89396-94-1,MFCD00923828
Catalog No.:AA00GT5V

89396-94-1 | Imidapril hydrochloride

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Purity
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5mg
≥98%
in stock  
$52.00   $36.00
- +
10mg
≥98%
in stock  
$95.00   $66.00
- +
25mg
98%(HPLC)powder
in stock  
$191.00   $134.00
- +
50mg
≥98%
in stock  
$368.00   $257.00
- +
100mg
>98.0%(T)(HPLC)
in stock  
$392.00   $275.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GT5V
Chemical Name:
Imidapril hydrochloride
CAS Number:
89396-94-1
Molecular Formula:
C20H28ClN3O6
Molecular Weight:
441.9058
MDL Number:
MFCD00923828
SMILES:
CCOC(=O)C(NC(C(=O)N1C(=O)N(CC1C(=O)O)C)C)CCc1ccccc1.Cl
Properties
Computed Properties
 
Complexity:
619  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: A comparison between imidapril and ramipril on attenuation of ventricular remodeling after myocardial infarction.

Journal: Journal of cardiovascular pharmacology 20120401

Title: Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120201

Title: Effects of olmesartan and imidapril on the plasma adiponectin, P-selectin, and MDA-LDL levels of diabetic nephropathy patients.

Journal: Clinica chimica acta; international journal of clinical chemistry 20120118

Title: Role of angiotensin II in plasma PAI-1 changes induced by imidapril or candesartan in hypertensive patients with metabolic syndrome.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20111201

Title: Identification of carboxylesterases expressed in rat intestine and effects of their hydrolyzing activity in predicting first-pass metabolism of ester prodrugs.

Journal: Die Pharmazie 20111101

Title: Suppressive effects of imidapril on Th1- and Th2-related chemokines in monocytes.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20111001

Title: Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110901

Title: Nicergoline improves dysphagia by upregulating substance P in the elderly.

Journal: Medicine 20110701

Title: Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110401

Title: Angiotensin-converting enzyme inhibition and fibrinolytic balance.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110401

Title: Candesartan versus imidapril in hypertension: a randomised study to assess effects of anti-AT1 receptor autoantibodies.

Journal: Heart (British Cardiac Society) 20110301

Title: UV derivative spectrophotometric and RP-HPLC methods for determination of imidapril hydrochloride in tablets and for its stability assessment in solid state.

Journal: Acta poloniae pharmaceutica 20110101

Title: Strong suppression of the renin-angiotensin system has a renal-protective effect in hypertensive patients: high-dose ARB with ACE inhibitor (Hawaii) study.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20101101

Title: Addition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without β-blockers.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20101101

Title: Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease.

Journal: Brain research 20100917

Title: Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100901

Title: Effect of combining ACE inhibitor and statin in lupus-prone mice.

Journal: Clinical immunology (Orlando, Fla.) 20100801

Title: Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp.

Journal: Frontiers in bioscience (Elite edition) 20100601

Title: [Combination therapy of hypertension in general clinical practice. The results of the KOHYBA study].

Journal: Vnitrni lekarstvi 20100301

Title: Comparison of the incidence of imidapril and enalapril induced cough.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100101

Title: Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20090901

Title: [Hospital pharmacists prevented advance of lithium intoxication through pharmaceutical interventions].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090801

Title: Effect on the atherogenic marker plasminogen activator inhibitor type-1 of addition of the ACE inhibitor imidapril to angiotensin II type 1 receptor antagonist therapy in hypertensive patients with abnormal glucose metabolism: a prospective cohort study in primary care.

Journal: Clinical drug investigation 20090101

Title: Recurrent severe angioedema associated with imidapril and diclofenac.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20081201

Title: [Renin-angiotensin system blocking agents reverse the myocardial hypertrophy in experimental hyperthyroid cardiomyopathy via altering intracellular calcium handling].

Journal: Zhonghua xin xue guan bing za zhi 20080801

Title: Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis.

Journal: Hypertension (Dallas, Tex. : 1979) 20080201

Title: Intron-2 conversion polymorphism of the aldosterone synthase gene and the antihypertensive response to angiotensin-converting enzyme inhibitors.

Journal: Journal of hypertension 20080201

Title: Vascular protecting effect of angiotensin receptor blocker (ARB) on the radial artery graft.

Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20080201

Title: A one-year study of the antiatherosclerotic effect of the angiotensin-II receptor blocker losartan in hypertensive patients. A comparison with angiotension-converting enzyme inhibitors.

Journal: International heart journal 20080101

Title: Comparison of monotherapy versus combination antihypertensive therapy in elderly patients with essential hypertension.

Journal: Angiology 20080101

Title: Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9.

Journal: Journal of molecular and cellular cardiology 20071201

Title: PAI-1 plays an important role in liver failure after excessive hepatectomy in the rat.

Journal: The Journal of surgical research 20071101

Title: Dechallenge and rechallenge method showed different incidences of cough among four ACE-Is.

Journal: Journal of clinical epidemiology 20070601

Title: Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin.

Journal: Investigative ophthalmology & visual science 20070501

Title: Clinical evaluation of imidapril in congestive heart failure in dogs: results of the EFFIC study.

Journal: The Journal of small animal practice 20070501

Title: Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats.

Journal: International journal of molecular medicine 20070401

Title: Clearance of imidapril, an Angiotensin-converting enzyme inhibitor, during hemodialysis in hypertensive renal failure patients: comparison with quinapril and enalapril.

Journal: Journal of clinical pharmacology 20070201

Title: A multicentre, 12-week study of imidapril and candesartan cilexetil in patients with mild to moderate hypertension using ambulatory blood pressure monitoring.

Journal: Clinical drug investigation 20070101

Title: Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure.

Journal: Drugs 20070101

Title: A twelve-week, multicenter, randomized, double-blind, parallel-group, noninferiority trial of the antihypertensive efficacy and tolerability of imidapril and candesartan in adult patients with mild to moderate essential hypertension: the Iberian Multicenter Imidapril Study on Hypertension (IMISH).

Journal: Clinical therapeutics 20061201

Title: Imidapril in heart failure.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20060901

Title: Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice.

Journal: Journal of the American Society of Nephrology : JASN 20060701

Title: Addition of spironolactone to an angiotensin-converting enzyme inhibitor decreases lung congestion and edema in Dahl hypertensive rats.

Journal: Heart and vessels 20060701

Title: Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors.

Journal: Clinical pharmacology and therapeutics 20060601

Title: Long-term treatment with imidapril but not with nifedipine enhances plasma NOx concentration in patients with essential hypertension.

Journal: Journal of pharmacological sciences 20060601

Title: Effects of imidapril on left ventricular mass in chronic hemodialysis patients.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20060401

Title: Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor.

Journal: Clinical and experimental pharmacology & physiology 20060101

Title: T1198C polymorphism of the angiotensinogen gene and antihypertensive response to angiotensin-converting enzyme inhibitors.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20051201

Title: Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20051101

Title: Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia.

Journal: British journal of cancer 20050822

Title: Long-term effect of imidapril hydrochloride compared with dilazep hydrochloride administration on blood pressure and renal function in patients with chronic glomerulonephritis.

Journal: International heart journal 20050701

Title: Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system.

Journal: American journal of physiology. Heart and circulatory physiology 20050601

Title: Sarcoplasmic reticulum Ca2+ transport and gene expression in congestive heart failure are modified by imidapril treatment.

Journal: American journal of physiology. Heart and circulatory physiology 20050401

Title: LC-MS determination and bioavailability study of imidapril hydrochloride after the oral administration of imidapril tablets in human volunteers.

Journal: Archives of pharmacal research 20050401

Title: Different effects of imidapril and enalapril on aminopeptidase P activity in the mouse trachea.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20050301

Title: Imidapril treatment improves the attenuated inotropic and intracellular calcium responses to ATP in heart failure due to myocardial infarction.

Journal: British journal of pharmacology 20050101

Title: Combination of half doses of angiotensin type 1 receptor antagonist and angiotensin-converting enzyme inhibitor in diabetic nephropathy.

Journal: American journal of hypertension 20050101

Title: Influence of long-term treatment of imidapril on mortality, cardiac function, and gene expression in congestive heart failure due to myocardial infarction.

Journal: Canadian journal of physiology and pharmacology 20041201

Title: Changes in beta-adrenoceptors in heart failure due to myocardial infarction are attenuated by blockade of renin-angiotensin system.

Journal: Molecular and cellular biochemistry 20040801

Title: Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats.

Journal: Journal of hypertension 20040701

Title: Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockade.

Journal: Canadian journal of physiology and pharmacology 20040701

Title: Diverse effects of long-term treatment with imidapril and irbesartan on cell growth signal, apoptosis and collagen type I expression in the left ventricle of spontaneously hypertensive rats.

Journal: Life sciences 20040611

Title: Mesenteric artery remodeling and effects of imidapril and irbesartan on it in spontaneously hypertensive rats.

Journal: World journal of gastroenterology 20040515

Title: A combinatorial therapy for pneumonia in elderly people.

Journal: Journal of the American Geriatrics Society 20040501

Title: Methods of assessing the functional status of patients with left ventricular systolic dysfunction in interventional studies: can brain natriuretic peptide measurement be used as surrogate for the traditional methods?

Journal: Cardiovascular drugs and therapy 20040501

Title: Effect of imidapril, an angiotensin-converting enzyme inhibitor, on fructose-induced insulin resistance in rats.

Journal: Endocrine journal 20040201

Title: Effects of imidapril, an angiotensin-converting enzyme inhibitor, on insulin sensitivity and responsiveness in streptozotocin-induced diabetic rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040101

Title: Relationship between polymorphism of the angiotensin-converting enzyme gene and the response to angiotensin-converting enzyme inhibition in hypertensive patients.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20031101

Title: Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril.

Journal: Journal of cellular and molecular medicine 20030101

Title: Angiotensin II and oxidative stress in Dahl Salt-sensitive rat with heart failure.

Journal: Hypertension (Dallas, Tex. : 1979) 20021201

Title: Alterations of sarcolemmal phospholipase D and phosphatidate phosphohydrolase in congestive heart failure.

Journal: Biochimica et biophysica acta 20020905

Title: Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition.

Journal: Journal of cardiovascular pharmacology 20020501

Title: Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: Role of intrarenal angiotensin-converting enzyme in nephropathy of type II diabetic rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20020301

Title: Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese with type 1 diabetes mellitus: a randomized controlled study (JAPAN-IDDM).

Journal: Diabetes research and clinical practice 20020201

Title: Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor.

Journal: Cardiovascular drug reviews 20020101

Title: Pharmacokinetic and dynamic interactions of the angiotensin-converting enzyme inhibitor imidapril with hydrochlorothiazide, bisoprolol and nilvadipine.

Journal: European journal of clinical pharmacology 20010701

Title: Regression by ACE inhibition of arteriosclerotic changes induced by chronic blockade of NO synthesis in rats.

Journal: American journal of physiology. Heart and circulatory physiology 20010501

Title: Different potentiating effects of imidapril and enalapril on kaolin-induced writhing reaction in mice.

Journal: Life sciences 20010413

Title: Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function.

Journal: Journal of the American College of Cardiology 20010301

Title: Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats.

Journal: Journal of molecular and cellular cardiology 20010201

Title: Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in essential hypertensive patients with left ventricular hypertrophy.

Journal: The Journal of international medical research 20010101

Title: A randomized, double-blind, parallel-group study to compare the anti-hypertensive effects of imidapril and nifedipine in the treatment of mild-to-moderate essential hypertension.

Journal: The Journal of international medical research 20010101

Title: Effects of imidapril and captopril on streptozotocin-induced diabetic nephropathy in mice.

Journal: European journal of pharmacology 20000623

Title: Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver.

Journal: Biological & pharmaceutical bulletin 19970801

Title: Reduction of the mortality rate by imidapril in a small coronary artery disease model, (NZW x BXSB)F1 male mice.

Journal: Japanese journal of pharmacology 19940201

Title: No relation of the suppressive effect on the sympathetic nervous system to the acute hypotension caused by imidapril and enalapril.

Journal: Japanese journal of pharmacology 19931101

Title: Robinson DM, et al. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78.

Title: Yamamoto D, et al. Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9. J Mol Cell Cardiol. 2007 Dec;43(6):670-6.

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Tags:89396-94-1 Molecular Formula|89396-94-1 MDL|89396-94-1 SMILES|89396-94-1 Imidapril hydrochloride
Catalog No.: AA00GT5V
89396-94-1,MFCD00923828
89396-94-1 | Imidapril hydrochloride
Pack Size: 5mg
Purity: ≥98%
in stock
$52.00 $36.00
Pack Size: 10mg
Purity: ≥98%
in stock
$95.00 $66.00
Pack Size: 25mg
Purity: 98%(HPLC)powder
in stock
$191.00 $134.00
Pack Size: 50mg
Purity: ≥98%
in stock
$368.00 $257.00
Pack Size: 100mg
Purity: >98.0%(T)(HPLC)
in stock
$392.00 $275.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00GT5V
Chemical Name: Imidapril hydrochloride
CAS Number: 89396-94-1
Molecular Formula: C20H28ClN3O6
Molecular Weight: 441.9058
MDL Number: MFCD00923828
SMILES: CCOC(=O)C(NC(C(=O)N1C(=O)N(CC1C(=O)O)C)C)CCc1ccccc1.Cl
Properties
Complexity: 619  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 10  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: A comparison between imidapril and ramipril on attenuation of ventricular remodeling after myocardial infarction.

Journal: Journal of cardiovascular pharmacology20120401

Title: Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20120201

Title: Effects of olmesartan and imidapril on the plasma adiponectin, P-selectin, and MDA-LDL levels of diabetic nephropathy patients.

Journal: Clinica chimica acta; international journal of clinical chemistry20120118

Title: Role of angiotensin II in plasma PAI-1 changes induced by imidapril or candesartan in hypertensive patients with metabolic syndrome.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20111201

Title: Identification of carboxylesterases expressed in rat intestine and effects of their hydrolyzing activity in predicting first-pass metabolism of ester prodrugs.

Journal: Die Pharmazie20111101

Title: Suppressive effects of imidapril on Th1- and Th2-related chemokines in monocytes.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research20111001

Title: Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20110901

Title: Nicergoline improves dysphagia by upregulating substance P in the elderly.

Journal: Medicine20110701

Title: Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20110401

Title: Angiotensin-converting enzyme inhibition and fibrinolytic balance.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20110401

Title: Candesartan versus imidapril in hypertension: a randomised study to assess effects of anti-AT1 receptor autoantibodies.

Journal: Heart (British Cardiac Society)20110301

Title: UV derivative spectrophotometric and RP-HPLC methods for determination of imidapril hydrochloride in tablets and for its stability assessment in solid state.

Journal: Acta poloniae pharmaceutica20110101

Title: Strong suppression of the renin-angiotensin system has a renal-protective effect in hypertensive patients: high-dose ARB with ACE inhibitor (Hawaii) study.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20101101

Title: Addition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without β-blockers.

Journal: Circulation journal : official journal of the Japanese Circulation Society20101101

Title: Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease.

Journal: Brain research20100917

Title: Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20100901

Title: Effect of combining ACE inhibitor and statin in lupus-prone mice.

Journal: Clinical immunology (Orlando, Fla.)20100801

Title: Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp.

Journal: Frontiers in bioscience (Elite edition)20100601

Title: [Combination therapy of hypertension in general clinical practice. The results of the KOHYBA study].

Journal: Vnitrni lekarstvi20100301

Title: Comparison of the incidence of imidapril and enalapril induced cough.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20100101

Title: Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20090901

Title: [Hospital pharmacists prevented advance of lithium intoxication through pharmaceutical interventions].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20090801

Title: Effect on the atherogenic marker plasminogen activator inhibitor type-1 of addition of the ACE inhibitor imidapril to angiotensin II type 1 receptor antagonist therapy in hypertensive patients with abnormal glucose metabolism: a prospective cohort study in primary care.

Journal: Clinical drug investigation20090101

Title: Recurrent severe angioedema associated with imidapril and diclofenac.

Journal: Allergology international : official journal of the Japanese Society of Allergology20081201

Title: [Renin-angiotensin system blocking agents reverse the myocardial hypertrophy in experimental hyperthyroid cardiomyopathy via altering intracellular calcium handling].

Journal: Zhonghua xin xue guan bing za zhi20080801

Title: Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis.

Journal: Hypertension (Dallas, Tex. : 1979)20080201

Title: Intron-2 conversion polymorphism of the aldosterone synthase gene and the antihypertensive response to angiotensin-converting enzyme inhibitors.

Journal: Journal of hypertension20080201

Title: Vascular protecting effect of angiotensin receptor blocker (ARB) on the radial artery graft.

Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia20080201

Title: A one-year study of the antiatherosclerotic effect of the angiotensin-II receptor blocker losartan in hypertensive patients. A comparison with angiotension-converting enzyme inhibitors.

Journal: International heart journal20080101

Title: Comparison of monotherapy versus combination antihypertensive therapy in elderly patients with essential hypertension.

Journal: Angiology20080101

Title: Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9.

Journal: Journal of molecular and cellular cardiology20071201

Title: PAI-1 plays an important role in liver failure after excessive hepatectomy in the rat.

Journal: The Journal of surgical research20071101

Title: Dechallenge and rechallenge method showed different incidences of cough among four ACE-Is.

Journal: Journal of clinical epidemiology20070601

Title: Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin.

Journal: Investigative ophthalmology & visual science20070501

Title: Clinical evaluation of imidapril in congestive heart failure in dogs: results of the EFFIC study.

Journal: The Journal of small animal practice20070501

Title: Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats.

Journal: International journal of molecular medicine20070401

Title: Clearance of imidapril, an Angiotensin-converting enzyme inhibitor, during hemodialysis in hypertensive renal failure patients: comparison with quinapril and enalapril.

Journal: Journal of clinical pharmacology20070201

Title: A multicentre, 12-week study of imidapril and candesartan cilexetil in patients with mild to moderate hypertension using ambulatory blood pressure monitoring.

Journal: Clinical drug investigation20070101

Title: Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure.

Journal: Drugs20070101

Title: A twelve-week, multicenter, randomized, double-blind, parallel-group, noninferiority trial of the antihypertensive efficacy and tolerability of imidapril and candesartan in adult patients with mild to moderate essential hypertension: the Iberian Multicenter Imidapril Study on Hypertension (IMISH).

Journal: Clinical therapeutics20061201

Title: Imidapril in heart failure.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS20060901

Title: Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice.

Journal: Journal of the American Society of Nephrology : JASN20060701

Title: Addition of spironolactone to an angiotensin-converting enzyme inhibitor decreases lung congestion and edema in Dahl hypertensive rats.

Journal: Heart and vessels20060701

Title: Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors.

Journal: Clinical pharmacology and therapeutics20060601

Title: Long-term treatment with imidapril but not with nifedipine enhances plasma NOx concentration in patients with essential hypertension.

Journal: Journal of pharmacological sciences20060601

Title: Effects of imidapril on left ventricular mass in chronic hemodialysis patients.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20060401

Title: Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor.

Journal: Clinical and experimental pharmacology & physiology20060101

Title: T1198C polymorphism of the angiotensinogen gene and antihypertensive response to angiotensin-converting enzyme inhibitors.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20051201

Title: Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20051101

Title: Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia.

Journal: British journal of cancer20050822

Title: Long-term effect of imidapril hydrochloride compared with dilazep hydrochloride administration on blood pressure and renal function in patients with chronic glomerulonephritis.

Journal: International heart journal20050701

Title: Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system.

Journal: American journal of physiology. Heart and circulatory physiology20050601

Title: Sarcoplasmic reticulum Ca2+ transport and gene expression in congestive heart failure are modified by imidapril treatment.

Journal: American journal of physiology. Heart and circulatory physiology20050401

Title: LC-MS determination and bioavailability study of imidapril hydrochloride after the oral administration of imidapril tablets in human volunteers.

Journal: Archives of pharmacal research20050401

Title: Different effects of imidapril and enalapril on aminopeptidase P activity in the mouse trachea.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20050301

Title: Imidapril treatment improves the attenuated inotropic and intracellular calcium responses to ATP in heart failure due to myocardial infarction.

Journal: British journal of pharmacology20050101

Title: Combination of half doses of angiotensin type 1 receptor antagonist and angiotensin-converting enzyme inhibitor in diabetic nephropathy.

Journal: American journal of hypertension20050101

Title: Influence of long-term treatment of imidapril on mortality, cardiac function, and gene expression in congestive heart failure due to myocardial infarction.

Journal: Canadian journal of physiology and pharmacology20041201

Title: Changes in beta-adrenoceptors in heart failure due to myocardial infarction are attenuated by blockade of renin-angiotensin system.

Journal: Molecular and cellular biochemistry20040801

Title: Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats.

Journal: Journal of hypertension20040701

Title: Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockade.

Journal: Canadian journal of physiology and pharmacology20040701

Title: Diverse effects of long-term treatment with imidapril and irbesartan on cell growth signal, apoptosis and collagen type I expression in the left ventricle of spontaneously hypertensive rats.

Journal: Life sciences20040611

Title: Mesenteric artery remodeling and effects of imidapril and irbesartan on it in spontaneously hypertensive rats.

Journal: World journal of gastroenterology20040515

Title: A combinatorial therapy for pneumonia in elderly people.

Journal: Journal of the American Geriatrics Society20040501

Title: Methods of assessing the functional status of patients with left ventricular systolic dysfunction in interventional studies: can brain natriuretic peptide measurement be used as surrogate for the traditional methods?

Journal: Cardiovascular drugs and therapy20040501

Title: Effect of imidapril, an angiotensin-converting enzyme inhibitor, on fructose-induced insulin resistance in rats.

Journal: Endocrine journal20040201

Title: Effects of imidapril, an angiotensin-converting enzyme inhibitor, on insulin sensitivity and responsiveness in streptozotocin-induced diabetic rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20040101

Title: Relationship between polymorphism of the angiotensin-converting enzyme gene and the response to angiotensin-converting enzyme inhibition in hypertensive patients.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20031101

Title: Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril.

Journal: Journal of cellular and molecular medicine20030101

Title: Angiotensin II and oxidative stress in Dahl Salt-sensitive rat with heart failure.

Journal: Hypertension (Dallas, Tex. : 1979)20021201

Title: Alterations of sarcolemmal phospholipase D and phosphatidate phosphohydrolase in congestive heart failure.

Journal: Biochimica et biophysica acta20020905

Title: Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition.

Journal: Journal of cardiovascular pharmacology20020501

Title: Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery.

Journal: American journal of physiology. Heart and circulatory physiology20020401

Title: Role of intrarenal angiotensin-converting enzyme in nephropathy of type II diabetic rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20020301

Title: Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese with type 1 diabetes mellitus: a randomized controlled study (JAPAN-IDDM).

Journal: Diabetes research and clinical practice20020201

Title: Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor.

Journal: Cardiovascular drug reviews20020101

Title: Pharmacokinetic and dynamic interactions of the angiotensin-converting enzyme inhibitor imidapril with hydrochlorothiazide, bisoprolol and nilvadipine.

Journal: European journal of clinical pharmacology20010701

Title: Regression by ACE inhibition of arteriosclerotic changes induced by chronic blockade of NO synthesis in rats.

Journal: American journal of physiology. Heart and circulatory physiology20010501

Title: Different potentiating effects of imidapril and enalapril on kaolin-induced writhing reaction in mice.

Journal: Life sciences20010413

Title: Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function.

Journal: Journal of the American College of Cardiology20010301

Title: Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats.

Journal: Journal of molecular and cellular cardiology20010201

Title: Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in essential hypertensive patients with left ventricular hypertrophy.

Journal: The Journal of international medical research20010101

Title: A randomized, double-blind, parallel-group study to compare the anti-hypertensive effects of imidapril and nifedipine in the treatment of mild-to-moderate essential hypertension.

Journal: The Journal of international medical research20010101

Title: Effects of imidapril and captopril on streptozotocin-induced diabetic nephropathy in mice.

Journal: European journal of pharmacology20000623

Title: Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver.

Journal: Biological & pharmaceutical bulletin19970801

Title: Reduction of the mortality rate by imidapril in a small coronary artery disease model, (NZW x BXSB)F1 male mice.

Journal: Japanese journal of pharmacology19940201

Title: No relation of the suppressive effect on the sympathetic nervous system to the acute hypotension caused by imidapril and enalapril.

Journal: Japanese journal of pharmacology19931101

Title: Robinson DM, et al. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78.

Title: Yamamoto D, et al. Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9. J Mol Cell Cardiol. 2007 Dec;43(6):670-6.

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