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942487-16-3,MFCD16659065
Catalog No.:AA00GU2L

942487-16-3 | Pf-03814735

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$53.00   $37.00
- +
5mg
≥95%
in stock  
$166.00   $116.00
- +
10mg
≥95%
in stock  
$305.00   $213.00
- +
50mg
≥95%
in stock  
$1,133.00   $793.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GU2L
Chemical Name:
Pf-03814735
CAS Number:
942487-16-3
Molecular Formula:
C23H25F3N6O2
Molecular Weight:
474.4788
MDL Number:
MFCD16659065
SMILES:
CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1c1c2ccc(c1)Nc1ncc(c(n1)NC1CCC1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
778  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3  

Literature

Title: Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmacodynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours.

Journal: European journal of cancer (Oxford, England : 1990) 20111001

Title: PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.

Journal: Molecular cancer therapeutics 20100401

Title: Jani JP, et al. PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy. Mol Cancer Ther. 2010 Apr;9(4):883-94.

Title: Hook KE, et al. An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. Mol Cancer Ther. 2012 Mar;11(3):710-9.

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SDS
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Tags:942487-16-3 Molecular Formula|942487-16-3 MDL|942487-16-3 SMILES|942487-16-3 Pf-03814735
Catalog No.: AA00GU2L
942487-16-3,MFCD16659065
942487-16-3 | Pf-03814735
Pack Size： 1mg
Purity： ≥95%
in stock
$53.00 $37.00
Pack Size： 5mg
Purity： ≥95%
in stock
$166.00 $116.00
Pack Size： 10mg
Purity： ≥95%
in stock
$305.00 $213.00
Pack Size： 50mg
Purity： ≥95%
in stock
$1,133.00 $793.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00GU2L
Chemical Name: Pf-03814735
CAS Number: 942487-16-3
Molecular Formula: C23H25F3N6O2
Molecular Weight: 474.4788
MDL Number: MFCD16659065
SMILES: CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1c1c2ccc(c1)Nc1ncc(c(n1)NC1CCC1)C(F)(F)F
Properties
Complexity: 778  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 34  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3  
Literature fold

Title: Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmacodynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours.

Journal: European journal of cancer (Oxford, England : 1990)20111001

Title: PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.

Journal: Molecular cancer therapeutics20100401

Title: Jani JP, et al. PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy. Mol Cancer Ther. 2010 Apr;9(4):883-94.

Title: Hook KE, et al. An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. Mol Cancer Ther. 2012 Mar;11(3):710-9.

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