Home Sulfonamines 147536-97-8
147536-97-8,MFCD00867375
Catalog No.:AA001EVE

147536-97-8 | Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-

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5mg
95%
in stock  
$43.00   $30.00
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10mg
95%
in stock  
$81.00   $57.00
- +
50mg
95%
in stock  
$139.00   $97.00
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100mg
95%
in stock  
$237.00   $166.00
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200mg
95%
in stock  
$394.00   $276.00
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500mg
95%
in stock  
$589.00   $413.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001EVE
Chemical Name:
Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-
CAS Number:
147536-97-8
Molecular Formula:
C27H29N5O6S
Molecular Weight:
551.6141
MDL Number:
MFCD00867375
SMILES:
OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1
Properties
Computed Properties
 
Complexity:
839  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
11  
XLogP3:
3.8  

Downstream Synthesis Route
107-21-1    150728-13-5   
potassium4-tert-butylbenzenesulfonate 
  147536-97-8 

[1]BioorganicandMedicinalChemistryLetters,1997,vol.7,p.2223-2228

[1]BioorganicandMedicinalChemistryLetters,1997,vol.7,p.2223-2228

[2]Patent:US2012/136015,2012,A1

[3]OrganicProcessResearchandDevelopment,2002,vol.6,p.120-124

[4]Patent:CN104193687,2017,B

[1]Patent:US2009/156811,2009,A1.Locationinpatent:Page/Pagecolumn4-5

[2]Patent:EP2072503,2009,A2.Locationinpatent:Page/Pagecolumn7

[3]Patent:US2009/156811,2009,A1.Locationinpatent:Page/Pagecolumn5

[4]Patent:WO2009/112954,2009,A2.Locationinpatent:Example5

[1]Patent:WO2010/15623,2010,A1.Locationinpatent:Page/Pagecolumn15

[1]Patent:WO2011/24056,2011,A2

[2]Patent:WO2011/24056,2011,A2

[3]Patent:US2012/136015,2012,A1

Literature

Title: Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.

Title: Akamata K, et al. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 3;16(2):R86.

Title: Iglarz M, et al. Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension. Life Sci. 2014 Nov 24;118(2):333-9.

Title: Son GY, et al. Endothelin Regulates Porphyromonas gingivalis-Induced Production of Inflammatory Cytokines. PLoS One. 2016 Dec 28;11(12):e0167713.

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SDS
Tags:147536-97-8 Molecular Formula|147536-97-8 MDL|147536-97-8 SMILES|147536-97-8 Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-