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128607-22-7,MFCD00871890
Catalog No.:AA000Y5K

128607-22-7 | Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-

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100mg
>98.0%(GC)
in stock  
$62.00   $44.00
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1g
>98.0%(GC)
in stock  
$147.00   $103.00
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5g
98%(HPLC)
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$697.00   $488.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000Y5K
Chemical Name:
Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-
CAS Number:
128607-22-7
Molecular Formula:
C24H23ClO2
Molecular Weight:
378.8912
MDL Number:
MFCD00871890
SMILES:
ClCC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCO)/c1ccccc1
Properties
Computed Properties
 
Complexity:
441  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
6.5  

Literature

Title: Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations.

Journal: Drug metabolism and drug interactions 20130101

Title: An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis.

Journal: Maturitas 20120301

Title: Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model.

Journal: Menopause (New York, N.Y.) 20120101

Title: Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.

Journal: Biochimica et biophysica acta 20110801

Title: Pharmacologic evaluation of ospemifene.

Journal: Expert opinion on drug metabolism & toxicology 20100601

Title: An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals.

Journal: Molecular endocrinology (Baltimore, Md.) 20100401

Title: Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro.

Journal: Glia 20100101

Title: Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study.

Journal: Menopause (New York, N.Y.) 20100101

Title: Endometrial safety: a key hurdle for selective estrogen receptor modulators in development.

Journal: Menopause (New York, N.Y.) 20100101

Title: Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis.

Journal: Journal of women's health (2002) 20091001

Title: Ospemifene use in postmenopausal women.

Journal: Expert opinion on investigational drugs 20090601

Title: Estrogen and the selective estrogen receptor modulator (SERM) protection against cell death in estrogen receptor alpha and beta expressing U2OS cells.

Journal: Molecular and cellular endocrinology 20080716

Title: Pharmacologic effects of ospemifene in rhesus macaques: a pilot study.

Journal: Basic & clinical pharmacology & toxicology 20080601

Title: Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro.

Journal: British journal of pharmacology 20070601

Title: The cardiovascular effects of selective estrogen receptor modulators.

Journal: Annals of the New York Academy of Sciences 20061201

Title: Effects of ospemifene and raloxifene on biochemical markers of bone turnover in postmenopausal women.

Journal: Journal of bone and mineral metabolism 20060101

Title: Ineffectiveness of American ginseng in the prevention of dimethylbenzanthracene-induced mammary tumors in mice.

Journal: Oncology research 20060101

Title: Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice.

Journal: The Journal of steroid biochemistry and molecular biology 20051101

Title: Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract, and tolerability in postmenopausal women.

Journal: Menopause (New York, N.Y.) 20050301

Title: Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ.

Journal: Breast cancer research : BCR 20050101

Title: Selective estrogen receptor modulators prevent neointima formation after vascular injury.

Journal: Molecular and cellular endocrinology 20041130

Title: Ospemifene Hormos.

Journal: Current opinion in investigational drugs (London, England : 2000) 20040401

Title: Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040301

Title: Comparative study of the short-term effects of a novel selective estrogen receptor modulator, ospemifene, and raloxifene and tamoxifen on rat uterus.

Journal: The Journal of steroid biochemistry and molecular biology 20040201

Title: Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial.

Journal: Menopause (New York, N.Y.) 20030101

Title: Effects of ospemifene, a novel SERM, on vascular markers and function in healthy, postmenopausal women.

Journal: Menopause (New York, N.Y.) 20030101

Title: Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women.

Journal: Maturitas 20021120

Title: In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer.

Journal: The Journal of steroid biochemistry and molecular biology 20010601

Title: Cone voltage and collision cell collision-induced dissociation study of triphenylethylenes of pharmaceutical interest.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Unkila M, et, al. Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause. J Steroid Biochem Mol Biol. 2013 Nov;138:107-15.

Title: Bruyniks N, et, al. Systematic indirect comparison of ospemifene versus local estrogens for vulvar and vaginal atrophy. Climacteric. 2017 Jun; 20(3): 195-204.

Title: Qiang Qv.et al.Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats. Endocrinology.Feb;141(2):809-20. 25. (2000).

Title: Tracy L. Taras et al.In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer. The Journal of Steroid Biochemistry and Molecular Biology 77(4-5):271-9,(2001).

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Tags:128607-22-7 Molecular Formula|128607-22-7 MDL|128607-22-7 SMILES|128607-22-7 Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-