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Home Other Building Blocks 1286739-19-2
1286739-19-2,MFCD25976723
Catalog No.:AA000Y78

1286739-19-2 | Frax597

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$46.00   $32.00
- +
2mg
98+%
in stock  
$68.00   $48.00
- +
5mg
98+%
in stock  
$95.00   $67.00
- +
10mg
98+%
in stock  
$132.00   $93.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000Y78
Chemical Name:
Frax597
CAS Number:
1286739-19-2
Molecular Formula:
C29H28ClN7OS
Molecular Weight:
558.0969
MDL Number:
MFCD25976723
SMILES:
CCn1c2nc(ncc2cc(c1=O)c1ccc(cc1Cl)c1cncs1)Nc1ccc(cc1)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
878  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
5.3  

Downstream Synthesis Route
Literature

Title: Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.

Journal: ACS medicinal chemistry letters 20150709

Title: FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.

Journal: The Journal of biological chemistry 20131004

Title: Licciulli S, et al. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem. 2013 Oct 4;288(40):29105-14.

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SDS
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