Boronic acids and esters are important building blocks in organic synthesis and medicinal chemistry because of their versatility as synthetic intermediates in the preparation of complex molecules. AA Blocks is pleased to offer a comprehensive list of boronic acids and esters for use in such reactions as the powerful carbon-carbon bond-forming Suzuki-Miyaura palladium catalyzed cross-coupling reaction, the Stille coupling, Lieberskind-Strogl coupling, Chan-Lam coupling, Sonogashira coupling, conjugate additions, homologations, and electrophilic allyl shifts. Boronic acids also have biological applications such as inhibition of serine proteases. The Raines group described pendant boronic acids enhancing the cytosolic delivery of a protein toxin by forming boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells.
