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115964-29-9,MFCD01711971
Catalog No.:AA000H5X

115964-29-9 | Tosufloxacin tosilate

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25mg
98%(HPLC)
in stock  
$43.00   $30.00
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100mg
≥95%
in stock  
$82.00   $57.00
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250mg
≥95%
in stock  
$139.00   $97.00
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500mg
≥95%
in stock  
$199.00   $139.00
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1g
≥95%
in stock  
$356.00   $249.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000H5X
Chemical Name:
Tosufloxacin tosilate
CAS Number:
115964-29-9
Molecular Formula:
C26H23F3N4O6S
Molecular Weight:
576.5442
MDL Number:
MFCD01711971
SMILES:
Cc1ccc(cc1)S(=O)(=O)O.NC1CCN(C1)c1nc2n(cc(c(=O)c2cc1F)C(=O)O)c1ccc(cc1F)F
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
915  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:TAINDIHENGYIPHARMACY-CN110041329,2019,ALocationinpatent:Paragraph0024-0027

Literature

Title: In vitro assessment of the cytotoxicity of six topical antibiotics to four cultured ocular surface cell lines.

Journal: Biocontrol science 20120601

Title: Synthesis of acrylonitriles through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120521

Title: [Intractable pediatric infectious disease: examining the ability of a new drug, tosufloxacin tosilate hydrate for pediatric (discussion)].

Journal: The Japanese journal of antibiotics 20111001

Title: [Intractable pediatric infectious disease: examining the ability of a new drug, tosufloxacin tosilate hydrate for pediatric].

Journal: The Japanese journal of antibiotics 20101201

Title: [Efficacy of tosufloxacin in genital chlamydial infections].

Journal: The Japanese journal of antibiotics 20091001

Title: Corneal deposits after topical tosufloxacin in a patient with poor tear secretion.

Journal: Cornea 20090101

Title: Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: Antibiotic prophylaxis for transrectal prostate biopsy: a prospective randomized study of tosufloxacin versus levofloxacin.

Journal: International journal of urology : official journal of the Japanese Urological Association 20080701

Title: Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones.

Journal: The British journal of ophthalmology 20080601

Title: In vitro susceptibilities of bacterial isolates from conjunctival flora to gatifloxacin, levofloxacin, tosufloxacin, and moxifloxacin.

Journal: Eye & contact lens 20080301

Title: [Effectiveness of switch therapy for peritonitis].

Journal: The Japanese journal of antibiotics 20070801

Title: Tosufloxacin tosilate-induced thrombocytopenic purpura.

Journal: The Journal of dermatology 20070701

Title: [Antibacterial activity of tosufloxacin against major organisms detected from patients with respiratory infections].

Journal: The Japanese journal of antibiotics 20070401

Title: [Evaluation of efficacy of oral quinolone against Streptococcus pneumoniae AND Haemophilus influenzae with the use of Monte Carlo simulation].

Journal: The Japanese journal of antibiotics 20061201

Title: Antibacterial activity of tosufloxacin against major organisms detected from patients with respiratory or otorhinological infections: comparison with the results obtained from organisms isolated about 10 years ago.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Pharmacodynamic evaluation of tosufloxacin against Streptococcus pneumoniae in an in vitro model simulating serum concentration.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060201

Title: In vitro activity of pazufloxacin, tosufloxacin and other quinolones against Legionella species.

Journal: The Journal of antimicrobial chemotherapy 20051201

Title: [Clinical experience of streptococcal balanoposthitis in 47 healthy adult males].

Journal: Hinyokika kiyo. Acta urologica Japonica 20051101

Title: Antimicrobial activities of tosufloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella branhamella catarrhalis isolated from otolaryngological infectious diseases.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20051001

Title: Terbium sensitized determination of tosufloxacin using electrochemiluminescence method.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050401

Title: VapB-positive Rhodococcus equi infection in an HIV-infected patient in Japan.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20050201

Title: [Clinical study of male urethritis in Oogaki Municipal Hospital].

Journal: Hinyokika kiyo. Acta urologica Japonica 20050101

Title: An unusual form of crystal-forming chronic interstitial nephritis following long-term exposure to tosufloxacin tosilate.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20041101

Title: Anaphylaxis due to tosufloxacin tosilate.

Journal: The Journal of dermatology 20030901

Title: [Salmonella infections].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: [Alteration of antibacterial activity of tosufloxacin and various antibacterial agents against Streptococcus pneumoniae].

Journal: The Japanese journal of antibiotics 20030201

Title: [In vitro antibacterial activity of prulifloxacin, a new oral fluoroquinolone].

Journal: The Japanese journal of antibiotics 20021201

Title: Pharmacokinetics and safety assessment of tosufloxacin tosilate.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20020301

Title: Clinical assessment of tosufloxacin tosilate.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20020301

Title: Evaluation of in-vitro and in-vivo antibacterial activity of tosufloxacin tosilate.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20011201

Title: Pulmonary infiltration with eosinophilia (PIE) syndrome induced by antibiotics, PIPC and TFLX during cancer treatment.

Journal: Oral oncology 20010701

Title: Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20010301

Title: Accumulation of ofloxacin and tosufloxacin in fluoroquinolone-resistant E coli.

Journal: Acta pharmacologica Sinica 20010301

Title: Comparative in-vitro activities of the new quinolone, Bay y 3118, and ciprofloxacin, sparfloxacin, tosufloxacin, CI-960 and CI-990.

Journal: The Journal of antimicrobial chemotherapy 19930401

Title: [Nephrotoxicity test on T-3262 in rats with experimental nephropathy].

Journal: The Japanese journal of antibiotics 19890401

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