Catalog No.:AA00GU0P

937812-80-1 | gamma-Secretase Modulators

Name: Name:gamma-Secretase Modulators
Brand: AABLOCKS
SKU: AA00GU0P
Rating: 90 (10 reviews)

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5mg

99%

1 week

$1,009.00 $707.00

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10mg

99%

1 week

$1,909.00 $1,337.00

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Technical Information
Properties
Literature
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Technical Information

Catalog Number:

AA00GU0P

Chemical Name:

gamma-Secretase Modulators

CAS Number:

937812-80-1

Molecular Formula:

C26H24F3N3O3

Molecular Weight:

483.4823

MDL Number:

MFCD13184813

SMILES:

COc1cc(ccc1n1cnc(c1)C)/C=C/1\CC[C@@H]2N(C1=O)[C@@H](COC2)c1cc(F)c(c(c1)F)F

Properties

Computed Properties

Complexity:

789

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

3.9

Literature

Title: Watahiki H, Yagishita S, Futai E, Ishiura S.CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.Neurosci Lett. 2012 Sep 27;526(2):96-9. Epub 2012 Aug 23.

Title: Wanngren J, Ottervald J, Parpal S, Portelius E, Str?mberg K, Borgeg?rd T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlstr?m H.Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.J Biol Chem. 2012 Jul 31.

Title: Wagner SL, Tanzi RE, Mobley WC, Galasko D.Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease.Arch Neurol. 2012 Jul 16:1-4.

Title: Bulic B, Ness J, Hahn S, Rennhack A, Jumpertz T, Weggen S.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease.Curr Neuropharmacol. 2011 Dec;9(4):598-622.

Title: Kretner, Benedikt; Fukumori, Akio; Gutsmiedl, Amelie; Page, Richard M.; Luebbers, Thomas; Galley, Guido; Baumann, Karlheinz; Haass, Christian; Steiner, Harald. Attenuated A.beta.42 Responses to Low Potency .gamma.-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds. Journal of Biological Chemistry (2011), 286(17), 15240-15251.

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