Name: Name:As1842856
Brand: AABLOCKS
SKU: AA00G7AP
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00G7AP

Chemical Name: As1842856

CAS Number: 836620-48-5

Molecular Formula: C18H22FN3O3

Molecular Weight: 347.3840

MDL Number: MFCD30718173

SMILES: CCn1cc(C(=O)O)c(=O)c2c1cc(NC1CCCCC1)c(c2N)F

Properties

Complexity: 562

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 25

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 4

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.6

Literature fold

Title: Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes.

Journal: Toxicology and applied pharmacology20151201

Title: Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice.

Journal: Molecular pharmacology20101101

Title: Nagashima T, et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010 Nov;78(5):961-70.

Title: He J, et al. The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. Biosci Rep. 2019 May 10;39(5). pii: BSR20190112.

836620-48-5 | As1842856