rat model for LGI1-related epilepsies.

Journal: Human molecular genetics 20120815

Title: Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20120810

Title: Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20120801

Title: Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II.

Journal: Bioorganic & medicinal chemistry 20120801

Title: Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives.

Journal: European journal of medicinal chemistry 20120801

Title: Does antiepileptogenesis affect sleep in genetic epileptic rats?

Journal: International journal of psychophysiology : official journal of the International Organization of Psychophysiology 20120701

Title: Treatment of idiopathic generalized epilepsy - a review of the evidence.

Journal: Expert opinion on pharmacotherapy 20120601

Title: Long-term effectiveness of ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.

Journal: Brain & development 20120501

Title: 8p deletion and 9p duplication in two children with electrical status epilepticus in sleep syndrome.

Journal: Seizure 20120501

Title: Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives.

Journal: Bioorganic & medicinal chemistry letters 20120501

Title: Cognitive function of idiopathic childhood epilepsy.

Journal: Korean journal of pediatrics 20120501

Title: Prevalence of treated epilepsy in Korea based on national health insurance data.

Journal: Journal of Korean medical science 20120301

Title: T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.

Journal: Science translational medicine 20120215

Title: Ethosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release.

Journal: Neuropharmacology 20120201

Title: Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones.

Journal: European journal of medicinal chemistry 20120201

Title: Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20120201

Title: Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain.

Journal: European journal of pharmacology 20120115

Title: Ethosuximide and phenobarbital promote wound healing via enhancing collagenization.

Journal: Chemical biology & drug design 20120101

Title: From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?

Journal: Pflugers Archiv : European journal of physiology 20120101

Title: Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders.

Journal: Expert opinion on drug metabolism & toxicology 20120101

Title: L type Ca²+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats.

Journal: Molecular pain 20120101

Title: Clinical utility of adjunctive retigabine in partial onset seizures in adults.

Journal: Therapeutics and clinical risk management 20120101

Title: Recent progress in anticonvulsant drug research: strategies for anticonvulsant drug development and applications of antiepileptic drugs for non-epileptic central nervous system disorders.

Journal: Current topics in medicinal chemistry 20120101

Title: Evaluation of lercanidipine in Paclitaxel-induced neuropathic pain model in rat: a preliminary study.

Journal: Pain research and treatment 20120101

Title: The adolescent or adult with generalized tonic-clonic seizures.

Journal: Annals of Indian Academy of Neurology 20120101

Title: Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder.

Journal: Journal of pharmacology & pharmacotherapeutics 20120101

Title: N- and L-type voltage-dependent Ca2+ channels contribute to the generation of after-discharges in the spinal ventral root after cessation of noxious mechanical stimulation.

Journal: Journal of pharmacological sciences 20120101

Title: Synthesis, anticonvulsant activity and 5-HT1A/5-HT7 receptors affinity of 1-[(4-arylpiperazin-1-yl)-propyl]-succinimides.

Journal: Pharmacological reports : PR 20120101

Title: The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation.

Journal: International journal of hepatology 20120101

Title: Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20120101

Title: Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.

Journal: Annals of agricultural and environmental medicine : AAEM 20120101

Title: [Therapeutic drug monitoring of ethosuximide].

Journal: Therapie 20120101

Title: Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20111201

Title: Transition to absence seizures and the role of GABA(A) receptors.

Journal: Epilepsy research 20111201

Title: Quantum mechanical and spectroscopic (FT-IR, FT-Raman, 13C, 1H and UV) investigations of antiepileptic drug Ethosuximide.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111201

Title: Design, synthesis and antiepileptic properties of novel 1-(substituted benzylidene)-3-(1-(morpholino/piperidino methyl)-2,3-dioxoindolin-5-yl)urea derivatives.

Journal: European journal of medicinal chemistry 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Early-onset childhood absence epilepsy: is it a distinct entity?

Journal: Epileptic disorders : international epilepsy journal with videotape 20111201

Title: Nitric oxide, epileptic seizures, and action of antiepileptic drugs.

Journal: CNS & neurological disorders drug targets 20111101

Title: Generic substitution of antiepileptic drugs: a systematic review of prospective and retrospective studies.

Journal: The Annals of pharmacotherapy 20111101

Title: Synthesis and anticonvulsant activity of new N-Mannich bases derived from 5-cyclopropyl-5-phenyl- and 5-cyclopropyl-5-(4-chlorophenyl)-imidazolidine-2,4-diones.

Journal: Bioorganic & medicinal chemistry 20111015

Title: Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.

Journal: European journal of medicinal chemistry 20111001

Title: Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism.

Journal: Journal of molecular medicine (Berlin, Germany) 20110901

Title: Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs.

Journal: European journal of medicinal chemistry 20110901

Title: The effects of ion channel blockers validate the conductance-based model of saccadic oscillations.

Journal: Annals of the New York Academy of Sciences 20110901

Title: Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.

Journal: Neuroscience 20110811

Title: Ethosuximide-induced mania in a 10-year-old boy.

Journal: Epilepsy & behavior : E&B 20110801

Title: Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.

Journal: Epilepsia 20110701

Title: Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges.

Journal: Epilepsia 20110701

Title: Ethosuximide was superior to valproate and lamotrigine in controlling seizures and minimising side effects.

Journal: Archives of disease in childhood. Education and practice edition 20110601

Title: Interictal paroxysmal EEG abnormalities in childhood absence epilepsy.

Journal: Seizure 20110501

Title: Orphenadrine induces secondarily generalized convulsive status epilepticus in rats.

Journal: Brain research bulletin 20110405

Title: Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy.

Journal: International journal of neural systems 20110401

Title: Synthesis and anticonvulsant activity of new n-mannich bases derived from 5-cyclopropyl-5-phenyl-hydantoins.

Journal: Archiv der Pharmazie 20110401

Title: Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures.

Journal: Neurobiology of disease 20110201

Title: Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats.

Journal: Pharmacology, biochemistry, and behavior 20110201

Title: Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency.

Journal: Journal of inherited metabolic disease 20110201

Title: Long term outcome in children affected by absence epilepsy with onset before the age of three years.

Journal: Epilepsy & behavior : E&B 20110201

Title: Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice.

Journal: Indian journal of pharmacology 20110201

Title: Epilepsy with myoclonic absences - favourable response to add-on rufinamide treatment in 3 cases.

Journal: Neuropediatrics 20110201

Title: An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.

Journal: Brain research 20110131

Title: Effects of L- and T-type Ca²(+) channel blockers on spermatogenesis and steroidogenesis in the prepubertal mouse testis.

Journal: Journal of assisted reproduction and genetics 20110101

Title: Association of antiepileptic drugs with nontraumatic fractures: a population-based analysis.

Journal: Archives of neurology 20110101

Title: [Symptoms and clinical course of epilepsy with myoclonic absences].

Journal: No to hattatsu = Brain and development 20110101

Title: Myoclonus.

Journal: Handbook of clinical neurology 20110101

Title: Transcriptomic analysis in a Drosophila model identifies previously implicated and novel pathways in the therapeutic mechanism in neuropsychiatric disorders.

Journal: Frontiers in neuroscience 20110101

Title: Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey.

Journal: BMC pediatrics 20110101

Title: [Does antiabsence drug ethosuximide exert antidepressant effect?].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20110101

Title: Experimental re-evaluation of flunarizine as add-on antiepileptic therapy.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis.

Journal: Reproductive biology and endocrinology : RB&E 20110101

Title: Update on rufinamide in childhood epilepsy.

Journal: Neuropsychiatric disease and treatment 20110101

Title: An integrative view of mechanisms underlying generalized spike-and-wave epileptic seizures and its implication on optimal therapeutic treatments.

Journal: PloS one 20110101

Title: Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors.

Journal: Advances in pharmacological sciences 20110101

Title: Severe myoclonic epilepsy of infancy (Dravet syndrome): Clinical and genetic features of nine Turkish patients.

Journal: Annals of Indian Academy of Neurology 20110101

Title: Acute alterations of somatodendritic action potential dynamics in hippocampal CA1 pyramidal cells after kainate-induced status epilepticus in mice.

Journal: PloS one 20110101

Title: Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands.

Journal: Molecular pain 20110101

Title: Studies of properties of 'Pain Networks' as predictors of targets of stimulation for treatment of pain.

Journal: Frontiers in integrative neuroscience 20110101

Title: Effect of Gentiana olivieri on experimental epilepsy models.

Journal: Pharmacognosy magazine 20110101

Title: [Transitory cognitive dysfunction in rolandic epilepsy].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: [Idiopathic focal epilepsies of infancy and childhood].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: Screening of the anticonvulsant activity of some plants from Fabaceae family in experimental seizure models in mice.

Journal: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

Title: [Epilepsies with electric status epilepticus in sleep: peculiarities of clinical course and rational approaches to treatment].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives.

Journal: European journal of medicinal chemistry 20101201

Title: Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status.

Journal: Epileptic disorders : international epilepsy journal with videotape 20101201

Title: Atypical benign partial epilepsy: recognition can prevent pseudocatastrophe.

Journal: Pediatric neurology 20101201

Title: 1-Benzyl-2,5-dioxopyrrolidine-3,4-diyl diacetate.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: Use of antiepileptic drugs for hyperkinetic movement disorders.

Journal: Current neuropharmacology 20101201

Title: 'Epileptic encephalopathy' of infancy and childhood: electro-clinical pictures and recent understandings.

Journal: Current neuropharmacology 20101201

Title: T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.

Journal: Neuropharmacology 20101101

Title: Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress.

Journal: Developmental medicine and child neurology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Treatment initiation in epilepsy: an expert consensus in Spain.

Journal: Epilepsy & behavior : E&B 20101101

Title: Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome.

Journal: Epilepsia 20101001

Title: Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones.

Journal: European journal of medicinal chemistry 20100901

Title: Antiepileptic drug interactions - principles and clinical implications.

Journal: Current neuropharmacology 20100901

Title: Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins.

Journal: Bioorganic & medicinal chemistry 20100815

Title: Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100804

Title: Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy.

Journal: Epilepsia 20100801

Title: Epilepsy: old drugs do the trick in childhood absence epilepsy.

Journal: Nature reviews. Neurology 20100801

Title: Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: one more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activity.

Journal: Bioorganic & medicinal chemistry letters 20100715

Title: Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides.

Journal: European journal of medicinal chemistry 20100701

Title: Gastaut type-idiopathic childhood occipital epilepsy and childhood absence epilepsy: a clinically significant association?

Journal: Seizure 20100701

Title: In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein.

Journal: Life sciences 20100605

Title: Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.

Journal: European journal of medicinal chemistry 20100601

Title: Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

Title: An older drug for childhood absence epilepsy.

Journal: The American journal of nursing 20100601

Title: When the past challenges the present: are older antiepileptic drugs still the best choice in childhood absence epilepsy?

Journal: The Lancet. Neurology 20100501

Title: Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening.

Journal: European journal of medicinal chemistry 20100401

Title: [Specific language impairment and electroencephalogram: which recommendations in clinical practice? A cohort of 24 children].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100401

Title: Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.

Journal: The New England journal of medicine 20100304

Title: Ethosuximide in childhood absence epilepsy--older and better.

Journal: The New England journal of medicine 20100304

Title: Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS).

Journal: Epilepsy research 20100301

Title: Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect.

Journal: Neuropharmacology 20100301

Title: Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster.

Journal: Biogerontology 20100201

Title: Pharmacological neuroprotection: that long, long road from idea to practice.

Journal: Korean journal of anesthesiology 20100201

Title: The effects of gabapentin pretreatment on brain injury induced by focal cerebral ischemia/reperfusion in the rat.

Journal: Korean journal of anesthesiology 20100201

Title: Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms.

Journal: Epilepsia 20100101

Title: Effects of antiepileptics on behavioral and electroencephalographic seizure induced by pentetrazol in mice.

Journal: Journal of pharmacological sciences 20100101

Title: Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor.

Journal: PloS one 20100101

Title: Epilepsy in patients with Angelman syndrome.

Journal: Italian journal of pediatrics 20100101

Title: Management of refractory complex partial seizures: current state of the art.

Journal: Neuropsychiatric disease and treatment 20100101

Title: Quality of life in childhood epilepsy with lateralized epileptogenic foci.

Journal: BMC neurology 20100101

Title: BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.

Journal: Molecular neurodegeneration 20100101

Title: Molecular and therapeutic potential and toxicity of valproic acid.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Oxcarbazepine-induced tardive dyskinesia: A rare adverse reaction.

Journal: Journal of pediatric neurosciences 20100101

Title: Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study.

Journal: BMJ (Clinical research ed.) 20100101

Title: Advances in epilepsy: new perspectives on new-onset epilepsy, comorbidities, and pharmacotherapy.

Journal: F1000 medicine reports 20100101

Title: Design and Synthesis of Some Novel 4-(4-substituted aryl) Semicarbazones as Anticonvulsant Agents.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients.

Journal: Nutrition journal 20100101

Title: [Absence epilepsy models in rodents].

Journal: Gaceta medica de Mexico 20100101

Title: Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.

Journal: Clinical pharmacology : advances and applications 20100101

Title: Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

Journal: Journal of medicinal chemistry 20091210

Title: A flexible drug delivery chip for the magnetically-controlled release of anti-epileptic drugs.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20091103

Title: Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.

Journal: Seizure 20091101

Title: Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice.

Journal: Diabetes 20091101

Title: Acceleration of pentylenetetrazol seizure kindling associated with induction of sensitized visual responses evoked by strobe stimulation.

Journal: Neuroscience 20091006

Title: Impact of antiepileptic drugs on cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy.

Journal: Epilepsy & behavior : E&B 20091001

Title: Use of a new antiepileptic drug or an old one as first drug for treatment of absence epilepsy.

Journal: Epilepsia 20090901

Title: Absence seizures: a review of recent reports with new concepts.

Journal: Epilepsy & behavior : E&B 20090801

Title: Ethosuximide-induced de novo systemic lupus erythematosus with anti-double-strand DNA antibodies: a case report with definite evidence.

Journal: Epilepsia 20090801

Title: Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years.

Journal: Epilepsia 20090801

Title: Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model.

Journal: Epilepsia 20090701

Title: [Anti-aging drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20090701

Title: Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES).

Journal: Epilepsia 20090601

Title: [Case report of dentatorubral pallidoluysian atrophy in a patient on a ketogenic diet].

Journal: Masui. The Japanese journal of anesthesiology 20090601

Title: Antiepileptic drug monotherapy: the initial approach in epilepsy management.

Journal: Current neuropharmacology 20090601

Title: Truly 'rational' polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects.

Journal: Current neuropharmacology 20090601

Title: New antiepileptic drugs: molecular targets.

Journal: Central nervous system agents in medicinal chemistry 20090601

Title: Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges.

Journal: Neuroscience 20090505

Title: Frontal-onset absences in children: associated with worse outcome? A replication study.

Journal: Seizure 20090501

Title: Infantile spasms and Down syndrome: a new animal model.

Journal: Pediatric research 20090501

Title: Effects of antiepileptics on lateral geniculate nucleus-kindled seizures in rats.

Journal: Journal of pharmacological sciences 20090401

Title: Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009.

Journal: Epilepsia 20090301

Title: The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice.

Journal: Circulation research 20090227

Title: Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels.

Journal: Neuropharmacology 20090201

Title: Dose adjustment of phenytoin for comedication in Japanese patients with epilepsy.

Journal: Therapeutic drug monitoring 20090201

Title: Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography.

Journal: Expert opinion on drug metabolism & toxicology 20090201

Title: Reversal of pentylenetetrazole-induced seizure activity in mice by nickel chloride.

Journal: Indian journal of pharmacology 20090201

Title: Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.

Journal: European journal of medicinal chemistry 20090101

Title: Successful treatment of intractable post-ictal psychosis with adjunctive ethosuximide.

Journal: Seizure 20090101

Title: A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs.

Journal: BMC systems biology 20090101

Title: Managing epilepsy in women of childbearing age.

Journal: Drug safety 20090101

Title: Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice.

Journal: Pharmacological reports : PR 20090101

Title: Psychopharmacology of ADHD in pediatrics: current advances and issues.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Causal hierarchy within the thalamo-cortical network in spike and wave discharges.

Journal: PloS one 20090101

Title: In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence.

Journal: PloS one 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?

Journal: Frontiers in behavioral neuroscience 20090101

Title: Neuroprotective effects of blockers for T-type calcium channels.

Journal: Molecular neurodegeneration 20090101

Title: Drug-induced hematologic syndromes.

Journal: Advances in hematology 20090101

Title: [Anticonvulsants as bioantioxidants under stress conditions].

Journal: Biomeditsinskaia khimiia 20090101

Title: Social phobia following maprotiline: the first case report.

Journal: Cases journal 20090101

Title: Anticonvulsant Activity of Argyreia speciosa in Mice.

Journal: Indian journal of pharmaceutical sciences 20090101

Title: Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents.

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20090101

Title: Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.

Journal: European journal of medicinal chemistry 20081201

Title: Lamotrigine monotherapy for newly diagnosed typical absence seizures in children.

Journal: Epilepsy research 20081201

Title: Treatment of Lennox-Gastaut syndrome: overview and recent findings.

Journal: Neuropsychiatric disease and treatment 20081201

Title: Pregabalin for the management of partial epilepsy.

Journal: Neuropsychiatric disease and treatment 20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081112

Title: Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20081101

Title: Television-provoked epilepsy in children: a follow-up survey from Isfahan, Iran.

Journal: Archives of Iranian medicine 20081101

Title: Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.

Journal: Journal of medicinal chemistry 20081023

Title: The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan.

Journal: PLoS genetics 20081001

Title: CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones.

Journal: European journal of medicinal chemistry 20080901

Title: Cognitive effects of antiepileptic drugs.

Journal: Journal of clinical neurology (Seoul, Korea) 20080901

Title: Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy.

Journal: Epilepsy & behavior : E&B 20080801

Title: Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice.

Journal: Journal of pharmacological sciences 20080801

Title: Drug interactions between chemotherapeutic regimens and antiepileptics.

Journal: Clinical therapeutics 20080801

Title: The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.

Journal: Epilepsia 20080701

Title: Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4.

Journal: Human molecular genetics 20080615

Title: Valproic acid extends Caenorhabditis elegans lifespan.

Journal: Aging cell 20080601

Title: The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.

Journal: Epilepsy research 20080501

Title: Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones.

Journal: Bioorganic & medicinal chemistry 20080501

Title: Early treatment suppresses the development of spike-wave epilepsy in a rat model.

Journal: Epilepsia 20080301

Title: Varied effects of conventional antiepileptics on responding maintained by negative versus positive reinforcement.

Journal: Physiology & behavior 20080227

Title: Inhibition of human aromatase complex (CYP19) by antiepileptic drugs.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080201

Title: Characterization of non-linear relationship between total and unbound serum concentrations of valproic acid in epileptic children.

Journal: Journal of clinical pharmacy and therapeutics 20080201

Title: Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis.

Journal: PLoS biology 20080201

Title: Monotherapy for partial epilepsy: focus on levetiracetam.

Journal: Neuropsychiatric disease and treatment 20080201

Title: Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones.

Journal: European journal of medicinal chemistry 20080101

Title: Childhood absence epilepsy with clinically apparent genetic and acquired burdens: a diagnostic consideration.

Journal: Journal of child neurology 20080101

Title: Effects of various antiepileptics on behavioral and electroencephalographic seizures induced by maximal electroshock in mice.

Journal: Journal of pharmacological sciences 20080101

Title: Absence seizures in children.

Journal: BMJ clinical evidence 20080101

Title: Iron-induced experimental cortical seizures: electroencephalographic mapping of seizure spread in the subcortical brain areas.

Journal: Seizure 20071201

Title: Treatment of pediatric epilepsy: European expert opinion, 2007.

Journal: Epileptic disorders : international epilepsy journal with videotape 20071201

Title: Cannabinoids in health and disease.

Journal: Dialogues in clinical neuroscience 20071201

Title: Hydrogen sulfide as a novel nociceptive messenger.

Journal: Pain 20071101

Title: Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice.

Journal: Seizure 20071001

Title: Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety.

Journal: Neuropharmacology 20071001

Title: Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis.

Journal: Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 20071001

Title: Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915

Title: Current treatment of myoclonic astatic epilepsy: clinical experience at the Children's Hospital of Philadelphia.

Journal: Epilepsia 20070901

Title: T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy.

Journal: Neuropharmacology 20070901

Title: Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Beneficial effects of antiepileptic medication on absence seizures and cognitive functioning in children.

Journal: Epilepsy & behavior : E&B 20070801

Title: Thalidomide inhibits pentylenetetrazole-induced seizures.

Journal: Journal of the neurological sciences 20070715

Title: Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice.

Journal: Epilepsy research 20070701

Title: Complex seizure disorder caused by Brunol4 deficiency in mice.

Journal: PLoS genetics 20070701

Title: Absence epilepsy in childhood: electroencephalography (EEG) does not predict outcome.

Journal: Journal of child neurology 20070701

Title: Juvenile myoclonic epilepsy: a benign disorder? Personality traits and psychiatric symptoms.

Journal: Epilepsy & behavior : E&B 20070601

Title: Antiepileptic drugs and visual function.

Journal: Pediatric neurology 20070601

Title: Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.

Journal: Journal of medicinal chemistry 20070517

Title: A novel high sensitivity HPLC assay for topiramate, using 4-chloro-7-nitrobenzofurazan as pre-column fluorescence derivatizing agent.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Title: Transgenic mice over-expressing GABA(B)R1a receptors acquire an atypical absence epilepsy-like phenotype.

Journal: Neurobiology of disease 20070501

Title: Effects of certain antiepileptics on behavioral and electromyographic seizure patterns induced by maximal electroshock in mice.

Journal: Journal of pharmacological sciences 20070501

Title: Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss.

Journal: Hearing research 20070401

Title: Is ethosuximide a risk factor for generalised tonic-clonic seizures in absence epilepsy?

Journal: Neuropediatrics 20070401

Title: Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.

Journal: European journal of pharmacology 20070322

Title: Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.

Journal: Experimental brain research 20070301

Title: Yale University School of Medicine: 2007 student thesis abstracts.

Journal: The Yale journal of biology and medicine 20070301

Title: The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures.

Journal: Brain research 20070216

Title: Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.

Journal: European journal of medicinal chemistry 20070201

Title: Effect of antiepileptic drugs on spontaneous seizures in epileptic rats.

Journal: Epilepsy research 20070201

Title: Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test.

Journal: Behavioural pharmacology 20070201

Title: Genetic and pharmacological factors that influence reproductive aging in nematodes.

Journal: PLoS genetics 20070201

Title: Sleep-related epilepsy in the A/J mouse.

Journal: Sleep 20070201

Title: Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy).

Journal: Neuropsychiatric disease and treatment 20070201

Title: Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers.

Journal: The Journal of physiology 20070101

Title: 7-12 Hz high-voltage rhythmic spike discharges in rats evaluated by antiepileptic drugs and flicker stimulation.

Journal: Journal of neurophysiology 20070101

Title: Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain.

Journal: Bioorganic & medicinal chemistry letters 20070101

Title: Redrawing Papez' circuit: a theory about how acute stress becomes chronic and causes disease.

Journal: Medical hypotheses 20070101

Title: Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress.

Journal: Medical hypotheses 20070101

Title: Arthritis and pain. Future targets to control osteoarthritis pain.

Journal: Arthritis research & therapy 20070101

Title: Negative effects of antiepileptic drugs on mood in patients with epilepsy.

Journal: Drug safety 20070101

Title: Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat.

Journal: BMC neuroscience 20070101

Title: Ethosuximide: from bench to bedside.

Journal: CNS drug reviews 20070101

Title: Glutamatergic alterations in the cortex of genetic absence epilepsy rats.

Journal: BMC neuroscience 20070101

Title: Response of spinal myoclonus to a combination therapy of autogenic training and biofeedback.

Journal: BioPsychoSocial medicine 20070101

Title: The effects of chronic administration of ethosuximide on learning and memory: a behavioral and biochemical study on nonepileptic rats.

Journal: Behavioural pharmacology 20061101

Title: Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze.

Journal: Behavioural pharmacology 20061101

Title: Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.

Journal: Epilepsia 20061101

Title: Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans.

Journal: Experimental gerontology 20061001

Title: Coexistence of idiopathic rolandic epilepsy and CSWS in two families.

Journal: Epilepsia 20061001

Title: Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20060901

Title: Levetiracetam-induced myoclonic status epilepticus in myoclonic-astatic epilepsy: a case report.

Journal: Epileptic disorders : international epilepsy journal with videotape 20060901

Title: Differences between prescribed daily doses and defined daily doses of antiepileptics--therapeutic drug monitoring as a marker of the quality of the treatment.

Journal: International journal of clinical pharmacology and therapeutics 20060901

Title: Zonisamide - a review of experience and use in partial seizures.

Journal: Neuropsychiatric disease and treatment 20060901

Title: Diagnostic issues and treatment of cryptogenic or symptomatic generalized epilepsies.

Journal: Epilepsy research 20060801

Title: GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures.

Journal: European journal of pharmacology 20060710

Title: Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice.

Journal: Journal of ethnopharmacology 20060630

Title: Early-onset absence epilepsy: clinical and electroencephalographic features in three children.

Journal: Brain & development 20060601

Title: Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders.

Journal: Brain & development 20060601

Title: Limited P-glycoprotein mediated efflux for anti-epileptic drugs.

Journal: Journal of drug targeting 20060601

Title: Yale University School of Medicine: 2006 student thesis abstracts.

Journal: The Yale journal of biology and medicine 20060601

Title: Effects of anticonvulsant drugs on life span.

Journal: Archives of neurology 20060401

Title: Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures.

Journal: Epilepsia 20060401

Title: Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents.

Journal: Epilepsia 20060301

Title: The effects of ethosuximide on amino acids in genetic absence epilepsy rat model.

Journal: Journal of pharmacological sciences 20060301

Title: Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro.

Journal: Neuropharmacology 20060101

Title: Influence of cimetidine on the anticonvulsant activity of conventional antiepileptic drugs against pentetrazole-induced seizures in mice.

Journal: Pharmacological reports : PR 20060101

Title: Valproate as a mainstay of therapy for pediatric epilepsy.

Journal: Paediatric drugs 20060101

Title: [Carbamazepine-induced systemic lupus erythematosus--a case report].

Journal: Neurologia i neurochirurgia polska 20060101

Title: Effects of calcium channel blockers on the spermatogenesis and gene expression in peripubertal mouse testis.

Journal: Archives of andrology 20060101

Title: Role of valproate across the ages. Treatment of epilepsy in children.

Journal: Acta neurologica Scandinavica. Supplementum 20060101

Title: Epilepsy with myoclonic absences.

Journal: CNS drugs 20060101

Title: Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice.

Journal: Pharmacological reports : PR 20060101

Title: Anticonvulsant and antidepressant activity of the selected terpene GABA derivatives in experimental tests in mice.

Journal: Pharmacological reports : PR 20060101

Title: Negative myoclonus. An overview of its clinical features, pathophysiological mechanisms, and management.

Journal: Neurophysiologie clinique = Clinical neurophysiology 20060101

Title: Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.

Journal: Epilepsy & behavior : E&B 20051201

Title: Neostigmine, but not metoclopramide, abolishes ethosuximide-induced functional gastrointestinal disturbances.

Journal: Pharmacology 20051201

Title: Photic-induced sensitization: acquisition of an augmenting spike-wave response in the adult rat through repeated strobe exposure.

Journal: Journal of neurophysiology 20051201

Title: Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome.

Journal: Epilepsia 20051201

Title: Gender aspects of pharmacokinetics of new and old AEDs: pregnancy and breast-feeding.

Journal: Therapeutic drug monitoring 20051201

Title: Treatment of pediatric epilepsy: expert opinion, 2005.

Journal: Journal of child neurology 20051201

Title: Role of a novel maintained low-voltage-activated inward current permeable to sodium and calcium in pacemaking of insect neurosecretory neurons.

Journal: Invertebrate neuroscience : IN 20051101

Title: Drug induced pseudolymphoma secondary to ethosuximide.

Journal: Journal of neurology, neurosurgery, and psychiatry 20051101

Title: Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Journal: The Cochrane database of systematic reviews 20051019

Title: The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.

Journal: European journal of pharmacology 20051003

Title: Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats.

Journal: Brain research 20050928

Title: Estimation of pK(a) values using microchip capillary electrophoresis and indirect fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

Title: Chiral aspects of the human metabolism of ethosuximide.

Journal: Biopharmaceutics & drug disposition 20050901

Title: Treatment of epilepsy in adults: expert opinion, 2005.

Journal: Epilepsy & behavior : E&B 20050901

Title: Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Journal: Journal of pharmaceutical sciences 20050701

Title: GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior.

Journal: Brain research. Developmental brain research 20050630

Title: Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats.

Journal: Neuropharmacology 20050601

Title: Motor impairment on awakening in a patient with an EEG pattern of 'unilateral, continuous spikes and waves during slow sleep'.

Journal: Epileptic disorders : international epilepsy journal with videotape 20050601

Title: Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats.

Journal: Epilepsia 20050601

Title: Voltage-dependent calcium channels.

Journal: General physiology and biophysics 20050601

Title: Antiepileptic drug monotherapy: pediatric concerns.

Journal: Seminars in pediatric neurology 20050601

Title: Absence seizures in children.

Journal: Clinical evidence 20050601

Title: Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050501

Title: Epilepsy with myoclonic absences.

Journal: Brain & development 20050401

Title: Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050330

Title: A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine.

Journal: Seizure 20050301

Title: Effect of antiepileptic drug polytherapy on crystalluria.

Journal: Pediatric neurology 20050201

Title: Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography.

Journal: Electrophoresis 20050201

Title: [Antiepileptic drugs in the treatment of autistic regression syndromes].

Journal: Revista de neurologia 20050115

Title: Anticonvulsant medications extend worm life-span.

Journal: Science (New York, N.Y.) 20050114

Title: Mechanisms of action of antiepileptic drugs.

Journal: Current topics in medicinal chemistry 20050101

Title: Voltage gated ion channels: targets for anticonvulsant drugs.

Journal: Current topics in medicinal chemistry 20050101

Title: A magnetoencephalographic study of negative myoclonus in a patient with atypical benign partial epilepsy.

Journal: Seizure 20050101

Title: [Electroencephalography in status epilepticus in sleep (ESES) in various clinical pictures].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20050101

Title: Bupropion-induced convulsions: preclinical evaluation of antiepileptic drugs.

Journal: Epilepsy research 20050101

Title: A chronic dysfunctional stress response can cause stroke by stimulating platelet activation, migraine, and hypertension.

Journal: Medical hypotheses 20050101

Title: Ion channels and epilepsy.

Journal: Current pharmaceutical design 20050101

Title: Influence of the antagonist of the glycine site of NMDA receptors, MRZ 2/576, on the anticonvulsant activity of conventional antiepileptic drugs in mice.

Journal: Pharmacological reports : PR 20050101

Title: Photosensitivity in idiopathic generalized epilepsies.

Journal: Epilepsia 20050101

Title: Best practice guidelines for the management of women with epilepsy.

Journal: Epilepsia 20050101

Title: Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies.

Journal: Epilepsia 20050101

Title: Evidence-based treatment of idiopathic generalized epilepsies with older antiepileptic drugs.

Journal: Epilepsia 20050101

Title: Management of Landau-Kleffner syndrome.

Journal: Paediatric drugs 20050101

Title: Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice.

Journal: Toxicology letters 20041201

Title: Learning and memory impairment in rats with chronic atypical absence seizures.

Journal: Experimental neurology 20041201

Title: Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.

Journal: Biological & pharmaceutical bulletin 20041201

Title: Effects of antiepileptic drugs on working memory as assessed by spatial alternation performance in rats.

Journal: Epilepsy & behavior : E&B 20041201

Title: Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels.

Journal: Epilepsy & behavior : E&B 20041201

Title: [Childhood and juvenile absence epilepsy. Treatment and prognosis].

Journal: Ugeskrift for laeger 20041108

Title: Fracture risk associated with use of antiepileptic drugs.

Journal: Epilepsia 20041101

Title: Refractory atypical absence seizures in rat: a two hit model.

Journal: Epilepsy research 20041101

Title: Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy.

Journal: Pharmacology, biochemistry, and behavior 20041101

Title: Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.

Journal: The Journal of pharmacology and experimental therapeutics 20041001

Title: Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines.

Journal: The Lancet. Neurology 20041001

Title: Simple and rapid micellar electrokinetic capillary chromatographic method for simultaneous determination of four antiepileptics in human serum.

Journal: Biomedical chromatography : BMC 20041001

Title: Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.

Journal: Epilepsia 20041001

Title: fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation.

Journal: Epilepsia 20041001

Title: Uptake of GABA and activity of GABA transaminase in blood platelets from children with absence epilepsy.

Journal: Neurochemical research 20041001

Title: PXR and the regulation of apoA1 and HDL-cholesterol in rodents.

Journal: Pharmacological research 20040901

Title: [Long-term follow-up of a case of eyelid myoclonia with absences].

Journal: No to hattatsu = Brain and development 20040901

Title: [Anticonvulsant hypersensitivity syndrome].

Journal: Orvosi hetilap 20040808

Title: Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040801

Title: Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models.

Journal: Seizure 20040701

Title: The activity of antiepileptic drugs as histone deacetylase inhibitors.

Journal: Epilepsia 20040701

Title: Absence seizures in children.

Journal: Clinical evidence 20040601

Title: Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy.

Journal: Pain 20040501

Title: Is the persistent sodium current a specific target of anti-absence drugs?

Journal: Neuroreport 20040429

Title: Pharmacology of recombinant low-voltage activated calcium channels.

Journal: Current drug targets. CNS and neurological disorders 20040401

Title: Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants.

Journal: Journal of neurobiology 20040301

Title: Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity?

Journal: Journal of neurophysiology 20040101

Title: Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats.

Journal: The Journal of pharmacology and experimental therapeutics 20040101

Title: Cortical-area specific block of genetically determined absence seizures by ethosuximide.

Journal: Neuroscience 20040101

Title: [Idiopathic epilepsies: some therapeutic aspects].

Journal: Revista de neurologia 20040101

Title: Speech and language deterioration in benign rolandic epilepsy.

Journal: Journal of child neurology 20040101

Title: Riluzole enhances the anti-seizure action of conventional antiepileptic drugs against pentetrazole-induced convulsions in mice.

Journal: Polish journal of pharmacology 20040101

Title: Effects of the combination of valproate and ethosuximide on spike wave discharges in WAG/Rij rats.

Journal: Epilepsy research 20040101

Title: Hippocampal afterdischarges in rats. I. Effects of antiepileptics.

Journal: Physiological research 20040101

Title: Therapeutic drug monitoring of old and newer anti-epileptic drugs.

Journal: Clinical chemistry and laboratory medicine 20040101

Title: When breastfeeding mothers need CNS-acting drugs.

Journal: The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20040101

Title: Diagnosis and treatment of epilepsy.

Journal: Epilepsia 20040101

Title: Assessment of anticonvulsant effectiveness and safety in patients with Angelman's syndrome using an Internet questionnaire.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031215

Title: Absence seizures in children.

Journal: Clinical evidence 20031201

Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

Journal: British journal of cancer 20031117

Title: Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro.

Journal: Epilepsia 20031101

Title: Ethosuximide induced agranulocytosis.

Journal: Brain & development 20031001

Title: Absence seizures in patients with localization-related epilepsy.

Journal: Brain & development 20030901

Title: Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats.

Journal: British journal of pharmacology 20030901

Title: Reversal of experimental neuropathic pain by T-type calcium channel blockers.

Journal: Pain 20030901

Title: Effects of Cyperus articulatus compared to effects of anticonvulsant compounds on the cortical wedge.

Journal: Journal of ethnopharmacology 20030701

Title: Epilepsy.

Journal: Disease-a-month : DM 20030701

Title: Thermal and rheological study of lipophilic ethosuximide suppositories.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030601

Title: Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy.

Journal: Epilepsia 20030501

Title: Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy.

Journal: Epilepsy research 20030501

Title: Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030301

Title: Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.

Journal: Neuroscience letters 20030102

Title: Effects of concomitant antiepileptic drugs on serum carbamazepine concentration in epileptic patients: quantitative analysis based on extracellular water volume as a transforming factor.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030101

Title: Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Journal: The Cochrane database of systematic reviews 20030101

Title: Clinical trials for treatment of primary generalized epilepsies.

Journal: Epilepsia 20030101

Title: Influence of vigabatrin, a novel antiepileptic drug, on the anticonvulsant activity of conventional antiepileptics in pentetrazole-induced seizures in mice.

Journal: Polish journal of pharmacology 20030101

Title: Angelman syndrome: etiology, clinical features, diagnosis, and management of symptoms.

Journal: Paediatric drugs 20030101

Title: Some antiepileptic compounds impair learning by rats in a Morris water maze.

Journal: Integrative physiological and behavioral science : the official journal of the Pavlovian Society 20030101

Title: Influence of SIB 1893, a selective mGluR5 receptor antagonist, on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy.

Journal: Polish journal of pharmacology 20030101

Title: [Modulating effect of anticonvulsive agents on Ca2+ dependent membrane fusion in cell-free model of neurosecretion].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

Title: Characteristics of flurothyl-induced seizures and the effect of antiepileptic drugs on flurothyl-induced seizures in Mongolian gerbils.

Journal: Pharmacology, biochemistry, and behavior 20021201

Title: Absence seizures in children.

Journal: Clinical evidence 20021201

Title: Primary standardization of assays for anticonvulsant drugs: comparison of accuracy and precision.

Journal: Clinical chemistry 20021101

Title: Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide.

Journal: Experimental brain research 20021001

Title: Does lamotrigine influence valproate concentrations?

Journal: Therapeutic drug monitoring 20021001

Title: T-channel-like pharmacological properties of high voltage-activated, nifedipine-insensitive Ca2+ currents in the rat terminal mesenteric artery.

Journal: British journal of pharmacology 20021001

Title: Early-onset absence epilepsy and paroxysmal dyskinesia.

Journal: Epilepsia 20021001

Title: Idiopathic generalised epilepsies with 3 Hz and faster spike wave discharges: a population-based study with evaluation and long-term follow-up in 71 patients.

Journal: Epileptic disorders : international epilepsy journal with videotape 20020901

Title: Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.

Journal: European journal of pharmacology 20020802

Title: Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.

Journal: Epilepsy research 20020801

Title: The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents.

Journal: British journal of pharmacology 20020701

Title: Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.

Journal: The Journal of pharmacy and pharmacology 20020701

Title: A sensitive gas chromatographic/mass spectrometric method for the resolution and quantification of ethosuximide enantiomers in biological fluids.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020605

Title: Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats.

Journal: Investigative ophthalmology & visual science 20020601

Title: Anti-epileptic drugs.

Journal: Journal of the Indian Medical Association 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020401

Title: Effect of some antiepileptic drugs on brain histaminergic systems in the rat.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

Title: Some common issues in the use of antiepileptic drugs.

Journal: Seminars in neurology 20020301

Title: Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices.

Journal: Brain research 20020104

Title: Anticonvulsants: aspects of their mechanisms of action.

Journal: European journal of pain (London, England) 20020101

Title: Interactions between antiepileptic drugs and hormonal contraception.

Journal: CNS drugs 20020101

Title: Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations.

Journal: Clinical pharmacokinetics 20020101

Title: Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity.

Journal: Molecular psychiatry 20020101

Title: Suggestion for another anti-epileptic drug to use for migraine prophylaxis.

Journal: Headache 20020101

Title: [Childhood absence epilepsy(pyknolepsy)].

Journal: Ryoikibetsu shokogun shirizu 20020101

Title: [Juvenile absence epilepsy(JAE)].

Journal: Ryoikibetsu shokogun shirizu 20020101

Title: [Epilepsy with myoclonic absences].

Journal: Ryoikibetsu shokogun shirizu 20020101

Title: [Epilepsy with continuous spikes and waves during slow sleep].

Journal: Ryoikibetsu shokogun shirizu 20020101

Title: Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy.

Journal: Epilepsy research 20011201

Title: Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.

Journal: Molecular pharmacology 20011101

Title: High-dose ethosuximide for epilepsy in Angelman syndrome: implication of GABA(A) receptor subunit.

Journal: Neurology 20011023

Title: Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced 'epilepsy'.

Journal: Stroke 20011001

Title: Possible induction of systemic lupus erythematosus by zonisamide.

Journal: Pediatric neurology 20011001

Title: Interaction of flunarizine with sodium valproate or ethosuximide in gamahydroxybutyrate induced absence seizures in rats.

Journal: Indian journal of experimental biology 20011001

Title: Lorazepam: an adjuvant therapy in patients with seizure and heliotaxis.

Journal: Neurology India 20010901

Title: Atypical evolution in childhood epilepsy with occipital paroxysms (Panayiotopoulos type).

Journal: Epileptic disorders : international epilepsy journal with videotape 20010901

Title: Therapeutic drug monitoring of antiepileptics by capillary electrophoresis. Characterization of assays via analysis of quality control sera containing 14 analytes.

Journal: Journal of chromatography. A 20010727

Title: Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier.

Journal: European journal of pediatrics 20010501

Title: Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures.

Journal: Pharmacology, biochemistry, and behavior 20010401

Title: Quantification of urinary excretion of ethosuximide enantiomers and their major metabolites in the rat.

Journal: Biopharmaceutics & drug disposition 20010401

Title: Forced normalization induced by ethosuximide therapy in a patient with intractable myoclonic epilepsy.

Journal: Brain & development 20010301

Title: Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats.

Journal: European journal of pharmacology 20010301

Title: The pharmacokinetics of ethosuximide enantiomers in the rat.

Journal: Biopharmaceutics & drug disposition 20010301

Title: A model of atypical absence seizures: EEG, pharmacology, and developmental characterization.

Journal: Neurology 20010213

Title: [Use of lamotrigine in the treatment of absence epilepsy crises].

Journal: Revista de neurologia 20010201

Title: Repeated administration of CGP 46381, a gamma-aminobutyric acidB antagonist, and ethosuximide suppresses seizure-associated cyclic adenosine 3'5' monophosphate response element- and activator protein-1 DNA-binding activities in lethargic (lh/lh) mice.

Journal: Neuroscience letters 20010119

Title: Time-related configuration change in benign focal epileptiform discharges of childhood: from a dipole to a negative monopole in a patient with generalized epilepsy.

Journal: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 20010101

Title: Effect of positively and negatively charged liposomes on skin permeation of drugs.

Journal: Journal of drug targeting 20010101

Title: Treatment of typical absence seizures and related epileptic syndromes.

Journal: Paediatric drugs 20010101

Title: Inhibition by anticonvulsants of prostate-specific antigen and interleukin-6 secretion by human prostate cancer cells.

Journal: Anticancer research 20010101

Title: The management of refractory idiopathic epilepsies.

Journal: Epilepsia 20010101

Title: [Hormonal contraception and epilepsy].

Journal: Akusherstvo i ginekologiia 20010101

Title: Ethosuximide induced lymphadenopathy--a case report.

Journal: The Central African journal of medicine 20010101

Title: Ethosuximide-associated lupus with cerebral and renal manifestations.

Journal: European journal of pediatrics 19980901

Title: Inappropriate use of carbamazepine and vigabatrin in typical absence seizures.

Journal: Developmental medicine and child neurology 19980801

Title: Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring.

Journal: Cancer causes & control : CCC 19970501

Title: Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.

Journal: The International journal of neuroscience 19961101

Title: Ethosuximide-induced lupus-like syndrome with renal involvement.

Journal: Internal medicine (Tokyo, Japan) 19960701

Title: Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.

Journal: Journal of pharmacological and toxicological methods 19960201

Title: Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.

Journal: The Journal of pharmacology and experimental therapeutics 19950901

Title: Aplastic anemia following therapy for absence seizures with ethosuximide.

Journal: Pediatric neurology 19940701

Title: Absence seizures and carbamazepine in adults.

Journal: Epilepsia 19940101

Title: Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.

Journal: Pharmacology, biochemistry, and behavior 19930401

Title: Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons.

Journal: Neuroscience 19921201

Title: Ethosuximide and tremor in Parkinson's disease: a pilot study.

Journal: Movement disorders : official journal of the Movement Disorder Society 19920101

Title: Effect of ethosuximide on rest tremor in the MPTP monkey model.

Journal: Movement disorders : official journal of the Movement Disorder Society 19920101

Title: In vivo evidence that ethosuximide is a substrate for cytochrome P450IIIA.

Journal: Pharmacology 19920101

Title: Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.

Journal: British journal of pharmacology 19900801

Title: Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio.

Journal: The Journal of pharmacology and experimental therapeutics 19900401

Title: Synthesis and anticonvulsant activity of 2-benzylglutarimides.

Journal: Journal of medicinal chemistry 19900301

Title: Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.

Journal: Journal of medicinal chemistry 19900101

Title: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons.

Journal: Annals of neurology 19890601

Title: Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons.

Journal: Neuroscience letters 19890313

Title: Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone.

Journal: Epilepsia 19890101

Title: Episodic barrel rotations induced by intrastriatal injection of quinolinic acid in rats. Inhibition by anticonvulsants.

Journal: Pharmacology, biochemistry, and behavior 19880901

Title: Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat.

Journal: Epilepsia 19880101

Title: Only certain antiepileptic drugs prevent seizures induced by pilocarpine.

Journal: Brain research 19870701

Title: Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions.

Journal: Brain research 19870407

Title: Use of ethosuximide and valproate in the treatment of epilepsy.

Journal: Neurologic clinics 19860801

Title: Phenytoin-induced benign intracranial hypertension.

Journal: Neurology 19860301

Title: Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats.

Journal: Epilepsia 19860101

Title: Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.

Journal: Arzneimittel-Forschung 19850101

Title: A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures.

Journal: Epilepsia 19840601

Title: Aplastic anemia during ethosuximide medication. Treatment with bolus-methylprednisolone.

Journal: Acta paediatrica Scandinavica 19831101

Title: Ethosuximide-induced liver dysfunction.

Journal: Archives of neurology 19830601

Title: Anticonvulsant sensitivity of absence seizures in the tottering mutant mouse.

Journal: Epilepsia 19830201

Title: Carbamazepine-induced choreoathetoid dyskinesias.

Journal: Journal of neurology, neurosurgery, and psychiatry 19820601

Title: A case of petit mal epilepsy aggravated by lithium.

Journal: The American journal of psychiatry 19810501

Title: Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.

Journal: Science (New York, N.Y.) 19801128

Title: Dyskinesia and akathisia induced by ethosuximide.

Journal: American journal of diseases of children (1960) 19780501

Title: Nephrotic syndrome associated with ethosuccimide.

Journal: American journal of diseases of children (1960) 19780101

Title: [Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy].

Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) 19770101

Title: Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits.

Journal: Research communications in chemical pathology and pharmacology 19770101

Title: Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.

Journal: The Journal of pediatrics 19760801

Title: Di-n-propylacetic acid--profile of anticonvulsant activity in mice.

Journal: Arzneimittel-Forschung 19760201

Title: Lupus-scleroderma syndrome induced by ethosuximide.

Journal: Archives of disease in childhood 19750801

Title: Serum clonazepam concentrations in children with absence seizures.

Journal: Neurology 19750301

Title: Dyskinesia-an unusual reaction to ethosuximide.

Journal: Archives of neurology 19750201

Title: Movement disorder as a manifestation of diphenylhydantoin toxicity.

Journal: Pediatrics 19740901

Title: Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.

Journal: Neurology 19740501

Title: Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.

Journal: Lancet (London, England) 19731117

Title: Pseudodegenerative disease due to diphenylhydantoin intoxication.

Journal: Archives of neurology 19691201

Title: Treatment of generalized epilepsy with acrisuxine.

Journal: Confinia neurologica 19690101

Title: Phenytoin (Dilantin) intoxication.

Journal: Acta neurologica Scandinavica 19670101

Title: Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide.

Journal: Epilepsia 19630301

Title: Chen X, et al. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10:51.

Title: Sondossi K, et al. Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells. Fundam Clin Pharmacol. 2014 Oct;28(5):512-8.

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Tags:77-67-8 Molecular Formula|77-67-8 MDL|77-67-8 SMILES|77-67-8 Ethosuximide
Catalog No.: AA003PW2
77-67-8,MFCD00072123
77-67-8 | Ethosuximide
Pack Size: 1mg
Purity: 98%
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$6.00 $4.00
Pack Size: 250mg
Purity: 98%
in stock
$20.00 $14.00
Pack Size: 1g
Purity: 98%
in stock
$43.00 $30.00
Pack Size: 5g
Purity: >98.0%(GC)(T)
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$52.00 $36.00
Pack Size: 25g
Purity: >98.0%(GC)(T)
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$148.00 $104.00
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Technical Information
Catalog Number: AA003PW2
Chemical Name: Ethosuximide
CAS Number: 77-67-8
Molecular Formula: C7H11NO2
Molecular Weight: 141.1677
MDL Number: MFCD00072123
SMILES: CC1(CC)CC(=O)NC1=O
Properties
BP: 150 °C / 12mmHg  
Form: Solid  
MP: 51 °C  
Refractive Index: 1.5026 (estimate)  
Solubility: ethanol: 100 mg/mL  
Storage: Inert atmosphere;2-8℃;  
Complexity: 188  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 10  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.4  
Literature fold

Title: Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway.

Journal: The Journal of biological chemistry20151120

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology20150518

Title: Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs.

Journal: Reproductive toxicology (Elmsford, N.Y.)20141101

Title: Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20121203

Title: Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring.

Journal: Biomedical chromatography : BMC20121201

Title: Non-convulsive status epilepticus of frontal origin in mucopolysaccharidosis type II successfully treated with ethosuximide.

Journal: Developmental medicine and child neurology20121001

Title: Quantum dot nanoparticles affect the reproductive system of Caenorhabditis elegans.

Journal: Environmental toxicology and chemistry20121001

Title: Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome.

Journal: Neuroscience20120918

Title: Synthesis and anticonvulsant properties of new mannich bases derived from 3,3-disubstituted pyrrolidine-2,5-diones. Part IV.

Journal: Archiv der Pharmazie20120901

Title: Randomised controlled monotherapy trials: which comparators to use?

Journal: Epileptic disorders : international epilepsy journal with videotape20120901

Title: A rat model for LGI1-related epilepsies.

Journal: Human molecular genetics20120815

Title: Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide.

Journal: Journal of controlled release : official journal of the Controlled Release Society20120810

Title: Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20120801

Title: Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II.

Journal: Bioorganic & medicinal chemistry20120801

Title: Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives.

Journal: European journal of medicinal chemistry20120801

Title: Does antiepileptogenesis affect sleep in genetic epileptic rats?

Journal: International journal of psychophysiology : official journal of the International Organization of Psychophysiology20120701

Title: Treatment of idiopathic generalized epilepsy - a review of the evidence.

Journal: Expert opinion on pharmacotherapy20120601

Title: Long-term effectiveness of ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.

Journal: Brain & development20120501

Title: 8p deletion and 9p duplication in two children with electrical status epilepticus in sleep syndrome.

Journal: Seizure20120501

Title: Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives.

Journal: Bioorganic & medicinal chemistry letters20120501

Title: Cognitive function of idiopathic childhood epilepsy.

Journal: Korean journal of pediatrics20120501

Title: Prevalence of treated epilepsy in Korea based on national health insurance data.

Journal: Journal of Korean medical science20120301

Title: T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.

Journal: Science translational medicine20120215

Title: Ethosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release.

Journal: Neuropharmacology20120201

Title: Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones.

Journal: European journal of medicinal chemistry20120201

Title: Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20120201

Title: Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain.

Journal: European journal of pharmacology20120115

Title: Ethosuximide and phenobarbital promote wound healing via enhancing collagenization.

Journal: Chemical biology & drug design20120101

Title: From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?

Journal: Pflugers Archiv : European journal of physiology20120101

Title: Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders.

Journal: Expert opinion on drug metabolism & toxicology20120101

Title: L type Ca²+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats.

Journal: Molecular pain20120101

Title: Clinical utility of adjunctive retigabine in partial onset seizures in adults.

Journal: Therapeutics and clinical risk management20120101

Title: Recent progress in anticonvulsant drug research: strategies for anticonvulsant drug development and applications of antiepileptic drugs for non-epileptic central nervous system disorders.

Journal: Current topics in medicinal chemistry20120101

Title: Evaluation of lercanidipine in Paclitaxel-induced neuropathic pain model in rat: a preliminary study.

Journal: Pain research and treatment20120101

Title: The adolescent or adult with generalized tonic-clonic seizures.

Journal: Annals of Indian Academy of Neurology20120101

Title: Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder.

Journal: Journal of pharmacology & pharmacotherapeutics20120101

Title: N- and L-type voltage-dependent Ca2+ channels contribute to the generation of after-discharges in the spinal ventral root after cessation of noxious mechanical stimulation.

Journal: Journal of pharmacological sciences20120101

Title: Synthesis, anticonvulsant activity and 5-HT1A/5-HT7 receptors affinity of 1-[(4-arylpiperazin-1-yl)-propyl]-succinimides.

Journal: Pharmacological reports : PR20120101

Title: The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation.

Journal: International journal of hepatology20120101

Title: Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions.

Journal: Prostaglandins, leukotrienes, and essential fatty acids20120101

Title: Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.

Journal: Annals of agricultural and environmental medicine : AAEM20120101

Title: [Therapeutic drug monitoring of ethosuximide].

Journal: Therapie20120101

Title: Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20111201

Title: Transition to absence seizures and the role of GABA(A) receptors.

Journal: Epilepsy research20111201

Title: Quantum mechanical and spectroscopic (FT-IR, FT-Raman, 13C, 1H and UV) investigations of antiepileptic drug Ethosuximide.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20111201

Title: Design, synthesis and antiepileptic properties of novel 1-(substituted benzylidene)-3-(1-(morpholino/piperidino methyl)-2,3-dioxoindolin-5-yl)urea derivatives.

Journal: European journal of medicinal chemistry20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Early-onset childhood absence epilepsy: is it a distinct entity?

Journal: Epileptic disorders : international epilepsy journal with videotape20111201

Title: Nitric oxide, epileptic seizures, and action of antiepileptic drugs.

Journal: CNS & neurological disorders drug targets20111101

Title: Generic substitution of antiepileptic drugs: a systematic review of prospective and retrospective studies.

Journal: The Annals of pharmacotherapy20111101

Title: Synthesis and anticonvulsant activity of new N-Mannich bases derived from 5-cyclopropyl-5-phenyl- and 5-cyclopropyl-5-(4-chlorophenyl)-imidazolidine-2,4-diones.

Journal: Bioorganic & medicinal chemistry20111015

Title: Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.

Journal: European journal of medicinal chemistry20111001

Title: Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.

Journal: Bioorganic & medicinal chemistry letters20111001

Title: Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism.

Journal: Journal of molecular medicine (Berlin, Germany)20110901

Title: Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs.

Journal: European journal of medicinal chemistry20110901

Title: The effects of ion channel blockers validate the conductance-based model of saccadic oscillations.

Journal: Annals of the New York Academy of Sciences20110901

Title: Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.

Journal: Neuroscience20110811

Title: Ethosuximide-induced mania in a 10-year-old boy.

Journal: Epilepsy & behavior : E&B20110801

Title: Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.

Journal: Epilepsia20110701

Title: Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges.

Journal: Epilepsia20110701

Title: Ethosuximide was superior to valproate and lamotrigine in controlling seizures and minimising side effects.

Journal: Archives of disease in childhood. Education and practice edition20110601

Title: Interictal paroxysmal EEG abnormalities in childhood absence epilepsy.

Journal: Seizure20110501

Title: Orphenadrine induces secondarily generalized convulsive status epilepticus in rats.

Journal: Brain research bulletin20110405

Title: Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy.

Journal: International journal of neural systems20110401

Title: Synthesis and anticonvulsant activity of new n-mannich bases derived from 5-cyclopropyl-5-phenyl-hydantoins.

Journal: Archiv der Pharmazie20110401

Title: Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures.

Journal: Neurobiology of disease20110201

Title: Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats.

Journal: Pharmacology, biochemistry, and behavior20110201

Title: Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency.

Journal: Journal of inherited metabolic disease20110201

Title: Long term outcome in children affected by absence epilepsy with onset before the age of three years.

Journal: Epilepsy & behavior : E&B20110201

Title: Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice.

Journal: Indian journal of pharmacology20110201

Title: Epilepsy with myoclonic absences - favourable response to add-on rufinamide treatment in 3 cases.

Journal: Neuropediatrics20110201

Title: An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.

Journal: Brain research20110131

Title: Effects of L- and T-type Ca²(+) channel blockers on spermatogenesis and steroidogenesis in the prepubertal mouse testis.

Journal: Journal of assisted reproduction and genetics20110101

Title: Association of antiepileptic drugs with nontraumatic fractures: a population-based analysis.

Journal: Archives of neurology20110101

Title: [Symptoms and clinical course of epilepsy with myoclonic absences].

Journal: No to hattatsu = Brain and development20110101

Title: Myoclonus.

Journal: Handbook of clinical neurology20110101

Title: Transcriptomic analysis in a Drosophila model identifies previously implicated and novel pathways in the therapeutic mechanism in neuropsychiatric disorders.

Journal: Frontiers in neuroscience20110101

Title: Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey.

Journal: BMC pediatrics20110101

Title: [Does antiabsence drug ethosuximide exert antidepressant effect?].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova20110101

Title: Experimental re-evaluation of flunarizine as add-on antiepileptic therapy.

Journal: Journal of pharmacy & bioallied sciences20110101

Title: Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis.

Journal: Reproductive biology and endocrinology : RB&E20110101

Title: Update on rufinamide in childhood epilepsy.

Journal: Neuropsychiatric disease and treatment20110101

Title: An integrative view of mechanisms underlying generalized spike-and-wave epileptic seizures and its implication on optimal therapeutic treatments.

Journal: PloS one20110101

Title: Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors.

Journal: Advances in pharmacological sciences20110101

Title: Severe myoclonic epilepsy of infancy (Dravet syndrome): Clinical and genetic features of nine Turkish patients.

Journal: Annals of Indian Academy of Neurology20110101

Title: Acute alterations of somatodendritic action potential dynamics in hippocampal CA1 pyramidal cells after kainate-induced status epilepticus in mice.

Journal: PloS one20110101

Title: Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands.

Journal: Molecular pain20110101

Title: Studies of properties of 'Pain Networks' as predictors of targets of stimulation for treatment of pain.

Journal: Frontiers in integrative neuroscience20110101

Title: Effect of Gentiana olivieri on experimental epilepsy models.

Journal: Pharmacognosy magazine20110101

Title: [Transitory cognitive dysfunction in rolandic epilepsy].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20110101

Title: [Idiopathic focal epilepsies of infancy and childhood].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20110101

Title: Screening of the anticonvulsant activity of some plants from Fabaceae family in experimental seizure models in mice.

Journal: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences20110101

Title: [Epilepsies with electric status epilepticus in sleep: peculiarities of clinical course and rational approaches to treatment].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals20101201

Title: Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives.

Journal: European journal of medicinal chemistry20101201

Title: Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status.

Journal: Epileptic disorders : international epilepsy journal with videotape20101201

Title: Atypical benign partial epilepsy: recognition can prevent pseudocatastrophe.

Journal: Pediatric neurology20101201

Title: 1-Benzyl-2,5-dioxopyrrolidine-3,4-diyl diacetate.

Journal: Acta crystallographica. Section E, Structure reports online20101201

Title: Use of antiepileptic drugs for hyperkinetic movement disorders.

Journal: Current neuropharmacology20101201

Title: 'Epileptic encephalopathy' of infancy and childhood: electro-clinical pictures and recent understandings.

Journal: Current neuropharmacology20101201

Title: T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.

Journal: Neuropharmacology20101101

Title: Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress.

Journal: Developmental medicine and child neurology20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Treatment initiation in epilepsy: an expert consensus in Spain.

Journal: Epilepsy & behavior : E&B20101101

Title: Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome.

Journal: Epilepsia20101001

Title: Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones.

Journal: European journal of medicinal chemistry20100901

Title: Antiepileptic drug interactions - principles and clinical implications.

Journal: Current neuropharmacology20100901

Title: Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins.

Journal: Bioorganic & medicinal chemistry20100815

Title: Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100804

Title: Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy.

Journal: Epilepsia20100801

Title: Epilepsy: old drugs do the trick in childhood absence epilepsy.

Journal: Nature reviews. Neurology20100801

Title: Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: one more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activity.

Journal: Bioorganic & medicinal chemistry letters20100715

Title: Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides.

Journal: European journal of medicinal chemistry20100701

Title: Gastaut type-idiopathic childhood occipital epilepsy and childhood absence epilepsy: a clinically significant association?

Journal: Seizure20100701

Title: In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein.

Journal: Life sciences20100605

Title: Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.

Journal: European journal of medicinal chemistry20100601

Title: Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20100601

Title: An older drug for childhood absence epilepsy.

Journal: The American journal of nursing20100601

Title: When the past challenges the present: are older antiepileptic drugs still the best choice in childhood absence epilepsy?

Journal: The Lancet. Neurology20100501

Title: Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening.

Journal: European journal of medicinal chemistry20100401

Title: [Specific language impairment and electroencephalogram: which recommendations in clinical practice? A cohort of 24 children].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie20100401

Title: Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.

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Title: Ethosuximide in childhood absence epilepsy--older and better.

Journal: The New England journal of medicine20100304

Title: Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS).

Journal: Epilepsy research20100301

Title: Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect.

Journal: Neuropharmacology20100301

Title: Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster.

Journal: Biogerontology20100201

Title: Pharmacological neuroprotection: that long, long road from idea to practice.

Journal: Korean journal of anesthesiology20100201

Title: The effects of gabapentin pretreatment on brain injury induced by focal cerebral ischemia/reperfusion in the rat.

Journal: Korean journal of anesthesiology20100201

Title: Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms.

Journal: Epilepsia20100101

Title: Effects of antiepileptics on behavioral and electroencephalographic seizure induced by pentetrazol in mice.

Journal: Journal of pharmacological sciences20100101

Title: Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor.

Journal: PloS one20100101

Title: Epilepsy in patients with Angelman syndrome.

Journal: Italian journal of pediatrics20100101

Title: Management of refractory complex partial seizures: current state of the art.

Journal: Neuropsychiatric disease and treatment20100101

Title: Quality of life in childhood epilepsy with lateralized epileptogenic foci.

Journal: BMC neurology20100101

Title: BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.

Journal: Molecular neurodegeneration20100101

Title: Molecular and therapeutic potential and toxicity of valproic acid.

Journal: Journal of biomedicine & biotechnology20100101

Title: Oxcarbazepine-induced tardive dyskinesia: A rare adverse reaction.

Journal: Journal of pediatric neurosciences20100101

Title: Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study.

Journal: BMJ (Clinical research ed.)20100101

Title: Advances in epilepsy: new perspectives on new-onset epilepsy, comorbidities, and pharmacotherapy.

Journal: F1000 medicine reports20100101

Title: Design and Synthesis of Some Novel 4-(4-substituted aryl) Semicarbazones as Anticonvulsant Agents.

Journal: Indian journal of pharmaceutical sciences20100101

Title: Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients.

Journal: Nutrition journal20100101

Title: [Absence epilepsy models in rodents].

Journal: Gaceta medica de Mexico20100101

Title: Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.

Journal: Clinical pharmacology : advances and applications20100101

Title: Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

Journal: Journal of medicinal chemistry20091210

Title: A flexible drug delivery chip for the magnetically-controlled release of anti-epileptic drugs.

Journal: Journal of controlled release : official journal of the Controlled Release Society20091103

Title: Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.

Journal: Seizure20091101

Title: Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice.

Journal: Diabetes20091101

Title: Acceleration of pentylenetetrazol seizure kindling associated with induction of sensitized visual responses evoked by strobe stimulation.

Journal: Neuroscience20091006

Title: Impact of antiepileptic drugs on cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy.

Journal: Epilepsy & behavior : E&B20091001

Title: Use of a new antiepileptic drug or an old one as first drug for treatment of absence epilepsy.

Journal: Epilepsia20090901

Title: Absence seizures: a review of recent reports with new concepts.

Journal: Epilepsy & behavior : E&B20090801

Title: Ethosuximide-induced de novo systemic lupus erythematosus with anti-double-strand DNA antibodies: a case report with definite evidence.

Journal: Epilepsia20090801

Title: Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years.

Journal: Epilepsia20090801

Title: Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model.

Journal: Epilepsia20090701

Title: [Anti-aging drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine20090701

Title: Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES).

Journal: Epilepsia20090601

Title: [Case report of dentatorubral pallidoluysian atrophy in a patient on a ketogenic diet].

Journal: Masui. The Japanese journal of anesthesiology20090601

Title: Antiepileptic drug monotherapy: the initial approach in epilepsy management.

Journal: Current neuropharmacology20090601

Title: Truly 'rational' polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects.

Journal: Current neuropharmacology20090601

Title: New antiepileptic drugs: molecular targets.

Journal: Central nervous system agents in medicinal chemistry20090601

Title: Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges.

Journal: Neuroscience20090505

Title: Frontal-onset absences in children: associated with worse outcome? A replication study.

Journal: Seizure20090501

Title: Infantile spasms and Down syndrome: a new animal model.

Journal: Pediatric research20090501

Title: Effects of antiepileptics on lateral geniculate nucleus-kindled seizures in rats.

Journal: Journal of pharmacological sciences20090401

Title: Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009.

Journal: Epilepsia20090301

Title: The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice.

Journal: Circulation research20090227

Title: Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels.

Journal: Neuropharmacology20090201

Title: Dose adjustment of phenytoin for comedication in Japanese patients with epilepsy.

Journal: Therapeutic drug monitoring20090201

Title: Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography.

Journal: Expert opinion on drug metabolism & toxicology20090201

Title: Reversal of pentylenetetrazole-induced seizure activity in mice by nickel chloride.

Journal: Indian journal of pharmacology20090201

Title: Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.

Journal: European journal of medicinal chemistry20090101

Title: Successful treatment of intractable post-ictal psychosis with adjunctive ethosuximide.

Journal: Seizure20090101

Title: A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs.

Journal: BMC systems biology20090101

Title: Managing epilepsy in women of childbearing age.

Journal: Drug safety20090101

Title: Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice.

Journal: Pharmacological reports : PR20090101

Title: Psychopharmacology of ADHD in pediatrics: current advances and issues.

Journal: Neuropsychiatric disease and treatment20090101

Title: Causal hierarchy within the thalamo-cortical network in spike and wave discharges.

Journal: PloS one20090101

Title: In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence.

Journal: PloS one20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one20090101

Title: Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?

Journal: Frontiers in behavioral neuroscience20090101

Title: Neuroprotective effects of blockers for T-type calcium channels.

Journal: Molecular neurodegeneration20090101

Title: Drug-induced hematologic syndromes.

Journal: Advances in hematology20090101

Title: [Anticonvulsants as bioantioxidants under stress conditions].

Journal: Biomeditsinskaia khimiia20090101

Title: Social phobia following maprotiline: the first case report.

Journal: Cases journal20090101

Title: Anticonvulsant Activity of Argyreia speciosa in Mice.

Journal: Indian journal of pharmaceutical sciences20090101

Title: Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents.

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM20090101

Title: Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.

Journal: European journal of medicinal chemistry20081201

Title: Lamotrigine monotherapy for newly diagnosed typical absence seizures in children.

Journal: Epilepsy research20081201

Title: Treatment of Lennox-Gastaut syndrome: overview and recent findings.

Journal: Neuropsychiatric disease and treatment20081201

Title: Pregabalin for the management of partial epilepsy.

Journal: Neuropsychiatric disease and treatment20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20081112

Title: Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20081101

Title: Television-provoked epilepsy in children: a follow-up survey from Isfahan, Iran.

Journal: Archives of Iranian medicine20081101

Title: Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.

Journal: Journal of medicinal chemistry20081023

Title: The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan.

Journal: PLoS genetics20081001

Title: CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones.

Journal: European journal of medicinal chemistry20080901

Title: Cognitive effects of antiepileptic drugs.

Journal: Journal of clinical neurology (Seoul, Korea)20080901

Title: Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy.

Journal: Epilepsy & behavior : E&B20080801

Title: Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice.

Journal: Journal of pharmacological sciences20080801

Title: Drug interactions between chemotherapeutic regimens and antiepileptics.

Journal: Clinical therapeutics20080801

Title: The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.

Journal: Epilepsia20080701

Title: Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4.

Journal: Human molecular genetics20080615

Title: Valproic acid extends Caenorhabditis elegans lifespan.

Journal: Aging cell20080601

Title: The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.

Journal: Epilepsy research20080501

Title: Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones.

Journal: Bioorganic & medicinal chemistry20080501

Title: Early treatment suppresses the development of spike-wave epilepsy in a rat model.

Journal: Epilepsia20080301

Title: Varied effects of conventional antiepileptics on responding maintained by negative versus positive reinforcement.

Journal: Physiology & behavior20080227

Title: Inhibition of human aromatase complex (CYP19) by antiepileptic drugs.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20080201

Title: Characterization of non-linear relationship between total and unbound serum concentrations of valproic acid in epileptic children.

Journal: Journal of clinical pharmacy and therapeutics20080201

Title: Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis.

Journal: PLoS biology20080201

Title: Monotherapy for partial epilepsy: focus on levetiracetam.

Journal: Neuropsychiatric disease and treatment20080201

Title: Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones.

Journal: European journal of medicinal chemistry20080101

Title: Childhood absence epilepsy with clinically apparent genetic and acquired burdens: a diagnostic consideration.

Journal: Journal of child neurology20080101

Title: Effects of various antiepileptics on behavioral and electroencephalographic seizures induced by maximal electroshock in mice.

Journal: Journal of pharmacological sciences20080101

Title: Absence seizures in children.

Journal: BMJ clinical evidence20080101

Title: Iron-induced experimental cortical seizures: electroencephalographic mapping of seizure spread in the subcortical brain areas.

Journal: Seizure20071201

Title: Treatment of pediatric epilepsy: European expert opinion, 2007.

Journal: Epileptic disorders : international epilepsy journal with videotape20071201

Title: Cannabinoids in health and disease.

Journal: Dialogues in clinical neuroscience20071201

Title: Hydrogen sulfide as a novel nociceptive messenger.

Journal: Pain20071101

Title: Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice.

Journal: Seizure20071001

Title: Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety.

Journal: Neuropharmacology20071001

Title: Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis.

Journal: Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie20071001

Title: Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070915

Title: Current treatment of myoclonic astatic epilepsy: clinical experience at the Children's Hospital of Philadelphia.

Journal: Epilepsia20070901

Title: T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy.

Journal: Neuropharmacology20070901

Title: Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury.

Journal: The Journal of pharmacology and experimental therapeutics20070801

Title: Beneficial effects of antiepileptic medication on absence seizures and cognitive functioning in children.

Journal: Epilepsy & behavior : E&B20070801

Title: Thalidomide inhibits pentylenetetrazole-induced seizures.

Journal: Journal of the neurological sciences20070715

Title: Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.

Journal: Bioorganic & medicinal chemistry letters20070701

Title: Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice.

Journal: Epilepsy research20070701

Title: Complex seizure disorder caused by Brunol4 deficiency in mice.

Journal: PLoS genetics20070701

Title: Absence epilepsy in childhood: electroencephalography (EEG) does not predict outcome.

Journal: Journal of child neurology20070701

Title: Juvenile myoclonic epilepsy: a benign disorder? Personality traits and psychiatric symptoms.

Journal: Epilepsy & behavior : E&B20070601

Title: Antiepileptic drugs and visual function.

Journal: Pediatric neurology20070601

Title: Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.

Journal: Journal of medicinal chemistry20070517

Title: A novel high sensitivity HPLC assay for topiramate, using 4-chloro-7-nitrobenzofurazan as pre-column fluorescence derivatizing agent.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070501

Title: Transgenic mice over-expressing GABA(B)R1a receptors acquire an atypical absence epilepsy-like phenotype.

Journal: Neurobiology of disease20070501

Title: Effects of certain antiepileptics on behavioral and electromyographic seizure patterns induced by maximal electroshock in mice.

Journal: Journal of pharmacological sciences20070501

Title: Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss.

Journal: Hearing research20070401

Title: Is ethosuximide a risk factor for generalised tonic-clonic seizures in absence epilepsy?

Journal: Neuropediatrics20070401

Title: Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.

Journal: European journal of pharmacology20070322

Title: Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.

Journal: Experimental brain research20070301

Title: Yale University School of Medicine: 2007 student thesis abstracts.

Journal: The Yale journal of biology and medicine20070301

Title: The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures.

Journal: Brain research20070216

Title: Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.

Journal: European journal of medicinal chemistry20070201

Title: Effect of antiepileptic drugs on spontaneous seizures in epileptic rats.

Journal: Epilepsy research20070201

Title: Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test.

Journal: Behavioural pharmacology20070201

Title: Genetic and pharmacological factors that influence reproductive aging in nematodes.

Journal: PLoS genetics20070201

Title: Sleep-related epilepsy in the A/J mouse.

Journal: Sleep20070201

Title: Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy).

Journal: Neuropsychiatric disease and treatment20070201

Title: Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers.

Journal: The Journal of physiology20070101

Title: 7-12 Hz high-voltage rhythmic spike discharges in rats evaluated by antiepileptic drugs and flicker stimulation.

Journal: Journal of neurophysiology20070101

Title: Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain.

Journal: Bioorganic & medicinal chemistry letters20070101

Title: Redrawing Papez' circuit: a theory about how acute stress becomes chronic and causes disease.

Journal: Medical hypotheses20070101

Title: Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress.

Journal: Medical hypotheses20070101

Title: Arthritis and pain. Future targets to control osteoarthritis pain.

Journal: Arthritis research & therapy20070101

Title: Negative effects of antiepileptic drugs on mood in patients with epilepsy.

Journal: Drug safety20070101

Title: Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat.

Journal: BMC neuroscience20070101

Title: Ethosuximide: from bench to bedside.

Journal: CNS drug reviews20070101

Title: Glutamatergic alterations in the cortex of genetic absence epilepsy rats.

Journal: BMC neuroscience20070101

Title: Response of spinal myoclonus to a combination therapy of autogenic training and biofeedback.

Journal: BioPsychoSocial medicine20070101

Title: The effects of chronic administration of ethosuximide on learning and memory: a behavioral and biochemical study on nonepileptic rats.

Journal: Behavioural pharmacology20061101

Title: Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze.

Journal: Behavioural pharmacology20061101

Title: Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.

Journal: Epilepsia20061101

Title: Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans.

Journal: Experimental gerontology20061001

Title: Coexistence of idiopathic rolandic epilepsy and CSWS in two families.

Journal: Epilepsia20061001

Title: Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.

Journal: The Journal of pharmacology and experimental therapeutics20060901

Title: Levetiracetam-induced myoclonic status epilepticus in myoclonic-astatic epilepsy: a case report.

Journal: Epileptic disorders : international epilepsy journal with videotape20060901

Title: Differences between prescribed daily doses and defined daily doses of antiepileptics--therapeutic drug monitoring as a marker of the quality of the treatment.

Journal: International journal of clinical pharmacology and therapeutics20060901

Title: Zonisamide - a review of experience and use in partial seizures.

Journal: Neuropsychiatric disease and treatment20060901

Title: Diagnostic issues and treatment of cryptogenic or symptomatic generalized epilepsies.

Journal: Epilepsy research20060801

Title: GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures.

Journal: European journal of pharmacology20060710

Title: Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice.

Journal: Journal of ethnopharmacology20060630

Title: Early-onset absence epilepsy: clinical and electroencephalographic features in three children.

Journal: Brain & development20060601

Title: Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders.

Journal: Brain & development20060601

Title: Limited P-glycoprotein mediated efflux for anti-epileptic drugs.

Journal: Journal of drug targeting20060601

Title: Yale University School of Medicine: 2006 student thesis abstracts.

Journal: The Yale journal of biology and medicine20060601

Title: Effects of anticonvulsant drugs on life span.

Journal: Archives of neurology20060401

Title: Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures.

Journal: Epilepsia20060401

Title: Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents.

Journal: Epilepsia20060301

Title: The effects of ethosuximide on amino acids in genetic absence epilepsy rat model.

Journal: Journal of pharmacological sciences20060301

Title: Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro.

Journal: Neuropharmacology20060101

Title: Influence of cimetidine on the anticonvulsant activity of conventional antiepileptic drugs against pentetrazole-induced seizures in mice.

Journal: Pharmacological reports : PR20060101

Title: Valproate as a mainstay of therapy for pediatric epilepsy.

Journal: Paediatric drugs20060101

Title: [Carbamazepine-induced systemic lupus erythematosus--a case report].

Journal: Neurologia i neurochirurgia polska20060101

Title: Effects of calcium channel blockers on the spermatogenesis and gene expression in peripubertal mouse testis.

Journal: Archives of andrology20060101

Title: Role of valproate across the ages. Treatment of epilepsy in children.

Journal: Acta neurologica Scandinavica. Supplementum20060101

Title: Epilepsy with myoclonic absences.

Journal: CNS drugs20060101

Title: Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice.

Journal: Pharmacological reports : PR20060101

Title: Anticonvulsant and antidepressant activity of the selected terpene GABA derivatives in experimental tests in mice.

Journal: Pharmacological reports : PR20060101

Title: Negative myoclonus. An overview of its clinical features, pathophysiological mechanisms, and management.

Journal: Neurophysiologie clinique = Clinical neurophysiology20060101

Title: Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.

Journal: Epilepsy & behavior : E&B20051201

Title: Neostigmine, but not metoclopramide, abolishes ethosuximide-induced functional gastrointestinal disturbances.

Journal: Pharmacology20051201

Title: Photic-induced sensitization: acquisition of an augmenting spike-wave response in the adult rat through repeated strobe exposure.

Journal: Journal of neurophysiology20051201

Title: Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome.

Journal: Epilepsia20051201

Title: Gender aspects of pharmacokinetics of new and old AEDs: pregnancy and breast-feeding.

Journal: Therapeutic drug monitoring20051201

Title: Treatment of pediatric epilepsy: expert opinion, 2005.

Journal: Journal of child neurology20051201

Title: Role of a novel maintained low-voltage-activated inward current permeable to sodium and calcium in pacemaking of insect neurosecretory neurons.

Journal: Invertebrate neuroscience : IN20051101

Title: Drug induced pseudolymphoma secondary to ethosuximide.

Journal: Journal of neurology, neurosurgery, and psychiatry20051101

Title: Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Journal: The Cochrane database of systematic reviews20051019

Title: The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.

Journal: European journal of pharmacology20051003

Title: Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats.

Journal: Brain research20050928

Title: Estimation of pK(a) values using microchip capillary electrophoresis and indirect fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20050925

Title: Chiral aspects of the human metabolism of ethosuximide.

Journal: Biopharmaceutics & drug disposition20050901

Title: Treatment of epilepsy in adults: expert opinion, 2005.

Journal: Epilepsy & behavior : E&B20050901

Title: Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Journal: Journal of pharmaceutical sciences20050701

Title: GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior.

Journal: Brain research. Developmental brain research20050630

Title: Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats.

Journal: Neuropharmacology20050601

Title: Motor impairment on awakening in a patient with an EEG pattern of 'unilateral, continuous spikes and waves during slow sleep'.

Journal: Epileptic disorders : international epilepsy journal with videotape20050601

Title: Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats.

Journal: Epilepsia20050601

Title: Voltage-dependent calcium channels.

Journal: General physiology and biophysics20050601

Title: Antiepileptic drug monotherapy: pediatric concerns.

Journal: Seminars in pediatric neurology20050601

Title: Absence seizures in children.

Journal: Clinical evidence20050601

Title: Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20050501

Title: Epilepsy with myoclonic absences.

Journal: Brain & development20050401

Title: Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050330

Title: A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine.

Journal: Seizure20050301

Title: Effect of antiepileptic drug polytherapy on crystalluria.

Journal: Pediatric neurology20050201

Title: Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography.

Journal: Electrophoresis20050201

Title: [Antiepileptic drugs in the treatment of autistic regression syndromes].

Journal: Revista de neurologia20050115

Title: Anticonvulsant medications extend worm life-span.

Journal: Science (New York, N.Y.)20050114

Title: Mechanisms of action of antiepileptic drugs.

Journal: Current topics in medicinal chemistry20050101

Title: Voltage gated ion channels: targets for anticonvulsant drugs.

Journal: Current topics in medicinal chemistry20050101

Title: A magnetoencephalographic study of negative myoclonus in a patient with atypical benign partial epilepsy.

Journal: Seizure20050101

Title: [Electroencephalography in status epilepticus in sleep (ESES) in various clinical pictures].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti20050101

Title: Bupropion-induced convulsions: preclinical evaluation of antiepileptic drugs.

Journal: Epilepsy research20050101

Title: A chronic dysfunctional stress response can cause stroke by stimulating platelet activation, migraine, and hypertension.

Journal: Medical hypotheses20050101

Title: Ion channels and epilepsy.

Journal: Current pharmaceutical design20050101

Title: Influence of the antagonist of the glycine site of NMDA receptors, MRZ 2/576, on the anticonvulsant activity of conventional antiepileptic drugs in mice.

Journal: Pharmacological reports : PR20050101

Title: Photosensitivity in idiopathic generalized epilepsies.

Journal: Epilepsia20050101

Title: Best practice guidelines for the management of women with epilepsy.

Journal: Epilepsia20050101

Title: Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies.

Journal: Epilepsia20050101

Title: Evidence-based treatment of idiopathic generalized epilepsies with older antiepileptic drugs.

Journal: Epilepsia20050101

Title: Management of Landau-Kleffner syndrome.

Journal: Paediatric drugs20050101

Title: Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice.

Journal: Toxicology letters20041201

Title: Learning and memory impairment in rats with chronic atypical absence seizures.

Journal: Experimental neurology20041201

Title: Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.

Journal: Biological & pharmaceutical bulletin20041201

Title: Effects of antiepileptic drugs on working memory as assessed by spatial alternation performance in rats.

Journal: Epilepsy & behavior : E&B20041201

Title: Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels.

Journal: Epilepsy & behavior : E&B20041201

Title: [Childhood and juvenile absence epilepsy. Treatment and prognosis].

Journal: Ugeskrift for laeger20041108

Title: Fracture risk associated with use of antiepileptic drugs.

Journal: Epilepsia20041101

Title: Refractory atypical absence seizures in rat: a two hit model.

Journal: Epilepsy research20041101

Title: Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy.

Journal: Pharmacology, biochemistry, and behavior20041101

Title: Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.

Journal: The Journal of pharmacology and experimental therapeutics20041001

Title: Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines.

Journal: The Lancet. Neurology20041001

Title: Simple and rapid micellar electrokinetic capillary chromatographic method for simultaneous determination of four antiepileptics in human serum.

Journal: Biomedical chromatography : BMC20041001

Title: Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.

Journal: Epilepsia20041001

Title: fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation.

Journal: Epilepsia20041001

Title: Uptake of GABA and activity of GABA transaminase in blood platelets from children with absence epilepsy.

Journal: Neurochemical research20041001

Title: PXR and the regulation of apoA1 and HDL-cholesterol in rodents.

Journal: Pharmacological research20040901

Title: [Long-term follow-up of a case of eyelid myoclonia with absences].

Journal: No to hattatsu = Brain and development20040901

Title: [Anticonvulsant hypersensitivity syndrome].

Journal: Orvosi hetilap20040808

Title: Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20040801

Title: Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models.

Journal: Seizure20040701

Title: The activity of antiepileptic drugs as histone deacetylase inhibitors.

Journal: Epilepsia20040701

Title: Absence seizures in children.

Journal: Clinical evidence20040601

Title: Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy.

Journal: Pain20040501

Title: Is the persistent sodium current a specific target of anti-absence drugs?

Journal: Neuroreport20040429

Title: Pharmacology of recombinant low-voltage activated calcium channels.

Journal: Current drug targets. CNS and neurological disorders20040401

Title: Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants.

Journal: Journal of neurobiology20040301

Title: Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity?

Journal: Journal of neurophysiology20040101

Title: Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats.

Journal: The Journal of pharmacology and experimental therapeutics20040101

Title: Cortical-area specific block of genetically determined absence seizures by ethosuximide.

Journal: Neuroscience20040101

Title: [Idiopathic epilepsies: some therapeutic aspects].

Journal: Revista de neurologia20040101

Title: Speech and language deterioration in benign rolandic epilepsy.

Journal: Journal of child neurology20040101

Title: Riluzole enhances the anti-seizure action of conventional antiepileptic drugs against pentetrazole-induced convulsions in mice.

Journal: Polish journal of pharmacology20040101

Title: Effects of the combination of valproate and ethosuximide on spike wave discharges in WAG/Rij rats.

Journal: Epilepsy research20040101

Title: Hippocampal afterdischarges in rats. I. Effects of antiepileptics.

Journal: Physiological research20040101

Title: Therapeutic drug monitoring of old and newer anti-epileptic drugs.

Journal: Clinical chemistry and laboratory medicine20040101

Title: When breastfeeding mothers need CNS-acting drugs.

Journal: The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique20040101

Title: Diagnosis and treatment of epilepsy.

Journal: Epilepsia20040101

Title: Assessment of anticonvulsant effectiveness and safety in patients with Angelman's syndrome using an Internet questionnaire.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20031215

Title: Absence seizures in children.

Journal: Clinical evidence20031201

Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

Journal: British journal of cancer20031117

Title: Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro.

Journal: Epilepsia20031101

Title: Ethosuximide induced agranulocytosis.

Journal: Brain & development20031001

Title: Absence seizures in patients with localization-related epilepsy.

Journal: Brain & development20030901

Title: Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats.

Journal: British journal of pharmacology20030901

Title: Reversal of experimental neuropathic pain by T-type calcium channel blockers.

Journal: Pain20030901

Title: Effects of Cyperus articulatus compared to effects of anticonvulsant compounds on the cortical wedge.

Journal: Journal of ethnopharmacology20030701

Title: Epilepsy.

Journal: Disease-a-month : DM20030701

Title: Thermal and rheological study of lipophilic ethosuximide suppositories.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20030601

Title: Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy.

Journal: Epilepsia20030501

Title: Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy.

Journal: Epilepsy research20030501

Title: Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20030301

Title: Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.

Journal: Neuroscience letters20030102

Title: Effects of concomitant antiepileptic drugs on serum carbamazepine concentration in epileptic patients: quantitative analysis based on extracellular water volume as a transforming factor.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20030101

Title: Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Journal: The Cochrane database of systematic reviews20030101

Title: Clinical trials for treatment of primary generalized epilepsies.

Journal: Epilepsia20030101

Title: Influence of vigabatrin, a novel antiepileptic drug, on the anticonvulsant activity of conventional antiepileptics in pentetrazole-induced seizures in mice.

Journal: Polish journal of pharmacology20030101

Title: Angelman syndrome: etiology, clinical features, diagnosis, and management of symptoms.

Journal: Paediatric drugs20030101

Title: Some antiepileptic compounds impair learning by rats in a Morris water maze.

Journal: Integrative physiological and behavioral science : the official journal of the Pavlovian Society20030101

Title: Influence of SIB 1893, a selective mGluR5 receptor antagonist, on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy.

Journal: Polish journal of pharmacology20030101

Title: [Modulating effect of anticonvulsive agents on Ca2+ dependent membrane fusion in cell-free model of neurosecretion].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 )20030101

Title: Characteristics of flurothyl-induced seizures and the effect of antiepileptic drugs on flurothyl-induced seizures in Mongolian gerbils.

Journal: Pharmacology, biochemistry, and behavior20021201

Title: Absence seizures in children.

Journal: Clinical evidence20021201

Title: Primary standardization of assays for anticonvulsant drugs: comparison of accuracy and precision.

Journal: Clinical chemistry20021101

Title: Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide.

Journal: Experimental brain research20021001

Title: Does lamotrigine influence valproate concentrations?

Journal: Therapeutic drug monitoring20021001

Title: T-channel-like pharmacological properties of high voltage-activated, nifedipine-insensitive Ca2+ currents in the rat terminal mesenteric artery.

Journal: British journal of pharmacology20021001

Title: Early-onset absence epilepsy and paroxysmal dyskinesia.

Journal: Epilepsia20021001

Title: Idiopathic generalised epilepsies with 3 Hz and faster spike wave discharges: a population-based study with evaluation and long-term follow-up in 71 patients.

Journal: Epileptic disorders : international epilepsy journal with videotape20020901

Title: Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.

Journal: European journal of pharmacology20020802

Title: Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.

Journal: Epilepsy research20020801

Title: The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents.

Journal: British journal of pharmacology20020701

Title: Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.

Journal: The Journal of pharmacy and pharmacology20020701

Title: A sensitive gas chromatographic/mass spectrometric method for the resolution and quantification of ethosuximide enantiomers in biological fluids.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20020605

Title: Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats.

Journal: Investigative ophthalmology & visual science20020601

Title: Anti-epileptic drugs.

Journal: Journal of the Indian Medical Association20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20020401

Title: Effect of some antiepileptic drugs on brain histaminergic systems in the rat.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20020401

Title: Some common issues in the use of antiepileptic drugs.

Journal: Seminars in neurology20020301

Title: Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices.

Journal: Brain research20020104

Title: Anticonvulsants: aspects of their mechanisms of action.

Journal: European journal of pain (London, England)20020101

Title: Interactions between antiepileptic drugs and hormonal contraception.

Journal: CNS drugs20020101

Title: Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations.

Journal: Clinical pharmacokinetics20020101

Title: Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity.

Journal: Molecular psychiatry20020101

Title: Suggestion for another anti-epileptic drug to use for migraine prophylaxis.

Journal: Headache20020101

Title: [Childhood absence epilepsy(pyknolepsy)].

Journal: Ryoikibetsu shokogun shirizu20020101

Title: [Juvenile absence epilepsy(JAE)].

Journal: Ryoikibetsu shokogun shirizu20020101

Title: [Epilepsy with myoclonic absences].

Journal: Ryoikibetsu shokogun shirizu20020101

Title: [Epilepsy with continuous spikes and waves during slow sleep].

Journal: Ryoikibetsu shokogun shirizu20020101

Title: Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy.

Journal: Epilepsy research20011201

Title: Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.

Journal: Molecular pharmacology20011101

Title: High-dose ethosuximide for epilepsy in Angelman syndrome: implication of GABA(A) receptor subunit.

Journal: Neurology20011023

Title: Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced 'epilepsy'.

Journal: Stroke20011001

Title: Possible induction of systemic lupus erythematosus by zonisamide.

Journal: Pediatric neurology20011001

Title: Interaction of flunarizine with sodium valproate or ethosuximide in gamahydroxybutyrate induced absence seizures in rats.

Journal: Indian journal of experimental biology20011001

Title: Lorazepam: an adjuvant therapy in patients with seizure and heliotaxis.

Journal: Neurology India20010901

Title: Atypical evolution in childhood epilepsy with occipital paroxysms (Panayiotopoulos type).

Journal: Epileptic disorders : international epilepsy journal with videotape20010901

Title: Therapeutic drug monitoring of antiepileptics by capillary electrophoresis. Characterization of assays via analysis of quality control sera containing 14 analytes.

Journal: Journal of chromatography. A20010727

Title: Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier.

Journal: European journal of pediatrics20010501

Title: Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures.

Journal: Pharmacology, biochemistry, and behavior20010401

Title: Quantification of urinary excretion of ethosuximide enantiomers and their major metabolites in the rat.

Journal: Biopharmaceutics & drug disposition20010401

Title: Forced normalization induced by ethosuximide therapy in a patient with intractable myoclonic epilepsy.

Journal: Brain & development20010301

Title: Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats.

Journal: European journal of pharmacology20010301

Title: The pharmacokinetics of ethosuximide enantiomers in the rat.

Journal: Biopharmaceutics & drug disposition20010301

Title: A model of atypical absence seizures: EEG, pharmacology, and developmental characterization.

Journal: Neurology20010213

Title: [Use of lamotrigine in the treatment of absence epilepsy crises].

Journal: Revista de neurologia20010201

Title: Repeated administration of CGP 46381, a gamma-aminobutyric acidB antagonist, and ethosuximide suppresses seizure-associated cyclic adenosine 3'5' monophosphate response element- and activator protein-1 DNA-binding activities in lethargic (lh/lh) mice.

Journal: Neuroscience letters20010119

Title: Time-related configuration change in benign focal epileptiform discharges of childhood: from a dipole to a negative monopole in a patient with generalized epilepsy.

Journal: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society20010101

Title: Effect of positively and negatively charged liposomes on skin permeation of drugs.

Journal: Journal of drug targeting20010101

Title: Treatment of typical absence seizures and related epileptic syndromes.

Journal: Paediatric drugs20010101

Title: Inhibition by anticonvulsants of prostate-specific antigen and interleukin-6 secretion by human prostate cancer cells.

Journal: Anticancer research20010101

Title: The management of refractory idiopathic epilepsies.

Journal: Epilepsia20010101

Title: [Hormonal contraception and epilepsy].

Journal: Akusherstvo i ginekologiia20010101

Title: Ethosuximide induced lymphadenopathy--a case report.

Journal: The Central African journal of medicine20010101

Title: Ethosuximide-associated lupus with cerebral and renal manifestations.

Journal: European journal of pediatrics19980901

Title: Inappropriate use of carbamazepine and vigabatrin in typical absence seizures.

Journal: Developmental medicine and child neurology19980801

Title: Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring.

Journal: Cancer causes & control : CCC19970501

Title: Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.

Journal: The International journal of neuroscience19961101

Title: Ethosuximide-induced lupus-like syndrome with renal involvement.

Journal: Internal medicine (Tokyo, Japan)19960701

Title: Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.

Journal: Journal of pharmacological and toxicological methods19960201

Title: Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.

Journal: The Journal of pharmacology and experimental therapeutics19950901

Title: Aplastic anemia following therapy for absence seizures with ethosuximide.

Journal: Pediatric neurology19940701

Title: Absence seizures and carbamazepine in adults.

Journal: Epilepsia19940101

Title: Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.

Journal: Pharmacology, biochemistry, and behavior19930401

Title: Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons.

Journal: Neuroscience19921201

Title: Ethosuximide and tremor in Parkinson's disease: a pilot study.

Journal: Movement disorders : official journal of the Movement Disorder Society19920101

Title: Effect of ethosuximide on rest tremor in the MPTP monkey model.

Journal: Movement disorders : official journal of the Movement Disorder Society19920101

Title: In vivo evidence that ethosuximide is a substrate for cytochrome P450IIIA.

Journal: Pharmacology19920101

Title: Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.

Journal: British journal of pharmacology19900801

Title: Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio.

Journal: The Journal of pharmacology and experimental therapeutics19900401

Title: Synthesis and anticonvulsant activity of 2-benzylglutarimides.

Journal: Journal of medicinal chemistry19900301

Title: Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.

Journal: Journal of medicinal chemistry19900101

Title: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons.

Journal: Annals of neurology19890601

Title: Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons.

Journal: Neuroscience letters19890313

Title: Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone.

Journal: Epilepsia19890101

Title: Episodic barrel rotations induced by intrastriatal injection of quinolinic acid in rats. Inhibition by anticonvulsants.

Journal: Pharmacology, biochemistry, and behavior19880901

Title: Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat.

Journal: Epilepsia19880101

Title: Only certain antiepileptic drugs prevent seizures induced by pilocarpine.

Journal: Brain research19870701

Title: Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions.

Journal: Brain research19870407

Title: Use of ethosuximide and valproate in the treatment of epilepsy.

Journal: Neurologic clinics19860801

Title: Phenytoin-induced benign intracranial hypertension.

Journal: Neurology19860301

Title: Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats.

Journal: Epilepsia19860101

Title: Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.

Journal: Arzneimittel-Forschung19850101

Title: A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures.

Journal: Epilepsia19840601

Title: Aplastic anemia during ethosuximide medication. Treatment with bolus-methylprednisolone.

Journal: Acta paediatrica Scandinavica19831101

Title: Ethosuximide-induced liver dysfunction.

Journal: Archives of neurology19830601

Title: Anticonvulsant sensitivity of absence seizures in the tottering mutant mouse.

Journal: Epilepsia19830201

Title: Carbamazepine-induced choreoathetoid dyskinesias.

Journal: Journal of neurology, neurosurgery, and psychiatry19820601

Title: A case of petit mal epilepsy aggravated by lithium.

Journal: The American journal of psychiatry19810501

Title: Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.

Journal: Science (New York, N.Y.)19801128

Title: Dyskinesia and akathisia induced by ethosuximide.

Journal: American journal of diseases of children (1960)19780501

Title: Nephrotic syndrome associated with ethosuccimide.

Journal: American journal of diseases of children (1960)19780101

Title: [Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy].

Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)19770101

Title: Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits.

Journal: Research communications in chemical pathology and pharmacology19770101

Title: Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.

Journal: The Journal of pediatrics19760801

Title: Di-n-propylacetic acid--profile of anticonvulsant activity in mice.

Journal: Arzneimittel-Forschung19760201

Title: Lupus-scleroderma syndrome induced by ethosuximide.

Journal: Archives of disease in childhood19750801

Title: Serum clonazepam concentrations in children with absence seizures.

Journal: Neurology19750301

Title: Dyskinesia-an unusual reaction to ethosuximide.

Journal: Archives of neurology19750201

Title: Movement disorder as a manifestation of diphenylhydantoin toxicity.

Journal: Pediatrics19740901

Title: Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.

Journal: Neurology19740501

Title: Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.

Journal: Lancet (London, England)19731117

Title: Pseudodegenerative disease due to diphenylhydantoin intoxication.

Journal: Archives of neurology19691201

Title: Treatment of generalized epilepsy with acrisuxine.

Journal: Confinia neurologica19690101

Title: Phenytoin (Dilantin) intoxication.

Journal: Acta neurologica Scandinavica19670101

Title: Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide.

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Title: Chen X, et al. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10:51.

Title: Sondossi K, et al. Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells. Fundam Clin Pharmacol. 2014 Oct;28(5):512-8.

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Fluorescin
AA003QJ4 | MFCD00046931
1438-91-1
1438-91-1
Furfuryl methyl sulfide
AA003QMN | MFCD00009604
635-39-2
635-39-2
Guanine, HCl
AA003QQX | MFCD00213670
51-74-1
51-74-1
Histamine diphosphate
AA003QUZ | MFCD00150816
84504-69-8
84504-69-8
Irsogladine maleate
AA003QZA | MFCD00873566
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