Name: Name:ONX-0912
Brand: AABLOCKS
SKU: AA00GU2D
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00GU2D

Chemical Name: ONX-0912

CAS Number: 935888-69-0

Molecular Formula: C25H32N4O7S

Molecular Weight: 532.6092

MDL Number: MFCD25976563

SMILES: COC[C@@H](C(=O)N[C@H](C(=O)[C@]1(C)OC1)Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cnc(s1)C)COC

Properties

Complexity: 825

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 4

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 37

Hydrogen Bond Acceptor Count: 9

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 14

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.1

Literature fold

Title: Molecular mechanisms of acquired proteasome inhibitor resistance.

Journal: Journal of medicinal chemistry20121213

Title: Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20121015

Title: Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.

Journal: The Journal of pharmacology and experimental therapeutics20120401

Title: Drugs: More shots on target.

Journal: Nature20111214

Title: Novel proteasome inhibitors to overcome bortezomib resistance.

Journal: Journal of the National Cancer Institute20110706

Title: A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma.

Journal: Blood20101202

Title: Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).

Journal: Journal of medicinal chemistry20090514