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Home Other Building Blocks 1401033-86-0
1401033-86-0,MFCD28155269
Catalog No.:AA001BYF

1401033-86-0 | Amg 925

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$46.00   $32.00
- +
5mg
≥95%
in stock  
$133.00   $93.00
- +
10mg
≥95%
in stock  
$219.00   $153.00
- +
25mg
≥95%
in stock  
$382.00   $267.00
- +
100mg
in stock  
$1,263.00   $884.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001BYF
Chemical Name:
Amg 925
CAS Number:
1401033-86-0
Molecular Formula:
C26H29N7O2
Molecular Weight:
471.5542
MDL Number:
MFCD28155269
SMILES:
OCC(=O)N1CCc2c(C1)ccc(n2)Nc1ncc2c(n1)n([C@@H]1CC[C@H](CC1)C)c1c2ccnc1
Properties
Computed Properties
 
Complexity:
747  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.7  

Downstream Synthesis Route

[1]Patent:US2012/244110,2012,A1

[2]JournalofMedicinalChemistry,2014,vol.57,p.3430-3449

[1]Patent:US2012/244110,2012,A1

[2]JournalofMedicinalChemistry,2014,vol.57,p.3430-3449

[1]Patent:US2012/244110,2012,A1

[2]JournalofMedicinalChemistry,2014,vol.57,p.3430-3449

[3]OrganicProcessResearchandDevelopment,2015,vol.19,p.476-485

[1]JournalofMedicinalChemistry,2014,vol.57,p.3430-3449

[2]OrganicProcessResearchandDevelopment,2015,vol.19,p.476-485

Literature

Title: Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.

Journal: Molecular cancer therapeutics 20140401

Title: Keegan K, et al. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Mol Cancer Ther. 2014 Apr;13(4):880-9.

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SDS
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