85081-18-1,MFCD08061467
Catalog No.:AA004RNP

85081-18-1 | Nbi-98782

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$2,812.00   $1,969.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA004RNP
Chemical Name:
Nbi-98782
CAS Number:
85081-18-1
Molecular Formula:
C19H29NO3
Molecular Weight:
319.4385
MDL Number:
MFCD08061467
SMILES:
COc1cc2c(cc1OC)CCN1[C@@H]2C[C@@H](O)[C@@H](C1)CC(C)C
Properties
Properties
 
Form:
Solid  
MP:
106-108℃(Solv: hexane (110-54-3))  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
389  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.2  

Literature

Title: Heterogeneity of cholinergic denervation in Parkinson's disease without dementia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120801

Title: DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function.

Journal: Neurobiology of aging 20120401

Title: In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers.

Journal: The American journal of psychiatry 20120101

Title: A concise synthesis of tetrabenazine: an intramolecular aza-Prins-type cyclization via oxidative C-H activation.

Journal: Organic letters 20111216

Title: Sigma receptor binding of tetrabenazine series tracers targeting VMAT2 in rat pancreas.

Journal: Nuclear medicine and biology 20111001

Title: Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20110901

Title: Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson's disease.

Journal: Brain : a journal of neurology 20110801

Title: Platelet vesicular monoamine transporter 2 density in the disruptive behavior disorders.

Journal: Journal of child and adolescent psychopharmacology 20110801

Title: Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: Assessment of mild dementia with amyloid and dopamine terminal positron emission tomography.

Journal: Brain : a journal of neurology 20110601

Title: Age-specific progression of nigrostriatal dysfunction in Parkinson's disease.

Journal: Annals of neurology 20110501

Title: Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors.

Journal: European journal of medicinal chemistry 20110501

Title: Rat pancreas uptake of [11C]dihydrotetrabenazine stereoisomers.

Journal: Nuclear medicine and biology 20101101

Title: The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20101001

Title: 11C-dihydrotetrabenazine beta-cell imaging.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100901

Title: Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100901

Title: Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans.

Journal: Synapse (New York, N.Y.) 20100601

Title: Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study.

Journal: Neurobiology of disease 20100601

Title: Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairment.

Journal: Archives of neurology 20100401

Title: The utility of [(11)C] dihydrotetrabenazine positron emission tomography scanning in assessing beta-cell performance after sleeve gastrectomy and duodenal-jejunal bypass.

Journal: Surgery 20100201

Title: Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function.

Journal: Synapse (New York, N.Y.) 20100201

Title: In vivo [11C]dihydrotetrabenazine binding in rat striatum: sensitivity to dopamine concentrations.

Journal: Nuclear medicine and biology 20100101

Title: Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).

Journal: Journal of medicinal chemistry 20091210

Title: Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20091201

Title: Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification.

Journal: NeuroImage 20090815

Title: Visualizing vesicular dopamine dynamics in Parkinson's disease.

Journal: Synapse (New York, N.Y.) 20090801

Title: Signal separation and parameter estimation in noninvasive dual-tracer PET scans using reference-region approaches.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090701

Title: Noninvasive imaging of pancreatic beta cells.

Journal: Nature reviews. Endocrinology 20090701

Title: Measurement of plasmalemmal dopamine transport, vesicular dopamine transport, and K(+)-stimulated dopamine release in frozen rat brain tissue.

Journal: Journal of neuroscience methods 20090615

Title: Asymmetric synthesis of tetrabenazine and dihydrotetrabenazine.

Journal: The Journal of organic chemistry 20090515

Title: Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.

Journal: Parkinsonism & related disorders 20090501

Title: Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome.

Journal: Neurology 20090421

Title: PET demonstrates reduced dopamine transporter expression in PD with dyskinesias.

Journal: Neurology 20090407

Title: Dyskinesia in Parkinson disease: back for the future?

Journal: Neurology 20090407

Title: Pancreatic imaging with 11C-dihydrotetrabenazine PET: a perspective.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090301

Title: 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090301

Title: Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism.

Journal: Journal of neurochemistry 20081201

Title: Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration.

Journal: Synapse (New York, N.Y.) 20081101

Title: Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080924

Title: Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20080915

Title: In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701

Title: Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole hemisphere autoradiography.

Journal: Psychiatry research 20080530

Title: VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.

Journal: Journal of neurochemistry 20080401

Title: Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates.

Journal: European journal of nuclear medicine and molecular imaging 20080401

Title: Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease.

Journal: Annals of neurology 20080301

Title: [Quick and simple synthesis of (11)C-(+)-alpha-dihydrotetrabenazine to be used as a PET radioligand of vesicular monoamine transporters].

Journal: Revista espanola de medicina nuclear 20080101

Title: [Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease].

Journal: Revista espanola de medicina nuclear 20080101

Title: Differentiating Alzheimer's disease from dementia with Lewy bodies and Parkinson's disease with (+)-[11C]dihydrotetrabenazine positron emission tomography.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association 20080101

Title: Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia.

Journal: Journal of neurogenetics 20080101

Title: In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070701

Title: Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070701

Title: Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain.

Journal: Nuclear medicine and biology 20070401

Title: Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters.

Journal: Nuclear medicine and biology 20070401

Title: Interaction of amphetamines and related compounds at the vesicular monoamine transporter.

Journal: The Journal of pharmacology and experimental therapeutics 20061001

Title: Visualizing pancreatic beta-cell mass with [11C]DTBZ.

Journal: Nuclear medicine and biology 20061001

Title: Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060901

Title: Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters.

Journal: Nuclear medicine and biology 20060801

Title: Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.

Journal: The Journal of clinical investigation 20060601

Title: Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20060101

Title: PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.

Journal: Brain : a journal of neurology 20051201

Title: Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia.

Journal: Psychiatry research 20050915

Title: The influence of measurement uncertainties on the evaluation of the distribution volume ratio and binding potential in rat studies on a microPET R4: a phantom study.

Journal: Physics in medicine and biology 20050621

Title: 11C-DTBZ and 18F-FDG PET measures in differentiating dementias.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050601

Title: Decreased platelet vesicular monoamine transporter density in children and adolescents with attention deficit/hyperactivity disorder.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050301

Title: Decreased platelet vesicular monoamine transporter density in habitual smokers.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050301

Title: The role of radiotracer imaging in Parkinson disease.

Journal: Neurology 20050125

Title: Lack of regional selectivity during the progression of Parkinson disease: implications for pathogenesis.

Journal: Archives of neurology 20041201

Title: Identification of tissue-restricted transcripts in human islets.

Journal: Endocrinology 20041001

Title: Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain.

Journal: Experimental neurology 20040801

Title: Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040701

Title: Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain.

Journal: Nuclear medicine and biology 20040701

Title: Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease.

Journal: Annals of neurology 20040601

Title: Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes.

Journal: Journal of neuroscience methods 20040215

Title: Dopamine transmission in DYT1 dystonia.

Journal: Advances in neurology 20040101

Title: [11C]DTBZ-PET correlates of levodopa responses in asymmetric Parkinson's disease.

Journal: Brain : a journal of neurology 20031201

Title: Raclopride studies of dopamine release: dependence on presynaptic integrity.

Journal: Biological psychiatry 20031201

Title: Apparent opposite effects of tetrabenazine and reserpine on the toxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine on nigro-striatal dopaminergic neurons.

Journal: Brain research 20031107

Title: Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease.

Journal: Experimental neurology 20031101

Title: Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001

Title: Increased ventral striatal monoaminergic innervation in Tourette syndrome.

Journal: Neurology 20030812

Title: REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA.

Journal: Neurology 20030708

Title: Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA.

Journal: Neurology 20030708

Title: VMAT2 binding is elevated in dopa-responsive dystonia: visualizing empty vesicles by PET.

Journal: Synapse (New York, N.Y.) 20030701

Title: Decreased limbic vesicular monoamine transporter 2 in a genetic rat model of depression.

Journal: Brain research 20030307

Title: Elevated platelet vesicular monoamine transporter density in untreated patients diagnosed with major depression.

Journal: Psychiatry research 20021115

Title: Methylphenidate redistributes vesicular monoamine transporter-2: role of dopamine receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021001

Title: Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice.

Journal: Journal of neuroendocrinology 20020901

Title: Increased platelet vesicular monoamine transporter density in adult schizophrenia patients.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020801

Title: Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020601

Title: In vivo measures of dopaminergic radioligands in the rat brain: equilibrium infusion studies.

Journal: Synapse (New York, N.Y.) 20020301

Title: Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity.

Journal: The Journal of pharmacology and experimental therapeutics 20020301

Title: Phencyclidine increases vesicular dopamine uptake.

Journal: European journal of pharmacology 20020301

Title: Dual-[11C]tracer single-acquisition positron emission tomography studies.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011201

Title: Characterization of high-affinity [3H]TBZOH binding to the human platelet vesicular monoamine transporter.

Journal: Life sciences 20010928

Title: Cocaine-induced increases in vesicular dopamine uptake: role of dopamine receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20010901

Title: Assessing the integrity of the dopamine system in Parkinson's disease: how best to do it?

Journal: Movement disorders : official journal of the Movement Disorder Society 20010901

Title: Decreased densities of dopamine and serotonin transporters and of vesicular monoamine transporter 2 in severely kainic acid lesioned subregions of the striatum.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: Kilbourn M, et al. Binding of alpha-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific. Eur J Pharmacol. 1995 May 24;278(3):249-52.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Historical Records
Tags:85081-18-1 Molecular Formula|85081-18-1 MDL|85081-18-1 SMILES|85081-18-1 Nbi-98782
Catalog No.: AA004RNP
85081-18-1,MFCD08061467
85081-18-1 | Nbi-98782
Pack Size: 100mg
Purity: 95%
in stock
$2,812.00 $1,969.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA004RNP
Chemical Name: Nbi-98782
CAS Number: 85081-18-1
Molecular Formula: C19H29NO3
Molecular Weight: 319.4385
MDL Number: MFCD08061467
SMILES: COc1cc2c(cc1OC)CCN1[C@@H]2C[C@@H](O)[C@@H](C1)CC(C)C
Properties
Form: Solid  
MP: 106-108℃(Solv: hexane (110-54-3))  
Storage: Keep in dry area;2-8℃;  
Complexity: 389  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.2  
Literature fold

Title: Heterogeneity of cholinergic denervation in Parkinson's disease without dementia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20120801

Title: DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function.

Journal: Neurobiology of aging20120401

Title: In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers.

Journal: The American journal of psychiatry20120101

Title: A concise synthesis of tetrabenazine: an intramolecular aza-Prins-type cyclization via oxidative C-H activation.

Journal: Organic letters20111216

Title: Sigma receptor binding of tetrabenazine series tracers targeting VMAT2 in rat pancreas.

Journal: Nuclear medicine and biology20111001

Title: Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20110901

Title: Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson's disease.

Journal: Brain : a journal of neurology20110801

Title: Platelet vesicular monoamine transporter 2 density in the disruptive behavior disorders.

Journal: Journal of child and adolescent psychopharmacology20110801

Title: Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands.

Journal: Bioorganic & medicinal chemistry letters20110601

Title: Assessment of mild dementia with amyloid and dopamine terminal positron emission tomography.

Journal: Brain : a journal of neurology20110601

Title: Age-specific progression of nigrostriatal dysfunction in Parkinson's disease.

Journal: Annals of neurology20110501

Title: Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors.

Journal: European journal of medicinal chemistry20110501

Title: Rat pancreas uptake of [11C]dihydrotetrabenazine stereoisomers.

Journal: Nuclear medicine and biology20101101

Title: The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20101001

Title: 11C-dihydrotetrabenazine beta-cell imaging.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20100901

Title: Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20100901

Title: Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans.

Journal: Synapse (New York, N.Y.)20100601

Title: Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study.

Journal: Neurobiology of disease20100601

Title: Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairment.

Journal: Archives of neurology20100401

Title: The utility of [(11)C] dihydrotetrabenazine positron emission tomography scanning in assessing beta-cell performance after sleeve gastrectomy and duodenal-jejunal bypass.

Journal: Surgery20100201

Title: Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function.

Journal: Synapse (New York, N.Y.)20100201

Title: In vivo [11C]dihydrotetrabenazine binding in rat striatum: sensitivity to dopamine concentrations.

Journal: Nuclear medicine and biology20100101

Title: Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).

Journal: Journal of medicinal chemistry20091210

Title: Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20091201

Title: Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2.

Journal: Bioorganic & medicinal chemistry letters20090901

Title: New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification.

Journal: NeuroImage20090815

Title: Visualizing vesicular dopamine dynamics in Parkinson's disease.

Journal: Synapse (New York, N.Y.)20090801

Title: Signal separation and parameter estimation in noninvasive dual-tracer PET scans using reference-region approaches.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20090701

Title: Noninvasive imaging of pancreatic beta cells.

Journal: Nature reviews. Endocrinology20090701

Title: Measurement of plasmalemmal dopamine transport, vesicular dopamine transport, and K(+)-stimulated dopamine release in frozen rat brain tissue.

Journal: Journal of neuroscience methods20090615

Title: Asymmetric synthesis of tetrabenazine and dihydrotetrabenazine.

Journal: The Journal of organic chemistry20090515

Title: Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.

Journal: Parkinsonism & related disorders20090501

Title: Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome.

Journal: Neurology20090421

Title: PET demonstrates reduced dopamine transporter expression in PD with dyskinesias.

Journal: Neurology20090407

Title: Dyskinesia in Parkinson disease: back for the future?

Journal: Neurology20090407

Title: Pancreatic imaging with 11C-dihydrotetrabenazine PET: a perspective.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20090301

Title: 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20090301

Title: Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism.

Journal: Journal of neurochemistry20081201

Title: Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration.

Journal: Synapse (New York, N.Y.)20081101

Title: Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080924

Title: Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists.

Journal: Bioorganic & medicinal chemistry letters20080915

Title: In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20080701

Title: Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole hemisphere autoradiography.

Journal: Psychiatry research20080530

Title: VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.

Journal: Journal of neurochemistry20080401

Title: Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates.

Journal: European journal of nuclear medicine and molecular imaging20080401

Title: Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease.

Journal: Annals of neurology20080301

Title: [Quick and simple synthesis of (11)C-(+)-alpha-dihydrotetrabenazine to be used as a PET radioligand of vesicular monoamine transporters].

Journal: Revista espanola de medicina nuclear20080101

Title: [Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease].

Journal: Revista espanola de medicina nuclear20080101

Title: Differentiating Alzheimer's disease from dementia with Lewy bodies and Parkinson's disease with (+)-[11C]dihydrotetrabenazine positron emission tomography.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association20080101

Title: Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia.

Journal: Journal of neurogenetics20080101

Title: In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20070701

Title: Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20070701

Title: Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain.

Journal: Nuclear medicine and biology20070401

Title: Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters.

Journal: Nuclear medicine and biology20070401

Title: Interaction of amphetamines and related compounds at the vesicular monoamine transporter.

Journal: The Journal of pharmacology and experimental therapeutics20061001

Title: Visualizing pancreatic beta-cell mass with [11C]DTBZ.

Journal: Nuclear medicine and biology20061001

Title: Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20060901

Title: Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters.

Journal: Nuclear medicine and biology20060801

Title: Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.

Journal: The Journal of clinical investigation20060601

Title: Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging20060101

Title: PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.

Journal: Brain : a journal of neurology20051201

Title: Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia.

Journal: Psychiatry research20050915

Title: The influence of measurement uncertainties on the evaluation of the distribution volume ratio and binding potential in rat studies on a microPET R4: a phantom study.

Journal: Physics in medicine and biology20050621

Title: 11C-DTBZ and 18F-FDG PET measures in differentiating dementias.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20050601

Title: Decreased platelet vesicular monoamine transporter density in children and adolescents with attention deficit/hyperactivity disorder.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20050301

Title: Decreased platelet vesicular monoamine transporter density in habitual smokers.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20050301

Title: The role of radiotracer imaging in Parkinson disease.

Journal: Neurology20050125

Title: Lack of regional selectivity during the progression of Parkinson disease: implications for pathogenesis.

Journal: Archives of neurology20041201

Title: Identification of tissue-restricted transcripts in human islets.

Journal: Endocrinology20041001

Title: Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain.

Journal: Experimental neurology20040801

Title: Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20040701

Title: Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain.

Journal: Nuclear medicine and biology20040701

Title: Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease.

Journal: Annals of neurology20040601

Title: Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes.

Journal: Journal of neuroscience methods20040215

Title: Dopamine transmission in DYT1 dystonia.

Journal: Advances in neurology20040101

Title: [11C]DTBZ-PET correlates of levodopa responses in asymmetric Parkinson's disease.

Journal: Brain : a journal of neurology20031201

Title: Raclopride studies of dopamine release: dependence on presynaptic integrity.

Journal: Biological psychiatry20031201

Title: Apparent opposite effects of tetrabenazine and reserpine on the toxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine on nigro-striatal dopaminergic neurons.

Journal: Brain research20031107

Title: Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease.

Journal: Experimental neurology20031101

Title: Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20031001

Title: Increased ventral striatal monoaminergic innervation in Tourette syndrome.

Journal: Neurology20030812

Title: REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA.

Journal: Neurology20030708

Title: Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA.

Journal: Neurology20030708

Title: VMAT2 binding is elevated in dopa-responsive dystonia: visualizing empty vesicles by PET.

Journal: Synapse (New York, N.Y.)20030701

Title: Decreased limbic vesicular monoamine transporter 2 in a genetic rat model of depression.

Journal: Brain research20030307

Title: Elevated platelet vesicular monoamine transporter density in untreated patients diagnosed with major depression.

Journal: Psychiatry research20021115

Title: Methylphenidate redistributes vesicular monoamine transporter-2: role of dopamine receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20021001

Title: Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice.

Journal: Journal of neuroendocrinology20020901

Title: Increased platelet vesicular monoamine transporter density in adult schizophrenia patients.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20020801

Title: Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20020601

Title: In vivo measures of dopaminergic radioligands in the rat brain: equilibrium infusion studies.

Journal: Synapse (New York, N.Y.)20020301

Title: Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity.

Journal: The Journal of pharmacology and experimental therapeutics20020301

Title: Phencyclidine increases vesicular dopamine uptake.

Journal: European journal of pharmacology20020301

Title: Dual-[11C]tracer single-acquisition positron emission tomography studies.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20011201

Title: Characterization of high-affinity [3H]TBZOH binding to the human platelet vesicular monoamine transporter.

Journal: Life sciences20010928

Title: Cocaine-induced increases in vesicular dopamine uptake: role of dopamine receptors.

Journal: The Journal of pharmacology and experimental therapeutics20010901

Title: Assessing the integrity of the dopamine system in Parkinson's disease: how best to do it?

Journal: Movement disorders : official journal of the Movement Disorder Society20010901

Title: Decreased densities of dopamine and serotonin transporters and of vesicular monoamine transporter 2 in severely kainic acid lesioned subregions of the striatum.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20010101

Title: Kilbourn M, et al. Binding of alpha-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific. Eur J Pharmacol. 1995 May 24;278(3):249-52.

Building Blocks More >
850568-01-3
850568-01-3
2-Bromomethyl-4-fluorophenylboronic acid
AA004SFI | MFCD06659867
867034-10-4
867034-10-4
Ethyl 7-chloro-1h-pyrrolo[2,3-c]pyridine-2-carboxylate
AA004T9E | MFCD13184346
866546-11-4
866546-11-4
1H-Pyrrolo[2,3-b]pyridine, 5-chloro-1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
AA004TUZ | MFCD16039195
855400-82-7
855400-82-7
5-Bromo-4-chloro-2-nitrophenol
AA004UO9 | MFCD22383651
852180-38-2
852180-38-2
Methyl 5-(3-pyridinyloxy)-2-furoate
AA004VVT | MFCD07368496
83341-28-0
83341-28-0
5-Fluoro-4-methyl-2-nitrophenol
AA004X6D | MFCD16658619
850623-44-8
850623-44-8
Potassium (2-benzyloxyphenyl)trifluoroborate
AA004YBT | MFCD04115742
799262-37-6
799262-37-6
3-(5-Methyl-1H-tetrazol-1-yl)benzoic acid
AA004Z6I | MFCD04113966
822-28-6
822-28-6
vinyl cetyl ether
AA0050A6 | MFCD00026649
82101-76-6
82101-76-6
Ethyl (Z)-3-(tributylstannyl)acrylate
AA0051FX | MFCD30478283
Submit
© 2017 AA BLOCKS, INC. All rights reserved.