[1]CurrentPatentAssignee:SumitomoPharma(in:SumitomoChemical);SUMITOMOCHEMICALCOMPANYLIMITED;SumitomoChemical(w/oDongwooFine-Chem)-WO2018/94275,2018,A1Locationinpatent:Page/Pagecolumn73
149577-05-9
[1]Patent:WO2018/94275,2018,A1.Locationinpatent:Page/Pagecolumn59;60
149577-05-9
[1]Patent:WO2018/94275,2018,A1
[1]CurrentPatentAssignee:SumitomoPharma(in:SumitomoChemical);SUMITOMOCHEMICALCOMPANYLIMITED;SumitomoChemical(w/oDongwooFine-Chem)-WO2018/94275,2018,A1Locationinpatent:Page/Pagecolumn49;50
[1]CurrentPatentAssignee:SumitomoPharma(in:SumitomoChemical);SUMITOMOCHEMICALCOMPANYLIMITED;SumitomoChemical(w/oDongwooFine-Chem)-WO2018/94275,2018,A1Locationinpatent:Page/Pagecolumn50;51
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Title: Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Journal: Scientific reports 20140101
Title: BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes.
Journal: Molecular and cellular biology 20130601
Title: Cyclin-dependent kinase inhibitor therapy for hematologic malignancies.
Journal: Expert opinion on investigational drugs 20130601
Title: Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Journal: Journal of medicinal chemistry 20130214
Title: Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells.
Journal: BMC pharmacology & toxicology 20130101
Title: Cyclin-dependent kinase modulators and cancer therapy.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20121201
Title: Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia.
Journal: Haematologica 20121101
Title: Identification of HEXIM1 as a positive regulator of p53.
Journal: The Journal of biological chemistry 20121019
Title: Use of ATP analogs to inhibit HIV-1 transcription.
Journal: Virology 20121010
Title: A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261.
Journal: Gynecologic oncology 20121001
Title: The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2.
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Title: CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.
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Title: ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.
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Title: Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines.
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Title: Outcome of patients with relapsed or refractory chronic lymphocytic leukemia treated with flavopiridol: impact of genetic features.
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Title: Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl+ hematological malignancies.
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Title: Cyclin-dependent kinase inhibition by flavoalkaloids.
Journal: Mini reviews in medicinal chemistry 20120601
Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Journal: Journal of medicinal chemistry 20120524
Title: The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508.
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Title: The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120501
Title: Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury.
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Title: A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors.
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Title: AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.
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Title: Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.
Journal: Cell cycle (Georgetown, Tex.) 20120315
Title: CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.
Journal: International journal of cancer 20120301
Title: Hematologic improvement after flavopiridol treatment of pentostatin and rituximab refractory hairy cell leukemia.
Journal: Leukemia & lymphoma 20120301
Title: Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach.
Journal: Haematologica 20120301
Title: Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies.
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Title: Fusarium proliferatum, an endophytic fungus from Dysoxylum binectariferum Hook.f, produces rohitukine, a chromane alkaloid possessing anti-cancer activity.
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Title: A mathematical model of cell cycle effects in gastric cancer chemotherapy.
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Title: GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons.
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Title: Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
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Title: Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis.
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Title: Modularity in protein complex and drug interactions reveals new polypharmacological properties.
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Title: Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma.
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Title: Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer.
Journal: Oncotarget 20120101
Title: African American patients with gout: efficacy and safety of febuxostat vs allopurinol.
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Title: Effects of α-adrenoceptor antagonists on ABCG2/BCRP-mediated resistance and transport.
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Title: Dissecting genetic architecture of grape proanthocyanidin composition through quantitative trait locus mapping.
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Title: Complex effects of flavopiridol on the expression of primary response genes.
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Title: State-of-the-Art Management of Patients Suffering from Chronic Lymphocytic Leukemia.
Journal: Clinical Medicine Insights. Oncology 20120101
Title: Cyclin K goes with Cdk12 and Cdk13.
Journal: Cell division 20120101
Title: Novel therapies for aggressive B-cell lymphoma.
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Title: Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of aberrant cell cycle diseases: an update.
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Title: Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
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Title: Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours.
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Title: Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro.
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Title: Curcumin enhances cytotoxic effects of bortezomib in human multiple myeloma H929 cells: potential roles of NF-κB/JNK.
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Title: A study on solubilization of poorly soluble drugs by cyclodextrins and micelles: complexation and binding characteristics of sulfamethoxazole and trimethoprim.
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Title: Role of STAT3 in Transformation and Drug Resistance in CML.
Journal: Frontiers in oncology 20120101
Title: Acute myeloid leukemia: focus on novel therapeutic strategies.
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Title: Radiation, inflammation, and immune responses in cancer.
Journal: Frontiers in oncology 20120101
Title: Targeted therapy in Ewing sarcoma.
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Title: Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate.
Journal: The Journal of pharmacology and experimental therapeutics 20111201
Title: Novel therapeutic approaches for acute lymphoblastic leukemia.
Journal: Hematology/oncology clinics of North America 20111201
Title: Control of HIV latency by epigenetic and non-epigenetic mechanisms.
Journal: Current HIV research 20111201
Title: Toxicological aspects of the use of phenolic compounds in disease prevention.
Journal: Interdisciplinary toxicology 20111201
Title: VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.
Journal: Cancer biology & therapy 20111101
Title: Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS.
Journal: NMR in biomedicine 20111101
Title: Comprehensive analysis of kinase inhibitor selectivity.
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Title: A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors.
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Title: Mantle cell lymphoma: the promise of new treatment options.
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Title: Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia.
Journal: Leukemia & lymphoma 20111001
Title: The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract.
Journal: International journal of oncology 20111001
Title: Combining proteasome with cell cycle inhibitors: a dual attack potentially applicable to multiple hematopoietic malignancies.
Journal: Expert review of hematology 20111001
Title: Systemic use of tumor necrosis factor alpha as an anticancer agent.
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Title: RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus.
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Title: ABT-737 induces apoptosis in mantle cell lymphoma cells with a Bcl-2high/Mcl-1low profile and synergizes with other antineoplastic agents.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110915
Title: Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol.
Journal: Leukemia 20110901
Title: Acute myeloid leukaemia: optimal management and recent developments.
Journal: Drugs 20110820
Title: Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis.
Journal: Cancer biology & therapy 20110815
Title: Cross-talk between cell cycle induction and mitochondrial dysfunction during oxidative stress and nerve growth factor withdrawal in differentiated PC12 cells.
Journal: Journal of neuroscience research 20110801
Title: Sustained activation of ERK and Cdk2/cyclin-A signaling pathway by pemetrexed leading to S-phase arrest and apoptosis in human non-small cell lung cancer A549 cells.
Journal: European journal of pharmacology 20110801
Title: [Present status and perspective of targeted therapy for B-cell lymphoma].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20110801
Title: Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.
Journal: Bioorganic & medicinal chemistry letters 20110701
Title: Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.
Journal: Cell death & disease 20110701
Title: Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms.
Journal: Cell death & disease 20110701
Title: NPMc(+) AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anticancer compounds.
Journal: Cell cycle (Georgetown, Tex.) 20110615
Title: Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1).
Journal: British journal of cancer 20110607
Title: Leukemia cutis in association With Grover's disease.
Journal: The American Journal of dermatopathology 20110601
Title: New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).
Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20110601
Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
Journal: European journal of medicinal chemistry 20110601
Title: Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition.
Journal: Pigment cell & melanoma research 20110601
Title: Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110515
Title: Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment.
Journal: Mutation research 20110510
Title: Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?
Journal: European journal of clinical pharmacology 20110501
Title: Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.
Journal: Journal of medicinal chemistry 20110428
Title: JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.
Journal: Brain : a journal of neurology 20110401
Title: High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
Journal: PLoS neglected tropical diseases 20110401
Title: Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias.
Journal: Blood 20110324
Title: Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway.
Journal: Microbiology and immunology 20110301
Title: The role of reactive oxygen species and autophagy in safingol-induced cell death.
Journal: Cell death & disease 20110301
Title: Homology modeling, molecular dynamic simulation and docking studies of cyclin dependent kinase 1.
Journal: Journal of molecular modeling 20110201
Title: Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20110201
Title: Identification of kinase inhibitors that target transcription initiation by RNA polymerase II.
Journal: Oncotarget 20110201
Title: Targeting transcription through inhibition of TBP.
Journal: Oncotarget 20110201
Title: Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract.
Journal: Archives of medical science : AMS 20110201
Title: Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells.
Journal: Blood 20110113
Title: Cytotoxic Activities of Physalis minima L. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Andrographolide: a new plant-derived antineoplastic entity on horizon.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
Journal: Leukemia 20110101
Title: State of the art treatment of chronic lymphocytic leukaemia.
Journal: Blood reviews 20110101
Title: Liposarcoma: molecular genetics and therapeutics.
Journal: Sarcoma 20110101
Title: Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.
Journal: PloS one 20110101
Title: CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation.
Journal: PloS one 20110101
Title: Transcription inhibition by DRB potentiates recombinational repair of UV lesions in mammalian cells.
Journal: PloS one 20110101
Title: PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy.
Journal: PloS one 20110101
Title: The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
Journal: BMC developmental biology 20110101
Title: Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4.
Journal: Molecular cancer 20110101
Title: Vorinostat induces reactive oxygen species and DNA damage in acute myeloid leukemia cells.
Journal: PloS one 20110101
Title: Anticancer activity of 2α, 3α, 19β, 23β-Tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid isolated from Sinojackia sarcocarpa.
Journal: PloS one 20110101
Title: Predicting a small molecule-kinase interaction map: A machine learning approach.
Journal: Journal of cheminformatics 20110101
Title: Promising molecular targeted therapies in breast cancer.
Journal: Indian journal of pharmacology 20110101
Title: Randomized, double-blind, controlled, comparative trial of formula food containing soy protein vs. milk protein in visceral fat obesity. -FLAVO study-.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20110101
Title: Acid phosphatases of budding yeast as a model of choice for transcription regulation research.
Journal: Enzyme research 20110101
Title: Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.
Journal: BMC research notes 20110101
Title: p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
Journal: PloS one 20110101
Title: Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas.
Journal: Journal of experimental & clinical cancer research : CR 20110101
Title: Knockdown of dystrophin Dp71 impairs PC12 cells cycle: localization in the spindle and cytokinesis structures implies a role for Dp71 in cell division.
Journal: PloS one 20110101
Title: Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells.
Journal: PloS one 20110101
Title: Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.
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Title: Choroid plexus transport: gene deletion studies.
Journal: Fluids and barriers of the CNS 20110101
Title: Kinase inhibitors from marine sponges.
Journal: Marine drugs 20110101
Title: Concurrent HDAC and mTORC1 inhibition attenuate androgen receptor and hypoxia signaling associated with alterations in microRNA expression.
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Title: Flavonoids: A versatile source of anticancer drugs.
Journal: Pharmacognosy reviews 20110101
Title: Arctic Ocean microbial community structure before and after the 2007 record sea ice minimum.
Journal: PloS one 20110101
Title: Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression.
Journal: PloS one 20110101
Title: Targeted treatment for chronic lymphocytic leukemia.
Journal: OncoTargets and therapy 20110101
Title: Genetic mechanisms underlying the methylation level of anthocyanins in grape (Vitis vinifera L.).
Journal: BMC plant biology 20110101
Title: Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.
Journal: PloS one 20110101
Title: Photo-irradiated biosynthesis of silver nanoparticles using edible mushroom pleurotus Florida and their antibacterial activity studies.
Journal: Bioinorganic chemistry and applications 20110101
Title: Protein kinase A regulates molecular chaperone transcription and protein aggregation.
Journal: PloS one 20110101
Title: Multidrug resistance in breast cancer: from in vitro models to clinical studies.
Journal: International journal of breast cancer 20110101
Title: RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing.
Journal: Genetics research international 20110101
Title: Updating the CTD Story: From Tail to Epic.
Journal: Genetics research international 20110101
Title: The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.
Journal: Genetics research international 20110101
Title: Targeting apoptosis signaling pathways for anticancer therapy.
Journal: Frontiers in oncology 20110101
Title: A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Journal: Journal of medicinal chemistry 20101223
Title: Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells.
Journal: Cancer letters 20101201
Title: The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro.
Journal: Toxicology and applied pharmacology 20101201
Title: CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.
Journal: Molecular endocrinology (Baltimore, Md.) 20101201
Title: Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
Journal: Oncology reports 20101201
Title: Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.
Journal: Proteomics 20101201
Title: Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53.
Journal: Molecular cancer therapeutics 20101201
Title: Novel agents for the treatment of chronic lymphocytic leukemia.
Journal: Clinical advances in hematology & oncology : H&O 20101201
Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.
Journal: Chemistry & biology 20101124
Title: Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Journal: Cancer biology & therapy 20101101
Title: A phase I clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol.
Journal: Cancer chemotherapy and pharmacology 20101101
Title: Standard of care and novel treatments for chronic lymphocytic leukemia.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101101
Title: EGFR-mutated lung cancer: a paradigm of molecular oncology.
Journal: Oncotarget 20101101
Title: Refractory chronic lymphocytic leukemia--new therapeutic strategies.
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Title: A flexible multiwell format for immunofluorescence screening microscopy of small-molecule inhibitors.
Journal: Assay and drug development technologies 20101001
Title: Chronic lymphocytic leukemia.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20101001
Title: Chronic lymphocytic leukemia: new concepts for future therapy.
Journal: Clinical lymphoma, myeloma & leukemia 20101001
Title: Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy.
Journal: Mini reviews in medicinal chemistry 20101001
Title: [Synergism of antitumor effects on ovarian carcinoma using autocatalytic caspase-3 combined with flavopiridol].
Journal: Zhonghua fu chan ke za zhi 20101001
Title: P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes.
Journal: The Journal of biological chemistry 20100924
Title: Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.
Journal: European journal of medicinal chemistry 20100901
Title: Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.
Journal: Nature cell biology 20100901
Title: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
Journal: Cancer metastasis reviews 20100901
Title: Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents.
Journal: Bioorganic & medicinal chemistry 20100815
Title: Inhibition of Eimeria tenella CDK-related kinase 2: From target identification to lead compounds.
Journal: ChemMedChem 20100802
Title: A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer.
Journal: American journal of clinical oncology 20100801
Title: Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100801
Title: Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome.
Journal: The Journal of clinical endocrinology and metabolism 20100801
Title: Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.
Journal: Molecular cancer therapeutics 20100801
Title: Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents.
Journal: Cancer chemotherapy and pharmacology 20100701
Title: Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia.
Journal: Leukemia research 20100701
Title: T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
Journal: Journal of cellular physiology 20100701
Title: Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
Journal: Biochemical pharmacology 20100701
Title: Sequential flavopiridol, mitoxantrone and cytosine arabinoside for newly diagnosed poor risk acute myeloid leukemia. What to do next?
Journal: Leukemia research 20100701
Title: Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.
Journal: Haematologica 20100701
Title: Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs.
Journal: British journal of cancer 20100629
Title: Dasatinib: is it all in the dose?
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20100601
Title: Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
Journal: The Journal of pharmacology and experimental therapeutics 20100601
Title: Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178.
Journal: Molecular and biochemical parasitology 20100601
Title: Specificity in the interaction of natural products with their target proteins--a biochemical and structural insight.
Journal: Mini reviews in medicinal chemistry 20100601
Title: Development of therapeutic agents for older patients with acute myelogenous leukemia.
Journal: Current opinion in investigational drugs (London, England : 2000) 20100601
Title: Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.
Journal: British journal of cancer 20100511
Title: A combination of cisplatin-eluting gelatin microspheres and flavopiridol enhances anti-tumour effects in a rabbit VX2 liver tumour model.
Journal: The British journal of radiology 20100501
Title: microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.
Journal: Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 20100501
Title: Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.
Journal: Blood 20100422
Title: Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.
Journal: The Journal of biological chemistry 20100416
Title: Exploiting cellular pathways to develop new treatment strategies for AML.
Journal: Cancer treatment reviews 20100401
Title: Chronic lymphocytic leukemia: putting new treatment options into perspective.
Journal: Cancer control : journal of the Moffitt Cancer Center 20100401
Title: Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.
Journal: Fitoterapia 20100301
Title: Synthesis and biological screening of a combinatorial library of beta-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents.
Journal: Bioorganic & medicinal chemistry 20100301
Title: CDK inhibitors: from the bench to clinical trials.
Journal: Current drug targets 20100301
Title: Cyclin-dependent kinase inhibitors as anticancer drugs.
Journal: Current drug targets 20100301
Title: Induction of monocyte chemoattractant protein-1 (MCP-1/CCL2) gene expression by human immunodeficiency virus-1 Tat in human astrocytes is CDK9 dependent.
Journal: Journal of neurovirology 20100301
Title: Therapy of chronic lymphocytic leukaemia.
Journal: Best practice & research. Clinical haematology 20100301
Title: Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents.
Journal: Bioorganic & medicinal chemistry 20100201
Title: Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100120
Title: Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells.
Journal: British journal of cancer 20100119
Title: Selective control of gene expression by CDK9 in human cells.
Journal: Journal of cellular physiology 20100101
Title: DNA polymerase-beta is required for 1-methyl-4-phenylpyridinium-induced apoptotic death in neurons.
Journal: Apoptosis : an international journal on programmed cell death 20100101
Title: Poised transcription factories prime silent uPA gene prior to activation.
Journal: PLoS biology 20100101
Title: 8-Amino-adenosine inhibits multiple mechanisms of transcription.
Journal: Molecular cancer therapeutics 20100101
Title: Shewanella spp. genomic evolution for a cold marine lifestyle and in-situ explosive biodegradation.
Journal: PloS one 20100101
Title: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors.
Journal: AIDS research and therapy 20100101
Title: New agents in chronic lymphocytic leukemia.
Journal: Current hematologic malignancy reports 20100101
Title: MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients.
Journal: BMC medical genomics 20100101
Title: Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-kappaB signaling and depleting Bcr-Abl.
Journal: Molecular cancer 20100101
Title: The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.
Journal: PloS one 20100101
Title: Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear and non-linear data analysis techniques.
Journal: BMC bioinformatics 20100101
Title: Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.
Journal: PloS one 20100101
Title: First-line treatment of chronic lymphocytic leukemia: role of alemtuzumab.
Journal: OncoTargets and therapy 20100101
Title: NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.
Journal: Molecular cancer 20100101
Title: A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients.
Journal: Molecular cancer 20100101
Title: Use of clofarabine for acute childhood leukemia.
Journal: Biologics : targets & therapy 20100101
Title: Personalized therapies in the cancer 'omics' era.
Journal: Molecular cancer 20100101
Title: R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair.
Journal: Molecular cancer 20100101
Title: Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models.
Journal: PloS one 20100101
Title: Molecular and therapeutic potential and toxicity of valproic acid.
Journal: Journal of biomedicine & biotechnology 20100101
Title: The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.
Journal: PloS one 20100101
Title: Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis.
Journal: PloS one 20100101
Title: Suberoylanilide hydroxamic acid induces apoptosis and sub-G1 arrest of 320 HSR colon cancer cells.
Journal: Journal of biomedical science 20100101
Title: Condensed mitotic chromosome structure at nanometer resolution using PALM and EGFP- histones.
Journal: PloS one 20100101
Title: Dynamic changes to survivin subcellular localization are initiated by DNA damage.
Journal: OncoTargets and therapy 20100101
Title: Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba.
Journal: Food & nutrition research 20100101
Title: Machine learning methods for prediction of CDK-inhibitors.
Journal: PloS one 20100101
Title: Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia.
Journal: Molecular cancer 20100101
Title: The binding of flavopiridol to blood serum albumin.
Journal: Chirality 20100101
Title: Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.
Journal: PloS one 20100101
Title: Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen.
Journal: BMC cancer 20100101
Title: Understanding and managing ultra high-risk chronic lymphocytic leukemia.
Journal: Hematology. American Society of Hematology. Education Program 20100101
Title: Survivin-T34A: molecular mechanism and therapeutic potential.
Journal: OncoTargets and therapy 20100101
Title: Application of new drugs in chronic lymphocytic leukemia.
Journal: Mediterranean journal of hematology and infectious diseases 20100101
Title: Allogeneic hematopoietic cell transplantation in the treatment of chronic lymphocytic leukemia: why and when?
Journal: Mediterranean journal of hematology and infectious diseases 20100101
Title: Allogeneic transplantation for chronic lymphocytic leukemia.
Journal: Mediterranean journal of hematology and infectious diseases 20100101
Title: Anticancer drugs from marine flora: an overview.
Journal: Journal of oncology 20100101
Title: Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II.
Journal: Nano reviews 20100101
Title: The role of ofatumumab in the treatment of chronic lymphocytic leukemia resistant to previous therapies.
Journal: Journal of blood medicine 20100101
Title: Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210
Title: Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis.
Journal: Leukemia 20091201
Title: Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091201
Title: Misguided transcriptional elongation causes mixed lineage leukemia.
Journal: PLoS biology 20091101
Title: Flavopiridol reduces the impedance of neural prostheses in vivo without affecting recording quality.
Journal: Journal of neuroscience methods 20091015
Title: SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.
Journal: Molecular cell 20091009
Title: Modern concepts in the treatment of chronic lymphocytic leukemia.
Journal: Hematology (Amsterdam, Netherlands) 20091001
Title: Emerging therapies for patients with advanced chronic lymphocytic leukaemia.
Journal: Blood reviews 20090901
Title: New agents in acute myeloid leukemia: beyond cytarabine and anthracyclines.
Journal: Current oncology reports 20090901
Title: Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication.
Journal: Chembiochem : a European journal of chemical biology 20090817
Title: CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.
Journal: EMBO reports 20090801
Title: Electron transfer properties and catalytic competence of cytochrome b5 in the fusion protein Hmwb5-EGFP in reactions catalyzed by cytochrome P450 3A4.
Journal: Biochemistry. Biokhimiia 20090801
Title: Treatment of fludarabine-refractory chronic lymphocytic leukemia.
Journal: Cancer 20090701
Title: The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity.
Journal: Haematologica 20090701
Title: Apoptosis of t(14;18)-positive lymphoma cells by a Bcl-2 interacting small molecule.
Journal: Journal of hematopathology 20090701
Title: Association between plasma homocysteine and riboflavin status in Acute Lymphoblastic Leukemia in children.
Journal: Indian journal of clinical biochemistry : IJCB 20090701
Title: Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism.
Journal: British journal of cancer 20090616
Title: Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.
Journal: Cardiovascular research 20090601
Title: Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Journal: Blood 20090507
Title: The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501
Title: Camptothecin releases P-TEFb from the inactive 7SK snRNP complex.
Journal: Cell cycle (Georgetown, Tex.) 20090415
Title: Transforming growth factor-{beta}-inducible phosphorylation of Smad3.
Journal: The Journal of biological chemistry 20090410
Title: Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.
Journal: British journal of cancer 20090407
Title: Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential.
Journal: British journal of cancer 20090407
Title: A cell cycle timer for asymmetric spindle positioning.
Journal: PLoS biology 20090401
Title: The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease.
Journal: Aging 20090401
Title: Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia.
Journal: Blood 20090319
Title: Targeting MET transcription as a therapeutic strategy in multiple myeloma.
Journal: Cancer chemotherapy and pharmacology 20090301
Title: Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol.
Journal: Leukemia 20090301
Title: Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro.
Journal: IUBMB life 20090301
Title: Role of the HIV-1 positive elongation factor P-TEFb and inhibitors thereof.
Journal: Mini reviews in medicinal chemistry 20090301
Title: Treatment resistance in chronic lymphocytic leukemia: the role of the p53 pathway.
Journal: Leukemia & lymphoma 20090301
Title: Development of cell-cycle inhibitors for cancer therapy.
Journal: Current oncology (Toronto, Ont.) 20090301
Title: Multiple, but concerted cellular activities of the human protein Hap46/BAG-1M and isoforms.
Journal: International journal of molecular sciences 20090301
Title: Molecular pathology of neuro-AIDS (CNS-HIV).
Journal: International journal of molecular sciences 20090301
Title: Enhancement of the activity of phenoxodiol by cisplatin in prostate cancer cells.
Journal: British journal of cancer 20090224
Title: Retinoblastoma tumor suppressor gene expression determines the response to sequential flavopiridol and doxorubicin treatment in small-cell lung carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215
Title: The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.
Journal: Oncology reports 20090201
Title: A novel liposomal formulation of flavopiridol.
Journal: International journal of pharmaceutics 20090105
Title: Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
Journal: PloS one 20090101
Title: Regulation of the retinoblastoma proteins by the human herpesviruses.
Journal: Cell division 20090101
Title: Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.
Journal: PloS one 20090101
Title: Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy.
Journal: Molecular cancer 20090101
Title: A novel endo-hydrogenase activity recycles hydrogen produced by nitrogen fixation.
Journal: PloS one 20090101
Title: Circulating tumor cells in HER-2 positive metastatic breast cancer patients treated with trastuzumab and chemotherapy.
Journal: The International journal of biological markers 20090101
Title: Changing patterns of West Nile virus transmission: altered vector competence and host susceptibility.
Journal: Veterinary research 20090101
Title: A phase II study of flavopiridol (Alvocidib) in combination with docetaxel in refractory, metastatic pancreatic cancer.
Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20090101
Title: Regioselective biooxidation of (+)-valencene by recombinant E. coli expressing CYP109B1 from Bacillus subtilis in a two-liquid-phase system.
Journal: Microbial cell factories 20090101
Title: Synergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia.
Journal: PloS one 20090101
Title: Update in the management of chronic lymphocytic leukemia.
Journal: Journal of hematology & oncology 20090101
Title: 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.
Journal: Virology journal 20090101
Title: Vorinostat in solid and hematologic malignancies.
Journal: Journal of hematology & oncology 20090101
Title: Gastrointestinal stromal tumor.
Journal: World journal of surgical oncology 20090101
Title: The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status.
Journal: BMC cancer 20090101
Title: Knocking-down cyclin A(2) by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin.
Journal: PloS one 20090101
Title: P-TEFb- the final frontier.
Journal: Cell division 20090101
Title: Malignant rhabdoid tumour of the liver in the young adult: report of first two cases.
Journal: HPB surgery : a world journal of hepatic, pancreatic and biliary surgery 20090101
Title: Flavopiridol in chronic lymphocytic leukemia: a concise review.
Journal: Clinical lymphoma & myeloma 20090101
Title: Proteomics, pathway array and signaling network-based medicine in cancer.
Journal: Cell division 20090101
Title: PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro.
Journal: Breast cancer research : BCR 20090101
Title: Mitotic exit in mammalian cells.
Journal: Molecular systems biology 20090101
Title: Current and emerging treatments for chronic lymphocytic leukaemia.
Journal: Drugs 20090101
Title: State-of-the-art treatment of chronic lymphocytic leukemia.
Journal: Hematology. American Society of Hematology. Education Program 20090101
Title: Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.
Journal: Retrovirology 20090101
Title: InPACdb--Indian plant anticancer compounds database.
Journal: Bioinformation 20090101
Title: Role of bendamustine in the treatment of chronic lymphocytic leukemia.
Journal: OncoTargets and therapy 20090101
Title: Effects of celecoxib and ly117018 combination on human breast cancer cells in vitro.
Journal: Breast cancer : basic and clinical research 20090101
Title: 4-arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients.
Journal: Experimental hematology 20081201
Title: Future research directions for the treatment of AML.
Journal: Clinical advances in hematology & oncology : H&O 20081101
Title: Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma.
Journal: Therapeutic drug monitoring 20081001
Title: Involvement of Pinus taeda MYB1 and MYB8 in phenylpropanoid metabolism and secondary cell wall biogenesis: a comparative in planta analysis.
Journal: Journal of experimental botany 20081001
Title: Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II.
Journal: PLoS genetics 20081001
Title: Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
Journal: British journal of cancer 20080902
Title: Combinatorial antileukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide 2-(2,4-difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and flavopiridol.
Journal: Molecular pharmacology 20080901
Title: Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity.
Journal: Bioorganic & medicinal chemistry 20080801
Title: Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed.
Journal: International journal of radiation oncology, biology, physics 20080801
Title: Novel agents in chronic lymphocytic leukemia: efficacy and tolerability of new therapies.
Journal: Clinical lymphoma & myeloma 20080801
Title: The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
Journal: The EMBO journal 20080709
Title: Mantle cell lymphoma: advances in biology and therapy.
Journal: Current opinion in hematology 20080701
Title: A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.
Journal: Nature chemical biology 20080601
Title: Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080601
Title: Flavopiridol-induced iNOS downregulation during apoptosis of chronic lymphocytic leukemia cells is caspase-dependent.
Journal: Leukemia research 20080501
Title: Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.
Journal: Journal of neurochemistry 20080501
Title: Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
Journal: Molecular pharmacology 20080501
Title: CDK9 a potential target for drug development.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20080501
Title: Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with non-small-cell lung cancer.
Journal: Clinical lung cancer 20080501
Title: Flavopiridol displays preclinical activity in acute lymphoblastic leukemia.
Journal: Pediatric blood & cancer 20080401
Title: Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin.
Journal: Chromosoma 20080401
Title: The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
Journal: Cancer research 20080401
Title: Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium.
Journal: Blood 20080315
Title: Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors.
Journal: British journal of cancer 20080311
Title: P-TEFb inhibitors interfere with activation of p53 by DNA-damaging agents.
Journal: Oncogene 20080221
Title: Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080201
Title: Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals.
Journal: Molecular cell 20080118
Title: Updates on p53: modulation of p53 degradation as a therapeutic approach.
Journal: British journal of cancer 20080115
Title: Rhabdoid tumor growth is inhibited by flavopiridol.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080115
Title: CDK inhibitors in cancer therapy: what is next?
Journal: Trends in pharmacological sciences 20080101
Title: A quantitative analysis of kinase inhibitor selectivity.
Journal: Nature biotechnology 20080101
Title: Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells.
Journal: Molecular cancer 20080101
Title: ABCG2: structure, function and role in drug response.
Journal: Expert opinion on drug metabolism & toxicology 20080101
Title: A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials.
Journal: PloS one 20080101
Title: Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.
Journal: BMC cancer 20080101
Title: Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.
Journal: Retrovirology 20080101
Title: Implications of the involvement of the endoplasmic reticulum stress pathway in drug-induced apoptosis.
Journal: Anticancer research 20080101
Title: Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways.
Journal: AIDS research and therapy 20080101
Title: Genotyping panel for assessing response to cancer chemotherapy.
Journal: BMC medical genomics 20080101
Title: Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds).
Journal: Genome biology 20080101
Title: Molecular targeted therapies for breast cancer treatment.
Journal: Breast cancer research : BCR 20080101
Title: Characterization of the p53 response to oncogene-induced senescence.
Journal: PloS one 20080101
Title: Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression.
Journal: BMC genomics 20080101
Title: Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene.
Journal: Retrovirology 20080101
Title: Gene expression profiling for molecular distinction and characterization of laser captured primary lung cancers.
Journal: Journal of translational medicine 20080101
Title: Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice.
Journal: BMC cell biology 20080101
Title: Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin.
Journal: Nutrition research and practice 20080101
Title: The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
Journal: The Journal of biological chemistry 20071221
Title: Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.
Journal: Gene 20071215
Title: Lack of association between common polymorphisms in UGT1A9 and gene expression and activity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071201
Title: Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.
Journal: Molecular cancer therapeutics 20071201
Title: Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat.
Journal: Biologics : targets & therapy 20071201
Title: Targeted therapies in the management of metastatic bladder cancer.
Journal: Biologics : targets & therapy 20071201
Title: Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F.
Journal: British journal of cancer 20071105
Title: Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury.
Journal: Brain : a journal of neurology 20071101
Title: Glutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071101
Title: Flavopiridol in the treatment of chronic lymphocytic leukemia.
Journal: Current opinion in oncology 20071101
Title: [Therapeutic effect of flavopiridol, a small molecular cyclin-dependent kinase inhibitor, in human ovarian carcinoma].
Journal: Zhonghua fu chan ke za zhi 20071101
Title: Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071001
Title: Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells.
Journal: International journal of cancer 20070915
Title: Novel agents and strategies for treatment of p53-defective chronic lymphocytic leukemia.
Journal: Best practice & research. Clinical haematology 20070901
Title: Zebrafish as a model system to screen radiation modifiers.
Journal: Current genomics 20070901
Title: The molecular genetics of breast cancer and targeted therapy.
Journal: Biologics : targets & therapy 20070901
Title: Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20070801
Title: Flavopiridol synergizes TRAIL cytotoxicity by downregulation of FLIPL.
Journal: Cancer chemotherapy and pharmacology 20070801
Title: UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers.
Journal: Pharmacogenetics and genomics 20070801
Title: Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070801
Title: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels.
Journal: Cancer research 20070715
Title: Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells.
Journal: British journal of cancer 20070521
Title: Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation.
Journal: Neuroscience letters 20070517
Title: Cell cycle inhibition and retinoblastoma protein overexpression prevent Purkinje cell death in organotypic slice cultures.
Journal: Developmental neurobiology 20070501
Title: [DMF induces apoptosis in human androgen-independent prostate cancer PC3 cells in vitro].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070501
Title: [Research on cyclin-dependent kinase inhibitors: state of the art and perspective].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070501
Title: Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons.
Journal: Neuroscience 20070425
Title: In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia.
Journal: British journal of haematology 20070401
Title: Levels of p27(kip1) determine Aplidin sensitivity.
Journal: Molecular cancer therapeutics 20070401
Title: Identifying the membrane proteome of HIV-1 latently infected cells.
Journal: The Journal of biological chemistry 20070316
Title: ABCG2: determining its relevance in clinical drug resistance.
Journal: Cancer metastasis reviews 20070301
Title: Small molecule inhibitors of Stat3 signaling pathway.
Journal: Current cancer drug targets 20070201
Title: Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.
Journal: Molecular cancer therapeutics 20070201
Title: Timed-sequential chemotherapy as induction and/or consolidation regimen for younger adults with acute myelogenous leukemia.
Journal: Hematology (Amsterdam, Netherlands) 20070201
Title: Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia.
Journal: Blood 20070115
Title: Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues.
Journal: Bioorganic & medicinal chemistry 20070115
Title: A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days.
Journal: British journal of cancer 20070115
Title: Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication.
Journal: PLoS pathogens 20070101
Title: Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression.
Journal: Molecular cancer 20070101
Title: Phylogeny and molecular signatures (conserved proteins and indels) that are specific for the Bacteroidetes and Chlorobi species.
Journal: BMC evolutionary biology 20070101
Title: Differential expression and role of p21cip/waf1 and p27kip1 in TNF-alpha-induced inhibition of proliferation in human glioma cells.
Journal: Molecular cancer 20070101
Title: Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex.
Journal: Retrovirology 20070101
Title: The effect of versican G3 domain on local breast cancer invasiveness and bony metastasis.
Journal: Breast cancer research : BCR 20070101
Title: Enhancing the anti-angiogenic action of histone deacetylase inhibitors.
Journal: Molecular cancer 20070101
Title: Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.
Journal: Bioorganic & medicinal chemistry 20061201
Title: Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.
Journal: Cancer research 20061201
Title: Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Journal: Annals of the New York Academy of Sciences 20061201
Title: A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia.
Journal: Cancer research 20061115
Title: Induction of apoptosis and down regulation of cell cycle proteins in mantle cell lymphoma by flavopiridol treatment.
Journal: Leukemia research 20061101
Title: Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos.
Journal: International journal of radiation oncology, biology, physics 20061001
Title: Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors, induce apoptosis, and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer.
Journal: The Prostate 20061001
Title: Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel, flavopiridol, and 5-fluorouracil.
Journal: Acta pharmacologica Sinica 20061001
Title: New directions in the treatment of mantle cell lymphoma: an overview.
Journal: Clinical lymphoma & myeloma 20061001
Title: The role of CDK5/P25 formation/inhibition in neurodegeneration.
Journal: Drug news & perspectives 20061001
Title: Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells.
Journal: Cancer research 20060915
Title: Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells.
Journal: Cancer research 20060915
Title: Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.
Journal: Cell death and differentiation 20060901
Title: Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells.
Journal: Cancer research 20060901
Title: The cyclin-dependent kinase inhibitor flavopiridol sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis.
Journal: International journal of molecular medicine 20060801
Title: Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20060801
Title: Alvocidib (Flavopiridol) suppresses tumor growth in SCID mice with human esophageal cancer xenografts without inducing apoptosis.
Journal: Surgical oncology 20060801
Title: MicroRNAs in leukemia.
Journal: Clinical advances in hematology & oncology : H&O 20060801
Title: A phase I study of flavopiridol and docetaxel.
Journal: Investigational new drugs 20060701
Title: Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons.
Journal: Life sciences 20060627
Title: Trypanosoma cruzi Tcp12CKS1 interacts with parasite CRKs and rescues the p13SUC1 fission yeast mutant.
Journal: Molecular and biochemical parasitology 20060601
Title: Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.
Journal: Cancer research 20060601
Title: Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01.
Journal: British journal of cancer 20060522
Title: HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription.
Journal: Archives of biochemistry and biophysics 20060515
Title: Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells.
Journal: Molecular cancer therapeutics 20060501
Title: Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization.
Journal: Biochemistry 20060425
Title: The reversibility of mitotic exit in vertebrate cells.
Journal: Nature 20060413
Title: Cyclin-dependent kinase pathways as targets for cancer treatment.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060410
Title: A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity.
Journal: Cancer research 20060315
Title: The first metal-based paullone derivative with high antiproliferative activity in vitro.
Journal: Inorganic chemistry 20060306
Title: Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points.
Journal: Haematologica 20060301
Title: Selectivity and potency of cyclin-dependent kinase inhibitors.
Journal: The AAPS journal 20060301
Title: TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt.
Journal: British journal of cancer 20060213
Title: Cyclin D1 overexpression increases the susceptibility of human U266 myeloma cells to CDK inhibitors through a process involving p130-, p107- and E2F-dependent S phase entry.
Journal: Cell cycle (Georgetown, Tex.) 20060201
Title: Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.
Journal: Molecular pharmacology 20060101
Title: Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol.
Journal: Cell cycle (Georgetown, Tex.) 20060101
Title: Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein.
Journal: Expert opinion on investigational drugs 20060101
Title: Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.
Journal: Molecular cancer therapeutics 20060101
Title: A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.
Journal: Journal of natural products 20060101
Title: Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53: necrosis vs. apoptosis.
Journal: Anticancer research 20060101
Title: Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.
Journal: Molecular cancer 20060101
Title: Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics.
Journal: Current pharmaceutical design 20060101
Title: Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells.
Journal: Retrovirology 20060101
Title: Targeting gonadotropins: an alternative option for Alzheimer disease treatment.
Journal: Journal of biomedicine & biotechnology 20060101
Title: Protein kinase inhibitors.
Journal: Folia biologica 20060101
Title: Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest.
Journal: Molecular cancer 20060101
Title: A Phase II Study of Flavopiridol in Patients With Previously Untreated Advanced Soft Tissue Sarcoma.
Journal: Sarcoma 20060101
Title: Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: a Children's Oncology Group Study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220
Title: Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication.
Journal: AIDS (London, England) 20051202
Title: Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051201
Title: Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.
Journal: Journal of medicinal chemistry 20051103
Title: Flavopiridol administered as a 24-hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity.
Journal: Leukemia research 20051101
Title: Ligand binding affinity determined by temperature-dependent circular dichroism: cyclin-dependent kinase 2 inhibitors.
Journal: Analytical biochemistry 20051015
Title: Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death.
Journal: Blood 20051001
Title: Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia.
Journal: British journal of haematology 20051001
Title: Transactivation of cyclin E gene by EWS-Fli1 and antitumor effects of cyclin dependent kinase inhibitor on Ewing's family tumor cells.
Journal: International journal of cancer 20050901
Title: Role of the cell cycle in the pathobiology of central nervous system trauma.
Journal: Cell cycle (Georgetown, Tex.) 20050901
Title: Biology and therapy of mantle cell lymphoma.
Journal: Current opinion in oncology 20050901
Title: Plants as a source of anti-cancer agents.
Journal: Journal of ethnopharmacology 20050822
Title: Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050815
Title: A phase II evaluation of flavopiridol as second-line chemotherapy of endometrial carcinoma: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20050801
Title: A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines.
Journal: Investigational new drugs 20050801
Title: Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics.
Journal: Cancer science 20050801
Title: A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
Journal: Cancer research 20050715
Title: Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.
Journal: Oncogene 20050714
Title: A phase II study of flavopiridol in patients with advanced renal cell carcinoma: results of Southwest Oncology Group Trial 0109.
Journal: Cancer chemotherapy and pharmacology 20050701
Title: Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy.
Journal: Neuro-oncology 20050701
Title: Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines.
Journal: Investigational new drugs 20050601
Title: Chronic lymphocytic leukemia: a niche for flavopiridol?
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050601
Title: Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: results from Cancer and Leukemia Group B study 19805.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050601
Title: Enhancement of radiation effects by flavopiridol in uterine cervix cancer cells.
Journal: Cancer research and treatment : official journal of Korean Cancer Association 20050601
Title: A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050515
Title: Drugging cell cycle kinases in cancer therapy.
Journal: Current drug targets 20050501
Title: Flavopiridol sensitivity of cancer cells isolated from ascites and pleural fluids.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050501
Title: Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.
Journal: Cancer research 20050501
Title: Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases.
Journal: Bioorganic & medicinal chemistry letters 20050401
Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.
Journal: Pharmacology & therapeutics 20050401
Title: Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin.
Journal: Cancer biology & therapy 20050401
Title: Recent progress in the discovery and development of cyclin-dependent kinase inhibitors.
Journal: Expert opinion on investigational drugs 20050401
Title: [A novel small molecule cyclin-dependent kinase inhibitor flavopiridol in cancer therapy].
Journal: Zhonghua yi xue za zhi 20050330
Title: Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice.
Journal: Oncogene 20050303
Title: A small molecule-kinase interaction map for clinical kinase inhibitors.
Journal: Nature biotechnology 20050301
Title: CDK2/4 regulate retinoic acid-induced G1 arrest in hepatocellular carcinoma cells.
Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20050301
Title: Flavopiridol blocks integrin-mediated survival in dormant breast cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050301
Title: Sequence dependent potentiation of gemcitabine by flavopiridol in human breast cancer cells.
Journal: Breast cancer research and treatment 20050301
Title: Advances on cyclin-dependent kinases (CDKs) as novel targets for antiviral drugs.
Journal: Current drug targets. Infectious disorders 20050301
Title: Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
Journal: Journal of medicinal chemistry 20050210
Title: Combination therapy for adult T-cell leukemia-xenografted mice: flavopiridol and anti-CD25 monoclonal antibody.
Journal: Blood 20050201
Title: A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation.
Journal: PLoS biology 20050201
Title: Clinical anticancer drug development: targeting the cyclin-dependent kinases.
Journal: British journal of cancer 20050117
Title: Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases.
Journal: Medical hypotheses 20050101
Title: Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer.
Journal: BMC urology 20050101
Title: Blockage of cyclin cdk's, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: evidence for interactive effects of flavopiridol, LY 294002, roscovitine,wortmannin and UCN-01.
Journal: Anticancer research 20050101
Title: Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons.
Journal: Journal of molecular neuroscience : MN 20050101
Title: New concepts in the treatment of acute myeloid malignancies: selected pathways for targeted therapy.
Journal: Journal of biological regulators and homeostatic agents 20050101
Title: ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.
Journal: Cancer cell international 20050101
Title: Cell cycle regulatory kinase modulators: interim progress and issues.
Journal: Current topics in medicinal chemistry 20050101
Title: Inhibitors of cyclin-dependent kinase modulators for cancer therapy.
Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20050101
Title: Tat gets the 'green' light on transcription initiation.
Journal: Retrovirology 20050101
Title: Flavopiridol, an inhibitor of cyclin-dependent kinases, induces growth inhibition and apoptosis in bladder cancer cells in vitro and in vivo.
Journal: Anticancer research 20050101
Title: Chemosensitization and radiosensitization of tumors by plant polyphenols.
Journal: Antioxidants & redox signaling 20050101
Title: Scutellaria baicalensis decreases ritonavir-induced nausea.
Journal: AIDS research and therapy 20050101
Title: SW-620 cells treated with topoisomerase I inhibitor SN-38: gene expression profiling.
Journal: Journal of translational medicine 20050101
Title: Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
Title: Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment.
Journal: British journal of cancer 20041213
Title: Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo.
Journal: Brain research. Molecular brain research 20041206
Title: Flavopiridol, an inhibitor of transcription: implications, problems and solutions.
Journal: Cell cycle (Georgetown, Tex.) 20041201
Title: E2F4 deficiency promotes drug-induced apoptosis.
Journal: Cancer biology & therapy 20041201
Title: The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.
Journal: Molecular cancer therapeutics 20041201
Title: Molecular models of cyclin-dependent kinase 1 complexed with inhibitors.
Journal: Biochemical and biophysical research communications 20041112
Title: Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation.
Journal: Leukemia 20041101
Title: Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
Journal: Molecular pharmacology 20041001
Title: From chemoprevention to chemotherapy: common targets and common goals.
Journal: Expert opinion on investigational drugs 20041001
Title: A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.
Journal: Cell cycle (Georgetown, Tex.) 20041001
Title: Nuclear survivin as a biomarker for non-small-cell lung cancer.
Journal: British journal of cancer 20040802
Title: Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma.
Journal: Investigational new drugs 20040801
Title: Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801
Title: Charge optimization of the interface between protein kinases and their ligands.
Journal: Journal of computational chemistry 20040801
Title: Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells.
Journal: Leukemia research 20040801
Title: Phase I trial of the cyclin-dependent kinase inhibitor flavopiridol in combination with docetaxel in patients with metastatic breast cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040801
Title: Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.
Journal: Blood 20040715
Title: Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse.
Journal: International journal of radiation oncology, biology, physics 20040715
Title: Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site.
Journal: Journal of medicinal chemistry 20040701
Title: Transcriptional signature of flavopiridol-induced tumor cell death.
Journal: Molecular cancer therapeutics 20040701
Title: Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?
Journal: Molecular cancer therapeutics 20040701
Title: Advances in chemotherapy for chronic lymphocytic leukemia.
Journal: Seminars in hematology 20040701
Title: Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040615
Title: Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases.
Journal: Bioorganic & medicinal chemistry letters 20040607
Title: Bioluminescent imaging of Cdk2 inhibition in vivo.
Journal: Nature medicine 20040601
Title: Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature.
Journal: Lung cancer (Amsterdam, Netherlands) 20040601
Title: Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.
Journal: European journal of biochemistry 20040601
Title: Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity.
Journal: Anti-cancer drugs 20040601
Title: Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
Journal: Cancer research 20040515
Title: Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor.
Journal: Cancer research 20040515
Title: Growth inhibition and induction of apoptosis by flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines.
Journal: Oncology reports 20040501
Title: Enhancement of radiation effects by combined docetaxel and flavopiridol treatment in lung cancer cells.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20040501
Title: Using patients as their own controls for cost evaluation of phase I clinical trials.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040401
Title: Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.
Journal: Molecular cancer therapeutics 20040401
Title: N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
Journal: Journal of medicinal chemistry 20040325
Title: Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication.
Journal: Biochimica et biophysica acta 20040311
Title: Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents.
Journal: Current oncology reports 20040301
Title: Combining flavopiridol with various signal transduction inhibitors.
Journal: Oncology reports 20040301
Title: Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol.
Journal: Molecular pharmacology 20040301
Title: Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040301
Title: Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Journal: The Journal of biological chemistry 20040206
Title: Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment.
Journal: The Journal of pharmacology and experimental therapeutics 20040201
Title: Mantle cell lymphoma: established therapeutic options and future directions.
Journal: Annals of hematology 20040201
Title: Flavopiridol: where do we stand in chronic lymphocytic leukemia?
Journal: Leukemia 20040201
Title: Flavopiridol inhibits the growth of GL261 gliomas in vivo: implications for malignant glioma therapy.
Journal: Cell cycle (Georgetown, Tex.) 20040201
Title: A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201
Title: Cyclosporin A enhances colchicine-induced apoptosis in rat cerebellar granule neurons.
Journal: British journal of pharmacology 20040201
Title: Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.
Journal: Molecular cell 20040116
Title: A novel approach to develop anti-HIV drugs: adapting non-nucleoside anticancer chemotherapeutics.
Journal: Antiviral research 20040101
Title: Cell-cycle targeted therapies.
Journal: The Lancet. Oncology 20040101
Title: 26th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 3-6 December 2003: update on preclinical and translational research.
Journal: Breast cancer research : BCR 20040101
Title: The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.
Journal: Retrovirology 20040101
Title: Diffuse aggressive lymphoma.
Journal: Hematology. American Society of Hematology. Education Program 20040101
Title: Flavopiridol as a radio-sensitizer for esophageal cancer cell lines.
Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20040101
Title: Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53.
Journal: Advances in enzyme regulation 20040101
Title: Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment.
Journal: Angiogenesis 20040101
Title: Acetaminophen and DMSO modulate growth and gemcitabine cytotoxicity in FM3A breast cancer cells in vitro.
Journal: Neoplasma 20040101
Title: In vitro cell growth pharmacodynamic studies: a new nonparametric approach to determining the relative importance of drug concentration and treatment time.
Journal: Cancer chemotherapy and pharmacology 20031201
Title: Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia.
Journal: Leukemia 20031201
Title: Perspectives on cancer therapy: cell cycle blockers and perturbators.
Journal: Current medicinal chemistry 20031201
Title: Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis.
Journal: Molecular pharmacology 20031201
Title: The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031201
Title: The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: impact on therapy.
Journal: International journal of clinical pharmacology and therapeutics 20031201
Title: The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols.
Journal: Annals of the New York Academy of Sciences 20031201
Title: Inhibition of CDKs: a strategy for preventing kainic acid-induced apoptosis in neurons.
Journal: Annals of the New York Academy of Sciences 20031201
Title: Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.
Journal: British journal of cancer 20031117
Title: Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
Journal: Molecular pharmacology 20031101
Title: Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity.
Journal: Cancer research 20031101
Title: Cell cycle modulators for the treatment of lung malignancies.
Journal: Clinical lung cancer 20031101
Title: Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells.
Journal: British journal of cancer 20031020
Title: Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).
Journal: Oncogene 20031020
Title: Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2).
Journal: Life sciences 20031017
Title: Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.
Journal: Oncogene 20031016
Title: Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031001
Title: Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.
Journal: Neuropharmacology 20031001
Title: Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.
Journal: The Journal of pharmacology and experimental therapeutics 20031001
Title: Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.
Journal: The Annals of pharmacotherapy 20031001
Title: Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
Title: Small-molecule cyclin-dependent kinase modulators.
Journal: Oncogene 20030929
Title: Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells.
Journal: Brain research. Molecular brain research 20030819
Title: Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030815
Title: Phase II study of flavopiridol in patients with advanced colorectal cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030801
Title: Cyclin-dependent kinase inhibitors.
Journal: Current opinion in pharmacology 20030801
Title: A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors.
Journal: Journal of medicinal chemistry 20030717
Title: Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.
Journal: Cancer research 20030715
Title: Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Journal: Cancer chemotherapy and pharmacology 20030701
Title: Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer.
Journal: Cancer research 20030701
Title: Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells.
Journal: Cancer research 20030615
Title: Commentary: effect of flavonoids on normal and leukemic cells.
Journal: Leukemia research 20030601
Title: Flavonoid effects on normal and leukemic cells.
Journal: Leukemia research 20030601
Title: Mantle cell lymphoma: therapeutic strategies are different from CLL.
Journal: Current treatment options in oncology 20030601
Title: The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines.
Journal: Melanoma research 20030601
Title: CDK inhibitors in clinical development for the treatment of cancer.
Journal: Expert opinion on investigational drugs 20030601
Title: Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells.
Journal: Molecular cancer therapeutics 20030601
Title: The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer.
Journal: Cell proliferation 20030601
Title: Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501
Title: Signal transduction inhibitors in the treatment of breast cancer.
Journal: Current medicinal chemistry. Anti-cancer agents 20030501
Title: Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: activation of the mitochondria-dependent death-signaling pathway.
Journal: The Journal of thoracic and cardiovascular surgery 20030501
Title: The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
Journal: Cancer research 20030415
Title: Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol.
Journal: The Journal of antimicrobial chemotherapy 20030401
Title: Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.
Journal: Molecular carcinogenesis 20030401
Title: 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.
Journal: Bioorganic & medicinal chemistry letters 20030324
Title: Mechanism of H-8 inhibition of cyclin-dependent kinase 9: study using inhibitor-immobilized matrices.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20030301
Title: Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030215
Title: Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines.
Journal: Cancer research 20030201
Title: Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms.
Journal: Anti-cancer drugs 20030201
Title: Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030201
Title: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway.
Journal: Molecular cancer therapeutics 20030201
Title: The use of cyclin-dependent kinase inhibitors alone or in combination with established cytotoxic drugs in cancer chemotherapy.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20030201
Title: Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.
Journal: Leukemia & lymphoma 20030201
Title: Signal transduction--directed cancer treatments.
Journal: Annual review of pharmacology and toxicology 20030101
Title: Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells.
Journal: Oral oncology 20030101
Title: Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.
Journal: Cancer research 20030101
Title: Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.
Journal: Cancer research 20030101
Title: Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.
Journal: Molecular cancer therapeutics 20030101
Title: Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.
Journal: Molecular cancer therapeutics 20030101
Title: Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030101
Title: The prolyl isomerase Pin1 in breast development and cancer.
Journal: Breast cancer research : BCR 20030101
Title: Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies.
Journal: Current medicinal chemistry. Anti-cancer agents 20030101
Title: Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.
Journal: Cell cycle (Georgetown, Tex.) 20030101
Title: Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor.
Journal: Cell cycle (Georgetown, Tex.) 20030101
Title: Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030101
Title: c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases.
Journal: Cell cycle (Georgetown, Tex.) 20030101
Title: Novel small molecule cyclin-dependent kinases modulators in human clinical trials.
Journal: Cancer biology & therapy 20030101
Title: Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis.
Journal: The Journal of biological chemistry 20021213
Title: New insights in the transcriptional activity and coregulator molecules in the arterial wall.
Journal: International journal of cardiology 20021201
Title: Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol.
Journal: Cancer chemotherapy and pharmacology 20021201
Title: Pharmacological treatments for prostate cancer.
Journal: Expert opinion on investigational drugs 20021201
Title: Cyclin-dependent kinases as cellular targets for antiviral drugs.
Journal: The Journal of antimicrobial chemotherapy 20021201
Title: New anti-HIV agents and targets.
Journal: Medicinal research reviews 20021101
Title: The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021101
Title: Flavonoids as anticancer agents: structure-activity relationship study.
Journal: Current medicinal chemistry. Anti-cancer agents 20021101
Title: Zebrafish: a preclinical model for drug screening.
Journal: Assay and drug development technologies 20021101
Title: Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021001
Title: Cyclin-dependent kinases as new targets for the prevention and treatment of cancer.
Journal: Hematology/oncology clinics of North America 20021001
Title: A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma.
Journal: Biomedical chromatography : BMC 20020901
Title: Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020901
Title: Clinical trials referral resource. Flavopiridol.
Journal: Oncology (Williston Park, N.Y.) 20020901
Title: Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
Journal: Journal of medicinal chemistry 20020829
Title: Progress toward the development of agents to modulate the cell cycle.
Journal: Current opinion in chemical biology 20020801
Title: Hematologic malignancies: new developments and future treatments.
Journal: Seminars in oncology 20020801
Title: New developments in anti-HIV chemotherapy.
Journal: Biochimica et biophysica acta 20020718
Title: Targeting the cell cycle for cancer therapy.
Journal: British journal of cancer 20020715
Title: Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells.
Journal: Cancer research 20020715
Title: Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
Journal: Leukemia 20020701
Title: Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.
Journal: Molecular cancer therapeutics 20020701
Title: Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma.
Journal: International journal of cancer 20020610
Title: Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.
Journal: Molecular pharmacology 20020601
Title: Review of flavopiridol, a cyclin-dependent kinase inhibitor, as breast cancer therapy.
Journal: Seminars in oncology 20020601
Title: Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity.
Journal: The Journal of pharmacology and experimental therapeutics 20020501
Title: Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development.
Journal: The Annals of pharmacotherapy 20020501
Title: Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi.
Journal: Molecular and biochemical parasitology 20020501
Title: In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes.
Journal: Pharmaceutical research 20020501
Title: Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol.
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Title: Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Journal: Journal of medicinal chemistry 20020425
Title: Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol.
Journal: Cancer research 20020415
Title: Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020415
Title: Developmental therapeutics program at the NCI: molecular target and drug discovery process.
Journal: Leukemia 20020401
Title: Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma.
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Journal: Mini reviews in medicinal chemistry 20020401
Title: Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.
Journal: Cancer research 20020315
Title: Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol.
Journal: Leukemia research 20020301
Title: Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors.
Journal: The Journal of biological chemistry 20020215
Title: Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y(2)-receptors.
Journal: British journal of cancer 20020212
Title: Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020201
Title: The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells.
Journal: Molecular cancer therapeutics 20020201
Title: Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals.
Journal: BMC biochemistry 20020101
Title: Finding the needle in the haystack: why high-throughput screening is good for your health.
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Title: The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.
Journal: The oncologist 20020101
Title: Cytotoxic agents in the era of molecular targets and genomics.
Journal: The oncologist 20020101
Title: Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis.
Journal: Cancer biology & therapy 20020101
Title: ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin.
Journal: Anticancer research 20020101
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Title: HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy.
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Title: CDK inhibitors: cell cycle arrest versus apoptosis.
Journal: Cell cycle (Georgetown, Tex.) 20020101
Title: Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel.
Journal: Cancer biology & therapy 20020101
Title: Role reversal for anticancer agents.
Journal: Cancer biology & therapy 20020101
Title: Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors.
Journal: Cell cycle (Georgetown, Tex.) 20020101
Title: Cyclin-dependent kinases as targets for cancer therapy.
Journal: Cancer chemotherapy and biological response modifiers 20020101
Title: Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes.
Journal: Journal of the American Society of Nephrology : JASN 20011201
Title: Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Title: Perspectives for cancer therapies with cdk2 inhibitors.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20011201
Title: Early development of cyclin dependent kinase modulators.
Journal: Current pharmaceutical design 20011101
Title: Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.
Journal: Molecular pharmacology 20011101
Title: Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.
Journal: Neoplasia (New York, N.Y.) 20011101
Title: Advances in cancer therapy with plant based natural products.
Journal: Current medicinal chemistry 20011001
Title: Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents.
Journal: Current medicinal chemistry 20011001
Title: Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity.
Journal: British journal of cancer 20010901
Title: Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.
Journal: The Journal of biological chemistry 20010824
Title: Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit.
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Title: Flavopiridol. National Cancer Institute.
Journal: Current opinion in investigational drugs (London, England : 2000) 20010801
Title: The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway.
Journal: Cell death and differentiation 20010701
Title: Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia.
Journal: British journal of haematology 20010701
Title: A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010601
Title: Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.
Journal: Leukemia 20010601
Title: Mechanisms of action of flavopiridol.
Journal: Critical reviews in oncology/hematology 20010501
Title: Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases.
Journal: Hepatology (Baltimore, Md.) 20010501
Title: Effect of P-glycoprotein on flavopiridol sensitivity.
Journal: British journal of cancer 20010501
Title: The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.
Journal: Molecular and biochemical parasitology 20010406
Title: In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: involvement of UDP-glucuronosyltransferases 1A1 and 1A9.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010401
Title: Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010401
Title: [CDK inhibitors for therapy of cancer].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20010401
Title: Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity.
Journal: Cancer research 20010315
Title: The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
Journal: Cancer research 20010315
Title: Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins.
Journal: Molecular and biochemical parasitology 20010301
Title: The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase.
Journal: Archives of biochemistry and biophysics 20010215
Title: Possible mechanisms of diarrheal side effects associated with the use of a novel chemotherapeutic agent, flavopiridol.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010201
Title: Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas.
Journal: Seminars in cancer biology 20010201
Title: Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Journal: The Journal of biological chemistry 20010105
Title: Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010101
Title: Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
Journal: Leukemia 20010101
Title: Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1.
Journal: Neoplasia (New York, N.Y.) 20010101
Title: Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.
Journal: Blood cells, molecules & diseases 20010101
Title: Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.
Journal: Genome biology 20010101
Title: Cyclin-dependent kinase modulators: a novel class of cell cycle regulators for cancer therapy.
Journal: Cancer chemotherapy and biological response modifiers 20010101
Title: Rational approaches to design of therapeutics targeting molecular markers.
Journal: Hematology. American Society of Hematology. Education Program 20010101
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Title: Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol.
Journal: International journal of oncology 20001001
Title: Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
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Title: Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat.
Journal: Circulation 19990810
Title: Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells.
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Title: Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.
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