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89778-26-7,MFCD00801070
Catalog No.:AA003ZXU

89778-26-7 | Toremifene

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Purity
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25mg
98%
in stock  
$149.00   $104.00
- +
100mg
98%
in stock  
$345.00   $242.00
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500mg
98%
in stock  
$1,345.00   $942.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003ZXU
Chemical Name:
Toremifene
CAS Number:
89778-26-7
Molecular Formula:
C26H28ClNO
Molecular Weight:
405.9596
MDL Number:
MFCD00801070
SMILES:
ClCC/C(=C(/c1ccccc1)\c1ccc(cc1)OCCN(C)C)/c1ccccc1
Properties
Properties
 
BP:
535.1 °C at 760 mmHg  
Form:
Solid  
MP:
108-110°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
483  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
7.2  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150601

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: [Osteoporosis in men receiving androgen deprivation therapy for non-metastatic prostate cancer].

Journal: Wiener medizinische Wochenschrift (1946) 20120901

Title: Toremifene versus tamoxifen for advanced breast cancer.

Journal: The Cochrane database of systematic reviews 20120711

Title: [A study of the efficacy of high-dose toremifene in advanced and recurrent breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20120701

Title: Sulfation of 4-hydroxy toremifene: individual variability, isoform specificity, and contribution to toremifene pharmacogenomics.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120601

Title: [Efficacy of high-dose toremifene as a second-line hormone therapy in patients with advanced or metastatic breast cancer resistant to aromatase inhibitor].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20120501

Title: Pharmacokinetic evaluation of toremifene and its clinical implications for the treatment of osteoporosis.

Journal: Expert opinion on drug metabolism & toxicology 20120401

Title: Racial differences in bone mineral density and fractures in men receiving androgen deprivation therapy for prostate cancer.

Journal: The Journal of urology 20120301

Title: Prognostic impact of the history of breast cancer and of hormone therapy in uterine carcinosarcoma.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120201

Title: MS2/TOF and LC-MS/TOF studies on toremifene to characterize its forced degradation products.

Journal: The Analyst 20111221

Title: Anti-oestrogen therapy in the treatment of desmoid tumours: a systematic review.

Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20111201

Title: Toremifene decreases vertebral fractures in men younger than 80 years receiving androgen deprivation therapy for prostate cancer.

Journal: The Journal of urology 20111201

Title: [A case of an elderly breast cancer patient achieving partial response with toremifene without efficacy of letrozole as a preoperative primary endocrine therapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Relevance of the selective oestrogen receptor modulators tamoxifen, toremifene and clomiphene in doping field: endogenous steroids urinary profile after multiple oral doses.

Journal: Steroids 20111101

Title: [Determination of 6 antiestrogens in fish tissues by ultra performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20111101

Title: Drug interaction potential of toremifene and N-desmethyltoremifene with multiple cytochrome P450 isoforms.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111001

Title: [Regulation mechanism of breast cancer resistance protein by toremifene to reverse BCRP-mediated multidrug resistance in breast cancer cells].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110901

Title: Urinary excretion profiles of toremifene metabolites by liquid chromatography-mass spectrometry. Towards targeted analysis to relevant metabolites in doping control.

Journal: Analytical and bioanalytical chemistry 20110801

Title: Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: results of four randomized trials.

Journal: Breast cancer research and treatment 20110801

Title: Effects of toremifene and anastrozole on serum lipids and bone metabolism in postmenopausal females with estrogen receptor-positive breast cancer: the results of a 2-year multicenter open randomized study.

Journal: Breast cancer research and treatment 20110801

Title: Factors associated with vertebral fractures in men treated with androgen deprivation therapy for prostate cancer.

Journal: The Journal of urology 20110801

Title: Mass spectrometric characterization of urinary toremifene metabolites for doping control analyses.

Journal: Journal of chromatography. A 20110722

Title: [A retrospective study of high-dose toremifene treatment for patients with aromatase inhibitor refractory advanced or metastatic hormone receptor-positive breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20110701

Title: Re: Toremifene to reduce fracture risk in men receiving androgen deprivation therapy for prostate cancer. M. R. Smith, R. A. Morton, K. G. Barnette, P. R. Sieber, S. B. Malkowicz, D. Rodriguez, M. L. Hancock and M. S. Steiner. J Urol 2010;184:1316-1321.

Journal: The Journal of urology 20110601

Title: Mass spectrometric characterization of toremifene metabolites in human urine by liquid chromatography-tandem mass spectrometry with different scan modes.

Journal: The Analyst 20110207

Title: Diethylenetriamine pentaacetic acid derivative of toremifene and in vitro evaluation in human breast cancer cell line MCF-7.

Journal: Cancer biotherapy & radiopharmaceuticals 20110201

Title: Prostate cancer: Reducing fracture risk in men on androgen deprivation therapy.

Journal: Nature reviews. Urology 20110101

Title: The effect of toremifene on lipid metabolism compared with that of tamoxifen in vitro.

Journal: Gynecologic and obstetric investigation 20110101

Title: [A case of aromatase inhibitor-tolerant metastatic breast cancer revealing complete remission with high-dose toremifene therapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20110101

Title: Breast pain.

Journal: BMJ clinical evidence 20110101

Title: Inhibition of FOSL1 overexpression in antiestrogen-resistant MCF-7 cells decreases cell growth and increases vacuolization and cell death.

Journal: Steroids 20110101

Title: [The combined effect of Paclitaxel and toremifene therapy for estrogen receptor positive and aromatase inhibitor resistant metastatic breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20101101

Title: Clinical usefulness of high-dose toremifene in patients relapsed on treatment with an aromatase inhibitor.

Journal: Breast cancer (Tokyo, Japan) 20101001

Title: Transcriptional modulation of BCRP gene to reverse multidrug resistance by toremifene in breast adenocarcinoma cells.

Journal: Breast cancer research and treatment 20101001

Title: Toremifene to reduce fracture risk in men receiving androgen deprivation therapy for prostate cancer.

Journal: The Journal of urology 20101001

Title: Androgen deprivation therapy in prostate cancer: anticipated side-effects and their management.

Journal: Current opinion in supportive and palliative care 20100901

Title: Effects of toremifene and tamoxifen on lipid profiles in post-menopausal patients with early breast cancer: interim results from a Japanese phase III trial.

Journal: Japanese journal of clinical oncology 20100701

Title: Uterine changes during tamoxifen, toremifene, and other therapy for breast cancer: evaluation with magnetic resonance imaging.

Journal: Japanese journal of radiology 20100701

Title: Potential role of the steroid receptor pattern in the response of inoperable intra-abdominal desmoid to toremifene after failure of tamoxifen therapy.

Journal: International journal of colorectal disease 20100601

Title: Excellent outcomes with adjuvant toremifene or tamoxifen in early stage breast cancer.

Journal: Cancer 20100515

Title: Synthesis, radiolabeling and In Vivo tissue distribution of an anti-oestrogen glucuronide compound, (99m)Tc-TOR-G.

Journal: Anticancer research 20100401

Title: Toremifene use does not alter serum inhibin A and B levels during mid-luteal phase in women with premenstrual mastalgia.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100201

Title: Analysis of prognostic factors in male breast cancer: a report of 72 cases from a single institution.

Journal: Chinese journal of cancer 20100201

Title: [Clinicopathological features of endometrial carcinoma in tamoxifen- and toremifene-treated breast cancer patients].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20100201

Title: [A case of recurrent breast cancer with extensive liver metastasis successfully treated with endocrine therapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20091201

Title: [A case of advanced breast cancer with multiple bone metastases responding to docetaxel and high-dose toremifene as fourth-line chemo-endocrine therapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20091201

Title: Synthesis of a novel antiestrogen radioligand (99mTc-TOR-DTPA).

Journal: Cancer biotherapy & radiopharmaceuticals 20091201

Title: Breast magnetic resonance imaging findings in women treated with toremifene for premenstrual mastalgia.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 20091101

Title: [The combined effect of paclitaxel and toremifene therapy for metastatic breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20091101

Title: [Efficacy and safety of high-dose toremifene for hormone-responsive advanced or metastatic breast cancer patients with failed prior treatment by aromatase inhibitors].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20090901

Title: Efficacy and tolerability of weekly paclitaxel in combination with high-dose toremifene citrate in patients with metastatic breast cancer.

Journal: Acta medica Okayama 20090801

Title: Electrochemistry meets enzymes: instrumental on-line simulation of oxidative and conjugative metabolism reactions of toremifene.

Journal: Analytical and bioanalytical chemistry 20090701

Title: [Efficacy of treatment with high-dose toremifene in patients with metastatic breast cancer resistant to aromatase inhibitor treatment].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20090601

Title: The effect of selective estrogen receptor modulator administration on the hypothalamic-pituitary-testicular axis in men with idiopathic oligozoospermia.

Journal: Fertility and sterility 20090401

Title: Prostate cancer: a serious disease suitable for prevention.

Journal: BJU international 20090401

Title: [A case of metastatic breast cancer resistant to anastrozole treatment responding to high-dose toremifene].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20090401

Title: Second non-breast primary cancer following adjuvant therapy for early breast cancer: a report from the International Breast Cancer Study Group.

Journal: European journal of cancer (Oxford, England : 1990) 20090301

Title: [Lipid metabolism disorders at the breast cancer patients receiving hormonotherapy].

Journal: Georgian medical news 20090301

Title: Comparing the effects of atamestane, toremifene and tamoxifen alone and in combination, on bone, serum lipids and uterus in ovariectomized rats.

Journal: The Journal of steroid biochemistry and molecular biology 20090201

Title: Pharmacokinetic analysis of a combined chemoendocrine treatment with paclitaxel and toremifene for metastatic breast cancer.

Journal: Breast cancer (Tokyo, Japan) 20090101

Title: [On prevention and treatment of arterial hypertension in patients with breast cancer, and undergoing hormonotherapy].

Journal: Georgian medical news 20090101

Title: Gene expression changes during the development of estrogen-independent and antiestrogen-resistant growth in breast cancer cell culture models.

Journal: Anti-cancer drugs 20090101

Title: Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithelial cells.

Journal: Prostate cancer and prostatic diseases 20090101

Title: [A case of advanced breast cancer successfully treated with paclitaxel and toremifene therapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20081101

Title: [Recurrence of skin and lymph nodes from asynchronous breast cancer successfully treated with paclitaxel and toremifene therapy--a case report].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20081101

Title: Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases.

Journal: Journal of cancer research and clinical oncology 20081001

Title: Clusterin: a potential target for improving response to antiestrogens.

Journal: International journal of oncology 20081001

Title: Toremifene decreases type I, type II and increases type III receptors in desmoid and fibroma and inhibits TGFbeta1 binding in desmoid fibroblasts.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080901

Title: Angiomyofibroblastoma of the vagina in a breast cancer patient.

Journal: Pathology 20080801

Title: The use of radiation therapy after breast-conserving surgery in hormonally treated breast cancer patients is dependent on patient age, geographic region, and surgeon specialty.

Journal: American journal of surgery 20080601

Title: Patterns and changes in gene expression following neo-adjuvant anti-estrogen treatment in estrogen receptor-positive breast cancer.

Journal: Endocrine-related cancer 20080601

Title: Toremifene improves lipid profiles in men receiving androgen-deprivation therapy for prostate cancer: interim analysis of a multicenter phase III study.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080410

Title: [Effect of tetrandrine, toremifene and their combination on the reversion of multidrug resistance of K562/A02 cell line].

Journal: Zhongguo shi yan xue ye xue za zhi 20080201

Title: Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model.

Journal: The Journal of steroid biochemistry and molecular biology 20080101

Title: Toremifene increases bone mineral density in men receiving androgen deprivation therapy for prostate cancer: interim analysis of a multicenter phase 3 clinical study.

Journal: The Journal of urology 20080101

Title: A mass spectrometric approach for the study of the metabolism of clomiphene, tamoxifen and toremifene by liquid chromatography time-of-flight spectroscopy.

Journal: European journal of mass spectrometry (Chichester, England) 20080101

Title: Effect of combined therapy with the antiestrogen agent toremifene and local hyperthermia on breast cancer cells implanted in nude mice.

Journal: Surgery today 20080101

Title: Phase III, double-blind, controlled trial of atamestane plus toremifene compared with letrozole in postmenopausal women with advanced receptor-positive breast cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071101

Title: The beneficial effects of toremifene administration on the hypothalamic-pituitary-testicular axis and sperm parameters in men with idiopathic oligozoospermia.

Journal: Fertility and sterility 20071001

Title: Chemoprevention of prostate cancer: agents and study designs.

Journal: The Journal of urology 20070901

Title: The effects of atamestane and toremifene alone and in combination compared with letrozole on bone, serum lipids and the uterus in an ovariectomized rat model.

Journal: Breast cancer research and treatment 20070701

Title: [Evaluation of combination therapy of high-dose toremifene and oral chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070701

Title: Relationship of cellular immunity, cytokines and CRP with clinical course in breast cancer patients with endocrine-dependent distant metastases treated with immunotherapy.

Journal: Cancer letters 20070628

Title: Toremifene might improve side effects of ADT.

Journal: The Lancet. Oncology 20070401

Title: Male breast cancer with mandibular metastasis. A case report.

Journal: Minerva stomatologica 20070401

Title: [A patient with advanced recurrent breast cancer who firmly resisted hair loss and was then treated by combination therapy with high-dose toremifene and capecitabine].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070301

Title: [A case of advanced breast cancer with multiple liver metastases resistant to chemotherapy responding to high-dose toremifene].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070301

Title: DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene.

Journal: Chemical research in toxicology 20070201

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: [A patient with advanced breast cancer refractory to chemotherapy accompanied by carcinomatous pleurisy and multiple bone metastasis that responded to combination therapy with high-dose toremifene and docetaxel].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070101

Title: Effects of selective estrogen receptor modulators and genistein on the expression of ERalpha/beta and COX-1/2 in ovarectomized mouse uteri.

Journal: European journal of gynaecological oncology 20070101

Title: Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs).

Journal: Current medicinal chemistry 20070101

Title: Breast pain.

Journal: BMJ clinical evidence 20070101

Title: The cardiovascular effects of selective estrogen receptor modulators.

Journal: Annals of the New York Academy of Sciences 20061201

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Toremifene for the prevention of prostate cancer in men with high grade prostatic intraepithelial neoplasia: results of a double-blind, placebo controlled, phase IIB clinical trial.

Journal: The Journal of urology 20060901

Title: Determinants of early distant metastatic disease in elderly patients with breast cancer.

Journal: American journal of surgery 20060901

Title: Experimental adenomyosis.

Journal: Best practice & research. Clinical obstetrics & gynaecology 20060801

Title: Histopathology and histomorphometry of the urogenital tract in 15-month old male and female rats treated neonatally with SERMs and estrogens.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060801

Title: Selective estrogen receptor modulators (SERMS).

Journal: Arquivos brasileiros de endocrinologia e metabologia 20060801

Title: Toremifene for premenstrual mastalgia: a randomised, placebo-controlled crossover study.

Journal: BJOG : an international journal of obstetrics and gynaecology 20060601

Title: DNA damage and altered gene expression of enzymes for metabolism and DNA repair by tamoxifen and toremifene in the female rat liver.

Journal: Cancer science 20060601

Title: Toremifene: an evaluation of its safety profile.

Journal: Breast (Edinburgh, Scotland) 20060401

Title: Hepatocellular neoplasms after intrahepatic transplantation of ovarian fragments into ovariectomized rats.

Journal: Hepatology (Baltimore, Md.) 20060401

Title: Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy.

Journal: Expert opinion on investigational drugs 20060301

Title: Absence of DNA adduct in the leukocytes from breast cancer patients treated with toremifene.

Journal: Chemical research in toxicology 20060301

Title: Steroid hormone receptors and coregulators in endocrine-resistant and estrogen-independent breast cancer cells.

Journal: International journal of cancer 20060215

Title: Adverse outcome and resistance to adjuvant antiestrogen therapy in node-positive postmenopausal breast cancer patients-The role of p53.

Journal: Breast (Edinburgh, Scotland) 20060201

Title: Ocular toxicity during adjuvant chemoendocrine therapy for early breast cancer: results from International Breast Cancer Study Group trials.

Journal: Cancer 20060201

Title: A double-blind randomized controlled trial of toremifen therapy for mastalgia.

Journal: Archives of surgery (Chicago, Ill. : 1960) 20060101

Title: Estrogen receptors as therapeutic targets in breast cancer.

Journal: Current topics in medicinal chemistry 20060101

Title: Mastalgia.

Journal: Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20060101

Title: Questioning the utility of pooling samples in microarray experiments with cell lines.

Journal: The International journal of biological markers 20060101

Title: Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells.

Journal: Apoptosis : an international journal on programmed cell death 20051201

Title: Drug resistance in chemotherapy for breast cancer.

Journal: Cancer chemotherapy and pharmacology 20051101

Title: Bone mineral density and lipid changes during 5 years of follow-up in a study of prevention of breast cancer with toremifene in healthy, high-risk pre- and post-menopausal women.

Journal: Breast cancer research and treatment 20051001

Title: [Experience of high-dose toremifene treatment for postmenopausal women with metastatic breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20051001

Title: Stabilization and regression of a recurrent desmoid tumor with the antiestrogen toremifene.

Journal: Fertility and sterility 20050801

Title: Beta-interferon and interleukin-2 prolong more than three times the survival of 26 consecutive endocrine dependent breast cancer patients with distant metastases: an exploratory trial.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20050601

Title: A highly vascular intracranial solitary fibrous tumor treated with radiotherapy and toremifene: case report.

Journal: Neurosurgery 20050601

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Endometrial K-ras mutations in postmenopausal breast cancer patients treated with adjuvant tamoxifen or toremifene.

Journal: Cancer chemotherapy and pharmacology 20050401

Title: K-ras mutation in the endometrium of tamoxifen-treated breast cancer patients, with a comparison of tamoxifen and toremifene.

Journal: British journal of cancer 20050328

Title: Ovarian luteinized thecoma with sclerosing peritonitis in an adult woman treated with leuprolide and toremifene in complete remission at 5 years.

Journal: Gynecologic oncology 20050301

Title: Role of 5a-reductase inhibitors and selective estrogen receptor modulators as potential chemopreventive agents for prostate cancer.

Journal: Clinical prostate cancer 20050301

Title: Effects of neonatal exposure to diethylstilbestrol, tamoxifen, and toremifene on the BALB/c mouse mammary gland.

Journal: Biology of reproduction 20050201

Title: [A patient with metastatic breast cancer associated with retention of pleural effusion with no response to both CMF and exemestane, whose life was saved by high-dose toremifene].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20050201

Title: Human desmoid fibroblasts: matrix metalloproteinases, their inhibitors and modulation by Toremifene.

Journal: BMC cancer 20050101

Title: Treatment of Postmenopausal Breast Cancer with Selective Estrogen Receptor Modulators (SERMs).

Journal: Breast disease 20050101

Title: Effect of anti-estrogens on the androgen receptor activity and cell proliferation in prostate cancer cells.

Journal: Urological research 20041201

Title: Toremifene and tamoxifen are equally effective for early-stage breast cancer: first results of International Breast Cancer Study Group Trials 12-93 and 14-93.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20041201

Title: Prospective evaluation of estrogen receptor-beta in predicting response to neoadjuvant antiestrogen therapy in elderly breast cancer patients.

Journal: Endocrine-related cancer 20041201

Title: Effects of toremifene (TOR) and tamoxifen (TAM) on serum lipids in postmenopausal patients with breast cancer.

Journal: Breast cancer research and treatment 20041101

Title: Crossover trial for lipid abnormality in postmenopausal breast cancer patients during selective estrogen receptor modulators (SERMs) administrations.

Journal: Breast cancer research and treatment 20041101

Title: Toremifene citrate (Fareston).

Journal: Clinical journal of oncology nursing 20041001

Title: [Activity of toremifene plus mitomycin, vindesin and cisplatin regimen in unresectable non-small cell lung cancer].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20040801

Title: Changes in bone mineral density during and after 3 years' use of tamoxifen or toremifene.

Journal: Maturitas 20040715

Title: [A case of breast cancer with multiple bone metastases demonstrating complete remission with high-dose toremifene therapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040601

Title: Requirements for transcriptional regulation by the orphan nuclear receptor ERRgamma.

Journal: Molecular and cellular endocrinology 20040430

Title: Primary toremifene treatment for elderly postmenopausal women with breast cancer.

Journal: Oncology reports 20040201

Title: A high serum matrix metalloproteinase-2 level is associated with an adverse prognosis in node-positive breast carcinoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201

Title: Antiangiogenic treatment of mesenteric desmoid tumors with toremifene and interferon alfa-2b: report of two cases.

Journal: Diseases of the colon and rectum 20040101

Title: Toxicity of selected cationic drugs in retinoblastomal cultures and in cocultures of retinoblastomal and retinal pigment epithelial cell lines.

Journal: Neurochemical research 20040101

Title: Differential effects of toremifene on doxorubicin, vinblastine and Tc-99m-sestamibi in P-glycoprotein-expressing breast and head and neck cancer cell lines.

Journal: Acta oncologica (Stockholm, Sweden) 20040101

Title: Kinetic studies of the radical-scavenging activity of estrogens and antiestrogens.

Journal: Anticancer research 20040101

Title: Matrix metalloproteinase-9 (MMP-9) immunoreactive protein has modest prognostic value in locally advanced breast carcinoma patients treated with an adjuvant antiestrogen therapy.

Journal: Anticancer research 20040101

Title: Toremifene, a new agent for treatment of mastalgia: an open study.

Journal: International journal of fertility and women's medicine 20040101

Title: Chronic effects of toremifene on the vasculature of menopause-induced rats.

Journal: Vascular pharmacology 20031201

Title: Estrogenic effects of toremifene and tamoxifen in postmenopausal breast cancer patients.

Journal: Breast cancer research and treatment 20031101

Title: Acute effects of toremifene on the vasculature of intact and menopause-induced rats.

Journal: Vascular pharmacology 20031101

Title: Ocular side-effects in breast cancer patients treated with tamoxifen and toremifene: a randomized follow-up study.

Journal: Acta ophthalmologica Scandinavica 20031001

Title: Kinetics of inhibition of glutamate uptake by antioestrogens.

Journal: Pharmacology & toxicology 20031001

Title: Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.

Journal: Chemical research in toxicology 20030901

Title: Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.

Journal: Chemical research in toxicology 20030701

Title: [Hormone therapy, chemotherapy and immunotherapy in breast carcinoma. The best strategy for your patient].

Journal: MMW Fortschritte der Medizin 20030612

Title: Phase IIA clinical trial to test the efficacy and safety of Toremifene in men with high-grade prostatic intraepithelial neoplasia.

Journal: Clinical prostate cancer 20030601

Title: [Combined effects of toremifene and paclitaxel on human breast cancer cell lines].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20030501

Title: Update on the current use of hormonals as therapy in advanced breast cancer.

Journal: Anti-cancer drugs 20030401

Title: Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030315

Title: The effects of tamoxifen and toremifene on bone cells involve changes in plasma membrane ion conductance.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030301

Title: Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.

Journal: Oncology reports 20030101

Title: [Perspectives for the hormonal therapy of breast cancer].

Journal: Magyar onkologia 20030101

Title: Antiproliferative properties of toremifene on AIDS-related Kaposi's sarcoma cells.

Journal: Chemotherapy 20021201

Title: [Combined chemoendocrine therapy using adriamycin, cyclophosphamide and high dose toremifene in patients with recurrent breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20021101

Title: [A case of metastatic breast cancer responding to weekly paclitaxel and high-dose toremifene administrated alternately].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20021101

Title: [Synergistic effect of toremifene and cisplatin on human lung cancer cell line A549].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20021101

Title: Glutamate uptake is inhibited by tamoxifen and toremifene in cultured retinal pigment epithelial cells.

Journal: Pharmacology & toxicology 20020901

Title: Toremifene metabolism in rat, mouse and human liver microsomes: identification of alpha-hydroxytoremifene by LC-MS.

Journal: Biomedical chromatography : BMC 20020801

Title: Estrogen and selective estrogen receptor modulator regulation of insulin-like growth factor binding protein 5 in the rat uterus.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20020801

Title: Tamoxifen and toremifene treatment of breast cancer and risk of subsequent endometrial cancer: a population-based case-control study.

Journal: International journal of cancer 20020720

Title: [Antiestrogen therapy in the treatment of breast neoplasms].

Journal: Minerva ginecologica 20020601

Title: Inhibitory effects of toremifene on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice.

Journal: Japanese journal of cancer research : Gann 20020601

Title: [Assessment of post-administration body distribution of toremifene and tamoxifen, and their administration regimens].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20020601

Title: Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice.

Journal: International journal of cancer 20020510

Title: Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice.

Journal: Pharmacology, biochemistry, and behavior 20020501

Title: Activation of Maxi Cl(-) channels by antiestrogens and phenothiazines in NIH3T3 fibroblasts.

Journal: Steroids 20020501

Title: Effects of transforming growth factor-beta1 and tumour necrosis factor-alpha on cultured fibroblasts from skin fibroma as modulated by toremifene.

Journal: International journal of cancer 20020420

Title: Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20020401

Title: 99mTc-sestamibi imaging in the assessment of toremifene as a modulator of multidrug resistance in patients with breast cancer.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020401

Title: Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model.

Journal: Cancer research 20020301

Title: Tamoxifen and toremifene cause impairment of learning and memory function in mice.

Journal: Pharmacology, biochemistry, and behavior 20020101

Title: [A case of locally recurrent breast cancer in which phlebothrombosis of the right leg after hormonal therapy using a high dose of toremifene citrate].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20020101

Title: Synergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.

Journal: Oncology reports 20020101

Title: Toxicity of antiestrogens.

Journal: The breast journal 20020101

Title: Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.

Journal: Clinical breast cancer 20020101

Title: A phase II trial of interferon-alpha and toremifene in advanced renal cell cancer patients.

Journal: Cancer investigation 20020101

Title: Breast-conservation treatment for bilateral breast cancer in five Japanese women.

Journal: Oncology reports 20020101

Title: An elderly patient with DCIS of the breast effectively treated with toremifene alone.

Journal: Oncology reports 20020101

Title: Evolving uses of hormonal agents for breast cancer therapy.

Journal: Clinical therapeutics 20020101

Title: [Selective estrogen receptor modulators (SERMs) in the practice].

Journal: Magyar onkologia 20020101

Title: Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.

Journal: Chemical research in toxicology 20011201

Title: Synthesis and secretion of transforming growth factor-beta1 by human desmoid fibroblast cell line and its modulation by toremifene.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20011101

Title: Okadaic acid-sensitive activation of Maxi Cl(-) channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells.

Journal: The Journal of physiology 20011001

Title: GTx begins next phase of clinical trials for prostate cancer.

Journal: Expert review of anticancer therapy 20011001

Title: Delayed effects of tamoxifen in hepatocarcinogenesis-resistant Fischer 344 rats as compared with susceptible strains.

Journal: Cancer letters 20010928

Title: Comparisons of the effects of tamoxifen, toremifene and raloxifene on enzyme induction and gene expression in the ovariectomised rat uterus.

Journal: The Journal of endocrinology 20010901

Title: [A case of breast cancer with bone marrow and liver metastases responding completely to low-dose weekly paclitaxel combined with toremifene].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010901

Title: Adenomyosis--a result of disordered stromal differentiation.

Journal: The American journal of pathology 20010801

Title: [Antiangiogenic and antimetastatic effects of toremifene citrate].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010801

Title: Induction of atypical ductal hyperplasia in mouse mammary gland organ culture.

Journal: Journal of the National Cancer Institute 20010718

Title: Cell-transforming activity and estrogenicity of bisphenol-A and 4 of its analogs in mammalian cells.

Journal: International journal of cancer 20010701

Title: [Endocrine therapy for advanced or recurrent breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010701

Title: Activity of high-dose toremifene plus cisplatin in platinum-treated non-small-cell lung cancer: a phase II California Cancer Consortium Trial.

Journal: Cancer chemotherapy and pharmacology 20010701

Title: The antiestrogen toremifene protects against alcoholic liver injury in female rats.

Journal: Journal of hepatology 20010701

Title: Phase II trial of toremifene in androgen-independent prostate cancer: a Penn cancer clinical trials group trial.

Journal: American journal of clinical oncology 20010601

Title: [A case of breast cancer with multiple bone metastases improved by high-dose toremifene].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010601

Title: Mechanism of lower genotoxicity of toremifene compared with tamoxifen.

Journal: Cancer research 20010515

Title: Sex difference in alcohol-related organ injury.

Journal: Alcoholism, clinical and experimental research 20010501

Title: Prospective study on gynaecological effects of two antioestrogens tamoxifen and toremifene in postmenopausal women.

Journal: British journal of cancer 20010401

Title: The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer.

Journal: British journal of cancer 20010401

Title: 3,3'-diindolylmethane, a major condensation product of indole-3-carbinol, is a potent estrogen in the rainbow trout.

Journal: Toxicology and applied pharmacology 20010201

Title: [A case of lung and pleural metastases from breast cancer responding to toremifene].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010201

Title: [A breast cancer patient with recurrence in the thoracic wall in whom a high-dose of toremifene was effective].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010201

Title: Non-steroidal anti-oestrogens inhibit the differentiation of synovial macrophages into dendritic cells.

Journal: Rheumatology (Oxford, England) 20010201

Title: Effect of the molecular weight of poly(epsilon-caprolactone-co-DL-lactide) on toremifene citrate release from copolymer/silica xerogel composites.

Journal: International journal of pharmaceutics 20010105

Title: The phagocytosis of rod outer segments is inhibited by selected drugs in retinal pigment epithelial cell cultures.

Journal: Pharmacology & toxicology 20010101

Title: Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention.

Journal: Oncology reports 20010101

Title: Matrix metalloproteinase-2 (MMP-2) is associated with the risk for a relapse in postmenopausal patients with node-positive breast carcinoma treated with antiestrogen adjuvant therapy.

Journal: Breast cancer research and treatment 20010101

Title: Phase III randomized trial of toremifene vs tamoxifen in hormonodependant advanced breast cancer.

Journal: Breast cancer research and treatment 20010101

Title: Cone voltage and collision cell collision-induced dissociation study of triphenylethylenes of pharmaceutical interest.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Postoperative PINP in serum reflects metastatic potential and poor survival in node-positive breast cancer.

Journal: Anticancer research 20010101

Title: Nuchal aggressive fibromatosis in childhood: two instructive case reports.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20010101

Title: Comparative tolerability of first-generation selective estrogen receptor modulators in breast cancer treatment and prevention.

Journal: Drug safety 20010101

Title: [Antiestrogens: mechanism of action and clinical applications].

Journal: Salud publica de Mexico 20010101

Title: Toremifene-induced fatty liver and NASH in breast cancer patients with breast-conservation treatment.

Journal: International journal of oncology 20001201

Title: Comparison of the effects of tamoxifen and toremifene on rat hepatocarcinogenesis.

Journal: Archives of toxicology 20000701

Title: Bezafibrate for tamoxifen-induced non-alcoholic steatohepatitis.

Journal: Lancet (London, England) 19990522

Title: Structure-activity relationships for triphenylethylene antiestrogens on hepatic phase-I and phase-II enzyme expression.

Journal: Biochemical pharmacology 19980801

Title: Initiating activity of the anti-estrogen tamoxifen, but not toremifene in rat liver.

Journal: Carcinogenesis 19971101

Title: A two-year dietary carcinogenicity study of the antiestrogen toremifene in Sprague-Dawley rats.

Journal: Drug and chemical toxicology 19961101

Title: Comparison of the effects of tamoxifen and toremifene on liver and kidney tumor promotion in female rats.

Journal: Carcinogenesis 19951101

Title: Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts.

Journal: Carcinogenesis 19950301

Title: Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen-induced hepatocarcinogenesis in the rat.

Journal: Carcinogenesis 19940501

Title: Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats.

Journal: Cancer research 19931001

Title: Toremifene enhances cell cycle block and growth inhibition by vinblastine in multidrug resistant human breast cancer cells.

Journal: Oncology research 19930101

Title: Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens.

Journal: Archives of toxicology 19930101

Title: Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35.

Title: Laura Cooper, et al. Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. J Med Chem. 2020 Sep 4.

Title: Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene - Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108(1-2): 1-7.

Title: Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31(5):523-9.

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Tags:89778-26-7 Molecular Formula|89778-26-7 MDL|89778-26-7 SMILES|89778-26-7 Toremifene