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1403783-31-2,MFCD28099804
Catalog No.:AA001C8E

1403783-31-2 | Nexturastat a

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
5mg
98%
in stock  
$39.00   $28.00
- +
50mg
98%
in stock  
$155.00   $109.00
- +
250mg
98%
in stock  
$421.00   $295.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001C8E
Chemical Name:
Nexturastat a
CAS Number:
1403783-31-2
Molecular Formula:
C19H23N3O3
Molecular Weight:
341.4042
MDL Number:
MFCD28099804
SMILES:
CCCCN(C(=O)Nc1ccccc1)Cc1ccc(cc1)C(=O)NO
Properties
Computed Properties
 
Complexity:
416  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
2.6  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2012,vol.55,#22,p.9891-9899

[1]JournalofMedicinalChemistry,2012,vol.55,#22,p.9891-9899

[1]JournalofMedicinalChemistry,2012,vol.55,#22,p.9891-9899

Literature

Title: Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.

Journal: Journal of medicinal chemistry 20121126

Title: Bergman JA, et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9.

Title: Magalie Géraldy,, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443.

Title: everin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.

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SDS
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