Product Index

2,2-DiMethylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3-hydroperoxy-3,7-diMethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester

Catalog No.: AA0094T8

CAS No.:1092716-42-1 MDL No.:

MF: C25H38O7 MW: 450.5650

Pricing and Availability

Loperamide EP impurity G

Catalog No.: AA01V1V9

CAS No.:109572-89-6 MDL No.:

MF: C29H33ClN2O3 MW: 493.0369

Pricing and Availability

IDX-989

Catalog No.: AA008Z4Z

CAS No.:1097733-15-7 MDL No.:

MF: C20H17ClN3O3P MW: 413.7940

Pricing and Availability

nucleoside oQ

Catalog No.: AA009TDS

CAS No.:107865-20-3 MDL No.:

MF: C17H23N5O8 MW: 425.3932

Pricing and Availability

3-Pyridinecarboxylicacid, 1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro-

Catalog No.: AA00845O

CAS No.:110283-79-9 MDL No.:

MF: C23H21F6NO3 MW: 473.4082

Pricing and Availability

TiaMulin IMpurity E (TiaMulone,11-Oxo TiaMulin)

Catalog No.: AA008WVL

CAS No.:113323-39-0 MDL No.:

MF: C28H45NO4S MW: 491.7262

Pricing and Availability

Glycine, L-g-glutamyl-S-(1,2,2-trichloroethenyl)-L-cysteinyl-

Catalog No.: AA00824R

CAS No.:111574-85-7 MDL No.: MFCD01724679

MF: C12H16Cl3N3O6S MW: 436.6959

Pricing and Availability

Demethyl Arbidol

Catalog No.: AA024OW8

CAS No.:1130901-04-0 MDL No.:

MF: C21H23BrN2O3S MW: 463.3879

Pricing and Availability

O-Methyl Losartan

Catalog No.: AA024L4P

CAS No.:114798-94-6 MDL No.:

MF: C23H25ClN6O MW: 436.9372

Pricing and Availability

2-[(Carboxymethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3,5-Pyridinedicarboxylic Acid 3-Ethyl Ester

Catalog No.: AA024JQQ

CAS No.:114018-75-6 MDL No.:

MF: C19H18ClNO7 MW: 407.8017

Pricing and Availability

Cholest-5-en-26-oic acid, 3,7-dihydroxy-, (3β,7α)-

Catalog No.: AA000G1V

CAS No.:115538-84-6 MDL No.: MFCD22416722

MF: C27H44O4 MW: 432.6359

Pricing and Availability

Lapatinib IMpurity 10

Catalog No.: AA0091TC

CAS No.:1152131-73-1 MDL No.:

MF: C26H17ClFN3O4 MW: 489.8823

Pricing and Availability

2-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOL-1-YL METHYL)-1,3-DIOXALANE-4-YL METHYL METHANE SULFONATE

Catalog No.: AA008UZQ

CAS No.:115897-54-6 MDL No.: MFCD00806008

MF: C14H15Cl2N3O5S MW: 408.2570

Pricing and Availability

8-(2-AMINOETHYLTHIO) GUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Catalog No.: AA008RBH

CAS No.:115974-70-4 MDL No.: MFCD04118009

MF: C12H16N6NaO7PS MW: 442.3200

Pricing and Availability

1,4-b-D-Xylotriitol

Catalog No.: AA01EAUH

CAS No.:116269-52-4 MDL No.:

MF: C15H28O13 MW: 416.3750

Pricing and Availability

5'-Adenylic acid, N-cyclopentyl-

Catalog No.: AA0077BB

CAS No.:117778-38-8 MDL No.:

MF: C15H22N5O7P MW: 415.3382

Pricing and Availability

PROPENE-2-D1

Catalog No.: AA008SXC

CAS No.:1184-59-4 MDL No.: MFCD01073918

MF: C3H6 MW: 42.0797

Pricing and Availability

12-N-methyl-7-nitrobenzo-2-oxa-1,3-diazolamino stearate

Catalog No.: AA009V2R

CAS No.:117056-67-4 MDL No.: MFCD00467278

MF: C25H40N4O5 MW: 476.6089

Pricing and Availability

2'-Deoxyuridine-5'-triphosphoric acid = dUTP

Catalog No.: AA008UIR

CAS No.:1173-82-6 MDL No.: MFCD01317292

MF: C9H15N2O14P3 MW: 468.1417

Pricing and Availability

Prazobind-d8

Catalog No.: AA0081GW

CAS No.:1189701-23-2 MDL No.: MFCD28899342

MF: C23H19D8N5O3 MW: 429.5415

Pricing and Availability

4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-7-oxo-3-(tetrahydro-2-furanyl)-, 2-propenyl ester, [5R-[3(S*),5α,6α(R*)]]-

Catalog No.: AA01P2BG

CAS No.:120705-68-2 MDL No.:

MF: C21H33NO5SSi MW: 439.6409

Pricing and Availability

O-Desmethyl Pantoprazole O-SulfateDiscontinued

Catalog No.: AA008WD8

CAS No.:1189856-53-8 MDL No.: MFCD09840385

MF: C15H13F2N3O7S2 MW: 449.4064

Pricing and Availability

3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-

Catalog No.: AA009L5J

CAS No.:1202073-26-4 MDL No.: MFCD18782732

MF: C26H22FN3O2S MW: 459.5352

Pricing and Availability

(1S,4R,4aS,8R,8aS)-decahydro-8-(1H-indol-3-ylmethyl)-4,4a-dimethyl-7-methylene-8a-(4-methyl-3-penten-1-yl)-1-naphthalenol

Catalog No.: AA01LIBI

CAS No.:120991-21-1 MDL No.:

MF: C28H39NO MW: 405.6154

Pricing and Availability

simvastatin acid

Catalog No.: AA0098TF

CAS No.:121009-77-6 MDL No.: MFCD00870460

MF: C25H40O6 MW: 436.5815

Pricing and Availability

1-Naphthalenol, 2,2-dibutyl-1,2,3,4-tetrahydro-5-(2-quinolinylmethoxy)-

Catalog No.: AA000IDW

CAS No.:119256-94-9 MDL No.:

MF: C28H35NO2 MW: 417.5830

Pricing and Availability

Erlotinib 13C6 HCl

Catalog No.: AA0094RV

CAS No.:1210610-07-3 MDL No.:

MF: C22H24ClN3O4 MW: 429.8967

Pricing and Availability

Desmethyl Thiosildenafil-d8

Catalog No.: AA009EFP

CAS No.:1215321-44-0 MDL No.: MFCD28138375

MF: C21H28N6O3S2 MW: 476.6154

Pricing and Availability

1-(DiphenylMethyl)-4-[(1RS,3E)-4-phenyl-1-[(E)-2-phenylethenyl)-3-buten-1-yl]piperazine

Catalog No.: AA008VSP

CAS No.:1199751-98-8 MDL No.: MFCD14584956

MF: C35H36N2 MW: 484.6737

Pricing and Availability

Ivabradine-d3

Catalog No.: AA024JAF

CAS No.:1217977-70-2 MDL No.:

MF: C27H33D3N2O5 MW: 471.6036

Pricing and Availability

rac Indapamide-N-(sulfonamido) Sulfate

Catalog No.: AA009E5B

CAS No.:1219174-77-2 MDL No.: MFCD28898418

MF: C16H16ClN3O6S2 MW: 445.8977

Pricing and Availability

(R)-Bicalutamide-d4

Catalog No.: AA01E08R

CAS No.:1217826-87-3 MDL No.: MFCD11977967

MF: C18H10D4F4N2O4S MW: 434.3980

Pricing and Availability

2',3'-dideoxyribosylinosine 5'-triphosphate

Catalog No.: AA00AFNK

CAS No.:122406-02-4 MDL No.:

MF: C10H15N4O12P3 MW: 476.1670

Pricing and Availability

Mifepristone-d3

Catalog No.: AA027GBM

CAS No.:1228097-18-4 MDL No.:

MF: C29H32D3NO2 MW: 432.6122

Pricing and Availability

JNJ-41443532

Catalog No.: AA027GBP

CAS No.:1228650-83-6 MDL No.:

MF: C22H25F3N4O3S MW: 482.5191

Pricing and Availability

N-lauroyl-1-desoxyMethylsphinganine (M17

Catalog No.: AA009HFF

CAS No.:1246298-41-8 MDL No.: MFCD22416665

MF: C29H59NO2 MW: 453.7843

Pricing and Availability

3ß-Hydroxy-7-oxo-5-cholestenoic Acid

Catalog No.: AA024IS8

CAS No.:1246298-64-5 MDL No.:

MF: C27H42O4 MW: 430.6200

Pricing and Availability

(25R)-cholest-5-en-26-oic acid, 3,7-hydroxy

Catalog No.: AA009HG1

CAS No.:1246298-66-7 MDL No.: MFCD22416723

MF: C27H44O4 MW: 432.6359

Pricing and Availability

Nicardipine Related CoMpound 4

Catalog No.: AA009JHA

CAS No.:123973-71-7 MDL No.:

MF: C25H27N3O6 MW: 465.4984

Pricing and Availability

5'-O-p-Anisoyl-N4-benzoyl-2',3'-dideoxycytidine

Catalog No.: AA01EGU7

CAS No.:1241674-34-9 MDL No.:

MF: C24H23N3O6 MW: 449.4559

Pricing and Availability

Pamapimod-d4

Catalog No.: AA01E0EE

CAS No.:1246814-57-2 MDL No.:

MF: C19H16D4F2N4O4 MW: 410.4080

Pricing and Availability

1-Tridecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) Sodium Salt

Catalog No.: AA024PN4

CAS No.:1246298-10-1 MDL No.:

MF: C19H38NaO9P MW: 464.4632

Pricing and Availability

D-Myo-inositol-1,3,4-trisphosphate (aMMoniuM salt)

Catalog No.: AA009HDX

CAS No.:1246355-66-7 MDL No.: MFCD00133232

MF: C6H18NO15P3 MW: 437.1261

Pricing and Availability

D-Myo-inositol-1,3,5-triphosphate (aMMoniuM salt)

Catalog No.: AA009HEK

CAS No.:1246355-67-8 MDL No.: MFCD22416804

MF: C6H18NO15P3 MW: 437.1261

Pricing and Availability

N-Boc Alogliptin

Catalog No.: AA027GDB

CAS No.:1246610-74-1 MDL No.:

MF: C23H29N5O4 MW: 439.5075

Pricing and Availability

N-Des(2-pyridinyl)-N-(5-hydroxymethyl-2-thiazolyl) Lornoxicam

Catalog No.: AA009EEJ

CAS No.:1246818-50-7 MDL No.: MFCD31562593

MF: C12H10ClN3O5S3 MW: 407.8729

Pricing and Availability

Dihydroxy Etravirine

Catalog No.: AA009JGD

CAS No.:1246818-67-6 MDL No.: MFCD24386675

MF: C20H15BrN6O3 MW: 467.2755

Pricing and Availability

Prulifloxacin-d8

Catalog No.: AA01E0I5

CAS No.:1246819-37-3 MDL No.:

MF: C21H12D8FN3O6S MW: 469.5127

Pricing and Availability

Methisosildenafil-d4

Catalog No.: AA01E0IC

CAS No.:1246819-66-8 MDL No.:

MF: C23H28D4N6O4S MW: 492.6276

Pricing and Availability

BACE-IN-1

Catalog No.: AA01EO9O

CAS No.:1254166-60-3 MDL No.: MFCD31544416

MF: C22H16ClN5O2 MW: 417.8477

Pricing and Availability

SAR156497

Catalog No.: AA01ENR1

CAS No.:1256137-14-0 MDL No.: MFCD28411357

MF: C27H24N4O4 MW: 468.5039

Pricing and Availability

VALIDAMYCIN D

Catalog No.: AA009JK5

CAS No.:12650-67-8 MDL No.: MFCD01675364

MF: C20H35NO13 MW: 497.4908

Pricing and Availability

Pemetrexed N,N-dimethylformamidine

Catalog No.: AA01V1FN

CAS No.:1265908-58-4 MDL No.:

MF: C23H26N6O6 MW: 482.4891

Pricing and Availability

Pemetrexed-5-methyl ester

Catalog No.: AA01V1FK

CAS No.:1265908-60-8 MDL No.:

MF: C21H23N5O6 MW: 441.4372

Pricing and Availability

Pemetrexed-1-methylEster

Catalog No.: AA01E0N1

CAS No.:1265908-63-1 MDL No.:

MF: C21H23N5O6 MW: 441.4372

Pricing and Availability

CI 951

Catalog No.: AA00A589

CAS No.:126661-07-2 MDL No.:

MF: C22H23F3N2O3 MW: 420.4248

Pricing and Availability

Deferasirox isopropyl ester

Catalog No.: AA01V1UF

CAS No.:1266741-29-0 MDL No.:

MF: C24H21N3O4 MW: 415.4412

Pricing and Availability

2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine-13C,15N2

Catalog No.: AA01E0N9

CAS No.:1267650-42-9 MDL No.: MFCD09840325

MF: C23H19F2N3O6 MW: 474.3897

Pricing and Availability

2'-O-Methyl-N-(phenoxyacetyl)-adenosine

Catalog No.: AA024PLJ

CAS No.:128219-80-7 MDL No.:

MF: C19H21N5O6 MW: 415.3999

Pricing and Availability

Tamolarizine

Catalog No.: AA00A78Y

CAS No.:128229-52-7 MDL No.: MFCD00868272

MF: C27H32N2O3 MW: 432.5546

Pricing and Availability

3'-Deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution

Catalog No.: AA01EARD

CAS No.:128524-26-5 MDL No.: MFCD00079155

MF: C10H16N2NaO13P3 MW: 488.1507

Pricing and Availability

[1S-[1α(2R*,3R*),3α,7β,8β(2S*,4S*),8aβ]]-3-Hydroxy-2-Methylbutanoic Acid 1,2,3,7,8,8a-hexahydro-3,7-diMethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran- 2-yl)ethyl]-1-naphthalenyl Ester

Catalog No.: AA009EHK

CAS No.:127910-58-1 MDL No.:

MF: C24H36O6 MW: 420.5390

Pricing and Availability

(S)-Fesoterodine HCl

Catalog No.: AA009JFF

CAS No.:1294517-14-8 MDL No.:

MF: C26H37NO3 MW: 411.5769

Pricing and Availability

IMpurity A of Tacalcitol

Catalog No.: AA009Y4J

CAS No.:1294517-97-7 MDL No.: MFCD25977211

MF: C27H44O3 MW: 416.6365

Pricing and Availability

N6-Isopentenyladenosine-5’-monophosphateSodiumSalt

Catalog No.: AA01E65O

CAS No.:128030-99-9 MDL No.:

MF: C15H22N5O7P MW: 415.3382

Pricing and Availability

8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT

Catalog No.: AA009BE4

CAS No.:129693-13-6 MDL No.: MFCD04113743

MF: C16H15ClN5O5PS2 MW: 487.8776

Pricing and Availability

MS 073

Catalog No.: AA00A7GQ

CAS No.:129716-45-6 MDL No.: MFCD00891854

MF: C31H33N3O2 MW: 479.6126

Pricing and Availability

(R)-Valiolamine Voglibose

Catalog No.: AA009E2G

CAS No.:1303996-67-9 MDL No.:

MF: C17H34N2O11 MW: 442.4587

Pricing and Availability

Fondenafil-d5

Catalog No.: AA01E0TW

CAS No.:1324230-58-1 MDL No.:

MF: C24H27D5N6O3 MW: 457.5801

Pricing and Availability

7-[(3-Chloro-6-Methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11(6H)-ylidene)aMino]heptanoic Acid

Catalog No.: AA009F93

CAS No.:131206-48-9 MDL No.: MFCD31562679

MF: C21H23ClN2O4S MW: 434.9363

Pricing and Availability

O-beta-ribosyl(1''-2')-guanosine-5''-phosphate

Catalog No.: AA00A7SA

CAS No.:131293-20-4 MDL No.:

MF: C15H22N5O12P MW: 495.3352

Pricing and Availability

gentamicin A

Catalog No.: AA00AGM8

CAS No.:13291-74-2 MDL No.: MFCD00153295

MF: C18H36N4O10 MW: 468.4992

Pricing and Availability

Ara-C triphosphate

Catalog No.: AA00A1CL

CAS No.:13191-15-6 MDL No.: MFCD00871798

MF: C9H16N3O14P3 MW: 483.1563

Pricing and Availability

Vardenafil Acetyl-d5 Analogue

Catalog No.: AA009EP3

CAS No.:1330171-51-1 MDL No.:

MF: C25H34N6O3 MW: 466.5759

Pricing and Availability

Des-1,2,4-triazol-3-one-5-methyl (2R,3R,2-(S))-Aprepitant Hydrochloride

Catalog No.: AA024POC

CAS No.:1333998-21-2 MDL No.:

MF: C20H19ClF7NO2 MW: 473.8122

Pricing and Availability

Fosaprepitant Morpholine Hydrochloride

Catalog No.: AA024PW4

CAS No.:1333998-27-8 MDL No.:

MF: C20H19ClF7NO2 MW: 473.8122

Pricing and Availability

Inosine,2'-deoxy-6-O-phenyl-, 3',5'-diacetate (9CI)

Catalog No.: AA01G3J2

CAS No.:133471-06-4 MDL No.:

MF: C20H20N4O6 MW: 412.3960

Pricing and Availability

4'-((1,7'-Dimethyl-2'-propyl-1H,1'H-[2,5'-bibenzo[d]imidazol]-1'-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile

Catalog No.: AA024P54

CAS No.:1338830-39-9 MDL No.:

MF: C33H29N5 MW: 495.6169

Pricing and Availability

6'-HYDROXY SIMVASTATIN

Catalog No.: AA009GLY

CAS No.:134523-09-4 MDL No.: MFCD09840775

MF: C25H38O6 MW: 434.5656

Pricing and Availability

Lansoprazole IMpurity H

Catalog No.: AA009JH1

CAS No.:1346598-28-4 MDL No.:

MF: C23H16F3N5OS MW: 467.4662

Pricing and Availability

5-O-Trityl-3'-deoxy-3'-fluorothymidine

Catalog No.: AA006ZA0

CAS No.:135197-63-6 MDL No.: MFCD07369688

MF: C29H27FN2O4 MW: 486.5341

Pricing and Availability

Fluconazole Glucuronide

Catalog No.: AA009XP6

CAS No.:136134-23-1 MDL No.: MFCD24386689

MF: C19H20F2N6O7 MW: 482.3949

Pricing and Availability

N-acetylgalactosaminyl-1-4-N-acetylglucosamine

Catalog No.: AA00A8OQ

CAS No.:136198-41-9 MDL No.:

MF: C16H28N2O11 MW: 424.4003

Pricing and Availability

Entacapone EP Impurity G

Catalog No.: AA009JJ9

CAS No.:1364322-41-7 MDL No.:

MF: C24H30F2O6S MW: 484.5532

Pricing and Availability

1-Propane-1,1,2,2,3,3,3-d7-sulfonamide, N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

Catalog No.: AA01S5HB

CAS No.:1365986-73-7 MDL No.:

MF: C23H11ClD7F2N3O3S MW: 496.9653

Pricing and Availability

Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-8-(phenylmethoxy)- (9CI)

Catalog No.: AA0012EO

CAS No.:136859-75-1 MDL No.: MFCD04973663

MF: C21H25N5O6 MW: 443.4531

Pricing and Availability

ProMethazine N-Glucuronide

Catalog No.: AA009EFF

CAS No.:137908-81-7 MDL No.: MFCD31562815

MF: C23H28N2O6S MW: 460.5432

Pricing and Availability

Paliperidone Desfluoro Impurity

Catalog No.: AA009X7W

CAS No.:1380413-60-4 MDL No.: MFCD24387080

MF: C23H28N4O3 MW: 408.4934

Pricing and Availability

(R)-5-IsopropylcarbonyloxyMethyl Tolterodine

Catalog No.: AA009EK5

CAS No.:1380491-70-2 MDL No.:

MF: C26H37NO3 MW: 411.5769

Pricing and Availability

5-Bromo-6-chloro-1H-indol-3-yl-a-D-mannopyranoside

Catalog No.: AA01E6KS

CAS No.:1384197-50-5 MDL No.:

MF: C14H15BrClNO6 MW: 408.6290

Pricing and Availability

Guanosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-

Catalog No.: AA001ANF

CAS No.:139307-94-1 MDL No.: MFCD02094088

MF: C10H14N5O12P3 MW: 489.1657

Pricing and Availability

1-[(4-Chlorophenyl)phenylmethyl]-4-(phenylsulfonyl)piperazine

Catalog No.: AA01E1QG

CAS No.:1391052-52-0 MDL No.: MFCD21363504

MF: C23H23ClN2O2S MW: 426.9589

Pricing and Availability

Linagliptin-13C-d3

Catalog No.: AA024P4W

CAS No.:1398044-43-3 MDL No.:

MF: C25H25D3N8O2 MW: 476.5534

Pricing and Availability

3',5'-DI-O-ACETYL-5-FLUORO-O4-(2,4,6-TRIMETHYLPHENYL)-2'-DEOXYURIDINE

Catalog No.: AA009BFF

CAS No.:141120-62-9 MDL No.: MFCD01631057

MF: C22H25FN2O7 MW: 448.4415

Pricing and Availability

Thymidine 5'-(tetrahydrogen triphosphate), α-hydroxy-

Catalog No.: AA001GRT

CAS No.:14167-70-5 MDL No.:

MF: C10H17N2O15P3 MW: 498.1677

Pricing and Availability

4'-AZIDOTHYMIDINE 5'-TRIPHOSPHONATE

Catalog No.: AA007ZUL

CAS No.:140158-13-0 MDL No.:

MF: C10H16N5O12P3 MW: 491.1816

Pricing and Availability

Acetic acid, 2-[[(3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester

Catalog No.: AA01SOYM

CAS No.:1402150-00-8 MDL No.:

MF: C19H29ClN4O5S MW: 460.9754

Pricing and Availability

Paliperidone Impurity 7

Catalog No.: AA027GI0

CAS No.:1415488-05-9 MDL No.:

MF: C27H45ClN2O3 MW: 481.1108

Pricing and Availability

17-ethynyl-4-estrene-3,17-diol-3-acetate-17-(3'-acetoxy-2'-butenoate)

Catalog No.: AA009JJO

CAS No.:142154-46-9 MDL No.:

MF: C28H36O6 MW: 468.5818

Pricing and Availability

Carbamic acid,[[2,6-bis(1-methylethyl)phenoxy]sulfonyl]-, 2,6-bis(1-methylethyl)phenyl ester(9CI)

Catalog No.: AA006XVW

CAS No.:142642-31-7 MDL No.:

MF: C25H35NO5S MW: 461.6141

Pricing and Availability