Name: Name:ADL-5859 Hydrochloride
Brand: AABLOCKS
SKU: AA00G3KI
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00G3KI

Chemical Name: ADL-5859 Hydrochloride

CAS Number: 850173-95-4

Molecular Formula: C24H29ClN2O3

Molecular Weight: 428.9517

MDL Number: MFCD17215195

SMILES: CCN(C(=O)c1ccc(cc1)C1=CC2(CCNCC2)Oc2c1c(O)ccc2)CC.Cl

Properties

Complexity: 601

Covalently-Bonded Unit Count: 2

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 30

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 4

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Literature fold

Title: δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.

Journal: The Journal of pharmacology and experimental therapeutics20120901

Title: Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

Journal: Journal of medicinal chemistry20081009

Title: Nozaki C, et al. δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization.J Pharmacol Exp Ther. 2012 Sep;342(3):799-807.

Title: Le Bourdonnec B, et al. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine-4-yl) benzamide (ADL5747).J Med Chem. 2009 Sep 24;52(18):5685-702.

Title: Le Bourdonnec B, Windh RT, Ajello CW, Leister LK, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Christ DD, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL,

Title: Le Bourdonnec B et al. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine-4-yl)benzamide (ADL5859) J Med Chem. 2008 Oct 9;51(19):5893-6.

850173-95-4 | ADL-5859 Hydrochloride