Catalog No.:AA000PF6

1197160-78-3 | PKI-587

Name: Name:PKI-587
Brand: AABLOCKS
SKU: AA000PF6
Availability: InStock
Rating: 90 (10 reviews)

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Purity

Availability

Price(USD)

Quantity

1mg

98%

in stock

$16.00 $11.00

- +

5mg

98%

in stock

$41.00 $29.00

- +

Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA000PF6

Chemical Name:

PKI-587

CAS Number:

1197160-78-3

Molecular Formula:

C32H41N9O4

Molecular Weight:

615.7258

MDL Number:

MFCD16875679

SMILES:

O=C(Nc1ccc(cc1)c1nc(nc(n1)N1CCOCC1)N1CCOCC1)Nc1ccc(cc1)C(=O)N1CCC(CC1)N(C)C

Properties

Computed Properties

Complexity:

913

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.4

Literature

Title: PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation.

Journal: The Journal of surgical research 20120801

Title: Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110515

Title: PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.

Journal: Journal of medicinal chemistry 20100325

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