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133059-99-1,MFCD00914937
Catalog No.:AA001434

133059-99-1 | 4-Pyrimidinamine, N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-, hydrochloride (1:1)

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5mg
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10mg
≥98%
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$173.00   $121.00
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25mg
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50mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001434
Chemical Name:
4-Pyrimidinamine, N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-, hydrochloride (1:1)
CAS Number:
133059-99-1
Molecular Formula:
C15H21ClN4
Molecular Weight:
292.8070
MDL Number:
MFCD00914937
SMILES:
CCN(c1cc(=NC)n(c(n1)C)C)c1ccccc1.Cl
Properties
Computed Properties
 
Complexity:
402  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  

Literature

Title: Resonance properties of different neuronal populations in the immature mouse neocortex.

Journal: The European journal of neuroscience 20120901

Title: The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting.

Journal: Physiology & behavior 20120820

Title: Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor.

Journal: The Journal of biological chemistry 20120706

Title: Neuromodulation of I(h) in layer II medial entorhinal cortex stellate cells: a voltage-clamp study.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120627

Title: Identification of a hyperpolarization-activated cyclic nucleotide-gated channel and its subtypes in the urinary bladder of the rat.

Journal: Urology 20120601

Title: SK- and h-current contribute to the generation of theta-like resonance of rat substantia nigra pars compacta dopaminergic neurons at hyperpolarized membrane potentials.

Journal: Brain structure & function 20120401

Title: An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120222

Title: Selective sinoatrial node optical mapping and the mechanism of sinus rate acceleration.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101

Title: The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20120101

Title: Know your current I(h): interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations.

Journal: PloS one 20120101

Title: Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.

Journal: PloS one 20120101

Title: Diverse precerebellar neurons share similar intrinsic excitability.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116

Title: HCN channels expressed in the inner ear are necessary for normal balance function.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116

Title: Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control.

Journal: Journal of neurophysiology 20111101

Title: Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia.

Journal: Journal of neurophysiology 20111101

Title: Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.

Journal: Anesthesiology 20111001

Title: The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I(h) and GABAergic synaptic integration.

Journal: Journal of neurophysiology 20111001

Title: The sound of silence: ionic mechanisms encoding sound termination.

Journal: Neuron 20110908

Title: Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831

Title: The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro.

Journal: The Journal of physiology 20110801

Title: The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110701

Title: Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus.

Journal: The European journal of neuroscience 20110501

Title: Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110202

Title: Pacemaker activity and ionic currents in mouse atrioventricular node cells.

Journal: Channels (Austin, Tex.) 20110101

Title: Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress-related behaviors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101215

Title: Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

Title: Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

Title: A hyperpolarization-activated inward current alters swim frequency of the pteropod mollusk Clione limacina.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20101201

Title: Ca2+ clock malfunction in a canine model of pacing-induced heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20101201

Title: Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101124

Title: Hyperpolarization-activated currents in gonadotropin-releasing hormone (GnRH) neurons contribute to intrinsic excitability and are regulated by gonadal steroid feedback.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101006

Title: Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats.

Journal: The Journal of pharmacology and experimental therapeutics 20101001

Title: Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition.

Journal: American journal of physiology. Heart and circulatory physiology 20100901

Title: Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100811

Title: Distinct modes of modulation of GABAergic transmission by Group I metabotropic glutamate receptors in rat entorhinal cortex.

Journal: Hippocampus 20100801

Title: The modulation of orexin A on HCN currents of pyramidal neurons in mouse prelimbic cortex.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20100701

Title: Multiple effects of serotonin and acetylcholine on hyperpolarization-activated inward current in locomotor activity-related neurons in Cfos-EGFP mice.

Journal: Journal of neurophysiology 20100701

Title: Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100519

Title: ZD7288-induced suppression of long-term potentiation was attenuated by exogenous NMDA at the Schaffer collateral-CA1 synapse in the rat in vivo.

Journal: European journal of pharmacology 20100410

Title: TASK channels contribute to the K+-dominated leak current regulating respiratory rhythm generation in vitro.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100324

Title: Hyperpolarization-activated cation currents in human epileptogenic neocortex.

Journal: Epilepsia 20100301

Title: Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217

Title: Induction of atrial ectopic beats with calcium release inhibition: Local hierarchy of automaticity in the right atrium.

Journal: Heart rhythm 20100101

Title: Hyperpolarization-activated current (I(h)) in ganglion-cell photoreceptors.

Journal: PloS one 20100101

Title: HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20091201

Title: Origin of the fast negative ERG component from isolated aspartate-treated mouse retina.

Journal: Journal of vision 20091117

Title: Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels.

Journal: Pflugers Archiv : European journal of physiology 20091101

Title: Effects of XE991, retigabine, losigamone and ZD7288 on kainate-induced theta-like and gamma network oscillations in the rat hippocampus in vitro.

Journal: Brain research 20091027

Title: Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test.

Journal: European journal of anaesthesiology 20091001

Title: Bidirectional control of spike timing by GABA(A) receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons.

Journal: Neuroreport 20090826

Title: Enhancement of Ih, but not inhibition of IM, is a key mechanism underlying the PACAP-induced increase in excitability of guinea pig intrinsic cardiac neurons.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090701

Title: Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study.

Journal: Journal of the Association for Research in Otolaryngology : JARO 20090601

Title: Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons.

Journal: Neurobiology of disease 20090401

Title: Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons.

Journal: The Journal of physiology 20090315

Title: Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090201

Title: HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090121

Title: Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.

Journal: Journal of neurophysiology 20090101

Title: Role of the hyperpolarization-activated current Ih in somatosensory neurons.

Journal: The Journal of physiology 20081215

Title: Funny currents are becoming serious players in nociceptor's sensitization.

Journal: The Journal of physiology 20081215

Title: Tuning of synaptic integration in the medial entorhinal cortex to the organization of grid cell firing fields.

Journal: Neuron 20081210

Title: Excitatory actions of peptide histidine isoleucine on thalamic relay neurons.

Journal: Neuropharmacology 20081201

Title: Conductances mediating intrinsic theta-frequency membrane potential oscillations in layer II parasubicular neurons.

Journal: Journal of neurophysiology 20081101

Title: Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel.

Journal: Cardiovascular research 20080901

Title: Ethanol effects on dopaminergic ventral tegmental area neurons during block of Ih: involvement of barium-sensitive potassium currents.

Journal: Journal of neurophysiology 20080901

Title: Hyperpolarization-activated cyclic nucleotide-gated channels in mouse vomeronasal sensory neurons.

Journal: Journal of neurophysiology 20080801

Title: Transient cerebral ischemia increases CA1 pyramidal neuron excitability.

Journal: Experimental neurology 20080801

Title: ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells.

Journal: Neuroscience letters 20080718

Title: Gonadotropin-releasing hormone-1 neuronal activity is independent of hyperpolarization-activated cyclic nucleotide-modulated channels but is sensitive to protein kinase a-dependent phosphorylation.

Journal: Endocrinology 20080701

Title: Direct measurement of somatic voltage clamp errors in central neurons.

Journal: Nature neuroscience 20080701

Title: The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080528

Title: Inhibition of Ih in striatal cholinergic interneurons early after transient forebrain ischemia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080501

Title: Dendritic Ih ensures high-fidelity dendritic spike responses of motion-sensitive neurons in rat superior colliculus.

Journal: Journal of neurophysiology 20080501

Title: Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay.

Journal: European journal of pharmacology 20080226

Title: Alpha2-adrenergic receptors modify dendritic spike generation via HCN channels in the prefrontal cortex.

Journal: Journal of neurophysiology 20080101

Title: Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080101

Title: Effects of intrathecal injection of a hyperpolarization-activated channel (Ih) inhibitor ZD7288 on bladder function in urethane-anesthetized rats.

Journal: Neurourology and urodynamics 20080101

Title: HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons.

Journal: Neuron 20071220

Title: A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria.

Journal: European journal of pharmacology 20071208

Title: Intrinsic excitability of cholinergic neurons in the rat parabigeminal nucleus.

Journal: Journal of neurophysiology 20071201

Title: alpha2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents.

Journal: The Journal of physiology 20071015

Title: Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels.

Journal: The Journal of pharmacology and experimental therapeutics 20070901

Title: Inhibition of hyperpolarization-activated cation currents by phencyclidine and some sigma ligands in rat hippocampal CA1 pyramidal neurons in vitro.

Journal: Neuropharmacology 20070901

Title: Involvement of hyperpolarization-activated cation channels in synaptic modulation.

Journal: Neuroreport 20070806

Title: Voltage-sensitive conductances of bushy cells of the Mammalian ventral cochlear nucleus.

Journal: Journal of neurophysiology 20070601

Title: Ih without Kir in adult rat retinal ganglion cells.

Journal: Journal of neurophysiology 20070501

Title: Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.

Journal: Cell 20070420

Title: Functional presynaptic HCN channels in the rat globus pallidus.

Journal: The European journal of neuroscience 20070401

Title: Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network.

Journal: Journal of neurophysiology 20070301

Title: Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20070301

Title: The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors.

Journal: Neuropharmacology 20070201

Title: Effects of serotonin on the intrinsic membrane properties of layer II medial entorhinal cortex neurons.

Journal: Hippocampus 20070101

Title: Pacemaking by HCN channels requires interaction with phosphoinositides.

Journal: Neuron 20061221

Title: Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins.

Journal: Neuroscience 20061201

Title: Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.

Journal: Neuroscience 20060915

Title: Modulation of thalamic neuron excitability by orexins.

Journal: Neuropharmacology 20060901

Title: The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission.

Journal: Neuropharmacology 20060901

Title: Hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 ion channels modulate synaptic transmission from nociceptive primary afferents containing substance P to secondary sensory neurons in laminae I-IIo of the rodent spinal dorsal horn.

Journal: The European journal of neuroscience 20060901

Title: Alpha-2 adrenergic regulation of pedunculopontine nucleus neurons during development.

Journal: Neuroscience 20060825

Title: Characterization of hyperpolarization-activated current (Ih) in dorsal root ganglion neurons innervating rat urinary bladder.

Journal: Brain research 20060622

Title: Theta-frequency membrane resonance and its ionic mechanisms in rat subicular pyramidal neurons.

Journal: Neuroscience 20060619

Title: Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life.

Journal: The European journal of neuroscience 20060601

Title: Decreased IH in hippocampal area CA1 pyramidal neurons after perinatal seizure-inducing hypoxia.

Journal: Epilepsia 20060601

Title: ZD7288 inhibits the synaptic transmission in the pathway from perforant pathway fibers to CA3 region in rat hippocampus.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060601

Title: Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.

Journal: Journal of neurophysiology 20060501

Title: Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices.

Journal: Synapse (New York, N.Y.) 20060401

Title: Persistent changes in action potential broadening and the slow afterhyperpolarization in rat CA1 pyramidal cells after febrile seizures.

Journal: The European journal of neuroscience 20060401

Title: Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node.

Journal: The Journal of physiology 20060315

Title: Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060301

Title: Slow oscillatory activity of rat globus pallidus neurons in vitro.

Journal: The European journal of neuroscience 20060101

Title: Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.

Journal: The European journal of neuroscience 20060101

Title: Prenatal exposure to cigarette smoke affects the physiology of pedunculopontine nucleus (PPN) neurons in development.

Journal: Neurotoxicology and teratology 20060101

Title: Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons.

Journal: Journal of neurophysiology 20051201

Title: Excitatory actions of dopamine via D1-like receptors in the rat lateral geniculate nucleus.

Journal: Journal of neurophysiology 20051201

Title: Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).

Journal: Nature neuroscience 20051101

Title: Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function.

Journal: The European journal of neuroscience 20051101

Title: Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20051026

Title: Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones.

Journal: The Journal of physiology 20051015

Title: Functional expression of the human HCN3 channel.

Journal: The Journal of biological chemistry 20051014

Title: Corticotrophin-releasing factor augments the I(H) in rat hypothalamic paraventricular nucleus parvocellular neurons in vitro.

Journal: Journal of neurophysiology 20050701

Title: Physiology and pharmacology of the cardiac pacemaker ('funny') current.

Journal: Pharmacology & therapeutics 20050701

Title: Persistent sodium currents in mesencephalic v neurons participate in burst generation and control of membrane excitability.

Journal: Journal of neurophysiology 20050501

Title: cAMP-mediated mechanisms for pain sensitization during opioid withdrawal.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413

Title: Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit.

Journal: Nature neuroscience 20050301

Title: Excitability of auditory brainstem neurons, in vivo, is increased by cyclic-AMP.

Journal: Hearing research 20050301

Title: Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.

Journal: Journal of neurophysiology 20050301

Title: Molecular and functional characterization of an I(h)-channel from lobster olfactory receptor neurons.

Journal: The European journal of neuroscience 20050301

Title: The mechanism of intrinsic amplification of hyperpolarizations and spontaneous bursting in striatal cholinergic interneurons.

Journal: Neuron 20050217

Title: Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers.

Journal: Circulation 20050104

Title: Suppression by an h current of spontaneous Na+ action potentials in human cone and rod photoreceptors.

Journal: Investigative ophthalmology & visual science 20050101

Title: Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture.

Journal: Neuroscience 20050101

Title: Pituitary adenylate cyclase-activating polypeptide enhances the hyperpolarization-activated nonselective cationic conductance, Ih, in dissociated guinea pig intracardiac neurons.

Journal: Regulatory peptides 20041215

Title: Frequency-dependent modulation of retinogeniculate transmission by serotonin.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

Title: Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.

Journal: Neuron 20041028

Title: Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1: a brake on the NMDA response.

Journal: Journal of neurophysiology 20041001

Title: Characterization of the human HCN1 channel and its inhibition by capsazepine.

Journal: British journal of pharmacology 20041001

Title: In vivo contribution of h-channels in the septal pacemaker to theta rhythm generation.

Journal: The European journal of neuroscience 20041001

Title: Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats Is mediated via the hyperpolarization-activated cation current, not by alpha-adrenoreceptors.

Journal: Anesthesiology 20040801

Title: An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.

Journal: The European journal of neuroscience 20040601

Title: Input resistance is voltage dependent due to activation of Ih channels in rat CA1 pyramidal cells.

Journal: Journal of neuroscience research 20040515

Title: Roles of Ca2+, hyperpolarization and cyclic nucleotide-activated channel activation, and actin in temporal synaptic tagging.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040428

Title: Characterisation of hyperpolarization-activated currents (I(h)) in the medial septum/diagonal band complex in the mouse.

Journal: Brain research 20040423

Title: Hippocampal theta rhythm is reduced by suppression of the H-current in septohippocampal GABAergic neurons.

Journal: The European journal of neuroscience 20040401

Title: ZD7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cell synapses.

Journal: The European journal of neuroscience 20040201

Title: The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031126

Title: Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitro.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031029

Title: Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz.

Journal: The Journal of physiology 20031015

Title: Role of the hyperpolarization-activated cation current (Ih) in pacemaker activity in area postrema neurons of rat brain slices.

Journal: The Journal of physiology 20031001

Title: Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity.

Journal: The Journal of physiology 20030915

Title: A simulation analysis on mechanisms of damped oscillation in retinal rod photoreceptor cells.

Journal: Vision research 20030901

Title: Hyperpolarization-activated (I(h)) conductances affect brainstem auditory neuron excitability.

Journal: Hearing research 20030901

Title: Vasoactive intestinal peptide selectively depolarizes thalamic relay neurons and attenuates intrathalamic rhythmic activity.

Journal: Journal of neurophysiology 20030801

Title: Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine.

Journal: The Journal of pharmacology and experimental therapeutics 20030801

Title: Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones.

Journal: British journal of pharmacology 20030801

Title: Dorsal and ventral distribution of excitable and synaptic properties of neurons of the bed nucleus of the stria terminalis.

Journal: Journal of neurophysiology 20030701

Title: Reexamination of the role of hyperpolarization-activated cation channels in short- and long-term plasticity at hippocampal mossy fiber synapses.

Journal: Neuropharmacology 20030601

Title: Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?

Journal: Journal of cardiovascular pharmacology and therapeutics 20030601

Title: Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus.

Journal: The Journal of physiology 20030501

Title: The role of the hyperpolarization-activated cationic current I(h) in the timing of interictal bursts in the neonatal hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501

Title: Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030401

Title: Activation of Ih is necessary for patterning of mGluR and mAChR induced network activity in the hippocampal CA3 region.

Journal: Neuropharmacology 20030301

Title: Development of inward rectification and control of membrane excitability in mesencephalic v neurons.

Journal: Journal of neurophysiology 20030301

Title: Ih blockers have a potential of antiepileptic effects.

Journal: Epilepsia 20030101

Title: Postnatal development of the hyperpolarization-activated excitatory current Ih in mouse hippocampal pyramidal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021015

Title: Blockade of hyperpolarization-activated channels modifies the effect of beta-adrenoceptor stimulation.

Journal: Bulletin of experimental biology and medicine 20020501

Title: Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells.

Journal: American journal of physiology. Cell physiology 20020401

Title: Influence of the hyperpolarization-activated cation current, I(h), on the electrotonic properties of the distal apical dendrites of hippocampal CA1 pyramidal neurones.

Journal: Brain research 20020315

Title: I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020215

Title: Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents.

Journal: Neuron 20020214

Title: Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels.

Journal: Science (New York, N.Y.) 20020104

Title: NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation.

Journal: Cardiovascular research 20011201

Title: Ionic basis of the caesium-induced depolarisation in rat supraoptic nucleus neurones.

Journal: The Journal of physiology 20011101

Title: Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons.

Journal: Journal of neurophysiology 20010701

Title: Dendritic mechanisms of phase precession in hippocampal CA1 pyramidal neurons.

Journal: Journal of neurophysiology 20010701

Title: Modulation of the hyperpolarisation-activated current, Ih, in rat facial motoneurones in vitro by ZD-7288.

Journal: Neuropharmacology 20010601

Title: Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons.

Journal: Neuroreport 20010212

Title: High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs.

Journal: Journal of neurophysiology 20010201

Title: Inhibition of the I(h) current in isolated peripheral nerve: a novel mode of peripheral antinociception?

Journal: Muscle & nerve 20010201

Title: Zhang XX, et al. ZD7288, a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. Neural Regen Res. 2016 May;11(5):779-86.

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Tags:133059-99-1 Molecular Formula|133059-99-1 MDL|133059-99-1 SMILES|133059-99-1 4-Pyrimidinamine, N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-, hydrochloride (1:1)