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1235-82-1,MFCD00797516
Catalog No.:AA000KM0

1235-82-1 | 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)

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5mg
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$94.00   $66.00
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25mg
95%
in stock  
$226.00   $158.00
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100mg
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$677.00   $474.00
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500mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000KM0
Chemical Name:
1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)
CAS Number:
1235-82-1
Molecular Formula:
C21H30ClNO
Molecular Weight:
347.9220
MDL Number:
MFCD00797516
SMILES:
OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1.Cl
Properties
Computed Properties
 
Complexity:
422  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
4  

Downstream Synthesis Route
Literature

Title: Human electrophysiological correlates of learned irrelevance: effects of the muscarinic M1 antagonist biperiden.

Journal: The international journal of neuropsychopharmacology 20121101

Title: Biperiden (M₁ antagonist) impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization.

Journal: Behavioural brain research 20120516

Title: The elevated T-maze task as an animal model to simultaneously investigate the effects of drugs on long-term memory and anxiety in mice.

Journal: Brain research bulletin 20120410

Title: Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference.

Journal: Neuroscience letters 20120404

Title: Novel PVC-membrane electrode for flow injection potentiometric determination of Biperiden in pharmaceutical preparations.

Journal: Talanta 20111215

Title: Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats.

Journal: Behavioural brain research 20111201

Title: Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder.

Journal: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20111201

Title: Biperiden-induced delirium in an adolescent patient.

Journal: Journal of child and adolescent psychopharmacology 20111001

Title: A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment.

Journal: Psychopharmacology 20110601

Title: Nucleus lentiformis--a new model for psychiatry?

Journal: Medical hypotheses 20110501

Title: Ziprasidone vs olanzapine in recent-onset schizophrenia and schizoaffective disorder: results of an 8-week double-blind randomized controlled trial.

Journal: Schizophrenia bulletin 20110301

Title: Hemiparkinsonism-hemiatrophy syndrome.

Journal: Archives of Iranian medicine 20110301

Title: Polypharmacy in the treatment of schizophrenic patients in three University Centers in the Federation of Bosnia and Herzegovina (F/BH).

Journal: Psychiatria Danubina 20110301

Title: Effects of discontinuation of long-term biperiden use on cognitive function and quality of life in schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110115

Title: Stercoral perforation of the sigmoid colon. A case report and brief review of the literature.

Journal: Il Giornale di chirurgia 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Comparison of the efficacy and impact on cognition of glycopyrrolate and biperiden for clozapine-induced sialorrhea in schizophrenic patients: a randomized, double-blind, crossover study.

Journal: Schizophrenia research 20100601

Title: [Doctor, I need an antidote for your antidote. A case biperidene induced anticholinergic syndrome].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20100501

Title: Psychogenic movement disorder after a venlafaxine-induced dystonia.

Journal: Movement disorders : official journal of the Movement Disorder Society 20100315

Title: Delirium caused by intramuscular administration of biperiden.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20100101

Title: Amisulpride treatment of adolescent patients with schizophrenia or schizo-affective disorders.

Journal: European child & adolescent psychiatry 20090801

Title: The antidepressant effects of anticholinergic drugs.

Journal: Journal of psychosocial nursing and mental health services 20090601

Title: Aripiprazole in combination with other antipsychotic drugs may worsen psychosis.

Journal: Journal of clinical pharmacy and therapeutics 20090401

Title: Neuroleptic malignant syndrome due to risperidone treatment in a child with Joubert syndrome.

Journal: Journal of the National Medical Association 20090301

Title: The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study.

Journal: British journal of clinical pharmacology 20090201

Title: Torticollis under cyclobenzaprine.

Journal: Pharmacology 20090101

Title: Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions.

Journal: European journal of pharmacology 20081203

Title: Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats.

Journal: Pharmacology, biochemistry, and behavior 20080601

Title: Severe extrapyramidal syndrome after exposition to isoamyl acetate vapour.

Journal: Journal of neurology 20080501

Title: A case of respiratory akathisia in a cancer patient: a case report.

Journal: Palliative & supportive care 20080301

Title: A somatic type delusional disorder secondary to peripheral neuropathy: a case report.

Journal: Psychiatria Danubina 20080301

Title: The successful use of ondansetron in a boy with both leukemia and Tourette syndrome.

Journal: Journal of child neurology 20080101

Title: Methamphetamine psychosis in which tardive dystonia was successfully treated with clonazepam.

Journal: Psychiatry and clinical neurosciences 20071201

Title: Empirical validation of competing definitions of schizophrenia: a poly-diagnostic study of cognitive impairment in non-affective psychosis.

Journal: Schizophrenia research 20070901

Title: Bipiperidinyl carboxylic acid amides as potent, selective, and functionally active CCR4 antagonists.

Journal: Chemical biology & drug design 20070901

Title: Gluteal abscess following intramuscular injection of dissolved biperiden tablets.

Journal: International journal of clinical practice 20070801

Title: Risperidone-induced sialorrhea responsive to biperiden treatment.

Journal: Schizophrenia research 20070701

Title: Development and validation of a stability-indicating high performance liquid chromatographic (HPLC) assay for biperiden in bulk form and pharmaceutical dosage forms.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

Title: The effectiveness of intramuscular biperiden in acute akathisia: a double-blind, randomized, placebo-controlled study.

Journal: Journal of clinical psychopharmacology 20070601

Title: Acute dystonia after injection of pegylated interferon alpha-2b.

Journal: Movement disorders : official journal of the Movement Disorder Society 20070415

Title: Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20070101

Title: So easy to forget.

Journal: Delaware medical journal 20070101

Title: [Therapy of postoperative nausea and vomiting in ENT--tardive dyskinesia as an adverse effect of metoclopramid--a case report].

Journal: Laryngo- rhino- otologie 20061101

Title: Biperiden-induced delirium model in rats: a behavioral and electroencephalographic study.

Journal: Brain research 20061018

Title: Antipsychotics-induced hypersensitivity of visual perception.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20060701

Title: Acute dystonia with low-dosage aripiprazole in Tourette's disorder.

Journal: The Annals of pharmacotherapy 20060401

Title: Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101

Title: Clozapine improves working memory updating in schizophrenia.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20051201

Title: Evaluation of the clinical efficacy of risperidone for untreated and treated cases of schizophrenia from various aspects.

Journal: Psychiatry and clinical neurosciences 20051001

Title: Scopolamine-induced convulsions in fasted mice after food intake: effects of glucose intake, antimuscarinic activity and anticonvulsant drugs.

Journal: Neuropharmacology 20050901

Title: Modulation of memory and visuospatial processes by biperiden and rivastigmine in elderly healthy subjects.

Journal: Psychopharmacology 20050901

Title: Administration of haloperidol with biperiden reduces mRNAs related to the ubiquitin-proteasome system in mice.

Journal: Synapse (New York, N.Y.) 20050615

Title: Ecstasy and acute dystonia.

Journal: Movement disorders : official journal of the Movement Disorder Society 20041101

Title: Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden.

Journal: Legal medicine (Tokyo, Japan) 20041001

Title: Reversible orofacial dyskinesia after ofloxacin treatment.

Journal: Movement disorders : official journal of the Movement Disorder Society 20040601

Title: Comparisons of psychotropic drug prescribing patterns in acute psychiatric wards across Europe.

Journal: European journal of clinical pharmacology 20040301

Title: Effects of discontinuation of long-term anticholinergic treatment in elderly schizophrenia patients.

Journal: International clinical psychopharmacology 20040101

Title: [Acute dystonic reaction due to quinine].

Journal: Anales de medicina interna (Madrid, Spain : 1984) 20031201

Title: Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia.

Journal: Experimental neurology 20031201

Title: Use of biperiden hydrochloride in a child with severe dyskinesia induced by phenytoin.

Journal: Journal of child neurology 20030701

Title: [Iatrogenic dementia?].

Journal: Praxis 20030409

Title: Biperiden for excessive sweating from methadone.

Journal: The American journal of psychiatry 20030201

Title: Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman.

Journal: Drug and chemical toxicology 20030201

Title: Transient and reversible parkinsonism after acute organophosphate poisoning.

Journal: Journal of toxicology. Clinical toxicology 20030101

Title: In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: Tardive dyskinesia with risperidone and anticholinergics.

Journal: The American journal of psychiatry 20021101

Title: Tardive dyskinesia model in the common marmoset.

Journal: Movement disorders : official journal of the Movement Disorder Society 20020301

Title: Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model.

Journal: Methods and findings in experimental and clinical pharmacology 20020301

Title: The determination of biperiden in plasma using gas chromatography mass spectrometry: pharmacokinetics after intramuscular administration to guinea pigs.

Journal: Biomedical chromatography : BMC 20020201

Title: Sexual disinhibition induced by risperidone in a child.

Journal: Journal of child and adolescent psychopharmacology 20020101

Title: A case of child abuse: haloperidol poisoning of a child caused by his mother.

Journal: European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20011201

Title: The influence of pilocarpine and biperiden on pH value and calcium, phosphate, and bicarbonate concentrations in saliva during and after radiotherapy for head and neck cancer.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20011101

Title: A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor.

Journal: Parkinsonism & related disorders 20010901

Title: Biperiden for excessive sweating from clozapine.

Journal: The American journal of psychiatry 20010801

Title: [Swollen tongue].

Journal: Nederlands tijdschrift voor tandheelkunde 20010401

Title: Modulation by muscarinic antagonists of the response to carbon dioxide challenge in panic disorder.

Journal: Archives of general psychiatry 20010201

Title: Insomnia related to biperiden withdrawal in two schizophrenic patients.

Journal: International clinical psychopharmacology 20001101

Title: Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus.

Journal: Pharmacology, biochemistry, and behavior 20001101

Title: Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice.

Journal: Biopharmaceutics & drug disposition 20000501

Title: [A case of amoxapine-induced tardive dystonia successfully treated with a low dose anti-cholinergic agent].

Journal: Rinsho shinkeigaku = Clinical neurology 20000401

Title: Prediction of catalepsies induced by amiodarone, aprindine and procaine: similarity in conformation of diethylaminoethyl side chain.

Journal: The Journal of pharmacology and experimental therapeutics 19981101

Title: Combined treatment of schizophrenic psychoses with haloperidol and valproate.

Journal: Pharmacopsychiatry 19980701

Title: Belly dystonia induced by levodopa and biperiden in a case of suspected multiple-system atrophy.

Journal: Movement disorders : official journal of the Movement Disorder Society 19960701

Title: Anticholinergic treatment for choreoathetosis in a child after induction with propofol.

Journal: Anesthesia and analgesia 19960301

Title: Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.

Journal: International clinical psychopharmacology 19950601

Title: Predictors of acute dystonia in first-episode psychotic patients.

Journal: The American journal of psychiatry 19941201

Title: [acute dystonias in combined abuse of cocaine and neuroleptics].

Journal: Nederlands tijdschrift voor geneeskunde 19941126

Title: [Drug-induced asterixis].

Journal: Deutsche medizinische Wochenschrift (1946) 19940422

Title: Acute dystonia due to clozapine.

Journal: Journal of neurology, neurosurgery, and psychiatry 19940101

Title: Chronic dementia in Parkinson's disease treated by anticholinergic agents. Neuropsychological and neuroradiological examination.

Journal: Advances in neurology 19930101

Title: Extrapyramidal syndrome responsive to dopaminergic treatment following recovery from central pontine myelinolysis.

Journal: European neurology 19930101

Title: Bradycardia due to biperiden.

Journal: Pharmacopsychiatry 19890101

Title: Drug-induced alzheimerism.

Journal: Archives of neurology 19880301

Title: [Dyskinetic syndrome in children following Thalamonal premedication].

Journal: Der Anaesthesist 19860401

Title: Effect of different neuroleptics in tardive dyskinesia and parkinsonism. A video-controlled multicenter study with chlorprothixene, perphenazine, haloperidol and haloperidol + biperiden. Nordic Dyskinesia Study Group.

Journal: Psychopharmacology 19860101

Title: Effects of serotonergic and anticholinergic drugs in haloperidol-induced dystonia in Cebus monkeys.

Journal: Clinical neuropharmacology 19860101

Title: Drugs for Parkinson's disease reduce tremor induced by physostigmine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19830701

Title: Dystonic reactions following thiethylperazine in children.

Journal: Toxicology letters 19821001

Title: The relationship between parkinsonism and tardive dyskinesia.

Journal: The American journal of psychiatry 19770701

Title: Mood elevating effect of trihexyphenidyl and biperiden in individuals taking antipsychotic medication.

Journal: Diseases of the nervous system 19770501

Title: [Uncharacteristic hypertonia resulting from treatment with metoclopramide (Primperan) in children with acute gastroenteritis].

Journal: Ugeskrift for laeger 19770101

Title: [Treatment of the neuroleptic syndrome by biperiden hydrochloride under its delayed-action form. A 9-month study on 55 hospitalized patients].

Journal: L'Encephale 19760101

Title: Visual hallucinations and delirium during treatment with amantadine (Symmetrel).

Journal: Journal of the American Geriatrics Society 19750501

Title: Fluphenazine enanthate induced decompensations.

Journal: Psychosomatics 19750101

Title: Biperiden (Akineton): effective prophylactic and therapeutic anti-parkinsonian agent.

Journal: Current therapeutic research, clinical and experimental 19740801

Title: Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia.

Journal: Psychopharmacologia 19740109

Title: Abnormal involuntary movements induced by anticholinergic therapy.

Journal: Acta neurologica Scandinavica 19740101

Title: Phenothiazine-induced decompensation.

Journal: Archives of general psychiatry 19740101

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Tags:1235-82-1 Molecular Formula|1235-82-1 MDL|1235-82-1 SMILES|1235-82-1 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)