789-02-6,MFCD00036120
Catalog No.:AA00G2GB

789-02-6 | O,P'-DDT

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Purity
Availability
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5mg
≥95%
in stock  
$116.00   $81.00
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10mg
≥95%
in stock  
$219.00   $153.00
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25mg
≥95%
in stock  
$520.00   $364.00
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  • Technical Information
  • Properties
  • Literature
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Technical Information
Catalog Number:
AA00G2GB
Chemical Name:
O,P'-DDT
CAS Number:
789-02-6
Molecular Formula:
C14H9Cl5
Molecular Weight:
354.4863
MDL Number:
MFCD00036120
SMILES:
Clc1ccc(cc1)C(C(Cl)(Cl)Cl)c1ccccc1Cl
Properties
Computed Properties
 
Complexity:
280  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
0  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
6.7  

Literature

Title: Novel Pathways of Endocrine Disruption Through Pesticides Interference With Human Mineralocorticoid Receptors.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180301

Title: Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201

Title: Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20180101

Title: Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.

Journal: The Journal of steroid biochemistry and molecular biology 20170701

Title: Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice.

Journal: Environmental health perspectives 20161101

Title: In Vitro Effects of the Endocrine Disruptor p,p'-DDT on Human Follitropin Receptor.

Journal: Environmental health perspectives 20160701

Title: Development and pre-validation of an in vitro transactivation assay for detection of (anti)androgenic potential compounds using 22Rv1/MMTV cells.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20160401

Title: Endocrine-Disrupting Effects of Pesticides through Interference with Human Glucocorticoid Receptor.

Journal: Environmental science & technology 20160105

Title: Mixture Effects of Estrogenic Pesticides at the Human Estrogen Receptor α and β.

Journal: PloS one 20160101

Title: Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals.

Journal: Endocrinology 20151201

Title: Effect-based assessment of persistent organic pollutant and pesticide dumpsite using mammalian CALUX reporter cell lines.

Journal: Environmental science and pollution research international 20151001

Title: Improved assays for xenosensor activation based on reverse transfection.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151001

Title: Understanding the molecular basis for differences in responses of fish estrogen receptor subtypes to environmental estrogens.

Journal: Environmental science & technology 20150616

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study.

Journal: Environmental health perspectives 20150101

Title: Endocrine disrupting effects of dichlorodiphenyltrichloroethane analogues on gonadotropin hormones in pituitary gonadotrope cells.

Journal: Environmental toxicology and pharmacology 20140501

Title: Regulation of hepatic drug transporter activity and expression by organochlorine pesticides.

Journal: Journal of biochemical and molecular toxicology 20140301

Title: Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Journal: Scientific reports 20140101

Title: Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.

Journal: PloS one 20140101

Title: o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats.

Journal: Toxicology and applied pharmacology 20131215

Title: Luteinizing hormone receptor (lhcgr) as a marker gene for characterizing estrogenic endocrine-disrupting chemicals in zebrafish ovarian follicle cells.

Journal: General and comparative endocrinology 20131001

Title: Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.

Journal: Journal of biochemical and molecular toxicology 20130201

Title: Effects of transovarian exposure to p,p'-DDT and p,p'-DDE on avian reproduction using Japanese quails.

Journal: The Journal of toxicological sciences 20130101

Title: Inhibition of cellular efflux pumps involved in multi xenobiotic resistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures.

Journal: Ecotoxicology (London, England) 20121101

Title: Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121101

Title: Levels of organochlorine pesticides residues in human adipose tissue, data from Tabasco, Mexico.

Journal: Bulletin of environmental contamination and toxicology 20121101

Title: Organochlorine pesticides in seawater and the surrounding atmosphere of the marginal seas of China: spatial distribution, sources and air-water exchange.

Journal: The Science of the total environment 20121001

Title: Residues of organochlorine pesticides in water and suspended particulate matter from Xiangshan Bay, East China Sea.

Journal: Bulletin of environmental contamination and toxicology 20121001

Title: The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells.

Journal: Environmental health perspectives 20120901

Title: Optimization of extractants, purifying packings, and eluents for analytical extraction of organochlorine pesticides in Hydragric Acrisols.

Journal: Environmental monitoring and assessment 20120801

Title: Occurrence and levels of organochlorine compounds in human breast milk in Bangladesh.

Journal: Chemosphere 20120801

Title: Heating of BDE-209 and BDE-47 in plant oil in presence of o,p'-DDT or iron(III) chloride can produce monochloro-polybromo diphenyl ethers.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

Title: Organochlorine pesticides and polychlorinated biphenyls in sediments and fish from freshwater cultured fish ponds in different agricultural contexts in north-eastern France.

Journal: Ecotoxicology and environmental safety 20120301

Title: Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120201

Title: Determination of polychlorinated biphenyls and organochlorine pesticides in human serum by gas chromatography with micro-electron capture detector.

Journal: Journal of chromatographic science 20120201

Title: Alterations in T-lymphocyte sub-set profiles and cytokine secretion by PBMC of systemic lupus erythematosus patients upon in vitro exposure to organochlorine pesticides.

Journal: Journal of immunotoxicology 20120101

Title: Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.

Journal: PloS one 20120101

Title: Enantioselective cytotoxicity profile of o,p'-DDT in PC 12 cells.

Journal: PloS one 20120101

Title: Low concentrations of o,p'-DDT inhibit gene expression and prostaglandin synthesis by estrogen receptor-independent mechanism in rat ovarian cells.

Journal: PloS one 20120101

Title: Use of comprehensive screening methods to detect selective human CAR activators.

Journal: Biochemical pharmacology 20111215

Title: The phytoremediation potential of bioenergy crop Ricinus communis for DDTs and cadmium co-contaminated soil.

Journal: Bioresource technology 20111201

Title: The sorption behavior of DDT onto sediment in the presence of surfactant cetyltrimethylammonium bromide.

Journal: Marine pollution bulletin 20111101

Title: Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.

Journal: Toxicology letters 20111010

Title: Daily intake and human risk assessment of organochlorine pesticides (OCPs) based on Cambodian market basket data.

Journal: Journal of hazardous materials 20110915

Title: Accumulation levels and characteristics of some pesticides in human adipose tissue samples from Southeast China.

Journal: Chemosphere 20110801

Title: Organochlorine pesticide in fresh and pasteurized cow's milk from Kampala markets.

Journal: Chemosphere 20110801

Title: Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Journal: Toxicology and applied pharmacology 20110501

Title: Pesticide residues in fruits at the market level in Accra Metropolis, Ghana, a preliminary study.

Journal: Environmental monitoring and assessment 20110401

Title: Determination of n-octanol/water partition coefficient for DDT-related compounds by RP-HPLC with a novel dual-point retention time correction.

Journal: Chemosphere 20110301

Title: Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.

Journal: Toxicology 20110227

Title: Organochlorine residual concentrations in cattle egret from the Punjab Province, Pakistan.

Journal: Environmental monitoring and assessment 20110201

Title: The level and distribution of selected organochlorine pesticides in sediments from River Chenab, Pakistan.

Journal: Environmental geochemistry and health 20110201

Title: Estrogen receptors in medaka (Oryzias latipes) and estrogenic environmental contaminants: an in vitro-in vivo correlation.

Journal: The Journal of steroid biochemistry and molecular biology 20110201

Title: Tamoxifen affects the toxicokinetics of o,p'-DDT in male Nile Tilapia (Oreochromis niloticus).

Journal: Bulletin of environmental contamination and toxicology 20101201

Title: Using the o,p'-DDT/p,p'-DDT ratio to identify DDT sources in China.

Journal: Chemosphere 20101101

Title: The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells.

Journal: Toxicology letters 20101020

Title: Effect of environmental pollutants on oxytocin synthesis and secretion from corpus luteum and on contractions of uterus from pregnant cows.

Journal: Toxicology and applied pharmacology 20100915

Title: Assessment of a recombinant androgen receptor binding assay: initial steps towards validation.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100801

Title: Assessment of a robust model protocol with accelerated throughput for a human recombinant full length estrogen receptor-alpha binding assay: protocol optimization and intralaboratory assay performance as initial steps towards validation.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100801

Title: The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: results of test performance and transferability.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100801

Title: Optimization and prevalidation of the in vitro ERalpha CALUX method to test estrogenic and antiestrogenic activity of compounds.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100801

Title: Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100801

Title: Estrogenic effects of o,p'-DDT exposure in Japanese medaka (Oryzias latipes).

Journal: The Journal of toxicological sciences 20100801

Title: Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens.

Journal: Toxicology and applied pharmacology 20100601

Title: Development and characterization of five rainbow trout pituitary single-cell clone lines capable of producing pituitary hormones.

Journal: The Journal of endocrinology 20100401

Title: Zebrafish seizure model identifies p,p -DDE as the dominant contaminant of fetal California sea lions that accounts for synergistic activity with domoic acid.

Journal: Environmental health perspectives 20100401

Title: Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.

Journal: Toxicology letters 20100215

Title: Spatial and seasonal variations of organochlorine compounds in air on an urban-rural transect across Tianjin, China.

Journal: Chemosphere 20100101

Title: Fenton (H2O2/Fe) reaction involved in Penicillium sp. culture for DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane)] degradation.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20091101

Title: Tiered aquatic ecological risk assessment of organochlorine pesticides and their mixture in Jiangsu reach of Huaihe River, China.

Journal: Environmental monitoring and assessment 20091001

Title: Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus.

Journal: Lupus 20091001

Title: Enantiomeric signatures of chiral organochlorine pesticides in consumer fish from South China.

Journal: Journal of agricultural and food chemistry 20090527

Title: Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds.

Journal: Toxicology and applied pharmacology 20090401

Title: Reproductive and developmental effects of transovarian exposure to o,p'-DDT in Japanese quails.

Journal: Environmental toxicology and chemistry 20090401

Title: Enantioselective estrogenicity of o,p'-dichlorodiphenyltrichloroethane in the MCF-7 human breast carcinoma cell line.

Journal: Environmental toxicology and chemistry 20090101

Title: Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase.

Journal: Carcinogenesis 20090101

Title: DDT exposure of zebrafish embryos enhances seizure susceptibility: relationship to fetal p,p'-DDE burden and domoic acid exposure of California sea lions.

Journal: Environmental health perspectives 20090101

Title: Heptachlor and o-p'DDT effects on protein kinase activities associated with human placenta particulate fractions.

Journal: Journal of biochemical and molecular toxicology 20090101

Title: Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green.

Journal: Journal of cellular biochemistry 20081215

Title: Molecular cloning, characterization, and evolutionary analysis of estrogen receptors from phylogenetically ancient fish.

Journal: Endocrinology 20081201

Title: o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways.

Journal: Toxicology and applied pharmacology 20081201

Title: A novel pretreatment approach for fast determination of organochlorine pesticides in biotic samples.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20080501

Title: Screening of some anti-progestin endocrine disruptors using a recombinant yeast based in vitro bioassay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080401

Title: Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Journal: Chemical research in toxicology 20080401

Title: o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080201

Title: Gene expression analysis of human endometrial endothelial cells exposed to op'-DDT.

Journal: Molecular human reproduction 20080201

Title: Mixed liquids for single-drop microextraction of organochlorine pesticides in vegetables.

Journal: Talanta 20080115

Title: The influence of non-toxic concentrations of DDT and DDE on the old world vulture estrogen receptor alpha.

Journal: General and comparative endocrinology 20080101

Title: Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.

Journal: BMC genomics 20080101

Title: DDT- and DDE-induced disruption of ovarian steroidogenesis in prepubertal porcine ovarian follicles: a possible interaction with the main steroidogenic enzymes and estrogen receptor beta.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201

Title: Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults.

Journal: Toxicology and applied pharmacology 20071015

Title: Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane.

Journal: Biology of reproduction 20071001

Title: A novel molecular assay to discriminate transcriptional effects caused by xenoestrogens.

Journal: Molecular and cellular endocrinology 20070930

Title: Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination.

Journal: Toxicology and applied pharmacology 20070715

Title: Genistein accumulates in body depots and is mobilized during fasting, reaching estrogenic levels in serum that counter the hormonal actions of estradiol and organochlorines.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070601

Title: Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070601

Title: In utero exposure to DDT and performance on the Brazelton neonatal behavioral assessment scale.

Journal: Neurotoxicology 20070501

Title: Investigation of the feasibility of TiO(2) nanotubes for the enrichment of DDT and its metabolites at trace levels in environmental water samples.

Journal: Journal of chromatography. A 20070413

Title: Chlorinated pesticide concentration in semen of fertile and infertile men and correlation with sperm quality.

Journal: Environmental toxicology and pharmacology 20070301

Title: Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070101

Title: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines.

Journal: Life sciences 20060815

Title: Persistent pesticides in human breast milk and cryptorchidism.

Journal: Environmental health perspectives 20060701

Title: Antiestrogens inhibit xenoestrogen-induced brain aromatase activity but do not prevent xenoestrogen-induced feminization in Japanese medaka (Oryzias latipes).

Journal: Environmental health perspectives 20060401

Title: DDT concentrations in soils of Brazzaville, Congo.

Journal: Bulletin of environmental contamination and toxicology 20060401

Title: Defective reproductive organ morphology and function in domestic rooster embryonically exposed to o,p'-DDT or ethynylestradiol.

Journal: Biology of reproduction 20060301

Title: Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary.

Journal: General and comparative endocrinology 20060115

Title: Validation study of OECD rodent uterotrophic assay for the assessment of estrogenic activity in Sprague-Dawley immature female rats.

Journal: Journal of toxicology and environmental health. Part A 20051210

Title: Chiral organochlorine pesticide signatures in global background soils.

Journal: Environmental science & technology 20051115

Title: Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

Journal: Journal of medicinal chemistry 20050908

Title: CAR and PXR: xenosensors of endocrine disrupters?

Journal: Chemico-biological interactions 20050815

Title: Organochlorine pesticide residues in European sardine, horse mackerel and Atlantic mackerel from Portugal.

Journal: Food additives and contaminants 20050701

Title: Brain aromatase in Japanese medaka (Oryzias latipes): Molecular characterization and role in xenoestrogen-induced sex reversal.

Journal: The Journal of steroid biochemistry and molecular biology 20050601

Title: Transcriptional induction of CYP3A4 by o,p'-DDT in HepG2 cells.

Journal: Toxicology letters 20050516

Title: [Establishment of reporter gene-based assays for the identification of (anti) androgenic effects of chemicals in CHO cells].

Journal: Wei sheng yan jiu = Journal of hygiene research 20050501

Title: [Determination of organochlorine pesticide residues in nine herbs by solid-phase extraction and capillary gas chromatography].

Journal: Se pu = Chinese journal of chromatography 20050501

Title: Determination of organochlorine pesticides and their metabolites in radish after headspace solid-phase microextraction using calix[4]arene fiber.

Journal: Talanta 20050430

Title: Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells.

Journal: Environmental health perspectives 20050401

Title: Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice.

Journal: Environmental health perspectives 20050301

Title: Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway.

Journal: Toxicology letters 20050215

Title: Pregnancy outcomes for mouse preimplantation embryos exposed in vitro to the estrogenic pesticide o,p'-DDT.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20050101

Title: HER-2/neu and CD117 (c-kit) overexpression in patients with pesticide exposure and extensive stage small cell lung carcinoma (ESSCLC).

Journal: Journal of carcinogenesis 20050101

Title: Biochemical characterization of the Arctic char (Salvelinus alpinus) ovarian progestin membrane receptor.

Journal: Reproductive biology and endocrinology : RB&E 20050101

Title: A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides.

Journal: Biochemical pharmacology 20041215

Title: Correlation of chlorinated pesticides concentration in semen with seminal vesicle and prostatic markers.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20041201

Title: Catalytic hydrotreating of 2,4'-DDT and 4,4'-DDT.

Journal: Journal of hazardous materials 20040809

Title: A novel flexible approach for evaluating fixed ratio mixtures of full and partial agonists.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040701

Title: Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

Journal: Environmental health perspectives 20040401

Title: Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p'-DDT in macrophages.

Journal: Toxicology letters 20040307

Title: Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors.

Journal: Analytical and bioanalytical chemistry 20040201

Title: Organophosphorous and organochlorine pesticides affect human placental phosphoinositides metabolism and PI-4 kinase activity.

Journal: Journal of biochemical and molecular toxicology 20040101

Title: An aromatase inhibitor and tamoxifen decrease plasma levels of o,p'-DDT and its metabolites in Nile tilapia (Oreochromis niloticus).

Journal: Marine environmental research 20040101

Title: Effect of single and repeated in vitro exposure of ovarian follicles to o,p'-DDT and p,p'-DDT and their metabolites.

Journal: Polish journal of pharmacology 20040101

Title: Determination of the estrogenic and antiestrogenic effects of environmental contaminants in chicken embryo hepatocyte cultures by quantitative-polymerase chain reaction.

Journal: Environmental toxicology and chemistry 20031001

Title: Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.

Journal: Chemical research in toxicology 20031001

Title: Forskolin-induced cyclic AMP signaling in single adherent bovine oviductal cells: effect of dichlorodiphenyltrichloroethane (DDT) and tris(4-chlorophenyl)methanol (TCPM).

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030601

Title: Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities.

Journal: Environmental health perspectives 20030401

Title: Dichlorodiphenyltrichloroethane suppresses neurite outgrowth and induces apoptosis in PC12 pheochromocytoma cells.

Journal: Toxicology letters 20030203

Title: Reproductive impairment in Japanese quail (Coturnix japonica) after in ovo exposure to o,p'-DDT.

Journal: Archives of toxicology 20030201

Title: Induction of vitellogenin synthesis in an Atlantic salmon (Salmo salar) hepatocyte culture: a sensitive in vitro bioassay for the oestrogenic and anti-oestrogenic activity of chemicals.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20030101

Title: Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice.

Journal: Endocrinology 20021201

Title: Effects of o,p'-DDT on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in murine Hepa-1c1c7 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021101

Title: DDT inhibits the functional activation of murine macrophages and decreases resistance to infection by Mycobacterium microti.

Journal: Toxicology 20020605

Title: Influence of tris(4-chlorophenyl)methanol (TCPM) on gap junction-mediated intercellular communication of cultured bovine granulosa cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20020401

Title: Assessment of interactions of diverse ternary mixtures in an estrogen receptor-alpha reporter assay.

Journal: Toxicology and applied pharmacology 20020401

Title: Estrogen mimics bind with similar affinity and specificity to the hepatic estrogen receptor in Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss).

Journal: General and comparative endocrinology 20020301

Title: Interaction of estrogen mimics, singly and in combination, with plasma sex steroid-binding proteins in rainbow trout (Oncorhynchus mykiss).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20020201

Title: Reductive metabolism of p,p'-DDT and o,p'-DDT by rat liver cytochrome P450.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201

Title: Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7.

Journal: The Journal of steroid biochemistry and molecular biology 20020101

Title: Determination of chiral ratio of o,p-DDT and o,p-DDD pesticides on polysaccharides chiral stationary phases by HPLC under reversed-phase mode.

Journal: Environmental toxicology 20020101

Title: Enantiomer-specific activity of o,p'-DDT with the human estrogen receptor.

Journal: Toxicology letters 20011215

Title: A reverse transcription-polymerase chain reaction bioassay for avian vitellogenin mRNA.

Journal: Toxicology and applied pharmacology 20011101

Title: Effect of 17beta-estradiol, o,p'-DDT, octylphenol and p,p'-DDE on gonadal development and liver and kidney pathology in juvenile male summer flounder (Paralichthys dentatus).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20010901

Title: Effects of prenatal exposure to low doses of diethylstilbestrol, o,p'DDT, and methoxychlor on postnatal growth and neurobehavioral development in male and female mice.

Journal: Hormones and behavior 20010901

Title: Differing effects of endocrine-disrupting chemicals on basal and FSH-stimulated progesterone production in rat granulosa-luteal cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20010601

Title: Effects of estrogenic (o,p'-DDT; octylphenol) and anti-androgenic (p,p'-DDE) chemicals on indicators of endocrine status in juvenile male summer flounder (Paralichthys dentatus).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20010401

Title: Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010401

Title: Mixtures of four organochlorines enhance human breast cancer cell proliferation.

Journal: Environmental health perspectives 20010401

Title: Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010301

Title: Cell response endpoints enhance sensitivity of the immature mouse uterotropic assay.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20010101

Title: Differential estrogen receptor binding of estrogenic substances: a species comparison.

Journal: The Journal of steroid biochemistry and molecular biology 20001115

Title: Relative binding affinity does not predict biological response to xenoestrogens in rat endometrial adenocarcinoma cells.

Journal: The Journal of steroid biochemistry and molecular biology 20001001

Title: Effects of xenoestrogen treatment on zona radiata protein and vitellogenin expression in Atlantic salmon (Salmo salar).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20000601

Title: Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity.

Journal: The Journal of steroid biochemistry and molecular biology 20000501

Title: Effects of environmental estrogens on tumor necrosis factor alpha-mediated apoptosis in MCF-7 cells.

Journal: Carcinogenesis 19991101

Title: Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food.

Journal: Environmental health perspectives 19981201

Title: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

Journal: Endocrinology 19981001

Title: Several environmental oestrogens are also anti-androgens.

Journal: The Journal of endocrinology 19980901

Title: Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.

Journal: Toxicology and applied pharmacology 19980701

Title: Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen.

Journal: Endocrinology 19980601

Title: Activation of c-Neu tyrosine kinase by o,p'-DDT and beta-HCH in cell-free and intact cell preparations from MCF-7 human breast cancer cells.

Journal: Journal of biochemical and molecular toxicology 19980101

Title: Xenobiotic interaction with and alteration of channel catfish estrogen receptor.

Journal: Toxicology and applied pharmacology 19971201

Title: Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins.

Journal: Environmental health perspectives 19970301

Title: Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator.

Journal: Environmental health perspectives 19961201

Title: Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays.

Journal: Environmental health perspectives 19961001

Title: Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behaviour in male mice.

Journal: Toxicology letters 19950501

Title: Multiple estrogenic action of O,P'-DDT: initiation and maintenance of pregnancy in the rat.

Journal: Toxicology 19881216

Title: Estrogen-like effects of O,P'-DDT on the progesterone receptor of rat uterine cytosol.

Journal: Research communications in chemical pathology and pharmacology 19800801

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Tags:789-02-6 Molecular Formula|789-02-6 MDL|789-02-6 SMILES|789-02-6 O,P'-DDT
Catalog No.: AA00G2GB
789-02-6,MFCD00036120
789-02-6 | O,P'-DDT
Pack Size: 5mg
Purity: ≥95%
in stock
$116.00 $81.00
Pack Size: 10mg
Purity: ≥95%
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$219.00 $153.00
Pack Size: 25mg
Purity: ≥95%
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$520.00 $364.00
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Technical Information
Catalog Number: AA00G2GB
Chemical Name: O,P'-DDT
CAS Number: 789-02-6
Molecular Formula: C14H9Cl5
Molecular Weight: 354.4863
MDL Number: MFCD00036120
SMILES: Clc1ccc(cc1)C(C(Cl)(Cl)Cl)c1ccccc1Cl
Properties
Complexity: 280  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 0  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 6.7  
Literature fold

Title: Novel Pathways of Endocrine Disruption Through Pesticides Interference With Human Mineralocorticoid Receptors.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20180301

Title: Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20180201

Title: Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity.

Journal: Reproductive toxicology (Elmsford, N.Y.)20180101

Title: Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.

Journal: The Journal of steroid biochemistry and molecular biology20170701

Title: Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice.

Journal: Environmental health perspectives20161101

Title: In Vitro Effects of the Endocrine Disruptor p,p'-DDT on Human Follitropin Receptor.

Journal: Environmental health perspectives20160701

Title: Development and pre-validation of an in vitro transactivation assay for detection of (anti)androgenic potential compounds using 22Rv1/MMTV cells.

Journal: Reproductive toxicology (Elmsford, N.Y.)20160401

Title: Endocrine-Disrupting Effects of Pesticides through Interference with Human Glucocorticoid Receptor.

Journal: Environmental science & technology20160105

Title: Mixture Effects of Estrogenic Pesticides at the Human Estrogen Receptor α and β.

Journal: PloS one20160101

Title: Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals.

Journal: Endocrinology20151201

Title: Effect-based assessment of persistent organic pollutant and pesticide dumpsite using mammalian CALUX reporter cell lines.

Journal: Environmental science and pollution research international20151001

Title: Improved assays for xenosensor activation based on reverse transfection.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20151001

Title: Understanding the molecular basis for differences in responses of fish estrogen receptor subtypes to environmental estrogens.

Journal: Environmental science & technology20150616

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20150201

Title: Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study.

Journal: Environmental health perspectives20150101

Title: Endocrine disrupting effects of dichlorodiphenyltrichloroethane analogues on gonadotropin hormones in pituitary gonadotrope cells.

Journal: Environmental toxicology and pharmacology20140501

Title: Regulation of hepatic drug transporter activity and expression by organochlorine pesticides.

Journal: Journal of biochemical and molecular toxicology20140301

Title: Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Journal: Scientific reports20140101

Title: Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.

Journal: PloS one20140101

Title: o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats.

Journal: Toxicology and applied pharmacology20131215

Title: Luteinizing hormone receptor (lhcgr) as a marker gene for characterizing estrogenic endocrine-disrupting chemicals in zebrafish ovarian follicle cells.

Journal: General and comparative endocrinology20131001

Title: Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.

Journal: Journal of biochemical and molecular toxicology20130201

Title: Effects of transovarian exposure to p,p'-DDT and p,p'-DDE on avian reproduction using Japanese quails.

Journal: The Journal of toxicological sciences20130101

Title: Inhibition of cellular efflux pumps involved in multi xenobiotic resistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures.

Journal: Ecotoxicology (London, England)20121101

Title: Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20121101

Title: Levels of organochlorine pesticides residues in human adipose tissue, data from Tabasco, Mexico.

Journal: Bulletin of environmental contamination and toxicology20121101

Title: Organochlorine pesticides in seawater and the surrounding atmosphere of the marginal seas of China: spatial distribution, sources and air-water exchange.

Journal: The Science of the total environment20121001

Title: Residues of organochlorine pesticides in water and suspended particulate matter from Xiangshan Bay, East China Sea.

Journal: Bulletin of environmental contamination and toxicology20121001

Title: The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells.

Journal: Environmental health perspectives20120901

Title: Optimization of extractants, purifying packings, and eluents for analytical extraction of organochlorine pesticides in Hydragric Acrisols.

Journal: Environmental monitoring and assessment20120801

Title: Occurrence and levels of organochlorine compounds in human breast milk in Bangladesh.

Journal: Chemosphere20120801

Title: Heating of BDE-209 and BDE-47 in plant oil in presence of o,p'-DDT or iron(III) chloride can produce monochloro-polybromo diphenyl ethers.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120501

Title: Organochlorine pesticides and polychlorinated biphenyls in sediments and fish from freshwater cultured fish ponds in different agricultural contexts in north-eastern France.

Journal: Ecotoxicology and environmental safety20120301

Title: Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20120201

Title: Determination of polychlorinated biphenyls and organochlorine pesticides in human serum by gas chromatography with micro-electron capture detector.

Journal: Journal of chromatographic science20120201

Title: Alterations in T-lymphocyte sub-set profiles and cytokine secretion by PBMC of systemic lupus erythematosus patients upon in vitro exposure to organochlorine pesticides.

Journal: Journal of immunotoxicology20120101

Title: Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.

Journal: PloS one20120101

Title: Enantioselective cytotoxicity profile of o,p'-DDT in PC 12 cells.

Journal: PloS one20120101

Title: Low concentrations of o,p'-DDT inhibit gene expression and prostaglandin synthesis by estrogen receptor-independent mechanism in rat ovarian cells.

Journal: PloS one20120101

Title: Use of comprehensive screening methods to detect selective human CAR activators.

Journal: Biochemical pharmacology20111215

Title: The phytoremediation potential of bioenergy crop Ricinus communis for DDTs and cadmium co-contaminated soil.

Journal: Bioresource technology20111201

Title: The sorption behavior of DDT onto sediment in the presence of surfactant cetyltrimethylammonium bromide.

Journal: Marine pollution bulletin20111101

Title: Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.

Journal: Toxicology letters20111010

Title: Daily intake and human risk assessment of organochlorine pesticides (OCPs) based on Cambodian market basket data.

Journal: Journal of hazardous materials20110915

Title: Accumulation levels and characteristics of some pesticides in human adipose tissue samples from Southeast China.

Journal: Chemosphere20110801

Title: Organochlorine pesticide in fresh and pasteurized cow's milk from Kampala markets.

Journal: Chemosphere20110801

Title: Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Journal: Toxicology and applied pharmacology20110501

Title: Pesticide residues in fruits at the market level in Accra Metropolis, Ghana, a preliminary study.

Journal: Environmental monitoring and assessment20110401

Title: Determination of n-octanol/water partition coefficient for DDT-related compounds by RP-HPLC with a novel dual-point retention time correction.

Journal: Chemosphere20110301

Title: Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.

Journal: Toxicology20110227

Title: Organochlorine residual concentrations in cattle egret from the Punjab Province, Pakistan.

Journal: Environmental monitoring and assessment20110201

Title: The level and distribution of selected organochlorine pesticides in sediments from River Chenab, Pakistan.

Journal: Environmental geochemistry and health20110201

Title: Estrogen receptors in medaka (Oryzias latipes) and estrogenic environmental contaminants: an in vitro-in vivo correlation.

Journal: The Journal of steroid biochemistry and molecular biology20110201

Title: Tamoxifen affects the toxicokinetics of o,p'-DDT in male Nile Tilapia (Oreochromis niloticus).

Journal: Bulletin of environmental contamination and toxicology20101201

Title: Using the o,p'-DDT/p,p'-DDT ratio to identify DDT sources in China.

Journal: Chemosphere20101101

Title: The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells.

Journal: Toxicology letters20101020

Title: Effect of environmental pollutants on oxytocin synthesis and secretion from corpus luteum and on contractions of uterus from pregnant cows.

Journal: Toxicology and applied pharmacology20100915

Title: Assessment of a recombinant androgen receptor binding assay: initial steps towards validation.

Journal: Reproductive toxicology (Elmsford, N.Y.)20100801

Title: Assessment of a robust model protocol with accelerated throughput for a human recombinant full length estrogen receptor-alpha binding assay: protocol optimization and intralaboratory assay performance as initial steps towards validation.

Journal: Reproductive toxicology (Elmsford, N.Y.)20100801

Title: The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: results of test performance and transferability.

Journal: Reproductive toxicology (Elmsford, N.Y.)20100801

Title: Optimization and prevalidation of the in vitro ERalpha CALUX method to test estrogenic and antiestrogenic activity of compounds.

Journal: Reproductive toxicology (Elmsford, N.Y.)20100801

Title: Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds.

Journal: Reproductive toxicology (Elmsford, N.Y.)20100801

Title: Estrogenic effects of o,p'-DDT exposure in Japanese medaka (Oryzias latipes).

Journal: The Journal of toxicological sciences20100801

Title: Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens.

Journal: Toxicology and applied pharmacology20100601

Title: Development and characterization of five rainbow trout pituitary single-cell clone lines capable of producing pituitary hormones.

Journal: The Journal of endocrinology20100401

Title: Zebrafish seizure model identifies p,p -DDE as the dominant contaminant of fetal California sea lions that accounts for synergistic activity with domoic acid.

Journal: Environmental health perspectives20100401

Title: Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.

Journal: Toxicology letters20100215

Title: Spatial and seasonal variations of organochlorine compounds in air on an urban-rural transect across Tianjin, China.

Journal: Chemosphere20100101

Title: Fenton (H2O2/Fe) reaction involved in Penicillium sp. culture for DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane)] degradation.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes20091101

Title: Tiered aquatic ecological risk assessment of organochlorine pesticides and their mixture in Jiangsu reach of Huaihe River, China.

Journal: Environmental monitoring and assessment20091001

Title: Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus.

Journal: Lupus20091001

Title: Enantiomeric signatures of chiral organochlorine pesticides in consumer fish from South China.

Journal: Journal of agricultural and food chemistry20090527

Title: Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds.

Journal: Toxicology and applied pharmacology20090401

Title: Reproductive and developmental effects of transovarian exposure to o,p'-DDT in Japanese quails.

Journal: Environmental toxicology and chemistry20090401

Title: Enantioselective estrogenicity of o,p'-dichlorodiphenyltrichloroethane in the MCF-7 human breast carcinoma cell line.

Journal: Environmental toxicology and chemistry20090101

Title: Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase.

Journal: Carcinogenesis20090101

Title: DDT exposure of zebrafish embryos enhances seizure susceptibility: relationship to fetal p,p'-DDE burden and domoic acid exposure of California sea lions.

Journal: Environmental health perspectives20090101

Title: Heptachlor and o-p'DDT effects on protein kinase activities associated with human placenta particulate fractions.

Journal: Journal of biochemical and molecular toxicology20090101

Title: Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green.

Journal: Journal of cellular biochemistry20081215

Title: Molecular cloning, characterization, and evolutionary analysis of estrogen receptors from phylogenetically ancient fish.

Journal: Endocrinology20081201

Title: o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways.

Journal: Toxicology and applied pharmacology20081201

Title: A novel pretreatment approach for fast determination of organochlorine pesticides in biotic samples.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes20080501

Title: Screening of some anti-progestin endocrine disruptors using a recombinant yeast based in vitro bioassay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20080401

Title: Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Journal: Chemical research in toxicology20080401

Title: o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20080201

Title: Gene expression analysis of human endometrial endothelial cells exposed to op'-DDT.

Journal: Molecular human reproduction20080201

Title: Mixed liquids for single-drop microextraction of organochlorine pesticides in vegetables.

Journal: Talanta20080115

Title: The influence of non-toxic concentrations of DDT and DDE on the old world vulture estrogen receptor alpha.

Journal: General and comparative endocrinology20080101

Title: Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.

Journal: BMC genomics20080101

Title: DDT- and DDE-induced disruption of ovarian steroidogenesis in prepubertal porcine ovarian follicles: a possible interaction with the main steroidogenic enzymes and estrogen receptor beta.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20071201

Title: Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults.

Journal: Toxicology and applied pharmacology20071015

Title: Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane.

Journal: Biology of reproduction20071001

Title: A novel molecular assay to discriminate transcriptional effects caused by xenoestrogens.

Journal: Molecular and cellular endocrinology20070930

Title: Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination.

Journal: Toxicology and applied pharmacology20070715

Title: Genistein accumulates in body depots and is mobilized during fasting, reaching estrogenic levels in serum that counter the hormonal actions of estradiol and organochlorines.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20070601

Title: Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro.

Journal: Reproductive toxicology (Elmsford, N.Y.)20070601

Title: In utero exposure to DDT and performance on the Brazelton neonatal behavioral assessment scale.

Journal: Neurotoxicology20070501

Title: Investigation of the feasibility of TiO(2) nanotubes for the enrichment of DDT and its metabolites at trace levels in environmental water samples.

Journal: Journal of chromatography. A20070413

Title: Chlorinated pesticide concentration in semen of fertile and infertile men and correlation with sperm quality.

Journal: Environmental toxicology and pharmacology20070301

Title: Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane.

Journal: Drug metabolism and disposition: the biological fate of chemicals20070101

Title: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines.

Journal: Life sciences20060815

Title: Persistent pesticides in human breast milk and cryptorchidism.

Journal: Environmental health perspectives20060701

Title: Antiestrogens inhibit xenoestrogen-induced brain aromatase activity but do not prevent xenoestrogen-induced feminization in Japanese medaka (Oryzias latipes).

Journal: Environmental health perspectives20060401

Title: DDT concentrations in soils of Brazzaville, Congo.

Journal: Bulletin of environmental contamination and toxicology20060401

Title: Defective reproductive organ morphology and function in domestic rooster embryonically exposed to o,p'-DDT or ethynylestradiol.

Journal: Biology of reproduction20060301

Title: Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary.

Journal: General and comparative endocrinology20060115

Title: Validation study of OECD rodent uterotrophic assay for the assessment of estrogenic activity in Sprague-Dawley immature female rats.

Journal: Journal of toxicology and environmental health. Part A20051210

Title: Chiral organochlorine pesticide signatures in global background soils.

Journal: Environmental science & technology20051115

Title: Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

Journal: Journal of medicinal chemistry20050908

Title: CAR and PXR: xenosensors of endocrine disrupters?

Journal: Chemico-biological interactions20050815

Title: Organochlorine pesticide residues in European sardine, horse mackerel and Atlantic mackerel from Portugal.

Journal: Food additives and contaminants20050701

Title: Brain aromatase in Japanese medaka (Oryzias latipes): Molecular characterization and role in xenoestrogen-induced sex reversal.

Journal: The Journal of steroid biochemistry and molecular biology20050601

Title: Transcriptional induction of CYP3A4 by o,p'-DDT in HepG2 cells.

Journal: Toxicology letters20050516

Title: [Establishment of reporter gene-based assays for the identification of (anti) androgenic effects of chemicals in CHO cells].

Journal: Wei sheng yan jiu = Journal of hygiene research20050501

Title: [Determination of organochlorine pesticide residues in nine herbs by solid-phase extraction and capillary gas chromatography].

Journal: Se pu = Chinese journal of chromatography20050501

Title: Determination of organochlorine pesticides and their metabolites in radish after headspace solid-phase microextraction using calix[4]arene fiber.

Journal: Talanta20050430

Title: Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells.

Journal: Environmental health perspectives20050401

Title: Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice.

Journal: Environmental health perspectives20050301

Title: Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway.

Journal: Toxicology letters20050215

Title: Pregnancy outcomes for mouse preimplantation embryos exposed in vitro to the estrogenic pesticide o,p'-DDT.

Journal: Reproductive toxicology (Elmsford, N.Y.)20050101

Title: HER-2/neu and CD117 (c-kit) overexpression in patients with pesticide exposure and extensive stage small cell lung carcinoma (ESSCLC).

Journal: Journal of carcinogenesis20050101

Title: Biochemical characterization of the Arctic char (Salvelinus alpinus) ovarian progestin membrane receptor.

Journal: Reproductive biology and endocrinology : RB&E20050101

Title: A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides.

Journal: Biochemical pharmacology20041215

Title: Correlation of chlorinated pesticides concentration in semen with seminal vesicle and prostatic markers.

Journal: Reproductive toxicology (Elmsford, N.Y.)20041201

Title: Catalytic hydrotreating of 2,4'-DDT and 4,4'-DDT.

Journal: Journal of hazardous materials20040809

Title: A novel flexible approach for evaluating fixed ratio mixtures of full and partial agonists.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20040701

Title: Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

Journal: Environmental health perspectives20040401

Title: Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p'-DDT in macrophages.

Journal: Toxicology letters20040307

Title: Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors.

Journal: Analytical and bioanalytical chemistry20040201

Title: Organophosphorous and organochlorine pesticides affect human placental phosphoinositides metabolism and PI-4 kinase activity.

Journal: Journal of biochemical and molecular toxicology20040101

Title: An aromatase inhibitor and tamoxifen decrease plasma levels of o,p'-DDT and its metabolites in Nile tilapia (Oreochromis niloticus).

Journal: Marine environmental research20040101

Title: Effect of single and repeated in vitro exposure of ovarian follicles to o,p'-DDT and p,p'-DDT and their metabolites.

Journal: Polish journal of pharmacology20040101

Title: Determination of the estrogenic and antiestrogenic effects of environmental contaminants in chicken embryo hepatocyte cultures by quantitative-polymerase chain reaction.

Journal: Environmental toxicology and chemistry20031001

Title: Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.

Journal: Chemical research in toxicology20031001

Title: Forskolin-induced cyclic AMP signaling in single adherent bovine oviductal cells: effect of dichlorodiphenyltrichloroethane (DDT) and tris(4-chlorophenyl)methanol (TCPM).

Journal: Toxicology in vitro : an international journal published in association with BIBRA20030601

Title: Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities.

Journal: Environmental health perspectives20030401

Title: Dichlorodiphenyltrichloroethane suppresses neurite outgrowth and induces apoptosis in PC12 pheochromocytoma cells.

Journal: Toxicology letters20030203

Title: Reproductive impairment in Japanese quail (Coturnix japonica) after in ovo exposure to o,p'-DDT.

Journal: Archives of toxicology20030201

Title: Induction of vitellogenin synthesis in an Atlantic salmon (Salmo salar) hepatocyte culture: a sensitive in vitro bioassay for the oestrogenic and anti-oestrogenic activity of chemicals.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals20030101

Title: Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice.

Journal: Endocrinology20021201

Title: Effects of o,p'-DDT on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in murine Hepa-1c1c7 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20021101

Title: DDT inhibits the functional activation of murine macrophages and decreases resistance to infection by Mycobacterium microti.

Journal: Toxicology20020605

Title: Influence of tris(4-chlorophenyl)methanol (TCPM) on gap junction-mediated intercellular communication of cultured bovine granulosa cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20020401

Title: Assessment of interactions of diverse ternary mixtures in an estrogen receptor-alpha reporter assay.

Journal: Toxicology and applied pharmacology20020401

Title: Estrogen mimics bind with similar affinity and specificity to the hepatic estrogen receptor in Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss).

Journal: General and comparative endocrinology20020301

Title: Interaction of estrogen mimics, singly and in combination, with plasma sex steroid-binding proteins in rainbow trout (Oncorhynchus mykiss).

Journal: Aquatic toxicology (Amsterdam, Netherlands)20020201

Title: Reductive metabolism of p,p'-DDT and o,p'-DDT by rat liver cytochrome P450.

Journal: Drug metabolism and disposition: the biological fate of chemicals20020201

Title: Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7.

Journal: The Journal of steroid biochemistry and molecular biology20020101

Title: Determination of chiral ratio of o,p-DDT and o,p-DDD pesticides on polysaccharides chiral stationary phases by HPLC under reversed-phase mode.

Journal: Environmental toxicology20020101

Title: Enantiomer-specific activity of o,p'-DDT with the human estrogen receptor.

Journal: Toxicology letters20011215

Title: A reverse transcription-polymerase chain reaction bioassay for avian vitellogenin mRNA.

Journal: Toxicology and applied pharmacology20011101

Title: Effect of 17beta-estradiol, o,p'-DDT, octylphenol and p,p'-DDE on gonadal development and liver and kidney pathology in juvenile male summer flounder (Paralichthys dentatus).

Journal: Aquatic toxicology (Amsterdam, Netherlands)20010901

Title: Effects of prenatal exposure to low doses of diethylstilbestrol, o,p'DDT, and methoxychlor on postnatal growth and neurobehavioral development in male and female mice.

Journal: Hormones and behavior20010901

Title: Differing effects of endocrine-disrupting chemicals on basal and FSH-stimulated progesterone production in rat granulosa-luteal cells.

Journal: Experimental biology and medicine (Maywood, N.J.)20010601

Title: Effects of estrogenic (o,p'-DDT; octylphenol) and anti-androgenic (p,p'-DDE) chemicals on indicators of endocrine status in juvenile male summer flounder (Paralichthys dentatus).

Journal: Aquatic toxicology (Amsterdam, Netherlands)20010401

Title: Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20010401

Title: Mixtures of four organochlorines enhance human breast cancer cell proliferation.

Journal: Environmental health perspectives20010401

Title: Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20010301

Title: Cell response endpoints enhance sensitivity of the immature mouse uterotropic assay.

Journal: Reproductive toxicology (Elmsford, N.Y.)20010101

Title: Differential estrogen receptor binding of estrogenic substances: a species comparison.

Journal: The Journal of steroid biochemistry and molecular biology20001115

Title: Relative binding affinity does not predict biological response to xenoestrogens in rat endometrial adenocarcinoma cells.

Journal: The Journal of steroid biochemistry and molecular biology20001001

Title: Effects of xenoestrogen treatment on zona radiata protein and vitellogenin expression in Atlantic salmon (Salmo salar).

Journal: Aquatic toxicology (Amsterdam, Netherlands)20000601

Title: Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity.

Journal: The Journal of steroid biochemistry and molecular biology20000501

Title: Effects of environmental estrogens on tumor necrosis factor alpha-mediated apoptosis in MCF-7 cells.

Journal: Carcinogenesis19991101

Title: Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food.

Journal: Environmental health perspectives19981201

Title: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

Journal: Endocrinology19981001

Title: Several environmental oestrogens are also anti-androgens.

Journal: The Journal of endocrinology19980901

Title: Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.

Journal: Toxicology and applied pharmacology19980701

Title: Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen.

Journal: Endocrinology19980601

Title: Activation of c-Neu tyrosine kinase by o,p'-DDT and beta-HCH in cell-free and intact cell preparations from MCF-7 human breast cancer cells.

Journal: Journal of biochemical and molecular toxicology19980101

Title: Xenobiotic interaction with and alteration of channel catfish estrogen receptor.

Journal: Toxicology and applied pharmacology19971201

Title: Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins.

Journal: Environmental health perspectives19970301

Title: Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator.

Journal: Environmental health perspectives19961201

Title: Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays.

Journal: Environmental health perspectives19961001

Title: Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behaviour in male mice.

Journal: Toxicology letters19950501

Title: Multiple estrogenic action of O,P'-DDT: initiation and maintenance of pregnancy in the rat.

Journal: Toxicology19881216

Title: Estrogen-like effects of O,P'-DDT on the progesterone receptor of rat uterine cytosol.

Journal: Research communications in chemical pathology and pharmacology19800801

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786728-89-0
786728-89-0
3-Dimethylsulfamoyl-4-methoxy-benzoic acid
AA00G2OX | MFCD06355946
76542-83-1
76542-83-1
Fmoc-leu-osu
AA00G2VN | MFCD00065659
85753-43-1
85753-43-1
K-252C
AA00G338 | MFCD00236435
853789-10-3
853789-10-3
1-(1H-Benzoimidazol-2-yl)ethylamine hydrochloride
AA00G3CB | MFCD08445279
849903-79-3
849903-79-3
3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
AA00G3JY | MFCD18207006
80734-02-7
80734-02-7
Lenampicillin hydrochloride
AA00G3PN | MFCD01745174
851169-47-6
851169-47-6
2-[2-(4-BROMOPHENYL)VINYL]-4-CHLORO-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
AA00G3TO | MFCD22124917
7585-63-9
7585-63-9
4-amino-3,4-dihydro-2H-1lambda6-benzothiopyran-1,1-dione hydrochloride
AA00G41D | MFCD07838334
802580-12-7
802580-12-7
3-Bromo-2-phenylimidazo[1,2-b]pyridazine
AA00G4DC | MFCD09832525
79885-43-1
79885-43-1
5-(1-Methoxyethyl)-1,3,4-thiadiazol-2-amine
AA00G4I1 | MFCD17078887
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