Name: Name:Ro4987655
Brand: AABLOCKS
SKU: AA00GU3C
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00GU3C

Chemical Name: Ro4987655

CAS Number: 874101-00-5

Molecular Formula: C20H19F3IN3O5

Molecular Weight: 565.2816

MDL Number: MFCD19443685

SMILES: OCCONC(=O)c1cc(CN2OCCCC2=O)c(c(c1Nc1ccc(cc1F)I)F)F

Properties

Complexity: 652

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 32

Hydrogen Bond Acceptor Count: 9

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 8

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3

Literature fold

Title: Phase I and pharmacokinetics/pharmacodynamics study of the MEK inhibitor RO4987655 in Japanese patients with advanced solid tumors.

Journal: Investigational new drugs20150601

Title: Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20140815

Title: MEK and the inhibitors: from bench to bedside.

Journal: Journal of hematology & oncology20130101

Title: Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655 (CH4987655) in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20120901

Title: Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

Journal: Bioorganic & medicinal chemistry letters20110315

Title: Hypertension in pregnancy: an invitational symposium.

Journal: The Journal of reproductive medicine19751101

Title: Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15(23):7368-74.

Title: Tegnebratt T, et al. Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F FDG-PET imaging combined with proteomic approaches. EJNMMI Res. 2014 Dec;4(1):34.

874101-00-5 | Ro4987655