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835904-51-3,MFCD30719243
Catalog No.:AA01EOFQ

835904-51-3 | Synta66

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98% by HPLC
in stock  
$83.00   $58.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EOFQ
Chemical Name:
Synta66
CAS Number:
835904-51-3
Molecular Formula:
C20H17FN2O3
Molecular Weight:
352.3590
MDL Number:
MFCD30719243
SMILES:
COc1ccc(c(c1)c1ccc(cc1)NC(=O)c1ccncc1F)OC
Properties
Computed Properties
 
Complexity:
456  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.4  

Literature

Title: Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.

Journal: Circulation research 20110513

Title: Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels.

Journal: The Journal of biological chemistry 20081114

Title: Molnár T, et al. Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. J Neurosci. 2016 Mar 16;36(11):3184-98.

Title: van Kruchten R, et al. Antithrombotic potential of blockers of store-operated calcium channels in platelets. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1717-23.

Title: Wajdner HE, et al. Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. Physiol Rep. 2017 Mar;5(5).

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Tags:835904-51-3 Molecular Formula|835904-51-3 MDL|835904-51-3 SMILES|835904-51-3 Synta66
Catalog No.: AA01EOFQ
835904-51-3,MFCD30719243
835904-51-3 | Synta66
Pack Size： 1mg
Purity： 98% by HPLC
in stock
$83.00 $58.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01EOFQ
Chemical Name: Synta66
CAS Number: 835904-51-3
Molecular Formula: C20H17FN2O3
Molecular Weight: 352.3590
MDL Number: MFCD30719243
SMILES: COc1ccc(c(c1)c1ccc(cc1)NC(=O)c1ccncc1F)OC
Properties
Complexity: 456  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.4  
Literature fold

Title: Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.

Journal: Circulation research20110513

Title: Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels.

Journal: The Journal of biological chemistry20081114

Title: Molnár T, et al. Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. J Neurosci. 2016 Mar 16;36(11):3184-98.

Title: van Kruchten R, et al. Antithrombotic potential of blockers of store-operated calcium channels in platelets. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1717-23.

Title: Wajdner HE, et al. Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. Physiol Rep. 2017 Mar;5(5).

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