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132834-56-1,MFCD00892750
Catalog No.:AA00115I

132834-56-1 | 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine

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100mg
95%
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$46.00   $32.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00115I
Chemical Name:
1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine
CAS Number:
132834-56-1
Molecular Formula:
C10H11ClF3N3
Molecular Weight:
265.6626
MDL Number:
MFCD00892750
SMILES:
FC(c1ccc(nc1Cl)N1CCNCC1)(F)F
Properties
Computed Properties
 
Complexity:
256  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2.5  

Upstream Synthesis Route

[1]Patent:US2004/38985,2004,A1,

Downstream Synthesis Route
407-25-0    132834-56-1   
1-4-(6-chloro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl-2,2,2-trifluoro-ethanone 

[1]Journaloflabelledcompoundsandradiopharmaceuticals,2002,vol.45,p.1169-1171

132834-56-1   
C10H10(3)HClF3N3 

[1]Journaloflabelledcompoundsandradiopharmaceuticals,2002,vol.45,p.1169-1171

132834-56-1   
C12H9(3)HClF6N3O 

[1]Journaloflabelledcompoundsandradiopharmaceuticals,2002,vol.45,p.1169-1171

132834-56-1   
1-4-(3-bromo-6-chloro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl-2,2,2-trifluoro-ethanone 

[1]Journaloflabelledcompoundsandradiopharmaceuticals,2002,vol.45,p.1169-1171

Literature

Title: Toward prediction of alkane/water partition coefficients.

Journal: Journal of medicinal chemistry 20080710

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040801

Title: Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20.

Title: Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.

Title: Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22.

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SDS
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Tags:132834-56-1 Molecular Formula|132834-56-1 MDL|132834-56-1 SMILES|132834-56-1 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine