Title: Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.
Journal: Bioorganic & medicinal chemistry 20140801
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
Journal: Molecular and cellular biochemistry 20121101
Title: Regulation of asthmatic airway relaxation by estrogen and heat shock protein 90.
Journal: Journal of cellular physiology 20120801
Title: Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors.
Journal: Journal of biomolecular screening 20120801
Title: Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization.
Journal: Molecular & cellular proteomics : MCP 20120701
Title: Hsp90 regulates O-linked β-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked β-N-acetylglucosamine modification in endothelial cells.
Journal: American journal of physiology. Cell physiology 20120615
Title: Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae.
Journal: Current genetics 20120601
Title: Geldanamycin and its derivatives as Hsp90 inhibitors.
Journal: Frontiers in bioscience (Landmark edition) 20120601
Title: Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells.
Journal: Bioorganic & medicinal chemistry 20120115
Title: Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.
Journal: Molecular and cellular biochemistry 20120101
Title: Preventing ascidian fouling in aquaculture: screening selected allelochemicals for anti-metamorphic properties in ascidian larvae.
Journal: Biofouling 20120101
Title: The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies.
Journal: ACS chemical biology 20111216
Title: The lipogenesis pathway as a cancer target.
Journal: Journal of medicinal chemistry 20110825
Title: Inhibition of HSP90-dependent telomerase activity in amyloid β-induced apoptosis of cerebral endothelial cells.
Journal: Journal of cellular physiology 20110801
Title: Obligatory role of heat shock protein 90 in iNOS induction.
Journal: American journal of physiology. Cell physiology 20110701
Title: Determination of the volume changes induced by ligand binding to heat shock protein 90 using high-pressure denaturation.
Journal: Analytical biochemistry 20110615
Title: Hsp90 is involved in the formation of P-bodies and stress granules.
Journal: Biochemical and biophysical research communications 20110422
Title: Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen.
Journal: Cellular microbiology 20110301
Title: Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis.
Journal: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20110301
Title: ATP-binding site of bacterial enzymes as a target for antibacterial drug design.
Journal: Journal of medicinal chemistry 20110224
Title: Specific inhibition of the halogenase for radicicol biosynthesis by bromide at the transcriptional level in Pochonia chlamydosporia.
Journal: Biotechnology letters 20110201
Title: Modulation of α(2C) adrenergic receptor temperature-sensitive trafficking by HSP90.
Journal: Biochimica et biophysica acta 20110201
Title: Rapid decrease of CD16 (FcγRIII) expression on heat-shocked neutrophils and their recognition by macrophages.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model.
Journal: Molecular vision 20110101
Title: Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs.
Journal: The Journal of biological chemistry 20101231
Title: N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms.
Journal: Biophysical chemistry 20101101
Title: The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.
Journal: The Journal of biological chemistry 20100924
Title: Protection of oligodendrocyte precursor cells by low doses of HSP90 inhibitors in cell culture.
Journal: Experimental neurology 20100901
Title: Inhibition of heat-shock protein 90 reduces Ebola virus replication.
Journal: Antiviral research 20100801
Title: RET is a heat shock protein 90 (HSP90) client protein and is knocked down upon HSP90 pharmacological block.
Journal: The Journal of clinical endocrinology and metabolism 20100701
Title: [Progress in the study of heat shock protein 90 inhibitors].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100701
Title: cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway.
Journal: Journal of the Association for Research in Otolaryngology : JARO 20100601
Title: A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta.
Journal: Biochemical pharmacology 20100601
Title: Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.
Journal: Chemistry & biology 20100528
Title: Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.
Journal: International journal of cancer 20100515
Title: Comprehensive screening of human genes with inhibitory effects on yeast growth and validation of a yeast cell-based system for screening chemicals.
Journal: Journal of biomolecular screening 20100401
Title: Single plasmids expressing human steroid hormone receptors and a reporter gene for use in yeast signaling assays.
Journal: Plasmid 20100301
Title: Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100301
Title: The protective effect of radicicol against renal ischemia--reperfusion injury in mice.
Journal: Journal of pharmacological sciences 20100101
Title: Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091215
Title: Antifungal metabolites (monorden, monocillins I, II, III) from Colletotrichum graminicola, a systemic vascular pathogen of maize.
Journal: Mycological research 20091201
Title: Inhibition of HSP90 with pochoximes: SAR and structure-based insights.
Journal: Chembiochem : a European journal of chemical biology 20091123
Title: Structure-based and in silico design of Hsp90 inhibitors.
Journal: ChemMedChem 20090901
Title: The effects of an hsp90 inhibitor on the paradoxical effect.
Journal: Japanese journal of infectious diseases 20090901
Title: Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin.
Journal: The Journal of organic chemistry 20090703
Title: Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
Journal: Bioorganic & medicinal chemistry 20090701
Title: HSP90alpha and HSP90beta isoforms selectively modulate MHC class II antigen presentation in B cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20090615
Title: Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle.
Journal: The Journal of pharmacology and experimental therapeutics 20090601
Title: Measurement of nanomolar dissociation constants by titration calorimetry and thermal shift assay - radicicol binding to Hsp90 and ethoxzolamide binding to CAII.
Journal: International journal of molecular sciences 20090601
Title: Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
Journal: Journal of molecular biology 20090522
Title: Structural basis of the radicicol resistance displayed by a fungal hsp90.
Journal: ACS chemical biology 20090417
Title: Hydrating for resistance to radicicol.
Journal: ACS chemical biology 20090417
Title: High cytotoxic sensitivity of the oligodendrocyte precursor cells to HSP90 inhibitors in cell cultures.
Journal: Experimental neurology 20090401
Title: The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities.
Journal: Molecular and biochemical parasitology 20090401
Title: Discovery and development of heat shock protein 90 inhibitors.
Journal: Bioorganic & medicinal chemistry 20090315
Title: Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells.
Journal: Cell stress & chaperones 20090301
Title: Drug-target identification from total cellular lysate by drug-induced conformational changes.
Journal: Analytical biochemistry 20090215
Title: Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
Journal: Anesthesiology 20090201
Title: Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.
Journal: Bioorganic & medicinal chemistry 20090115
Title: High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
Journal: American journal of physiology. Cell physiology 20090101
Title: Hsp90 inhibition with resorcyclic acid lactones (RALs).
Journal: Current topics in medicinal chemistry 20090101
Title: Inhibition and function of heat shock proteins 70 and 90.
Journal: Current topics in medicinal chemistry 20090101
Title: Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversii.
Journal: Chemistry & biology 20081222
Title: Neurite outgrowth of NG108-15 cells induced by heat shock protein 90 inhibitors.
Journal: Cell biochemistry and function 20081201
Title: Radicicol, a heat shock protein 90 inhibitor, reduces glomerular filtration rate.
Journal: American journal of physiology. Renal physiology 20081001
Title: Radicicol improves regeneration of skeletal muscle previously damaged by crotoxin in mice.
Journal: Toxicon : official journal of the International Society on Toxinology 20080701
Title: Synthesis of Hsp90 inhibitor dimers as potential antitumor agents.
Journal: Bioorganic & medicinal chemistry 20080601
Title: Sgt1 has co-chaperone properties and is up-regulated by heat shock.
Journal: Biochemical and biophysical research communications 20080523
Title: The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ.
Journal: Journal of molecular biology 20080523
Title: Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells.
Journal: European journal of pharmacology 20080428
Title: Kinase-dependent adhesion to fibronectin: regulation by calreticulin.
Journal: Experimental cell research 20080401
Title: Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cells.
Journal: European journal of pharmacology 20080317
Title: Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.
Journal: Bioorganic & medicinal chemistry letters 20080301
Title: Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms.
Journal: Structure (London, England : 1993) 20080301
Title: Inhibition of Ca2+-signal-dependent growth regulation by radicicol in budding yeast.
Journal: Bioscience, biotechnology, and biochemistry 20080101
Title: Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor.
Journal: Angewandte Chemie (International ed. in English) 20080101
Title: The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability.
Journal: BMC microbiology 20080101
Title: Radicicol-mediated inhibition of Bcr-Abl in K562 cells induced p38-MAPK dependent erythroid differentiation and PU.1 down-regulation.
Journal: BioFactors (Oxford, England) 20080101
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: The ATPase cycle of the endoplasmic chaperone Grp94.
Journal: The Journal of biological chemistry 20071207
Title: A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion.
Journal: The Journal of biological chemistry 20071207
Title: Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90.
Journal: American journal of physiology. Lung cellular and molecular physiology 20071201
Title: The effect of the fungal metabolite radicicol analog A on mRNA degradation.
Journal: Genomics 20071201
Title: Derrubone, an inhibitor of the Hsp90 protein folding machinery.
Journal: Journal of natural products 20071201
Title: Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
Journal: Journal of natural products 20071201
Title: Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs.
Journal: Journal of molecular biology 20071005
Title: Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis.
Journal: American journal of respiratory and critical care medicine 20071001
Title: The role of hsp90 in 17alpha-ethynylestradiol-induced endocrine disruption in rainbow trout hepatocytes.
Journal: Ecotoxicology and environmental safety 20070901
Title: Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.
Journal: The FEBS journal 20070901
Title: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.
Journal: Structure (London, England : 1993) 20070801
Title: Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells.
Journal: Journal of molecular endocrinology 20070801
Title: Effect of radicicol infusion on the Src tyrosine kinase activity of rat hippocampus before and after training in an inhibitory avoidance task.
Journal: Neurochemical research 20070701
Title: A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome.
Journal: Proteomics 20070701
Title: Heat shock protein 90 modulates endothelial nitric oxide synthase activity and vascular reactivity in the newborn piglet pulmonary circulation.
Journal: American journal of physiology. Lung cellular and molecular physiology 20070601
Title: Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses.
Journal: Virology 20070525
Title: Protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in rat cortical neuron-glia cultures.
Journal: Life sciences 20070410
Title: Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Journal: Cancer research 20070401
Title: Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol.
Journal: Journal of the American Chemical Society 20070321
Title: Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice.
Journal: Biochemical and biophysical research communications 20070223
Title: Dipalmitoylation of radicicol results in improved efficacy against tumor growth and angiogenesis in vivo.
Journal: Cancer science 20070201
Title: Chemistry and biology of resorcylic acid lactones.
Journal: Chemical communications (Cambridge, England) 20070107
Title: Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors.
Journal: Angewandte Chemie (International ed. in English) 20070101
Title: Effects of CpG-B ODN on the protein expression profile of swine PBMC.
Journal: Veterinary research 20070101
Title: The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase.
Journal: Biochemical pharmacology 20061115
Title: Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis.
Journal: Neurobiology of disease 20061101
Title: Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.
Journal: Chemistry & biology 20061101
Title: Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90.
Journal: The Journal of organic chemistry 20060929
Title: 7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.
Journal: Journal of medicinal chemistry 20060824
Title: Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation.
Journal: American journal of physiology. Heart and circulatory physiology 20060701
Title: The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?
Journal: International journal of cancer 20060601
Title: Radanamycin, a macrocyclic chimera of radicicol and geldanamycin.
Journal: Bioorganic & medicinal chemistry letters 20060501
Title: FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus.
Journal: The Journal of biological chemistry 20060421
Title: Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning.
Journal: American journal of physiology. Cell physiology 20060401
Title: Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
Journal: Journal of natural products 20060201
Title: Association between Hsp90 and the ClC-2 chloride channel upregulates channel function.
Journal: American journal of physiology. Cell physiology 20060101
Title: Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells.
Journal: Journal of cellular biochemistry 20060101
Title: Using natural product inhibitors to validate Hsp90 as a molecular target in cancer.
Journal: Current topics in medicinal chemistry 20060101
Title: Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site.
Journal: Current topics in medicinal chemistry 20060101
Title: Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.
Journal: Biochemistry 20051213
Title: Concise synthesis of pochonin A, an HSP90 inhibitor.
Journal: Organic letters 20051208
Title: Structure-based discovery of a new class of Hsp90 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20051201
Title: Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin.
Journal: International journal of oncology 20051201
Title: Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?
Journal: Journal of medicinal chemistry 20051201
Title: Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20050819
Title: Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation.
Journal: Bioorganic & medicinal chemistry 20050815
Title: HEAT SHOCK PROTEIN 90C is a bona fide Hsp90 that interacts with plastidic HSP70B in Chlamydomonas reinhardtii.
Journal: Plant physiology 20050801
Title: Gymnoascolides A-C: aromatic butenolides from an Australian isolate of the soil ascomycete Gymnoascus reessii.
Journal: Journal of natural products 20050801
Title: Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
Journal: Journal of medicinal chemistry 20050630
Title: Multiple proteins with single activities or a single protein with multiple activities: the conundrum of cell surface NADH oxidoreductases.
Journal: Biochimica et biophysica acta 20050601
Title: Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues.
Journal: Journal of the American Chemical Society 20050518
Title: IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050501
Title: Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor.
Journal: International journal of radiation biology 20050101
Title: Identification of diverse microbial metabolites as potent inhibitors of HIV-1 Tat transactivation.
Journal: Chemistry & biodiversity 20050101
Title: Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
Journal: The Journal of biological chemistry 20041217
Title: Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.
Journal: Molecular and cellular endocrinology 20041130
Title: Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide.
Journal: Organic letters 20041125
Title: Hsp90 chaperones wild-type p53 tumor suppressor protein.
Journal: The Journal of biological chemistry 20041119
Title: Radicicol activates heat shock protein expression and cardioprotection in neonatal rat cardiomyocytes.
Journal: American journal of physiology. Heart and circulatory physiology 20040901
Title: The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.
Journal: The Journal of biological chemistry 20040716
Title: Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.
Journal: Oncogene 20040708
Title: Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach.
Journal: Human molecular genetics 20040701
Title: Radicicol potentiates heat-induced cell killing in a human oesophageal cancer cell line: the Hsp90 chaperone complex as a new molecular target for enhancement of thermosensitivity.
Journal: International journal of radiation biology 20040701
Title: Evidence that hsp90 is involved in the altered interactions of Acanthamoeba castellanii variants with bacteria.
Journal: Eukaryotic cell 20040601
Title: Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
Journal: The Journal of biological chemistry 20040521
Title: Hsp90 inhibitors attenuate effect of dexamethasone on activated NF-kappaB and AP-1.
Journal: Life sciences 20040305
Title: Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts.
Journal: The Journal of biological chemistry 20040227
Title: Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity.
Journal: American journal of physiology. Heart and circulatory physiology 20040201
Title: Altered states: selectively drugging the Hsp90 cancer chaperone.
Journal: Trends in molecular medicine 20040201
Title: Modulation of dexamethasone-induced thymocyte apoptosis by heat-shock protein 90-binding agents.
Journal: The Bulletin of Tokyo Dental College 20040201
Title: Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.
Journal: Bioorganic & medicinal chemistry letters 20040119
Title: Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90.
Journal: Molecular and cellular endocrinology 20040115
Title: Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis.
Journal: The International journal of developmental biology 20040101
Title: Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.
Journal: The Journal of biological chemistry 20031128
Title: Association of sustained ERK activity with integrin beta3 induction during receptor activator of nuclear factor kappaB ligand (RANKL)-directed osteoclast differentiation.
Journal: Experimental cell research 20031001
Title: Development of radicicol analogues.
Journal: Current cancer drug targets 20031001
Title: Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events.
Journal: The Journal of biological chemistry 20030912
Title: NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol.
Journal: Chembiochem : a European journal of chemical biology 20030905
Title: Modulation of prion protein structural integrity by geldanamycin.
Journal: Glycobiology 20030901
Title: Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.
Journal: Journal of medicinal chemistry 20030605
Title: Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
Journal: Journal of natural products 20030601
Title: Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification.
Journal: Current medicinal chemistry 20030501
Title: A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1.
Journal: Journal of cell science 20030415
Title: Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
Journal: The Biochemical journal 20030315
Title: Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines.
Journal: International journal of cancer 20030110
Title: Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.
Journal: Gene 20030102
Title: Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex.
Journal: The EMBO journal 20021115
Title: Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities.
Journal: Bioorganic & medicinal chemistry 20021101
Title: Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol.
Journal: Molecular pharmacology 20021101
Title: Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly.
Journal: The Journal of biological chemistry 20020913
Title: Inhibition of branched-chain alpha-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol.
Journal: Molecular pharmacology 20020801
Title: Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors.
Journal: Leukemia 20020801
Title: hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.
Journal: The Journal of biological chemistry 20020607
Title: Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression.
Journal: Cell stress & chaperones 20020401
Title: HSP90 inhibitors alter capsaicin- and ATP-induced currents in rat dorsal root ganglion neurons.
Journal: Neuroreport 20020325
Title: HSP90 function is required for morphogenesis in ascidian and echinoid embryos.
Journal: Development genes and evolution 20020301
Title: Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90.
Journal: Molecular and cellular endocrinology 20020225
Title: A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts.
Journal: Japanese journal of cancer research : Gann 20011201
Title: NO/cGMP signaling and HSP90 activity represses metamorphosis in the sea urchin Lytechinus pictus.
Journal: The Biological bulletin 20011201
Title: Stereospecific antitumor activity of radicicol oxime derivatives.
Journal: Cancer chemotherapy and pharmacology 20011201
Title: Concise asymmetric syntheses of radicicol and monocillin I.
Journal: Journal of the American Chemical Society 20011107
Title: Radicicol suppresses transformation and restores tropomyosin-2 expression in both ras- and MEK-transformed cells without inhibiting the Raf/MEK/ERK signaling cascade.
Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20011101
Title: Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast.
Journal: Bioscience, biotechnology, and biochemistry 20011101
Title: Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1.
Journal: International immunopharmacology 20010901
Title: Effects of infusions of the tyrosine kinase inhibitor radicicol into the hippocampus on short- and long-term memory of the inhibitory avoidance task.
Journal: Behavioural pharmacology 20010701
Title: Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons.
Journal: Neuropharmacology 20010601
Title: UCS15A, a non-kinase inhibitor of Src signal transduction.
Journal: Oncogene 20010419
Title: Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins.
Journal: Biological chemistry 20010301
Title: Androgen receptor signalling: comparative analysis of androgen response elements and implication of heat-shock protein 90 and 14-3-3eta.
Journal: Molecular and cellular endocrinology 20010227
Title: Inhibition of endotoxin-induced TNF-alpha production in macrophages by 5Z-7-oxo-zeaenol and other fungal resorcylic acid lactones.
Journal: International journal of immunopharmacology 19991201
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