81129-83-1,MFCD08459332
Catalog No.:AA0055B8

81129-83-1 | Cilastatin sodium

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98%(HPLC)
in stock  
$43.00   $30.00
- +
100mg
98%(HPLC)
in stock  
$126.00   $88.00
- +
250mg
98%(HPLC)
in stock  
$275.00   $193.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0055B8
Chemical Name:
Cilastatin sodium
CAS Number:
81129-83-1
Molecular Formula:
C16H25N2NaO5S
Molecular Weight:
380.4349
MDL Number:
MFCD08459332
SMILES:
OC(=O)[C@H](CSCCCC/C=C(/C(=O)[O-])\NC(=O)[C@H]1CC1(C)C)N.[Na+]
Properties
Properties
 
Form:
Solid  
MP:
>160°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
525  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Cilastatin attenuates vancomycin-induced nephrotoxicity via P-glycoprotein.

Journal: Toxicology letters 20170805

Title: Doripenem: excess mortality.

Journal: Prescrire international 20120901

Title: A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit.

Journal: The Journal of surgical research 20120801

Title: Antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in South African hospitals (SMART Study 2004-2009): impact of the new carbapenem breakpoints.

Journal: Surgical infections 20120201

Title: Actinomycetoma of the chest wall attributed to Nocardia nova after reconstructive surgery.

Journal: Dermatology online journal 20120115

Title: Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia.

Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120101

Title: Early use of imipenem/cilastatin and vancomycin followed by de-escalation versus conventional antimicrobials without de-escalation for patients with hospital-acquired pneumonia in a medical ICU: a randomized clinical trial.

Journal: Critical care (London, England) 20120101

Title: The footprints of gut microbial-mammalian co-metabolism.

Journal: Journal of proteome research 20111202

Title: Elemental bioimaging in kidney by LA-ICP-MS as a tool to study nephrotoxicity and renal protective strategies in cisplatin therapies.

Journal: Analytical chemistry 20111015

Title: [The characteristics of various forms of complicated surgery infections of the diabetic foot syndrome and their antibacterial treatment].

Journal: Georgian medical news 20110101

Title: Peritonitis after gynecological and gastroscopic examinations in a peritoneal dialysis patient.

Journal: Clinical nephrology 20101201

Title: Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.

Journal: Diagnostic microbiology and infectious disease 20101101

Title: Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration: comparison with imipenem/cilastatin.

Journal: Pulmonary pharmacology & therapeutics 20101001

Title: Cost-effectiveness model of empiric doripenem compared with imipenem-cilastatin in ventilator-associated pneumonia.

Journal: Surgical infections 20101001

Title: Empiric, broad-spectrum antibiotic therapy with an aggressive de-escalation strategy does not induce gram-negative pathogen resistance in ventilator-associated pneumonia.

Journal: Surgical infections 20101001

Title: Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia.

Journal: Diagnostic microbiology and infectious disease 20101001

Title: Piperacillin/tazobactam versus imipenem/cilastatin for severe diabetic foot infections: a prospective, randomized clinical trial in a university hospital.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100801

Title: Cilastatin attenuates cisplatin-induced proximal tubular cell damage.

Journal: The Journal of pharmacology and experimental therapeutics 20100801

Title: Ruptured pulmonary artery caused by isolated pulmonary valve endocarditis: case report.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20100701

Title: Human anaplasmosis and Anaplasma ovis variant.

Journal: Emerging infectious diseases 20100601

Title: Imipenem-cilastatin versus piperacillin-tazobactam as monotherapy in febrile neutropenia.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20100401

Title: Dipeptide hydrolysis by the dinuclear zinc enzyme human renal dipeptidase: mechanistic insights from DFT calculations.

Journal: Journal of inorganic biochemistry 20100101

Title: Therapeutic equivalence of generic imipenem/cilastatin for therapy of infections at Siriraj Hospital.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100101

Title: Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal infections: a randomized controlled trial.

Journal: BMC infectious diseases 20100101

Title: A multicenter, randomized controlled clinical study on biapenem and imipenem/cilastatin injection in the treatment of respiratory and urinary tract infections.

Journal: Chemotherapy 20100101

Title: Cross-reactivity and tolerability of imipenem in patients with delayed-type, cell-mediated hypersensitivity to beta-lactams.

Journal: Allergy 20091101

Title: Assessment of an alternative meropenem dosing strategy compared with imipenem-cilastatin or traditional meropenem dosing after cefepime failure or intolerance in adults with neutropenic fever.

Journal: Pharmacotherapy 20090801

Title: Incompatibility of imipenem-cilastatin and amoxicillin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090715

Title: Hydrophilic interaction chromatography/tandem mass spectrometry for the simultaneous determination of three polar non-structurally related compounds, imipenem, cilastatin and an investigational beta-lactamase inhibitor, MK-4698, in biological matrices.

Journal: Rapid communications in mass spectrometry : RCM 20090701

Title: [Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil].

Journal: The Japanese journal of antibiotics 20090601

Title: Effect of antibiotic prophylaxis on acute necrotizing pancreatitis: results of a randomized controlled trial.

Journal: Journal of gastroenterology and hepatology 20090501

Title: Necrotizing pancreatitis and antibiotic prophylaxis. To use or not to use ... that is the question.

Journal: Journal of gastroenterology and hepatology 20090501

Title: An unusual cause of seizures during subarachnoid anesthesia in a patient undergoing transurethral resection of the prostate: a case report.

Journal: Minerva anestesiologica 20090401

Title: Imipenem/cilastatin with or without glycopeptide as initial antibiotic therapy for recipients of autologous stem cell transplantation: results of a Spanish multicenter study.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20090401

Title: [A community acquired pneumonia case caused by Ralstonia pickettii].

Journal: Mikrobiyoloji bulteni 20090401

Title: Necrotizing pancreatitis after transcatheter arterial chemoembolization for hepatocellular carcinoma.

Journal: Diagnostic and interventional radiology (Ankara, Turkey) 20090301

Title: Safety of imipenem/cilastatin in neurocritical care patients.

Journal: Neurocritical care 20090101

Title: Comparison of in vivo nephrotoxicity in the rabbit by a pyrrolidinyl-thio Carbapenem CW-270031.

Journal: Journal of microbiology and biotechnology 20081101

Title: The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections - the European experience.

Journal: Journal of chemotherapy (Florence, Italy) 20081001

Title: Serious postpartum infection due to MRSA in an asymptomatic carrier: case report and review.

Journal: American journal of perinatology 20080801

Title: Acute disseminated encephalomyelitis in a renal transplant recipient: a case report.

Journal: Transplantation proceedings 20080601

Title: [Epidemiological study on cigar-shaped clostridia isolated in a local Japanese general hospital].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20080501

Title: Pharmacokinetic-pharmacodynamic modeling and simulation for in vivo bactericidal effect in murine infection model.

Journal: Journal of pharmaceutical sciences 20080401

Title: [Postoperative penicillin-resistant streptococcus pneumonia in lung cancer patient].

Journal: Kyobu geka. The Japanese journal of thoracic surgery 20080301

Title: Management and prevention of diabetic foot ulcers and infections: a health economic review.

Journal: PharmacoEconomics 20080101

Title: Combination carbapenem-sulbactam therapy for critically ill patients with multidrug-resistant Acinetobacter baumannii bacteremia: four case reports and an in vitro combination synergy study.

Journal: Pharmacotherapy 20071101

Title: Choroid plexitis in a case of systemic nocardiosis.

Journal: Emergency radiology 20071001

Title: [Study of the cases with multidrug-resistant Pseudomonas aeruginosa by sputum culture].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20071001

Title: Safe use of meropenem in a patient with a possible nonimmediate allergy to imipenem.

Journal: Pharmacotherapy 20070901

Title: A randomized prospective study of cefepime plus metronidazole with imipenem-cilastatin in the treatment of intra-abdominal infections.

Journal: Infection 20070601

Title: Antimicrobial treatment of Capnocytophaga infections.

Journal: International journal of antimicrobial agents 20070401

Title: Predictors of efficacy and health resource utilization in treatment of complicated intra-abdominal infections: evidence for pooled clinical studies comparing tigecycline with imipenem-cilastatin.

Journal: Surgical infections 20070401

Title: CW-270033, a novel pyrrolidinyl-thio carbapenem, has potent antimicrobial activity in vitro and in vivo.

Journal: Biological & pharmaceutical bulletin 20070301

Title: Cilastatin protection against cyclosporin A-induced nephrotoxicity: clinical evidence.

Journal: Current medical research and opinion 20070301

Title: Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study.

Journal: Hepato-gastroenterology 20070301

Title: Ertapenem resistance of Escherichia coli.

Journal: Emerging infectious diseases 20070201

Title: Successful use of sodium hypochlorite pack plus systemic and local antibiotic therapy for the treatment of pseudomonas infection of peritoneal dialysis catheter exit-site.

Journal: Contributions to nephrology 20070101

Title: First detection of a VIM-1 metallo-beta-lactamase in a carbapenem-resistant Citrobacter freundii clinical isolate in an acute hospital in Germany.

Journal: Scandinavian journal of infectious diseases 20070101

Title: [Sepsis in the sphenoiditis patient].

Journal: Otolaryngologia polska = The Polish otolaryngology 20070101

Title: [Imipenem-cilastatin use in a university hospital in Chile].

Journal: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia 20061201

Title: Empysematous gastritis--a case report with literature review.

Journal: JPMA. The Journal of the Pakistan Medical Association 20061201

Title: [A case of Mycobacterium abscessus pulmonary infection; effectiveness of clarithromycin, amikacin and imipenem/cilastatin].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20061101

Title: Impact of carbapenem administration on systemic endotoxemia in patients with severe sepsis and Gram-negative bacteremia.

Journal: Journal of chemotherapy (Florence, Italy) 20061001

Title: Comparison of piperacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 h for treatment of nosocomial pneumonia.

Journal: Respiratory medicine 20060901

Title: A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus.

Journal: Clinical therapeutics 20060801

Title: Risk factors of superinfection following imipenem/cilastatin therapy in hospitalised patients with acute exacerbations of severe chronic obstructive pulmonary disease.

Journal: International journal of clinical practice 20060701

Title: Antidepressant activity of beta-lactam antibiotics and their effects on the severity of serotonin edema.

Journal: Bulletin of experimental biology and medicine 20060701

Title: Imipenem in patients with immediate hypersensitivity to penicillins.

Journal: The New England journal of medicine 20060629

Title: Piperacillin/tazobactam vs imipenem/cilastatin in the treatment of nosocomial pneumonia--a double blind prospective multicentre study.

Journal: Infection 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Cost-utility analysis comparing meropenem with imipenem plus cilastatin in the treatment of severe infections in intensive care.

Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20060301

Title: Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of Acinetobacter bacteremia.

Journal: Yonsei medical journal 20060227

Title: Pulmonary nocardiosis in a patient with idiopathic thrombocytopenic purpura.

Journal: The Journal of infection 20060201

Title: Clinical comparative study of sulbactam/ampicillin and imipenem/cilastatin in elderly patients with community-acquired pneumonia.

Journal: Internal medicine (Tokyo, Japan) 20060101

Title: [A case of acute respiratory distress syndrome in a female patient with a single lung].

Journal: Problemy tuberkuleza i boleznei legkikh 20060101

Title: Using imipenem and cilastatin during continuous renal replacement therapy.

Journal: Pharmacy world & science : PWS 20051001

Title: The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050901

Title: Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses.

Journal: Journal of veterinary pharmacology and therapeutics 20050801

Title: A successfully treated case of mycetoma due to Nocardia veterana.

Journal: The British journal of dermatology 20050601

Title: Imipenem/cilastatin versus piperacillin/tazobactam plus amikacin for empirical therapy in febrile neutropenic patients: results of the COSTINE study.

Journal: Current medical research and opinion 20050501

Title: Systematic review comparing meropenem with imipenem plus cilastatin in the treatment of severe infections.

Journal: Current medical research and opinion 20050501

Title: [A case of successful medical treatment for necrotizing fasciitis of the chest wall with diabetic nephropathy].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20050301

Title: Quinolones for treatment of nosocomial pneumonia: a meta-analysis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050215

Title: Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050215

Title: Clinical study of the effectiveness of imipenem/cilastatin sodium as the antibiotics of first choice in the expectant management of patients with preterm premature rupture of membranes.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20050201

Title: Vertically acquired neonatal citrobacter brain abscess - case report and review of the literature.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050201

Title: Elevated plasma cysteinylglycine levels caused by cilastatin-associated antibiotic treatment.

Journal: Clinical chemistry and laboratory medicine 20050101

Title: Imipenem-cilastatin induced pure white cell aplasia.

Journal: Scandinavian journal of infectious diseases 20050101

Title: Meropenem versus imipenem-cilastatin for the treatment of hospitalized patients with complicated skin and skin structure infections: results of a multicenter, randomized, double-blind comparative study.

Journal: Surgical infections 20050101

Title: Pharmacodynamic modeling of beta-lactam antibiotics for the empiric treatment of secondary peritonitis: a report from the OPTAMA program.

Journal: Surgical infections 20050101

Title: A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744].

Journal: BMC infectious diseases 20050101

Title: Pharmacodynamic modeling of imipenem-cilastatin, meropenem, and piperacillin-tazobactam for empiric therapy of skin and soft tissue infections: a report from the OPTAMA Program.

Journal: Surgical infections 20050101

Title: Is it safe to use carbapenems in patients with a history of allergy to penicillin?

Journal: The Journal of antimicrobial chemotherapy 20041201

Title: Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041001

Title: [A case of radiofrequency ablation therapy for recurrent hepatomas with tumor fever--efficacy of hepatic arterial infusion therapy with antibiotics and anticancer drugs].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20041001

Title: [A case of pseudomembranous enterocolitis caused by methicillin-resistant Staphylococcus aureus].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20041001

Title: Appropriate use of the carbapenems.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20041001

Title: Successful therapy of severe pneumonia-associated ARDS after pneumonectomy with ECMO and steroids.

Journal: The Annals of thoracic surgery 20040701

Title: Randomized comparison of piperacillin/tazobactam versus imipenem/cilastatin in the treatment of patients with intra-abdominal infection.

Journal: Asian journal of surgery 20040701

Title: [A case of M. fortuitum lung disease with small-cell lung cancer].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20040501

Title: [Strategy for bacterial translocation in acute pancreatitis].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20040501

Title: [Nocardial brain abscess: surgery and postoperative antibiotic therapy].

Journal: No shinkei geka. Neurological surgery 20040501

Title: Induction of audiogenic seizures in imipenem/cilastatin-treated rats.

Journal: Epilepsy & behavior : E&B 20040401

Title: The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.

Journal: Acta neurologica Belgica 20040301

Title: Effect of moxifloxacin versus imipenem/cilastatin treatment on the mortality of mice infected intravenously with different strains of Bacteroides fragilis and Escherichia coli.

Journal: The Journal of antimicrobial chemotherapy 20040201

Title: Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats.

Journal: The Indian journal of medical research 20040201

Title: [Investigation on the antibiotic resistance and risky factors of nosocomial infections caused by Stenotrophomonas maltophilia].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20040201

Title: [Proper use of carbapenem antibiotics based on the feature in the treatment of infectious diseases (discussion)]].

Journal: The Japanese journal of antibiotics 20040201

Title: Lack of cross-reactivity to meropenem in a patient with an allergy to imipenem-cilastatin.

Journal: The Journal of allergy and clinical immunology 20040101

Title: Pharmacodynamics of meropenem and imipenem against Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Journal: Pharmacotherapy 20040101

Title: [The trend and susceptibility to antibacterial agents of enterococcus species from urinary tract infections].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20040101

Title: [Otogenic intracranial abscesses. Description of 6 cases].

Journal: Anales otorrinolaringologicos ibero-americanos 20040101

Title: A prospective, randomized study comparing cefepime and imipenem-cilastatin in the empirical treatment of febrile neutropenia in patients treated for haematological malignancies.

Journal: Scandinavian journal of infectious diseases 20040101

Title: Cefazolin plus ceftazidime versus imipenem/cilastatin monotherapy for treatment of CAPD peritonitis--a randomized controlled trial.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20040101

Title: The cost-effectiveness of cefepime plus metronidazole versus imipenem/cilastatin in the treatment of complicated intra-abdominal infection.

Journal: Surgical infections 20040101

Title: Early antibiotic treatment (prophylaxis) of septic complications in severe acute necrotizing pancreatitis: a prospective, randomized, multicenter study comparing two regimens with imipenem-cilastatin.

Journal: Intensive care medicine 20031101

Title: [A case of lung infection due to Mycobacterium abscessus].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20030801

Title: [Clinical analysis of 29 children with early infectious complications following hematopoietic stem cells transplantation].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20030701

Title: [A case of pulmonaly bulla infection with Mycobacterium fortuitum].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20030601

Title: Combined effect of clarithromycin and imipenem/cilastatin against urinary biofilm infection after pyeloplasty.

Journal: International journal of urology : official journal of the Japanese Urological Association 20030401

Title: Rapid imipenem/cilastatin desensitization for multidrug-resistant Acinetobacter pneumonia.

Journal: The Annals of pharmacotherapy 20030401

Title: [Antibacterial activity of biapenem against recent clinical isolates].

Journal: The Japanese journal of antibiotics 20030401

Title: A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase.

Journal: Bioorganic & medicinal chemistry 20030320

Title: Levofloxacin compared with imipenem/cilastatin followed by ciprofloxacin in adult patients with nosocomial pneumonia: a multicenter, prospective, randomized, open-label study.

Journal: Clinical therapeutics 20030201

Title: [Evaluation of the effect of medicines on biological properties of Clostridium difficile].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20030101

Title: [Conservative treatment of a large retroperitoneal hematoma following extracorporeal shock wave lithotripsy (ESWL): case report and literature review].

Journal: Annali italiani di chirurgia 20030101

Title: Carbapenems in the treatment of severe community-acquired pneumonia in hospitalized elderly patients: a comparative study against standard therapy.

Journal: Journal of chemotherapy (Florence, Italy) 20021201

Title: [Investigation on administration method of carbapenems].

Journal: The Japanese journal of antibiotics 20021201

Title: A randomized, controlled clinical trial on meropenem versus imipenem/cilastatin for the treatment of bacterial infections.

Journal: Chinese medical journal 20021201

Title: Empiric carbapenem monotherapy in pediatric bone marrow transplant recipients.

Journal: The Annals of pharmacotherapy 20020901

Title: [A case with severe acute pancreatitis treated by regional arterial infusion of nafamostat mesilate and imipenem via both celiac artery and superior mesenteric artery].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20020901

Title: The in vitro elution characteristics of vancomycin combined with imipenem-cilastatin in acrylic bone-cements: a pharmacokinetic study.

Journal: The Journal of arthroplasty 20020801

Title: [In vitro and in vivo antibacterial activities of pazufloxacin mesilate, a new injectable quinolone].

Journal: The Japanese journal of antibiotics 20020801

Title: Comparison of ampicillin-sulbactam and imipenem-cilastatin for the treatment of acinetobacter ventilator-associated pneumonia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020601

Title: [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].

Journal: The Japanese journal of antibiotics 20020601

Title: Pulmonary nocardiosis in a patient treated with corticosteroid therapy.

Journal: Respirology (Carlton, Vic.) 20020301

Title: Piperacillin 2 g/tazobactam 0.5 g is as effective as imipenem 0.5 g/cilastatin 0.5 g for the treatment of acute uncomplicated pyelonephritis and complicated urinary tract infections.

Journal: International journal of antimicrobial agents 20020201

Title: Recurrent bacteremia caused by Rhodococcus equi in a non-neutropenic patient with acute myeloid leukemia in complete remission.

Journal: Haematologica 20020101

Title: [Mycobacterium abscessus infection complicated with diabetes mellitus].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20020101

Title: Pseudomembranous tracheobronchitis caused by methicillin-resistant Staphylococcus aureus.

Journal: Scandinavian journal of infectious diseases 20020101

Title: Carbapenems.

Journal: Seminars in pediatric infectious diseases 20020101

Title: [Efficacy of imipenem-cilastatin in combined therapy of severe anaerobic-aerobic infection of bones and soft tissues].

Journal: Khirurgiia 20020101

Title: [Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology].

Journal: Urologiia (Moscow, Russia : 1999) 20020101

Title: Lung abscess (6 cm) of unexplained origin in a 36-year-old woman.

Journal: Wiener medizinische Wochenschrift (1946) 20020101

Title: [Antibacterial activity of imipenem/cilastatin (thienam) against agents causing pyoseptic processes].

Journal: Khirurgiia 20020101

Title: Effects of parenterally administered ciprofloxacin in a murine model of pulmonary Pseudomonas aeruginosa infection mimicking ventilator-associated pneumonia.

Journal: Chemotherapy 20011201

Title: Therapeutic drug monitoring-guided high teicoplanin dosage regimen required to treat a hypoalbuminemic renal transplant patient undergoing continuous venovenous hemofiltration.

Journal: Therapeutic drug monitoring 20011001

Title: [A randomized, controlled clinical trial of meropenem and imipenem/cilastatin in the treatment of acute bacterial infections].

Journal: Zhonghua nei ke za zhi 20010901

Title: [Imipenem/cilastatin-induced acute thrombocytopenia].

Journal: Medicina clinica 20010707

Title: [In vitro and in vivo activities of panipenem against penicillin-resistant Streptococcus pneumoniae].

Journal: The Japanese journal of antibiotics 20010701

Title: Cholangiopathy after short-term administration of piperacillin and imipenem/cilastatin.

Journal: Liver 20010601

Title: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.

Journal: European journal of pharmacology 20010511

Title: [Comparative study of piperacillin/tazobactam versus imipenem/cilastatin in febrile neutropenia (1994-1996)].

Journal: Medicina clinica 20010505

Title: [Combination therapy of antibiotics and intravenous immunoglobulin].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010401

Title: An open, randomised, multi-centre study comparing the safety and efficacy of sitafloxacin and imipenem/cilastatin in the intravenous treatment of hospitalised patients with pneumonia.

Journal: International journal of antimicrobial agents 20010301

Title: Pulmonary nocardiosis associated with idiopathic thrombocytopenic purpura.

Journal: Internal medicine (Tokyo, Japan) 20010301

Title: Epidemiology, resistance, and outcomes of Acinetobacter baumannii bacteremia treated with imipenem-cilastatin or ampicillin-sulbactam.

Journal: Pharmacotherapy 20010201

Title: Results of a clinical trial of clinafloxacin versus imipenem/cilastatin for intraabdominal infections.

Journal: Annals of surgery 20010101

Title: Cost efficacy of tazobactam/piperacillin versus imipenem/cilastatin in the treatment of intra-abdominal infection.

Journal: PharmacoEconomics 20010101

Title: [Thienam treatment in early postoperative period after pneumonectomy in patients with lung cancer].

Journal: Khirurgiia 20010101

Title: Imipenem but not meropenem induces convulsions in DBA/2 mice, unrelated to cerebrospinal fluid concentrations.

Journal: Fundamental & clinical pharmacology 20000101

Title: Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.

Journal: Pediatric hematology and oncology 20000101

Title: Effects of fosfomycin and imipenem-cilastatin on the nephrotoxicity of vancomycin and cisplatin in rats.

Journal: The Journal of pharmacy and pharmacology 19990201

Title: Neurotoxicity due to imipenem/cilastatin in patients on continuous ambulatory peritoneal dialysis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19990101

Title: Neurological complication during imipenem/cilastatin therapy in uraemic patients.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19980701

Title: Formulary review of the carbapenems: comparison of imipenem/cilastatin and meropenem.

Journal: Connecticut medicine 19980301

Title: Imipenem-cilastatin-induced leukocytoclastic vasculitis.

Journal: Journal of the American Podiatric Medical Association 19970501

Title: Impact of dosage-monitoring system on frequency of seizures associated with imipenem-cilastatin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 19960901

Title: Seizures related to use of imipenem-cilastatin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 19960701

Title: The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

Journal: Antimicrobial agents and chemotherapy 19950701

Title: Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem.

Journal: Toxicology letters 19950401

Title: Comparative convulsant potencies of two carbapenem derivatives in C57 and DBA/2 mice.

Journal: The Journal of pharmacy and pharmacology 19950401

Title: Worsening of myasthenia gravis on treatment with imipenem/cilastatin.

Journal: Journal of neurology, neurosurgery, and psychiatry 19940301

Title: Prospective surveillance of imipenem/cilastatin use and associated seizures using a hospital information system.

Journal: The Annals of pharmacotherapy 19930401

Title: Risk/benefit in the treatment of children with imipenem-cilastatin for meningitis caused by penicillin-resistant pneumococcus.

Journal: Journal of chemotherapy (Florence, Italy) 19930401

Title: [Cholestasis in imipenem/cilastatin treatment].

Journal: Zeitschrift fur Gastroenterologie 19930201

Title: Imipenem/cilastatin-associated hiccups.

Journal: The Annals of pharmacotherapy 19921101

Title: Imipenem/cilastatin. A reappraisal of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.

Journal: Drugs 19920901

Title: Vertigo caused by intravenous imipenem/cilastatin.

Journal: DICP : the annals of pharmacotherapy 19910901

Title: Evaluation of an imipenem/cilastatin target drug program.

Journal: DICP : the annals of pharmacotherapy 19910401

Title: Seizure activity associated with imipenem use: clinical case reports and review of the literature.

Journal: DICP : the annals of pharmacotherapy 19910401

Title: Imipenem/cilastatin treatment of bacterial meningitis in children.

Journal: The Pediatric infectious disease journal 19910201

Title: The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem.

Journal: Journal of the American Society of Nephrology : JASN 19901101

Title: Meropenem: evidence of lack of proconvulsive tendency in mice.

Journal: The Journal of antimicrobial chemotherapy 19890901

Title: [Seizure and tremor occurring in acute leukemia patients treated with imipenem/cilastatin].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 19890301

Title: Neurotoxicity of beta-lactam antibiotics. Experimental kinetic and neurophysiological studies.

Journal: Scandinavian journal of infectious diseases. Supplementum 19880101

Title: Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids.

Journal: Journal of medicinal chemistry 19870601

Title: Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.

Journal: Drugs 19870301

Title: Imipenem-cilastatin sodium, a broad-spectrum carbapenem antibiotic combination.

Journal: Clinical pharmacy 19860901

Title: Carbapenems, a new class of beta-lactam antibiotics. Discovery and development of imipenem/cilastatin.

Journal: The American journal of medicine 19850607

Title: Thienamycin: development of imipenen-cilastatin.

Journal: The Journal of antimicrobial chemotherapy 19831201

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Related Products of 81129-83-1
Tags:81129-83-1 Molecular Formula|81129-83-1 MDL|81129-83-1 SMILES|81129-83-1 Cilastatin sodium
Catalog No.: AA0055B8
81129-83-1,MFCD08459332
81129-83-1 | Cilastatin sodium
Pack Size: 25mg
Purity: 98%(HPLC)
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Pack Size: 100mg
Purity: 98%(HPLC)
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Technical Information
Catalog Number: AA0055B8
Chemical Name: Cilastatin sodium
CAS Number: 81129-83-1
Molecular Formula: C16H25N2NaO5S
Molecular Weight: 380.4349
MDL Number: MFCD08459332
SMILES: OC(=O)[C@H](CSCCCC/C=C(/C(=O)[O-])\NC(=O)[C@H]1CC1(C)C)N.[Na+]
Properties
Form: Solid  
MP: >160°C (dec.)  
Storage: -20 ℃;  
Complexity: 525  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 25  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 11  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Cilastatin attenuates vancomycin-induced nephrotoxicity via P-glycoprotein.

Journal: Toxicology letters20170805

Title: Doripenem: excess mortality.

Journal: Prescrire international20120901

Title: A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit.

Journal: The Journal of surgical research20120801

Title: Antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in South African hospitals (SMART Study 2004-2009): impact of the new carbapenem breakpoints.

Journal: Surgical infections20120201

Title: Actinomycetoma of the chest wall attributed to Nocardia nova after reconstructive surgery.

Journal: Dermatology online journal20120115

Title: Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia.

Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases20120101

Title: Early use of imipenem/cilastatin and vancomycin followed by de-escalation versus conventional antimicrobials without de-escalation for patients with hospital-acquired pneumonia in a medical ICU: a randomized clinical trial.

Journal: Critical care (London, England)20120101

Title: The footprints of gut microbial-mammalian co-metabolism.

Journal: Journal of proteome research20111202

Title: Elemental bioimaging in kidney by LA-ICP-MS as a tool to study nephrotoxicity and renal protective strategies in cisplatin therapies.

Journal: Analytical chemistry20111015

Title: [The characteristics of various forms of complicated surgery infections of the diabetic foot syndrome and their antibacterial treatment].

Journal: Georgian medical news20110101

Title: Peritonitis after gynecological and gastroscopic examinations in a peritoneal dialysis patient.

Journal: Clinical nephrology20101201

Title: Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.

Journal: Diagnostic microbiology and infectious disease20101101

Title: Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration: comparison with imipenem/cilastatin.

Journal: Pulmonary pharmacology & therapeutics20101001

Title: Cost-effectiveness model of empiric doripenem compared with imipenem-cilastatin in ventilator-associated pneumonia.

Journal: Surgical infections20101001

Title: Empiric, broad-spectrum antibiotic therapy with an aggressive de-escalation strategy does not induce gram-negative pathogen resistance in ventilator-associated pneumonia.

Journal: Surgical infections20101001

Title: Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia.

Journal: Diagnostic microbiology and infectious disease20101001

Title: Piperacillin/tazobactam versus imipenem/cilastatin for severe diabetic foot infections: a prospective, randomized clinical trial in a university hospital.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases20100801

Title: Cilastatin attenuates cisplatin-induced proximal tubular cell damage.

Journal: The Journal of pharmacology and experimental therapeutics20100801

Title: Ruptured pulmonary artery caused by isolated pulmonary valve endocarditis: case report.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society20100701

Title: Human anaplasmosis and Anaplasma ovis variant.

Journal: Emerging infectious diseases20100601

Title: Imipenem-cilastatin versus piperacillin-tazobactam as monotherapy in febrile neutropenia.

Journal: Pediatrics international : official journal of the Japan Pediatric Society20100401

Title: Dipeptide hydrolysis by the dinuclear zinc enzyme human renal dipeptidase: mechanistic insights from DFT calculations.

Journal: Journal of inorganic biochemistry20100101

Title: Therapeutic equivalence of generic imipenem/cilastatin for therapy of infections at Siriraj Hospital.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20100101

Title: Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal infections: a randomized controlled trial.

Journal: BMC infectious diseases20100101

Title: A multicenter, randomized controlled clinical study on biapenem and imipenem/cilastatin injection in the treatment of respiratory and urinary tract infections.

Journal: Chemotherapy20100101

Title: Cross-reactivity and tolerability of imipenem in patients with delayed-type, cell-mediated hypersensitivity to beta-lactams.

Journal: Allergy20091101

Title: Assessment of an alternative meropenem dosing strategy compared with imipenem-cilastatin or traditional meropenem dosing after cefepime failure or intolerance in adults with neutropenic fever.

Journal: Pharmacotherapy20090801

Title: Incompatibility of imipenem-cilastatin and amoxicillin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20090715

Title: Hydrophilic interaction chromatography/tandem mass spectrometry for the simultaneous determination of three polar non-structurally related compounds, imipenem, cilastatin and an investigational beta-lactamase inhibitor, MK-4698, in biological matrices.

Journal: Rapid communications in mass spectrometry : RCM20090701

Title: [Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil].

Journal: The Japanese journal of antibiotics20090601

Title: Effect of antibiotic prophylaxis on acute necrotizing pancreatitis: results of a randomized controlled trial.

Journal: Journal of gastroenterology and hepatology20090501

Title: Necrotizing pancreatitis and antibiotic prophylaxis. To use or not to use ... that is the question.

Journal: Journal of gastroenterology and hepatology20090501

Title: An unusual cause of seizures during subarachnoid anesthesia in a patient undergoing transurethral resection of the prostate: a case report.

Journal: Minerva anestesiologica20090401

Title: Imipenem/cilastatin with or without glycopeptide as initial antibiotic therapy for recipients of autologous stem cell transplantation: results of a Spanish multicenter study.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation20090401

Title: [A community acquired pneumonia case caused by Ralstonia pickettii].

Journal: Mikrobiyoloji bulteni20090401

Title: Necrotizing pancreatitis after transcatheter arterial chemoembolization for hepatocellular carcinoma.

Journal: Diagnostic and interventional radiology (Ankara, Turkey)20090301

Title: Safety of imipenem/cilastatin in neurocritical care patients.

Journal: Neurocritical care20090101

Title: Comparison of in vivo nephrotoxicity in the rabbit by a pyrrolidinyl-thio Carbapenem CW-270031.

Journal: Journal of microbiology and biotechnology20081101

Title: The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections - the European experience.

Journal: Journal of chemotherapy (Florence, Italy)20081001

Title: Serious postpartum infection due to MRSA in an asymptomatic carrier: case report and review.

Journal: American journal of perinatology20080801

Title: Acute disseminated encephalomyelitis in a renal transplant recipient: a case report.

Journal: Transplantation proceedings20080601

Title: [Epidemiological study on cigar-shaped clostridia isolated in a local Japanese general hospital].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases20080501

Title: Pharmacokinetic-pharmacodynamic modeling and simulation for in vivo bactericidal effect in murine infection model.

Journal: Journal of pharmaceutical sciences20080401

Title: [Postoperative penicillin-resistant streptococcus pneumonia in lung cancer patient].

Journal: Kyobu geka. The Japanese journal of thoracic surgery20080301

Title: Management and prevention of diabetic foot ulcers and infections: a health economic review.

Journal: PharmacoEconomics20080101

Title: Combination carbapenem-sulbactam therapy for critically ill patients with multidrug-resistant Acinetobacter baumannii bacteremia: four case reports and an in vitro combination synergy study.

Journal: Pharmacotherapy20071101

Title: Choroid plexitis in a case of systemic nocardiosis.

Journal: Emergency radiology20071001

Title: [Study of the cases with multidrug-resistant Pseudomonas aeruginosa by sputum culture].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20071001

Title: Safe use of meropenem in a patient with a possible nonimmediate allergy to imipenem.

Journal: Pharmacotherapy20070901

Title: A randomized prospective study of cefepime plus metronidazole with imipenem-cilastatin in the treatment of intra-abdominal infections.

Journal: Infection20070601

Title: Antimicrobial treatment of Capnocytophaga infections.

Journal: International journal of antimicrobial agents20070401

Title: Predictors of efficacy and health resource utilization in treatment of complicated intra-abdominal infections: evidence for pooled clinical studies comparing tigecycline with imipenem-cilastatin.

Journal: Surgical infections20070401

Title: CW-270033, a novel pyrrolidinyl-thio carbapenem, has potent antimicrobial activity in vitro and in vivo.

Journal: Biological & pharmaceutical bulletin20070301

Title: Cilastatin protection against cyclosporin A-induced nephrotoxicity: clinical evidence.

Journal: Current medical research and opinion20070301

Title: Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study.

Journal: Hepato-gastroenterology20070301

Title: Ertapenem resistance of Escherichia coli.

Journal: Emerging infectious diseases20070201

Title: Successful use of sodium hypochlorite pack plus systemic and local antibiotic therapy for the treatment of pseudomonas infection of peritoneal dialysis catheter exit-site.

Journal: Contributions to nephrology20070101

Title: First detection of a VIM-1 metallo-beta-lactamase in a carbapenem-resistant Citrobacter freundii clinical isolate in an acute hospital in Germany.

Journal: Scandinavian journal of infectious diseases20070101

Title: [Sepsis in the sphenoiditis patient].

Journal: Otolaryngologia polska = The Polish otolaryngology20070101

Title: [Imipenem-cilastatin use in a university hospital in Chile].

Journal: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia20061201

Title: Empysematous gastritis--a case report with literature review.

Journal: JPMA. The Journal of the Pakistan Medical Association20061201

Title: [A case of Mycobacterium abscessus pulmonary infection; effectiveness of clarithromycin, amikacin and imipenem/cilastatin].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20061101

Title: Impact of carbapenem administration on systemic endotoxemia in patients with severe sepsis and Gram-negative bacteremia.

Journal: Journal of chemotherapy (Florence, Italy)20061001

Title: Comparison of piperacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 h for treatment of nosocomial pneumonia.

Journal: Respiratory medicine20060901

Title: A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus.

Journal: Clinical therapeutics20060801

Title: Risk factors of superinfection following imipenem/cilastatin therapy in hospitalised patients with acute exacerbations of severe chronic obstructive pulmonary disease.

Journal: International journal of clinical practice20060701

Title: Antidepressant activity of beta-lactam antibiotics and their effects on the severity of serotonin edema.

Journal: Bulletin of experimental biology and medicine20060701

Title: Imipenem in patients with immediate hypersensitivity to penicillins.

Journal: The New England journal of medicine20060629

Title: Piperacillin/tazobactam vs imipenem/cilastatin in the treatment of nosocomial pneumonia--a double blind prospective multicentre study.

Journal: Infection20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Cost-utility analysis comparing meropenem with imipenem plus cilastatin in the treatment of severe infections in intensive care.

Journal: The European journal of health economics : HEPAC : health economics in prevention and care20060301

Title: Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of Acinetobacter bacteremia.

Journal: Yonsei medical journal20060227

Title: Pulmonary nocardiosis in a patient with idiopathic thrombocytopenic purpura.

Journal: The Journal of infection20060201

Title: Clinical comparative study of sulbactam/ampicillin and imipenem/cilastatin in elderly patients with community-acquired pneumonia.

Journal: Internal medicine (Tokyo, Japan)20060101

Title: [A case of acute respiratory distress syndrome in a female patient with a single lung].

Journal: Problemy tuberkuleza i boleznei legkikh20060101

Title: Using imipenem and cilastatin during continuous renal replacement therapy.

Journal: Pharmacy world & science : PWS20051001

Title: The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20050901

Title: Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses.

Journal: Journal of veterinary pharmacology and therapeutics20050801

Title: A successfully treated case of mycetoma due to Nocardia veterana.

Journal: The British journal of dermatology20050601

Title: Imipenem/cilastatin versus piperacillin/tazobactam plus amikacin for empirical therapy in febrile neutropenic patients: results of the COSTINE study.

Journal: Current medical research and opinion20050501

Title: Systematic review comparing meropenem with imipenem plus cilastatin in the treatment of severe infections.

Journal: Current medical research and opinion20050501

Title: [A case of successful medical treatment for necrotizing fasciitis of the chest wall with diabetic nephropathy].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20050301

Title: Quinolones for treatment of nosocomial pneumonia: a meta-analysis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20050215

Title: Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20050215

Title: Clinical study of the effectiveness of imipenem/cilastatin sodium as the antibiotics of first choice in the expectant management of patients with preterm premature rupture of membranes.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy20050201

Title: Vertically acquired neonatal citrobacter brain abscess - case report and review of the literature.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia20050201

Title: Elevated plasma cysteinylglycine levels caused by cilastatin-associated antibiotic treatment.

Journal: Clinical chemistry and laboratory medicine20050101

Title: Imipenem-cilastatin induced pure white cell aplasia.

Journal: Scandinavian journal of infectious diseases20050101

Title: Meropenem versus imipenem-cilastatin for the treatment of hospitalized patients with complicated skin and skin structure infections: results of a multicenter, randomized, double-blind comparative study.

Journal: Surgical infections20050101

Title: Pharmacodynamic modeling of beta-lactam antibiotics for the empiric treatment of secondary peritonitis: a report from the OPTAMA program.

Journal: Surgical infections20050101

Title: A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744].

Journal: BMC infectious diseases20050101

Title: Pharmacodynamic modeling of imipenem-cilastatin, meropenem, and piperacillin-tazobactam for empiric therapy of skin and soft tissue infections: a report from the OPTAMA Program.

Journal: Surgical infections20050101

Title: Is it safe to use carbapenems in patients with a history of allergy to penicillin?

Journal: The Journal of antimicrobial chemotherapy20041201

Title: Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20041001

Title: [A case of radiofrequency ablation therapy for recurrent hepatomas with tumor fever--efficacy of hepatic arterial infusion therapy with antibiotics and anticancer drugs].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20041001

Title: [A case of pseudomembranous enterocolitis caused by methicillin-resistant Staphylococcus aureus].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases20041001

Title: Appropriate use of the carbapenems.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde20041001

Title: Successful therapy of severe pneumonia-associated ARDS after pneumonectomy with ECMO and steroids.

Journal: The Annals of thoracic surgery20040701

Title: Randomized comparison of piperacillin/tazobactam versus imipenem/cilastatin in the treatment of patients with intra-abdominal infection.

Journal: Asian journal of surgery20040701

Title: [A case of M. fortuitum lung disease with small-cell lung cancer].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20040501

Title: [Strategy for bacterial translocation in acute pancreatitis].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology20040501

Title: [Nocardial brain abscess: surgery and postoperative antibiotic therapy].

Journal: No shinkei geka. Neurological surgery20040501

Title: Induction of audiogenic seizures in imipenem/cilastatin-treated rats.

Journal: Epilepsy & behavior : E&B20040401

Title: The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.

Journal: Acta neurologica Belgica20040301

Title: Effect of moxifloxacin versus imipenem/cilastatin treatment on the mortality of mice infected intravenously with different strains of Bacteroides fragilis and Escherichia coli.

Journal: The Journal of antimicrobial chemotherapy20040201

Title: Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats.

Journal: The Indian journal of medical research20040201

Title: [Investigation on the antibiotic resistance and risky factors of nosocomial infections caused by Stenotrophomonas maltophilia].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns20040201

Title: [Proper use of carbapenem antibiotics based on the feature in the treatment of infectious diseases (discussion)]].

Journal: The Japanese journal of antibiotics20040201

Title: Lack of cross-reactivity to meropenem in a patient with an allergy to imipenem-cilastatin.

Journal: The Journal of allergy and clinical immunology20040101

Title: Pharmacodynamics of meropenem and imipenem against Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Journal: Pharmacotherapy20040101

Title: [The trend and susceptibility to antibacterial agents of enterococcus species from urinary tract infections].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology20040101

Title: [Otogenic intracranial abscesses. Description of 6 cases].

Journal: Anales otorrinolaringologicos ibero-americanos20040101

Title: A prospective, randomized study comparing cefepime and imipenem-cilastatin in the empirical treatment of febrile neutropenia in patients treated for haematological malignancies.

Journal: Scandinavian journal of infectious diseases20040101

Title: Cefazolin plus ceftazidime versus imipenem/cilastatin monotherapy for treatment of CAPD peritonitis--a randomized controlled trial.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis20040101

Title: The cost-effectiveness of cefepime plus metronidazole versus imipenem/cilastatin in the treatment of complicated intra-abdominal infection.

Journal: Surgical infections20040101

Title: Early antibiotic treatment (prophylaxis) of septic complications in severe acute necrotizing pancreatitis: a prospective, randomized, multicenter study comparing two regimens with imipenem-cilastatin.

Journal: Intensive care medicine20031101

Title: [A case of lung infection due to Mycobacterium abscessus].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20030801

Title: [Clinical analysis of 29 children with early infectious complications following hematopoietic stem cells transplantation].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics20030701

Title: [A case of pulmonaly bulla infection with Mycobacterium fortuitum].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases20030601

Title: Combined effect of clarithromycin and imipenem/cilastatin against urinary biofilm infection after pyeloplasty.

Journal: International journal of urology : official journal of the Japanese Urological Association20030401

Title: Rapid imipenem/cilastatin desensitization for multidrug-resistant Acinetobacter pneumonia.

Journal: The Annals of pharmacotherapy20030401

Title: [Antibacterial activity of biapenem against recent clinical isolates].

Journal: The Japanese journal of antibiotics20030401

Title: A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase.

Journal: Bioorganic & medicinal chemistry20030320

Title: Levofloxacin compared with imipenem/cilastatin followed by ciprofloxacin in adult patients with nosocomial pneumonia: a multicenter, prospective, randomized, open-label study.

Journal: Clinical therapeutics20030201

Title: [Evaluation of the effect of medicines on biological properties of Clostridium difficile].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii20030101

Title: [Conservative treatment of a large retroperitoneal hematoma following extracorporeal shock wave lithotripsy (ESWL): case report and literature review].

Journal: Annali italiani di chirurgia20030101

Title: Carbapenems in the treatment of severe community-acquired pneumonia in hospitalized elderly patients: a comparative study against standard therapy.

Journal: Journal of chemotherapy (Florence, Italy)20021201

Title: [Investigation on administration method of carbapenems].

Journal: The Japanese journal of antibiotics20021201

Title: A randomized, controlled clinical trial on meropenem versus imipenem/cilastatin for the treatment of bacterial infections.

Journal: Chinese medical journal20021201

Title: Empiric carbapenem monotherapy in pediatric bone marrow transplant recipients.

Journal: The Annals of pharmacotherapy20020901

Title: [A case with severe acute pancreatitis treated by regional arterial infusion of nafamostat mesilate and imipenem via both celiac artery and superior mesenteric artery].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology20020901

Title: The in vitro elution characteristics of vancomycin combined with imipenem-cilastatin in acrylic bone-cements: a pharmacokinetic study.

Journal: The Journal of arthroplasty20020801

Title: [In vitro and in vivo antibacterial activities of pazufloxacin mesilate, a new injectable quinolone].

Journal: The Japanese journal of antibiotics20020801

Title: Comparison of ampicillin-sulbactam and imipenem-cilastatin for the treatment of acinetobacter ventilator-associated pneumonia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20020601

Title: [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].

Journal: The Japanese journal of antibiotics20020601

Title: Pulmonary nocardiosis in a patient treated with corticosteroid therapy.

Journal: Respirology (Carlton, Vic.)20020301

Title: Piperacillin 2 g/tazobactam 0.5 g is as effective as imipenem 0.5 g/cilastatin 0.5 g for the treatment of acute uncomplicated pyelonephritis and complicated urinary tract infections.

Journal: International journal of antimicrobial agents20020201

Title: Recurrent bacteremia caused by Rhodococcus equi in a non-neutropenic patient with acute myeloid leukemia in complete remission.

Journal: Haematologica20020101

Title: [Mycobacterium abscessus infection complicated with diabetes mellitus].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20020101

Title: Pseudomembranous tracheobronchitis caused by methicillin-resistant Staphylococcus aureus.

Journal: Scandinavian journal of infectious diseases20020101

Title: Carbapenems.

Journal: Seminars in pediatric infectious diseases20020101

Title: [Efficacy of imipenem-cilastatin in combined therapy of severe anaerobic-aerobic infection of bones and soft tissues].

Journal: Khirurgiia20020101

Title: [Effectiveness of imipenem/cilastatin (Tienam, MSD) in treating complicated infections in urology].

Journal: Urologiia (Moscow, Russia : 1999)20020101

Title: Lung abscess (6 cm) of unexplained origin in a 36-year-old woman.

Journal: Wiener medizinische Wochenschrift (1946)20020101

Title: [Antibacterial activity of imipenem/cilastatin (thienam) against agents causing pyoseptic processes].

Journal: Khirurgiia20020101

Title: Effects of parenterally administered ciprofloxacin in a murine model of pulmonary Pseudomonas aeruginosa infection mimicking ventilator-associated pneumonia.

Journal: Chemotherapy20011201

Title: Therapeutic drug monitoring-guided high teicoplanin dosage regimen required to treat a hypoalbuminemic renal transplant patient undergoing continuous venovenous hemofiltration.

Journal: Therapeutic drug monitoring20011001

Title: [A randomized, controlled clinical trial of meropenem and imipenem/cilastatin in the treatment of acute bacterial infections].

Journal: Zhonghua nei ke za zhi20010901

Title: [Imipenem/cilastatin-induced acute thrombocytopenia].

Journal: Medicina clinica20010707

Title: [In vitro and in vivo activities of panipenem against penicillin-resistant Streptococcus pneumoniae].

Journal: The Japanese journal of antibiotics20010701

Title: Cholangiopathy after short-term administration of piperacillin and imipenem/cilastatin.

Journal: Liver20010601

Title: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.

Journal: European journal of pharmacology20010511

Title: [Comparative study of piperacillin/tazobactam versus imipenem/cilastatin in febrile neutropenia (1994-1996)].

Journal: Medicina clinica20010505

Title: [Combination therapy of antibiotics and intravenous immunoglobulin].

Journal: Nihon rinsho. Japanese journal of clinical medicine20010401

Title: An open, randomised, multi-centre study comparing the safety and efficacy of sitafloxacin and imipenem/cilastatin in the intravenous treatment of hospitalised patients with pneumonia.

Journal: International journal of antimicrobial agents20010301

Title: Pulmonary nocardiosis associated with idiopathic thrombocytopenic purpura.

Journal: Internal medicine (Tokyo, Japan)20010301

Title: Epidemiology, resistance, and outcomes of Acinetobacter baumannii bacteremia treated with imipenem-cilastatin or ampicillin-sulbactam.

Journal: Pharmacotherapy20010201

Title: Results of a clinical trial of clinafloxacin versus imipenem/cilastatin for intraabdominal infections.

Journal: Annals of surgery20010101

Title: Cost efficacy of tazobactam/piperacillin versus imipenem/cilastatin in the treatment of intra-abdominal infection.

Journal: PharmacoEconomics20010101

Title: [Thienam treatment in early postoperative period after pneumonectomy in patients with lung cancer].

Journal: Khirurgiia20010101

Title: Imipenem but not meropenem induces convulsions in DBA/2 mice, unrelated to cerebrospinal fluid concentrations.

Journal: Fundamental & clinical pharmacology20000101

Title: Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.

Journal: Pediatric hematology and oncology20000101

Title: Effects of fosfomycin and imipenem-cilastatin on the nephrotoxicity of vancomycin and cisplatin in rats.

Journal: The Journal of pharmacy and pharmacology19990201

Title: Neurotoxicity due to imipenem/cilastatin in patients on continuous ambulatory peritoneal dialysis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association19990101

Title: Neurological complication during imipenem/cilastatin therapy in uraemic patients.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association19980701

Title: Formulary review of the carbapenems: comparison of imipenem/cilastatin and meropenem.

Journal: Connecticut medicine19980301

Title: Imipenem-cilastatin-induced leukocytoclastic vasculitis.

Journal: Journal of the American Podiatric Medical Association19970501

Title: Impact of dosage-monitoring system on frequency of seizures associated with imipenem-cilastatin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists19960901

Title: Seizures related to use of imipenem-cilastatin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists19960701

Title: The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

Journal: Antimicrobial agents and chemotherapy19950701

Title: Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem.

Journal: Toxicology letters19950401

Title: Comparative convulsant potencies of two carbapenem derivatives in C57 and DBA/2 mice.

Journal: The Journal of pharmacy and pharmacology19950401

Title: Worsening of myasthenia gravis on treatment with imipenem/cilastatin.

Journal: Journal of neurology, neurosurgery, and psychiatry19940301

Title: Prospective surveillance of imipenem/cilastatin use and associated seizures using a hospital information system.

Journal: The Annals of pharmacotherapy19930401

Title: Risk/benefit in the treatment of children with imipenem-cilastatin for meningitis caused by penicillin-resistant pneumococcus.

Journal: Journal of chemotherapy (Florence, Italy)19930401

Title: [Cholestasis in imipenem/cilastatin treatment].

Journal: Zeitschrift fur Gastroenterologie19930201

Title: Imipenem/cilastatin-associated hiccups.

Journal: The Annals of pharmacotherapy19921101

Title: Imipenem/cilastatin. A reappraisal of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.

Journal: Drugs19920901

Title: Vertigo caused by intravenous imipenem/cilastatin.

Journal: DICP : the annals of pharmacotherapy19910901

Title: Evaluation of an imipenem/cilastatin target drug program.

Journal: DICP : the annals of pharmacotherapy19910401

Title: Seizure activity associated with imipenem use: clinical case reports and review of the literature.

Journal: DICP : the annals of pharmacotherapy19910401

Title: Imipenem/cilastatin treatment of bacterial meningitis in children.

Journal: The Pediatric infectious disease journal19910201

Title: The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem.

Journal: Journal of the American Society of Nephrology : JASN19901101

Title: Meropenem: evidence of lack of proconvulsive tendency in mice.

Journal: The Journal of antimicrobial chemotherapy19890901

Title: [Seizure and tremor occurring in acute leukemia patients treated with imipenem/cilastatin].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology19890301

Title: Neurotoxicity of beta-lactam antibiotics. Experimental kinetic and neurophysiological studies.

Journal: Scandinavian journal of infectious diseases. Supplementum19880101

Title: Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids.

Journal: Journal of medicinal chemistry19870601

Title: Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.

Journal: Drugs19870301

Title: Imipenem-cilastatin sodium, a broad-spectrum carbapenem antibiotic combination.

Journal: Clinical pharmacy19860901

Title: Carbapenems, a new class of beta-lactam antibiotics. Discovery and development of imipenem/cilastatin.

Journal: The American journal of medicine19850607

Title: Thienamycin: development of imipenen-cilastatin.

Journal: The Journal of antimicrobial chemotherapy19831201

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