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Home Amines 1370261-96-3
1370261-96-3,MFCD22580425
Catalog No.:AA0012N7

1370261-96-3 | 4-(3-(2H-1,2,3-Triazo-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino) pyrimidine-5-carboxamide acetate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$120.00   $84.00
- +
5mg
99%
in stock  
$234.00   $164.00
- +
25mg
99%
in stock  
$647.00   $453.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0012N7
Chemical Name:
4-(3-(2H-1,2,3-Triazo-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino) pyrimidine-5-carboxamide acetate
CAS Number:
1370261-96-3
Molecular Formula:
C19H23N9O
Molecular Weight:
393.4456
MDL Number:
MFCD22580425
SMILES:
N[C@H]1CCCC[C@H]1Nc1ncc(c(n1)Nc1cccc(c1)n1nccn1)C(=O)N
Properties
Computed Properties
 
Complexity:
544  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
2.2  

Downstream Synthesis Route

[1]Patent:WO2013/78468,2013,A1.Locationinpatent:Paragraph0360;0361

[1]Patent:WO2013/78468,2013,A1.Locationinpatent:Paragraph0715;0744;0745

1370261-96-3   
(R)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(2-oxocyclohexylamino)pyrimidin-5-carboxamide 

[1]Patent:WO2013/78468,2013,A1

[1]Patent:WO2013/78468,2013,A1

Literature

Title: Rational design of highly selective spleen tyrosine kinase inhibitors.

Journal: Journal of medicinal chemistry 20121213

Title: Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration.

Journal: Leukemia 20120701

Title: Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis.

Journal: The Journal of pharmacology and experimental therapeutics 20120201

Title: Coffey G, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Feb;340(2):350-9.

Title: Spurgeon SE, et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87.

Title: Hoellenriegel J, et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia. 2012 Jul;26(7):1576-83.

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SDS
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Tags:1370261-96-3 Molecular Formula|1370261-96-3 MDL|1370261-96-3 SMILES|1370261-96-3 4-(3-(2H-1,2,3-Triazo-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino) pyrimidine-5-carboxamide acetate