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146033-02-5,MFCD17215974
Catalog No.:AA001DJM

146033-02-5 | Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, hydrochloride (1:1)

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1mg
≥95%
in stock  
$33.00   $23.00
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5mg
≥95%
in stock  
$90.00   $63.00
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10mg
≥95%
in stock  
$162.00   $113.00
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25mg
≥95%
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$362.00   $253.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001DJM
Chemical Name:
Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, hydrochloride (1:1)
CAS Number:
146033-02-5
Molecular Formula:
C22H20Cl2N4O3
Molecular Weight:
459.3252
MDL Number:
MFCD17215974
SMILES:
O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCc1ccncc1.Cl
Properties
Computed Properties
 
Complexity:
601  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain.

Journal: Hypertension (Dallas, Tex. : 1979) 20120401

Title: Prostaglandin E2 receptor 1 activity regulates cell survival following hypoxia in cultured rat cortical neurons.

Journal: Neuroscience letters 20120202

Title: Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy.

Journal: Neuroscience letters 20111031

Title: Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice.

Journal: Epilepsy research 20100901

Title: Prostanoid EP1 receptor antagonist reduces blood-brain barrier leakage after cerebral ischemia.

Journal: European journal of pharmacology 20100825

Title: Potential for control of detrusor smooth muscle spontaneous rhythmic contraction by cyclooxygenase products released by interstitial cells of Cajal.

Journal: Journal of cellular and molecular medicine 20090901

Title: The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090101

Title: Microglial inhibition of neuroprotection by antagonists of the EP1 prostaglandin E2 receptor.

Journal: Journal of neuroinflammation 20090101

Title: Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway.

Journal: Neurobiology of disease 20080301

Title: ONO-54918-07, a stable prostacyclin analogue, mimics the effect of prostaglandin PGE1 on NG108-15 cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20071101

Title: Involvement of EP1 and EP2 receptors in the regulation of the Na,K-ATPase by prostaglandins in MDCK cells.

Journal: Prostaglandins & other lipid mediators 20060301

Title: Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089.

Journal: Journal of neuro-oncology 20040201

Title: Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine.

Journal: British journal of pharmacology 20021201

Title: A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.

Journal: British journal of pharmacology 20010901

Title: 2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist.

Journal: Bioorganic & medicinal chemistry 20010101

Title: Comparison of prostaglandin E1- and prostaglandin E2-induced hyperalgesia in the rat.

Journal: Neuroscience 19940901

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Tags:146033-02-5 Molecular Formula|146033-02-5 MDL|146033-02-5 SMILES|146033-02-5 Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, hydrochloride (1:1)