Bis(triphenylphosphine)palladium(II) chloride (13965-03-2) is a versatile catalyst employed in various palladium-catalyzed cross-coupling reactions, facilitating the synthesis of diverse organic compounds with high efficiency and selectivity. Its applications encompass a range of transformations, including the coupling of 2-iodoanisole and terminal alkynes to produce 2,3-disubstituted benzofurans, and the copper-free Sonogashira cross-coupling reaction yielding diphenylacetylene. Additionally, it enables the regioselective hydrocarboxylation of styrene and the Negishi coupling of fluoroarylzinc pivalates, leading to the preparation of fluorinated oligophenyls. Furthermore, Bis(triphenylphosphine)palladium(II) chloride facilitates the coupling of iodo-α-β-unsaturated esters, resulting in the formation of tetrasubstituted olefins. Its efficacy in promoting these reactions underscores its importance as a catalyst in modern organic synthesis, enabling the efficient construction of complex organic molecules with diverse structural motifs.
