Home Other Building Blocks 1258861-20-9
1258861-20-9,MFCD21609264
Catalog No.:AA000OU8

1258861-20-9 | Ly2940680

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$88.00   $61.00
- +
5mg
98%
in stock  
$100.00   $70.00
- +
25mg
98%
in stock  
$267.00   $187.00
- +
100mg
98%
in stock  
$743.00   $520.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000OU8
Chemical Name:
Ly2940680
CAS Number:
1258861-20-9
Molecular Formula:
C26H24F4N6O
Molecular Weight:
512.5020
MDL Number:
MFCD21609264
SMILES:
Fc1ccc(c(c1)C(F)(F)F)C(=O)N(C1CCN(CC1)c1nnc(c2c1cccc2)c1ccnn1C)C
Properties
Computed Properties
 
Complexity:
794  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
9  
Rotatable Bond Count:
4  
XLogP3:
4.3  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10(11):e0142124.

Title: Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29(5):1817-29.

Title: Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

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SDS
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