Title: Synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites for probing cytosine function in RNA.
Journal: The Journal of organic chemistry 20091106
2-Amino-5-bromopyrimidine is utilized in various synthetic routes to produce pyridine, pyrimidine, and pyridinone C-nucleoside phosphoramidites, as well as 2-phthalimido-5-bromopyrimidine. It serves as an intermediate in the synthesis of sulfanilamides and amino acids containing the pyrimidine ring system, with the resulting products exhibiting potential antiviral activity. This compound's versatility in organic synthesis makes it a valuable building block for the preparation of pharmaceuticals and bioactive molecules targeting viral infections.