92285-01-3,MFCD06411561
Catalog No.:AA00GW7O

92285-01-3 | CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-

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1mg
≥95%
in stock  
$139.00   $97.00
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5mg
≥95%
in stock  
$619.00   $433.00
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10mg
≥95%
in stock  
$1,098.00   $768.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GW7O
Chemical Name:
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
CAS Number:
92285-01-3
Molecular Formula:
C9H14OS3
Molecular Weight:
234.4019
MDL Number:
MFCD06411561
SMILES:
C=CCSS/C=C/CS(=O)CC=C
NSC Number:
614554
Properties
Computed Properties
 
Complexity:
199  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.7  

Literature

Title: The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20161001

Title: Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide.

Journal: The Journal of biological chemistry 20160624

Title: Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds.

Journal: Veterinary parasitology 20121123

Title: Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells.

Journal: European journal of medicinal chemistry 20120401

Title: Transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation.

Journal: TheScientificWorldJournal 20120101

Title: [In vitro synergisms among hydrazones, ajoeno and posaconazole against Cryptococcus spp].

Journal: Investigacion clinica 20111201

Title: Potential beneficial effects of garlic in oncohematology.

Journal: Mini reviews in medicinal chemistry 20110601

Title: Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines.

Journal: Anti-cancer agents in medicinal chemistry 20110301

Title: Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

Journal: Antioxidants & redox signaling 20110115

Title: Garlic derivatives (PTS and PTS-O) differently affect the ecology of swine faecal microbiota in vitro.

Journal: Veterinary microbiology 20100729

Title: Enhanced activation of the transient receptor potential channel TRPA1 by ajoene, an allicin derivative.

Journal: Neuroscience research 20100101

Title: Garlic-derived anticancer agents: structure and biological activity of ajoene.

Journal: BioFactors (Oxford, England) 20100101

Title: Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis.

Journal: Phytotherapy research : PTR 20090401

Title: Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells.

Journal: Melanoma research 20090401

Title: Substituted ajoenes as novel anti-cancer agents.

Journal: Bioorganic & medicinal chemistry letters 20081001

Title: [Synergy between ajoene and ketoconazole in isolates of Microsporum canis. A preliminary study using fractional inhibitory concentration technique (FIC)].

Journal: Revista iberoamericana de micologia 20080930

Title: Enhancement of ajoene-induced apoptosis by conjugated linoleic acid in 3T3-L1 adipocytes.

Journal: Apoptosis : an international journal on programmed cell death 20070601

Title: [Characteristics of uptake, transport and efflux of Z- and E-ajoenes in Caco-2 cell monolayers in vitro].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070101

Title: Chromoblastomycosis in children and adolescents in the endemic area of the Falcón State, Venezuela.

Journal: Medical mycology 20060801

Title: [Ajoene the main active compound of garlic (Allium sativum): a new antifungal agent].

Journal: Revista iberoamericana de micologia 20060601

Title: Prophylactic effects of ajoene on cerebral injury in stroke-prone spontaneously hypertensive rats (SHRSP).

Journal: Biological & pharmaceutical bulletin 20060401

Title: Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes.

Journal: Obesity (Silver Spring, Md.) 20060301

Title: Antidiabetic effects of ajoene in genetically diabetic KK-A(y) mice.

Journal: Journal of nutritional science and vitaminology 20051001

Title: Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes.

Journal: Current medicinal chemistry 20050101

Title: Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice.

Journal: Pharmacology, biochemistry, and behavior 20040801

Title: Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy.

Journal: Leukemia research 20040701

Title: Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells.

Journal: Fundamental & clinical pharmacology 20040401

Title: Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the alpha(4)beta(1) integrin.

Journal: Cancer letters 20040331

Title: Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study.

Journal: Medical mycology 20031201

Title: Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene.

Journal: Xenotransplantation 20030701

Title: The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum).

Journal: The Journal of antimicrobial chemotherapy 20030301

Title: Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.

Journal: British journal of pharmacology 20030301

Title: Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK.

Journal: Oncogene 20030130

Title: Inhibition by ajoene of skin-tumor promotion in mice.

Journal: Bioscience, biotechnology, and biochemistry 20021001

Title: Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties.

Journal: Carcinogenesis 20020401

Title: Ajoene, an experimental anti-leukemic drug: mechanism of cell death.

Journal: Leukemia 20020101

Title: Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage.

Journal: Nutrition and cancer 20020101

Title: Protective effect of ajoene on acetaminophen-induced hepatic injury in mice.

Journal: Bioscience, biotechnology, and biochemistry 20011101

Title: Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?

Journal: Biochemical pharmacology 20010301

Title: Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells.

Journal: Anticancer research 20010101

Title: In vitro suppression of HIV-1 replication by ajoene [(e)-(z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide].

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 19970101

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Related Products of 92285-01-3
Tags:92285-01-3 Molecular Formula|92285-01-3 MDL|92285-01-3 SMILES|92285-01-3 CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
Catalog No.: AA00GW7O
92285-01-3,MFCD06411561
92285-01-3 | CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
Pack Size: 1mg
Purity: ≥95%
in stock
$139.00 $97.00
Pack Size: 5mg
Purity: ≥95%
in stock
$619.00 $433.00
Pack Size: 10mg
Purity: ≥95%
in stock
$1,098.00 $768.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00GW7O
Chemical Name: CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
CAS Number: 92285-01-3
Molecular Formula: C9H14OS3
Molecular Weight: 234.4019
MDL Number: MFCD06411561
SMILES: C=CCSS/C=C/CS(=O)CC=C
NSC Number: 614554
Properties
Complexity: 199  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.7  
Literature fold

Title: The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20161001

Title: Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide.

Journal: The Journal of biological chemistry20160624

Title: Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds.

Journal: Veterinary parasitology20121123

Title: Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells.

Journal: European journal of medicinal chemistry20120401

Title: Transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation.

Journal: TheScientificWorldJournal20120101

Title: [In vitro synergisms among hydrazones, ajoeno and posaconazole against Cryptococcus spp].

Journal: Investigacion clinica20111201

Title: Potential beneficial effects of garlic in oncohematology.

Journal: Mini reviews in medicinal chemistry20110601

Title: Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines.

Journal: Anti-cancer agents in medicinal chemistry20110301

Title: Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

Journal: Antioxidants & redox signaling20110115

Title: Garlic derivatives (PTS and PTS-O) differently affect the ecology of swine faecal microbiota in vitro.

Journal: Veterinary microbiology20100729

Title: Enhanced activation of the transient receptor potential channel TRPA1 by ajoene, an allicin derivative.

Journal: Neuroscience research20100101

Title: Garlic-derived anticancer agents: structure and biological activity of ajoene.

Journal: BioFactors (Oxford, England)20100101

Title: Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis.

Journal: Phytotherapy research : PTR20090401

Title: Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells.

Journal: Melanoma research20090401

Title: Substituted ajoenes as novel anti-cancer agents.

Journal: Bioorganic & medicinal chemistry letters20081001

Title: [Synergy between ajoene and ketoconazole in isolates of Microsporum canis. A preliminary study using fractional inhibitory concentration technique (FIC)].

Journal: Revista iberoamericana de micologia20080930

Title: Enhancement of ajoene-induced apoptosis by conjugated linoleic acid in 3T3-L1 adipocytes.

Journal: Apoptosis : an international journal on programmed cell death20070601

Title: [Characteristics of uptake, transport and efflux of Z- and E-ajoenes in Caco-2 cell monolayers in vitro].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20070101

Title: Chromoblastomycosis in children and adolescents in the endemic area of the Falcón State, Venezuela.

Journal: Medical mycology20060801

Title: [Ajoene the main active compound of garlic (Allium sativum): a new antifungal agent].

Journal: Revista iberoamericana de micologia20060601

Title: Prophylactic effects of ajoene on cerebral injury in stroke-prone spontaneously hypertensive rats (SHRSP).

Journal: Biological & pharmaceutical bulletin20060401

Title: Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes.

Journal: Obesity (Silver Spring, Md.)20060301

Title: Antidiabetic effects of ajoene in genetically diabetic KK-A(y) mice.

Journal: Journal of nutritional science and vitaminology20051001

Title: Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes.

Journal: Current medicinal chemistry20050101

Title: Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice.

Journal: Pharmacology, biochemistry, and behavior20040801

Title: Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy.

Journal: Leukemia research20040701

Title: Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells.

Journal: Fundamental & clinical pharmacology20040401

Title: Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the alpha(4)beta(1) integrin.

Journal: Cancer letters20040331

Title: Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study.

Journal: Medical mycology20031201

Title: Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene.

Journal: Xenotransplantation20030701

Title: The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum).

Journal: The Journal of antimicrobial chemotherapy20030301

Title: Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.

Journal: British journal of pharmacology20030301

Title: Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK.

Journal: Oncogene20030130

Title: Inhibition by ajoene of skin-tumor promotion in mice.

Journal: Bioscience, biotechnology, and biochemistry20021001

Title: Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties.

Journal: Carcinogenesis20020401

Title: Ajoene, an experimental anti-leukemic drug: mechanism of cell death.

Journal: Leukemia20020101

Title: Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage.

Journal: Nutrition and cancer20020101

Title: Protective effect of ajoene on acetaminophen-induced hepatic injury in mice.

Journal: Bioscience, biotechnology, and biochemistry20011101

Title: Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?

Journal: Biochemical pharmacology20010301

Title: Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells.

Journal: Anticancer research20010101

Title: In vitro suppression of HIV-1 replication by ajoene [(e)-(z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide].

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie19970101

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