857064-38-1,MFCD12912450
Catalog No.:AA004ZIZ

857064-38-1 | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-n-(1-phenylethyl)acrylamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98%(HPLC)
in stock  
$32.00   $23.00
- +
100mg
98%(HPLC)
in stock  
$94.00   $66.00
- +
250mg
98%(HPLC)
in stock  
$156.00   $109.00
- +
1g
98%
in stock  
$244.00   $171.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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Technical Information
Catalog Number:
AA004ZIZ
Chemical Name:
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-n-(1-phenylethyl)acrylamide
CAS Number:
857064-38-1
Molecular Formula:
C17H14BrN3O
Molecular Weight:
356.2166
MDL Number:
MFCD12912450
SMILES:
N#C/C(=C\c1cccc(n1)Br)/C(=O)N[C@H](c1ccccc1)C
Properties
Properties
 
Form:
Solid  
MP:
90-93ºC  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
462  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.4  

Literature

Title: Molecular mechanisms of 3,3'4,4',5-pentachlorobiphenyl-induced epithelial-mesenchymal transition in human hepatocellular carcinoma cells.

Journal: Toxicology and applied pharmacology 20170501

Title: The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.

Journal: Toxicology 20140801

Title: Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.

Journal: The Journal of biological chemistry 20140502

Title: Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140201

Title: Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation.

Journal: Basic research in cardiology 20120501

Title: Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma.

Journal: Bioorganic & medicinal chemistry 20111201

Title: Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways.

Journal: Oncology reports 20111101

Title: Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3.

Journal: Stem cells (Dayton, Ohio) 20111101

Title: STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma.

Journal: British journal of cancer 20100525

Title: WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080201

Title: WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.

Journal: Cancer research 20071201

Title: A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.

Journal: Oncogene 20070412

Title: Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796.

Title: Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of WP1066 in murine melanoma models. Int J Cancer, 2012, 131(1), 8-17

Title: Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67(23), 11291-11299.

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Tags:857064-38-1 Molecular Formula|857064-38-1 MDL|857064-38-1 SMILES|857064-38-1 (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-n-(1-phenylethyl)acrylamide
Catalog No.: AA004ZIZ
857064-38-1,MFCD12912450
857064-38-1 | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-n-(1-phenylethyl)acrylamide
Pack Size: 25mg
Purity: 98%(HPLC)
in stock
$32.00 $23.00
Pack Size: 100mg
Purity: 98%(HPLC)
in stock
$94.00 $66.00
Pack Size: 250mg
Purity: 98%(HPLC)
in stock
$156.00 $109.00
Pack Size: 1g
Purity: 98%
in stock
$244.00 $171.00
Quantity
- +
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Technical Information
Catalog Number: AA004ZIZ
Chemical Name: (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-n-(1-phenylethyl)acrylamide
CAS Number: 857064-38-1
Molecular Formula: C17H14BrN3O
Molecular Weight: 356.2166
MDL Number: MFCD12912450
SMILES: N#C/C(=C\c1cccc(n1)Br)/C(=O)N[C@H](c1ccccc1)C
Properties
Form: Solid  
MP: 90-93ºC  
Storage: Inert atmosphere;2-8℃;  
Complexity: 462  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.4  
Literature fold

Title: Molecular mechanisms of 3,3'4,4',5-pentachlorobiphenyl-induced epithelial-mesenchymal transition in human hepatocellular carcinoma cells.

Journal: Toxicology and applied pharmacology20170501

Title: The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.

Journal: Toxicology20140801

Title: Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.

Journal: The Journal of biological chemistry20140502

Title: Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20140201

Title: Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation.

Journal: Basic research in cardiology20120501

Title: Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma.

Journal: Bioorganic & medicinal chemistry20111201

Title: Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways.

Journal: Oncology reports20111101

Title: Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3.

Journal: Stem cells (Dayton, Ohio)20111101

Title: STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma.

Journal: British journal of cancer20100525

Title: WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20080201

Title: WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.

Journal: Cancer research20071201

Title: A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.

Journal: Oncogene20070412

Title: Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796.

Title: Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of WP1066 in murine melanoma models. Int J Cancer, 2012, 131(1), 8-17

Title: Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67(23), 11291-11299.

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