937174-76-0,MFCD14105605
Catalog No.:AA00GRSB

937174-76-0 | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$40.00   $28.00
- +
5mg
98+%
in stock  
$100.00   $70.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GRSB
Chemical Name:
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
CAS Number:
937174-76-0
Molecular Formula:
C21H27N7O3
Molecular Weight:
425.4842
MDL Number:
MFCD14105605
SMILES:
CCn1c(nc2c1c(OC[C@@H]1CCCNC1)cnc2C#CC(O)(C)C)c1nonc1N
Properties
Properties
 
BP:
683.8 °C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
680  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.3  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells.

Journal: Molecular cancer therapeutics 20120701

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.

Journal: The Journal of biological chemistry 20111028

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells.

Journal: The Prostate 20101101

Title: Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.

Journal: Biological psychiatry 20100815

Title: Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.

Journal: BMC genomics 20100101

Title: Personalized therapies in the cancer 'omics' era.

Journal: Molecular cancer 20100101

Title: Aminofurazans as potent inhibitors of AKT kinase.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: Mechanism and management of AKT inhibitor-induced hyperglycemia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

Title: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

Journal: Journal of medicinal chemistry 20080925

Title: Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.

Journal: Cancer research 20080401

Title: Rhodes N, et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res, 2008, 68(7), 2366-2374.

Title: Levy DS, et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood, 2009, 113(8), 1723-1729.

Title: Altomare DA, et al. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res, 2010, 16(2), 486-496.

Title: Konno H, et al. Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep. 2018 Apr 24;23(4):1112-1123.

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Tags:937174-76-0 Molecular Formula|937174-76-0 MDL|937174-76-0 SMILES|937174-76-0 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Catalog No.: AA00GRSB
937174-76-0,MFCD14105605
937174-76-0 | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Pack Size: 1mg
Purity: 98+%
in stock
$40.00 $28.00
Pack Size: 5mg
Purity: 98+%
in stock
$100.00 $70.00
Quantity
- +
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Technical Information
Catalog Number: AA00GRSB
Chemical Name: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
CAS Number: 937174-76-0
Molecular Formula: C21H27N7O3
Molecular Weight: 425.4842
MDL Number: MFCD14105605
SMILES: CCn1c(nc2c1c(OC[C@@H]1CCCNC1)cnc2C#CC(O)(C)C)c1nonc1N
Properties
BP: 683.8 °C at 760 mmHg  
Form: Solid  
Storage: Inert atmosphere;2-8℃;  
Complexity: 680  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.3  
Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells.

Journal: Molecular cancer therapeutics20120701

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology20111030

Title: IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.

Journal: The Journal of biological chemistry20111028

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology20101124

Title: 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells.

Journal: The Prostate20101101

Title: Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.

Journal: Biological psychiatry20100815

Title: Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.

Journal: BMC genomics20100101

Title: Personalized therapies in the cancer 'omics' era.

Journal: Molecular cancer20100101

Title: Aminofurazans as potent inhibitors of AKT kinase.

Journal: Bioorganic & medicinal chemistry letters20090301

Title: Mechanism and management of AKT inhibitor-induced hyperglycemia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20090101

Title: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

Journal: Journal of medicinal chemistry20080925

Title: Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.

Journal: Cancer research20080401

Title: Rhodes N, et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res, 2008, 68(7), 2366-2374.

Title: Levy DS, et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood, 2009, 113(8), 1723-1729.

Title: Altomare DA, et al. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res, 2010, 16(2), 486-496.

Title: Konno H, et al. Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep. 2018 Apr 24;23(4):1112-1123.

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