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125572-93-2,MFCD00870193
Catalog No.:AA000NU0

125572-93-2 | Rotigotine

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50mg
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100mg
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500mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000NU0
Chemical Name:
Rotigotine
CAS Number:
125572-93-2
Molecular Formula:
C19H26ClNOS
Molecular Weight:
351.9338
MDL Number:
MFCD00870193
SMILES:
CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1.Cl
Properties
Computed Properties
 
Complexity:
337  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  

Literature

Title: Rotigotine transdermal patch for the treatment of Parkinson's Disease.

Journal: Fundamental & clinical pharmacology 20130201

Title: Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in Cynomolgus monkeys.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130201

Title: Dopamine D₂-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer's disease patients.

Journal: Neuropharmacology 20130101

Title: The powerful pre-treatment effect: placebo responses in restless legs syndrome trials.

Journal: European journal of neurology 20121001

Title: ADMET considerations for restless leg syndrome drug treatments.

Journal: Expert opinion on drug metabolism & toxicology 20121001

Title: Preparation of rotigotine-loaded microspheres and their combination use with L-DOPA to modify dyskinesias in 6-OHDA-lesioned rats.

Journal: Pharmaceutical research 20120901

Title: In brief: transdermal rotigotine (Neupro).

Journal: The Medical letter on drugs and therapeutics 20120820

Title: The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke.

Journal: Brain : a journal of neurology 20120801

Title: Long-term safety and tolerability of rotigotine transdermal system in patients with early-stage idiopathic Parkinson's disease: a prospective, open-label extension study.

Journal: Parkinsonism & related disorders 20120601

Title: Augmentation in the treatment of restless legs syndrome with transdermal rotigotine.

Journal: Sleep medicine 20120601

Title: Drug safety evaluation of rotigotine.

Journal: Expert opinion on drug safety 20120501

Title: Steady-state plasma concentration profile of transdermal rotigotine: an integrated analysis of three, open-label, randomized, phase I multiple dose studies.

Journal: Clinical therapeutics 20120401

Title: Transdermal rotigotine causes impulse control disorders in patients with restless legs syndrome.

Journal: Parkinsonism & related disorders 20120201

Title: Breakthrough symptoms during the daytime in patients with restless legs syndrome (Willis-Ekbom disease).

Journal: Sleep medicine 20120201

Title: Single dose pharmacokinetics of the transdermal rotigotine patch in patients with impaired renal function.

Journal: British journal of clinical pharmacology 20120101

Title: Outcomes from switching from rotigotine patch to alternate therapies in Parkinson's disease.

Journal: The International journal of neuroscience 20120101

Title: The impact of rotigotine on cardiovascular autonomic function in early Parkinson's disease.

Journal: European neurology 20120101

Title: Spotlight on rotigotine transdermal patch in Parkinson's disease.

Journal: Drugs & aging 20111201

Title: Safety and efficacy of rotigotine in individuals with Parkinson's disease aged 75 and older.

Journal: Journal of the American Geriatrics Society 20111201

Title: Rotigotine transdermal patch in combination therapy for Parkinson's disease--observations in routine clinical practice.

Journal: Current medical research and opinion 20111001

Title: Effect of rotigotine on sleep and quality of life in Parkinson's disease patients: post hoc analysis of RECOVER patients who were symptomatic at baseline.

Journal: Expert opinion on pharmacotherapy 20110901

Title: Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study.

Journal: The Lancet. Neurology 20110801

Title: Another dopamine agonist for treatment of restless legs syndrome.

Journal: The Lancet. Neurology 20110801

Title: Rotigotine transdermal patch: a review of its use in the treatment of Parkinson's disease.

Journal: CNS drugs 20110801

Title: Rotigotine-induced nail dyschromia in a patient with Parkinson disease.

Journal: Neurology 20110503

Title: Hypersexuality and compulsive over-eating associated with transdermal dopamine agonist therapy.

Journal: Parkinsonism & related disorders 20110501

Title: Rotigotine effects on early morning motor function and sleep in Parkinson's disease: a double-blind, randomized, placebo-controlled study (RECOVER).

Journal: Movement disorders : official journal of the Movement Disorder Society 20110101

Title: Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands.

Journal: Neuropharmacology 20110101

Title: Cutaneous reactions to transdermal therapeutic systems.

Journal: Dermatitis : contact, atopic, occupational, drug 20110101

Title: 'You never told me I would turn into a gambler': a first person account of dopamine agonist--induced gambling addiction in a patient with restless legs syndrome.

Journal: BMJ case reports 20110101

Title: Rotigotine transdermal system for control of early morning motor impairment and sleep disturbances in patients with Parkinson's disease.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20101201

Title: Rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome: a randomized, placebo-controlled polysomnographic study.

Journal: Sleep medicine 20101001

Title: High compliance with rotigotine transdermal patch in the treatment of idiopathic Parkinson's disease.

Journal: Parkinsonism & related disorders 20100901

Title: Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States.

Journal: Movement disorders : official journal of the Movement Disorder Society 20100815

Title: Transdermal rotigotine for the perioperative management of Parkinson's disease.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20100701

Title: Rotigotine transdermal patch for the treatment of Parkinson's disease and restless legs syndrome.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100701

Title: [Pharmacology sheet. Transdermal Rotigotine (Neupro)].

Journal: Journal de pharmacie de Belgique 20100601

Title: Treating restless legs syndrome with rotigotine.

Journal: British journal of hospital medicine (London, England : 2005) 20100401

Title: Rotigotine transdermal delivery for the treatment of restless legs syndrome.

Journal: Expert opinion on pharmacotherapy 20100301

Title: Comparing different salt forms of rotigotine to improve transdermal iontophoretic delivery.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100201

Title: Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets.

Journal: Experimental neurology 20100101

Title: Rotigotine adverse effects affecting patient's sexual partner.

Journal: Clinical neuropharmacology 20100101

Title: The concept of continuous dopaminergic stimulation: what we should consider when starting Parkinson's disease treatment.

Journal: Neuro-degenerative diseases 20100101

Title: Rotigotine transdermal patch in the management of Parkinson's disease (PD) and its night-time use for PD-related sleep disorders.

Journal: Functional neurology 20100101

Title: [Continuous dopaminergic stimulation - clinical experience].

Journal: Neurologia i neurochirurgia polska 20100101

Title: Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch.

Journal: BMC neurology 20100101

Title: Night-time use of rotigotine in advanced Parkinson's disease.

Journal: Functional neurology 20100101

Title: Dopamine dysregulation syndrome in a patient with early onset Parkinsonism and Parkin gene mutations.

Journal: Movement disorders : official journal of the Movement Disorder Society 20091215

Title: Transdermal rotigotine: a clinically innovative dopamine-receptor agonist for the management of Parkinson's disease.

Journal: Pharmacotherapy 20091201

Title: Absorption, disposition, metabolic fate, and elimination of the dopamine agonist rotigotine in man: administration by intravenous infusion or transdermal delivery.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20091001

Title: Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction.

Journal: Experimental neurology 20091001

Title: Rotigotine and restless legs syndrome: new indication. The worst dopamine agonist. Just as unsatisfactory; defective design.

Journal: Prescrire international 20091001

Title: Lack of pharmacokinetic interactions between transdermal rotigotine and oral levodopa/carbidopa.

Journal: Journal of clinical pharmacology 20090901

Title: Influence of transdermal rotigotine on ovulation suppression by a combined oral contraceptive.

Journal: British journal of clinical pharmacology 20090901

Title: Rotigotine for restless legs syndrome.

Journal: Drugs of today (Barcelona, Spain : 1998) 20090901

Title: Enantiospecific binding of Rotigotine and its antipode to serum albumins: Investigation of binding constants and binding sites by partial-filling ACE.

Journal: Electrophoresis 20090801

Title: Pramipexole induced compulsive behaviors abate after initiation of rotigitine.

Journal: Movement disorders : official journal of the Movement Disorder Society 20090515

Title: Rotigotine transdermal delivery for the treatment of Parkinson's disease.

Journal: Expert opinion on pharmacotherapy 20090301

Title: Transdermal dopaminergic stimulation with rotigotine in Parkinsonian akinetic crisis.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090201

Title: Influence of domperidone on pharmacokinetics, safety and tolerability of the dopamine agonist rotigotine.

Journal: British journal of clinical pharmacology 20090201

Title: Cardiac and noncardiac fibrotic reactions caused by ergot-and nonergot-derived dopamine agonists.

Journal: Movement disorders : official journal of the Movement Disorder Society 20090115

Title: The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090101

Title: Impulse control disorders arising in 3 patients treated with rotigotine.

Journal: Clinical neuropharmacology 20090101

Title: High doses of rotigotine transdermal patch: results of an open-label, dose-escalation trial in patients with advanced-stage, idiopathic Parkinson disease.

Journal: Clinical neuropharmacology 20090101

Title: Sleep attack associated to rotigotine.

Journal: Clinical neuropharmacology 20090101

Title: Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions.

Journal: European journal of pharmacology 20081203

Title: One year open-label safety and efficacy trial with rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome.

Journal: Sleep medicine 20081201

Title: Thorough QT/QTc study in patients with advanced Parkinson's disease: cardiac safety of rotigotine.

Journal: Clinical pharmacology and therapeutics 20081101

Title: Crystallisation within transdermal rotigotine patch: is there cause for concern?

Journal: Expert opinion on drug delivery 20081101

Title: Continuous versus pulsatile administration of rotigotine in 6-OHDA-lesioned rats: contralateral rotations and abnormal involuntary movements.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20081001

Title: Restless legs syndrome sees the light of day.

Journal: The Lancet. Neurology 20080701

Title: Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial.

Journal: The Lancet. Neurology 20080701

Title: Rotigotine transdermal system for the treatment of Parkinson's disease.

Journal: Clinical therapeutics 20080501

Title: Simultaneous enantioseparation of antiparkinsonian medication Rotigotine and related chiral impurities by capillary zone electrophoresis using dual cyclodextrin system.

Journal: Journal of pharmaceutical and biomedical analysis 20080414

Title: Continuous stimulation of dopaminergic receptors by rotigotine does not interfere with the sleep-wake cycle in the rat.

Journal: European journal of pharmacology 20080414

Title: New drug update: 2007.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20080401

Title: Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe.

Journal: Sleep medicine 20080301

Title: [Rotigotine in the treatment of Parkinson's disease. A study on a sample of 150 patients].

Journal: Revista de neurologia 20080301

Title: Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson's disease.

Journal: Neuroscience letters 20080213

Title: Constant dopaminergic stimulation by transdermal delivery of dopaminergic drugs: a new treatment paradigm in Parkinson's disease.

Journal: European journal of neurology 20080101

Title: Parkinson's disease and movement disorders: moving forward.

Journal: The Lancet. Neurology 20080101

Title: Spotlight on rotigotine in Parkinson's disease.

Journal: Drugs & aging 20080101

Title: Rotigotine transdermal patch: in restless legs syndrome.

Journal: CNS drugs 20080101

Title: Sleep disorders and neuromuscular diseases.

Journal: Reviews in neurological diseases 20080101

Title: Rotigotine transdermal patch in early Parkinson's disease: a randomized, double-blind, controlled study versus placebo and ropinirole.

Journal: Movement disorders : official journal of the Movement Disorder Society 20071201

Title: Notice of redundant publication: 'Transdermal rotigotine: double-blind, placebo-controlled trial in Parkinson disease' (Arch Neurol. 2007;64[5]:676-682).

Journal: Archives of neurology 20071201

Title: Transdermal rotigotine (Neupro) for Parkinson's disease.

Journal: The Medical letter on drugs and therapeutics 20070827

Title: Transdermal therapy in Parkinson's disease.

Journal: The Lancet. Neurology 20070601

Title: Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial.

Journal: The Lancet. Neurology 20070601

Title: Rotigotine transdermal patch in the treatment of Parkinson's disease and restless legs syndrome.

Journal: Expert opinion on pharmacotherapy 20070601

Title: Transdermal rotigotine: double-blind, placebo-controlled trial in Parkinson disease.

Journal: Archives of neurology 20070501

Title: Advanced Parkinson disease treated with rotigotine transdermal system: PREFER Study.

Journal: Neurology 20070417

Title: Transdermal rotigotine: a new non-ergot dopamine agonist for the treatment of Parkinson's disease.

Journal: Expert opinion on drug delivery 20070301

Title: Plasma levels of rotigotine and the reversal of motor deficits in MPTP-treated primates.

Journal: Behavioural pharmacology 20070301

Title: The use of transdermal rotigotine in a patient with advanced Parkinson's disease and dysphagia.

Journal: Palliative medicine 20070301

Title: Rotigotine treatment partially protects from MPTP toxicity in a progressive macaque model of Parkinson's disease.

Journal: Experimental neurology 20070201

Title: Rotigotine transdermal system for perioperative administration.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070201

Title: Rotigotine: transdermal dopamine agonist treatment of Parkinson's disease and restless legs syndrome.

Journal: The Annals of pharmacotherapy 20070201

Title: Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson disease.

Journal: Neurology 20070123

Title: Determination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070101

Title: Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulation.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070101

Title: [Transdermal drugs in neurology].

Journal: Neurologia (Barcelona, Spain) 20070101

Title: New drugs: retapamulin, bismuth subcitrate potassium, and rotigotine.

Journal: Journal of the American Pharmacists Association : JAPhA 20070101

Title: Transdermal administration of radiolabelled [14C]rotigotine by a patch formulation: a mass balance trial.

Journal: Clinical pharmacokinetics 20070101

Title: Overnight switch from oral dopaminergic agonists to transdermal rotigotine patch in subjects with Parkinson disease.

Journal: Clinical neuropharmacology 20070101

Title: Rotigotine transdermal patch: a review of its use in the management of Parkinson's disease.

Journal: CNS drugs 20070101

Title: Antidepressant properties of rotigotine in experimental models of depression.

Journal: European journal of pharmacology 20061024

Title: Rotigotine for the treatment of Parkinson's disease.

Journal: Expert review of neurotherapeutics 20060901

Title: [Transdermal rotigotine as monotherapy for Parkinson disease].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20060601

Title: Rotigotine: a novel dopamine agonist for the transdermal treatment of Parkinson's disease.

Journal: Drugs of today (Barcelona, Spain : 1998) 20060101

Title: Rotigotine transdermal patch enables rapid titration to effective doses in advanced-stage idiopathic Parkinson disease: subanalysis of a parallel group, open-label, dose-escalation study.

Journal: Clinical neuropharmacology 20060101

Title: Clinical studies with transdermal rotigotine in early Parkinson's disease.

Journal: Neurology 20050726

Title: A novel dopamine agonist for the transdermal treatment of Parkinson's disease.

Journal: Neurology 20050726

Title: A promising new technology for Parkinson's disease.

Journal: Neurology 20050726

Title: Safety, tolerability, and efficacy of continuous transdermal dopaminergic stimulation with rotigotine patch in early-stage idiopathic Parkinson disease.

Journal: Clinical neuropharmacology 20050101

Title: Rotigotine: in Parkinson's disease.

Journal: CNS drugs 20050101

Title: Rotigotine: a viewpoint by Peter LeWitt.

Journal: CNS drugs 20050101

Title: Rotigotine: a viewpoint by Tomislav Babic.

Journal: CNS drugs 20050101

Title: Patch application of the dopamine agonist rotigotine to patients with moderate to advanced stages of restless legs syndrome: a double-blind, placebo-controlled pilot study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20041201

Title: Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCl concentration.

Journal: Pharmaceutical research 20040501

Title: Transdermal iontophoresis of rotigotine: influence of concentration, temperature and current density in human skin in vitro.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20040416

Title: A controlled trial of rotigotine monotherapy in early Parkinson's disease.

Journal: Archives of neurology 20031201

Title: Skin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulations.

Journal: Pharmaceutical research 20031001

Title: Rotigotine Schwarz Pharma.

Journal: IDrugs : the investigational drugs journal 20030901

Title: Restless legs syndrome.

Journal: The New England journal of medicine 20030821

Title: Non-oral drug delivery in Parkinson's disease: a summary from the symposium at the 7th International Congress of Parkinson's Disease and Movement Disorders. 10-14 November 2002, Miami, FL, USA.

Journal: Expert opinion on pharmacotherapy 20030401

Title: Transdermal dopaminergic D(2) receptor agonist therapy in Parkinson's disease with N-0923 TDS: a double-blind, placebo-controlled study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20010501

Title: Continuous transdermal dopaminergic stimulation in advanced Parkinson's disease.

Journal: Clinical neuropharmacology 20010101

Title: Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35.

Title: Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.

Title: Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91.

Title: Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP? and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.

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Tags:125572-93-2 Molecular Formula|125572-93-2 MDL|125572-93-2 SMILES|125572-93-2 Rotigotine