Home Other Building Blocks 1005504-62-0
1005504-62-0,MFCD28716151
Catalog No.:AA000280

1005504-62-0 | Rg3039(pf-06687859)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$48.00   $33.00
- +
5mg
≥98%
in stock  
$129.00   $90.00
- +
10mg
≥98%
in stock  
$235.00   $164.00
- +
25mg
≥98%
in stock  
$525.00   $367.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000280
Chemical Name:
Rg3039(pf-06687859)
CAS Number:
1005504-62-0
Molecular Formula:
C21H23Cl2N5O
Molecular Weight:
432.3462
MDL Number:
MFCD28716151
SMILES:
Nc1nc(N)c2c(n1)cccc2OCC1CCN(CC1)Cc1c(Cl)cccc1Cl
Properties
Computed Properties
 
Complexity:
511  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.3  

Literature

Title: Gopalsamy A, et al. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem. 2017 Apr 13;60(7):3094-3108.

Title: Gogliotti RG, et al. The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models. Hum Mol Genet. 2013 Oct 15;22(20):4084-101.

Title: Van Meerbeke J, et al. The DcpS inhibitor RG3039 improves motor function in SMA mice. Hum Mol Genet. 2013 Oct 15;22(20):4074-83.

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SDS
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Tags:1005504-62-0 Molecular Formula|1005504-62-0 MDL|1005504-62-0 SMILES|1005504-62-0 Rg3039(pf-06687859)