Name: Name:TP-10
Brand: AABLOCKS
SKU: AA00GU6S
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00GU6S

Chemical Name: TP-10

CAS Number: 898563-00-3

Molecular Formula: C26H19F3N4O

Molecular Weight: 460.4505

MDL Number: MFCD17167072

SMILES: FC(Cn1nc(c(c1)c1ccncc1)c1ccc(cc1)OCc1ccc2c(n1)cccc2)(F)F

Properties

Complexity: 636

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 34

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 5.3

Literature fold

Title: Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.

Journal: Bioorganic & medicinal chemistry letters20120301

Title: Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.

Journal: European journal of medicinal chemistry20110901

Title: Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease.

Journal: The Journal of pharmacology and experimental therapeutics20110101

Title: Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease.

Journal: PloS one20100101

Title: Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia.

Journal: Journal of medicinal chemistry20090827

Title: Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia.

Journal: The Journal of pharmacology and experimental therapeutics20080501

898563-00-3 | TP-10