Home Amines 121524-09-2
121524-09-2,MFCD00886563
Catalog No.:AA00155P

121524-09-2 | Acetic acid, [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester, hydrochloride (1:1)

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1mg
≥98%
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$80.00   $56.00
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5mg
≥98%
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$173.00   $121.00
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10mg
≥98%
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$309.00   $216.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00155P
Chemical Name:
Acetic acid, [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester, hydrochloride (1:1)
CAS Number:
121524-09-2
Molecular Formula:
C22H27Cl2NO4
Molecular Weight:
440.3601
MDL Number:
MFCD00886563
SMILES:
CCOC(=O)COc1ccc2c(c1)C[C@H](CC2)NC[C@@H](c1cccc(c1)Cl)O.Cl
Properties
Computed Properties
 
Complexity:
491  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  

Literature

Title: Noradrenergic activity regulated dexamethasone-induced increase of 5-HT₃ receptor-mediated glutamate release in the rat's prelimbic cortex.

Journal: Biochimica et biophysica acta 20121201

Title: The beta3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20101001

Title: GPR40 is partially required for insulin secretion following activation of beta3-adrenergic receptors.

Journal: Molecular and cellular endocrinology 20100830

Title: Evaluation of the role of superoxide anions in endotoxin-induced impairment of beta-adrenoceptor-mediated vasodilation in equine digital veins.

Journal: American journal of veterinary research 20100701

Title: Implication of beta3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress.

Journal: Behavioural brain research 20100120

Title: Rabbit, a relevant model for the study of cardiac beta 3-adrenoceptors.

Journal: Experimental physiology 20090401

Title: Effects of the beta3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile.

Journal: Neuroscience 20081002

Title: The beta3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080901

Title: Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.

Journal: Journal of medicinal chemistry 20080814

Title: Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression.

Journal: Pharmacology, biochemistry, and behavior 20080601

Title: Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080201

Title: Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?

Journal: European journal of pharmacology 20071114

Title: Effect of SR58611A, a potent beta-3 adrenoceptor agonist, on cutaneous wound healing in diabetic and obese mice.

Journal: European journal of pharmacology 20060104

Title: Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management.

Journal: Journal of the American College of Cardiology 20050719

Title: Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats.

Journal: Autonomic neuroscience : basic & clinical 20050331

Title: Beta3-adrenoceptors: relaxant function and mRNA detection in smooth muscle cells isolated from the human colon.

Journal: Canadian journal of physiology and pharmacology 20040701

Title: beta3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human beta3-adrenergic receptor.

Journal: Cardiovascular research 20030801

Title: Evaluation of beta3-adrenoceptor-mediated relaxation in intact and endotoxin-treated equine digital veins.

Journal: American journal of veterinary research 20030601

Title: SR 58611A: SR 58611.

Journal: Drugs in R&D 20030101

Title: Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway.

Journal: British journal of pharmacology 20020901

Title: Effect of SR 58611A, a beta-3 receptor agonist, against experimental gastro-duodenal ulcers.

Journal: Indian journal of physiology and pharmacology 20020101

Title: Cardiovascular effects of beta 3-adrenoceptor stimulation in perinephritic hypertension.

Journal: European journal of clinical investigation 20010801

Title: Beta(3)-adrenoceptors control Cl(-) conductance in rabbit nasal epithelium.

Journal: European journal of pharmacology 20010622

Title: Enhancement of memory consolidation in chicks by beta(3)-adrenoceptor agonists.

Journal: European journal of pharmacology 20010216

Title: Involvement of beta1- and beta2- but not beta3-adrenoceptor activation in adrenergic PYY secretion from the isolated colon.

Journal: The Journal of endocrinology 20010101

Title: Peripheral cardiovascular actions of SR 58611 A, a beta 3-adrenoceptor agonist, in the dog: lack of central effect.

Journal: Fundamental & clinical pharmacology 19990101

Title: SR59230A blocks beta3-adrenoceptor-linked modulation of upcoupling protein-1 and leptin in rat brown adipocytes.

Journal: European journal of pharmacology 19980703

Title: Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.

Journal: Molecular pharmacology 19960101

Title: Bianchetti A, et al. In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon. Br J Pharmacol. 1990 Aug;100(4):831-9.

Title: Simiand J, et al. Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors. Eur J Pharmacol. 1992 Aug 25;219(2):193-201.

Title: Claustre Y, et al. Effects of the beta3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience. 2008 Oct 2;156(2):353-64.

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Tags:121524-09-2 Molecular Formula|121524-09-2 MDL|121524-09-2 SMILES|121524-09-2 Acetic acid, [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester, hydrochloride (1:1)