78613-38-4,MFCD00903738
Catalog No.:AA003NT6

78613-38-4 | Amorolfine HCl

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Purity
Availability
Price(USD)
Quantity
  
100mg
98%(HPLC)
in stock  
$81.00   $57.00
- +
200mg
>98.0%(T)
in stock  
$91.00   $64.00
- +
1g
>98.0%(T)
in stock  
$272.00   $191.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003NT6
Chemical Name:
Amorolfine HCl
CAS Number:
78613-38-4
Molecular Formula:
C21H36ClNO
Molecular Weight:
353.9696
MDL Number:
MFCD00903738
SMILES:
CCC(c1ccc(cc1)CC(CN1C[C@H](C)O[C@@H](C1)C)C)(C)C.Cl
Properties
Properties
 
BP:
407.1°C at 760 mmHg  
Form:
Solid  
MP:
203-205°C  
Solubility:
DMSO: ≥5mg/mL (warmed)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
336  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Case of Fusarium paronychia successfully treated with occlusive dressing of antifungal cream.

Journal: The Journal of dermatology 20140401

Title: [When the nail is the polished one].

Journal: MMW Fortschritte der Medizin 20120531

Title: Simultaneous determination of triacetin, acetic ether, butyl acetate and amorolfine hydrochloride in amorolfine liniment by HPLC.

Journal: Pakistan journal of pharmaceutical sciences 20120401

Title: Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].

Journal: Annals of the New York Academy of Sciences 20120401

Title: Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors.

Journal: PloS one 20120101

Title: Selection of thrombin-binding aptamers by using computational approach for aptasensor application.

Journal: Biosensors & bioelectronics 20110715

Title: Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20100801

Title: Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents.

Journal: The Journal of pharmacy and pharmacology 20100601

Title: [Allergic contact dermatitis due to amorolfine in nail lacquer].

Journal: Actas dermo-sifiliograficas 20100401

Title: Onychomycosis.

Journal: Clinics in dermatology 20100304

Title: Long-term follow-up of toenail onychomycosis caused by dermatophytes after successful treatment with systemic antifungal agents.

Journal: Journal of the American Academy of Dermatology 20100301

Title: Hydrosoluble medicated nail lacquers: in vitro drug permeation and corresponding antimycotic activity.

Journal: The British journal of dermatology 20100201

Title: Onychomycosis insensitive to systemic terbinafine and azole treatments reveals non-dermatophyte moulds as infectious agents.

Journal: Dermatology (Basel, Switzerland) 20100101

Title: Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection.

Journal: Medical mycology 20091101

Title: Onychomycosis and diabetes.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20091001

Title: [Fungicidal activity of liranaftate against dermatophytes].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101

Title: Toenail onychomycosis in diabetic patients: issues and management.

Journal: American journal of clinical dermatology 20090101

Title: [Guidelines for diagnosis and treatment of mucocutaneous candidiasis].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101

Title: Tinea capitis due to Trichophyton soudanense with a papular IDE reaction in Northern Italy.

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20081201

Title: In vitro antifungal activity of sertaconazole nitrate against recent isolates of onychomycosis causative agents.

Journal: Journal of chemotherapy (Florence, Italy) 20080801

Title: A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement.

Journal: The British journal of dermatology 20070701

Title: Toenail onychomycosis: current and future treatment options.

Journal: Dermatologic therapy 20070101

Title: 1-Phenylethynylpyrene (1-PEPy) as refined excimer forming alternative to pyrene: case of DNA major groove excimer.

Journal: Bioconjugate chemistry 20070101

Title: An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis.

Journal: Indian journal of dermatology, venereology and leprology 20070101

Title: Sublimation of antimycotic agents as proved by various analytical methods.

Journal: Die Pharmazie 20061201

Title: Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails.

Journal: Die Pharmazie 20060701

Title: Rapid response of distal subungual onychomycosis to 5% amorolfine nail lacquer in a 20-month-old healthy infant.

Journal: Pediatric dermatology 20060101

Title: New insights into the effect of amorolfine nail lacquer.

Journal: Mycoses 20050301

Title: Topical antifungal drugs for the treatment of onychomycosis: an overview of current strategies for monotherapy and combination therapy.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20050101

Title: Candida-related denture stomatitis: a pilot study of the efficacy of an amorolfine antifungal varnish.

Journal: The International journal of prosthodontics 20050101

Title: Treatment costs of three nail lacquers used in onychomycosis.

Journal: The Journal of dermatological treatment 20050101

Title: In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China.

Journal: Mycoses 20041001

Title: Disseminated dermatophytosis caused by Microsporum gypseum in an AIDS patient: response to terbinafine and amorolfine.

Journal: Mycoses 20040601

Title: Combination treatment of candidal fingernail onychomycosis.

Journal: The British journal of dermatology 20040601

Title: Allergic contact dermatitis due to amorolfine nail lacquer.

Journal: Dermatitis : contact, atopic, occupational, drug 20040301

Title: [Onychomycosis].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20040201

Title: A randomized comparison of nail surface remanence of three nail lacquers, containing amorolfine 5%, ciclopirox 8% or tioconazole 28%, in healthy volunteers.

Journal: International journal of tissue reactions 20040101

Title: [Dual therapy of onychomycoses. Only Schwaben Province physicians also think of costs].

Journal: MMW Fortschritte der Medizin 20031009

Title: Pharmacoeconomic issues in onychomycosis.

Journal: The British journal of dermatology 20030901

Title: A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis.

Journal: The British journal of dermatology 20030701

Title: The use of topical therapies to treat onychomycosis.

Journal: Dermatologic clinics 20030701

Title: Actin gene-targeted RT-PCR could be a useful method for evaluating in vitro fungicidal activity against dermatophytes.

Journal: The Journal of international medical research 20030101

Title: [Assessment of mycological and clinical factors on the course and results of treatment of mycotic infections in patients with recurrent onychomycosis].

Journal: Annales Academiae Medicae Stetinensis 20030101

Title: Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20021201

Title: 'Deep' white superficial onychomycosis due to molds.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20020901

Title: [Fungicidal activity of liranaftate against Trichophyton rubrum].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20020101

Title: [Fungal nail diseases. What the pharmacist can do for his clients].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20011201

Title: [Leukonychia: whitish pigmentation of the ungueal lamina].

Journal: Enfermedades infecciosas y microbiologia clinica 20011101

Title: Topical amorolfine for 15 months combined with 12 weeks of oral terbinafine, a cost-effective treatment for onychomycosis.

Journal: The British journal of dermatology 20011001

Title: Amorolfine and itraconazole combination for severe toenail onychomycosis; results of an open randomized trial in Spain.

Journal: The British journal of dermatology 20011001

Title: The rationale for combination therapy.

Journal: The British journal of dermatology 20011001

Title: Best foot forward.

Journal: Nursing standard (Royal College of Nursing (Great Britain) : 1987) 20010901

Title: Superficial white onychomycosis in a 3-year-old human immunodeficiency virus-infected child.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

Title: [The treatment of extensive onychomycosis in aged patients].

Journal: Wiadomosci parazytologiczne 20010101

Title: Further studies on the in vitro antifungal activity of amorolfine.

Journal: Mycoses 19960101

Title: Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7.

Title: Richardson, M.D., G.S. Shankland, and C.A. Gray, Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses, 1989. 32(5): p. 245-9.

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SDS
Tags:78613-38-4 Molecular Formula|78613-38-4 MDL|78613-38-4 SMILES|78613-38-4 Amorolfine HCl
Catalog No.: AA003NT6
78613-38-4,MFCD00903738
78613-38-4 | Amorolfine HCl
Pack Size: 100mg
Purity: 98%(HPLC)
in stock
$81.00 $57.00
Pack Size: 200mg
Purity: >98.0%(T)
in stock
$91.00 $64.00
Pack Size: 1g
Purity: >98.0%(T)
in stock
$272.00 $191.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA003NT6
Chemical Name: Amorolfine HCl
CAS Number: 78613-38-4
Molecular Formula: C21H36ClNO
Molecular Weight: 353.9696
MDL Number: MFCD00903738
SMILES: CCC(c1ccc(cc1)CC(CN1C[C@H](C)O[C@@H](C1)C)C)(C)C.Cl
Properties
BP: 407.1°C at 760 mmHg  
Form: Solid  
MP: 203-205°C  
Solubility: DMSO: ≥5mg/mL (warmed)  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 336  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Case of Fusarium paronychia successfully treated with occlusive dressing of antifungal cream.

Journal: The Journal of dermatology20140401

Title: [When the nail is the polished one].

Journal: MMW Fortschritte der Medizin20120531

Title: Simultaneous determination of triacetin, acetic ether, butyl acetate and amorolfine hydrochloride in amorolfine liniment by HPLC.

Journal: Pakistan journal of pharmaceutical sciences20120401

Title: Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].

Journal: Annals of the New York Academy of Sciences20120401

Title: Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors.

Journal: PloS one20120101

Title: Selection of thrombin-binding aptamers by using computational approach for aptasensor application.

Journal: Biosensors & bioelectronics20110715

Title: Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV20100801

Title: Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents.

Journal: The Journal of pharmacy and pharmacology20100601

Title: [Allergic contact dermatitis due to amorolfine in nail lacquer].

Journal: Actas dermo-sifiliograficas20100401

Title: Onychomycosis.

Journal: Clinics in dermatology20100304

Title: Long-term follow-up of toenail onychomycosis caused by dermatophytes after successful treatment with systemic antifungal agents.

Journal: Journal of the American Academy of Dermatology20100301

Title: Hydrosoluble medicated nail lacquers: in vitro drug permeation and corresponding antimycotic activity.

Journal: The British journal of dermatology20100201

Title: Onychomycosis insensitive to systemic terbinafine and azole treatments reveals non-dermatophyte moulds as infectious agents.

Journal: Dermatology (Basel, Switzerland)20100101

Title: Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection.

Journal: Medical mycology20091101

Title: Onychomycosis and diabetes.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV20091001

Title: [Fungicidal activity of liranaftate against dermatophytes].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology20090101

Title: Toenail onychomycosis in diabetic patients: issues and management.

Journal: American journal of clinical dermatology20090101

Title: [Guidelines for diagnosis and treatment of mucocutaneous candidiasis].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology20090101

Title: Tinea capitis due to Trichophyton soudanense with a papular IDE reaction in Northern Italy.

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia20081201

Title: In vitro antifungal activity of sertaconazole nitrate against recent isolates of onychomycosis causative agents.

Journal: Journal of chemotherapy (Florence, Italy)20080801

Title: A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement.

Journal: The British journal of dermatology20070701

Title: Toenail onychomycosis: current and future treatment options.

Journal: Dermatologic therapy20070101

Title: 1-Phenylethynylpyrene (1-PEPy) as refined excimer forming alternative to pyrene: case of DNA major groove excimer.

Journal: Bioconjugate chemistry20070101

Title: An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis.

Journal: Indian journal of dermatology, venereology and leprology20070101

Title: Sublimation of antimycotic agents as proved by various analytical methods.

Journal: Die Pharmazie20061201

Title: Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails.

Journal: Die Pharmazie20060701

Title: Rapid response of distal subungual onychomycosis to 5% amorolfine nail lacquer in a 20-month-old healthy infant.

Journal: Pediatric dermatology20060101

Title: New insights into the effect of amorolfine nail lacquer.

Journal: Mycoses20050301

Title: Topical antifungal drugs for the treatment of onychomycosis: an overview of current strategies for monotherapy and combination therapy.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV20050101

Title: Candida-related denture stomatitis: a pilot study of the efficacy of an amorolfine antifungal varnish.

Journal: The International journal of prosthodontics20050101

Title: Treatment costs of three nail lacquers used in onychomycosis.

Journal: The Journal of dermatological treatment20050101

Title: In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China.

Journal: Mycoses20041001

Title: Disseminated dermatophytosis caused by Microsporum gypseum in an AIDS patient: response to terbinafine and amorolfine.

Journal: Mycoses20040601

Title: Combination treatment of candidal fingernail onychomycosis.

Journal: The British journal of dermatology20040601

Title: Allergic contact dermatitis due to amorolfine nail lacquer.

Journal: Dermatitis : contact, atopic, occupational, drug20040301

Title: [Onychomycosis].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete20040201

Title: A randomized comparison of nail surface remanence of three nail lacquers, containing amorolfine 5%, ciclopirox 8% or tioconazole 28%, in healthy volunteers.

Journal: International journal of tissue reactions20040101

Title: [Dual therapy of onychomycoses. Only Schwaben Province physicians also think of costs].

Journal: MMW Fortschritte der Medizin20031009

Title: Pharmacoeconomic issues in onychomycosis.

Journal: The British journal of dermatology20030901

Title: A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis.

Journal: The British journal of dermatology20030701

Title: The use of topical therapies to treat onychomycosis.

Journal: Dermatologic clinics20030701

Title: Actin gene-targeted RT-PCR could be a useful method for evaluating in vitro fungicidal activity against dermatophytes.

Journal: The Journal of international medical research20030101

Title: [Assessment of mycological and clinical factors on the course and results of treatment of mycotic infections in patients with recurrent onychomycosis].

Journal: Annales Academiae Medicae Stetinensis20030101

Title: Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy20021201

Title: 'Deep' white superficial onychomycosis due to molds.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV20020901

Title: [Fungicidal activity of liranaftate against Trichophyton rubrum].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology20020101

Title: [Fungal nail diseases. What the pharmacist can do for his clients].

Journal: Medizinische Monatsschrift fur Pharmazeuten20011201

Title: [Leukonychia: whitish pigmentation of the ungueal lamina].

Journal: Enfermedades infecciosas y microbiologia clinica20011101

Title: Topical amorolfine for 15 months combined with 12 weeks of oral terbinafine, a cost-effective treatment for onychomycosis.

Journal: The British journal of dermatology20011001

Title: Amorolfine and itraconazole combination for severe toenail onychomycosis; results of an open randomized trial in Spain.

Journal: The British journal of dermatology20011001

Title: The rationale for combination therapy.

Journal: The British journal of dermatology20011001

Title: Best foot forward.

Journal: Nursing standard (Royal College of Nursing (Great Britain) : 1987)20010901

Title: Superficial white onychomycosis in a 3-year-old human immunodeficiency virus-infected child.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV20010101

Title: [The treatment of extensive onychomycosis in aged patients].

Journal: Wiadomosci parazytologiczne20010101

Title: Further studies on the in vitro antifungal activity of amorolfine.

Journal: Mycoses19960101

Title: Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7.

Title: Richardson, M.D., G.S. Shankland, and C.A. Gray, Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses, 1989. 32(5): p. 245-9.

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