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541-41-3,MFCD00000644
Catalog No.:AA00DPJA

541-41-3 | Ethyl chloroformate

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DPJA
Chemical Name:
Ethyl chloroformate
CAS Number:
541-41-3
MDL Number:
MFCD00000644
UN Number:
1182
Properties
Properties
 
BP:
95.0°C  
Form:
Liquid  
MP:
-81 °C  
Refractive Index:
n20/D 1.395(lit.)  
Stability:
Moisture Sensitive  
Storage:
2-8℃;Inert atmosphere;  

Computed Properties
 
Complexity:
52.8  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
6  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
1.5  

Literature

Title: Development, validation and comparison of two microextraction techniques for the rapid and sensitive determination of pregabalin in urine and pharmaceutical formulations after ethyl chloroformate derivatization followed by gas chromatography-mass spectrometric analysis.

Journal: Journal of pharmaceutical and biomedical analysis 20121101

Title: Rapid and simultaneous determination of twenty amino acids in complex biological and food samples by solid-phase microextraction and gas chromatography-mass spectrometry with the aid of experimental design after ethyl chloroformate derivatization.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121015

Title: Intramolecular cyclization manifolds of 4-alkylpyridines bearing ambiphilic side chains: construction of spirodihydropyridines or benzylic cyclization via anhydrobase intermediates.

Journal: The Journal of organic chemistry 20120921

Title: GC/MS determination of ibotenic acid and muscimol in the urine of patients intoxicated with Amanita pantherina.

Journal: International journal of legal medicine 20120701

Title: Letter to the Editor regarding 'GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia'.

Journal: Analytical and bioanalytical chemistry 20120701

Title: Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

Journal: Journal of medicinal chemistry 20120308

Title: Highly selective and sensitive determination of free and total amino acids in Apocynum venetum L. (Luobuma tea) by a developed HPLC-FLD method coupled with pre-column fluorescent labelling.

Journal: International journal of food sciences and nutrition 20120301

Title: Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation.

Journal: Journal of experimental botany 20120201

Title: Ethyl 3-[(6-chloro-pyridin-3-yl)meth-yl]-2-oxoimidazolidine-1-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: Use of Linear Free Energy Relationships (LFERs) to elucidate the mechanisms of reaction of a γ-methyl-β-alkynyl and an ortho-substituted aryl chloroformate ester.

Journal: International journal of molecular sciences 20120101

Title: Biogenic amines in raw and processed seafood.

Journal: Frontiers in microbiology 20120101

Title: Self-assembled squalenoyl-cytarabine nanostructures as a potent nanomedicine for treatment of leukemic diseases.

Journal: International journal of nanomedicine 20120101

Title: Metabonomic Evaluation of ZHENG Differentiation and Treatment by Fuzhenghuayu Tablet in Hepatitis-B-Caused Cirrhosis.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Uses of 2-ethoxy-4(3H) quinazolinone in synthesis of quinazoline and quinazolinone derivatives of antimicrobial activity: the solvent effect.

Journal: Global journal of health science 20120101

Title: Reactivity of 2-ethoxyquinazolin- 4-yl hydrazine and its use in synthesis of novel quinazoline derivatives of antimicrobial activity.

Journal: Global journal of health science 20120101

Title: Extractive ethoxycarbonylation in high-temperature gas chromatography-mass spectrometry based analysis of serum estrogens.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111201

Title: rac-N,N'-Dimethyl-N,N'-(1,1'-binaphthyl-2,2'-di-yl)diformamide.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: 1,2-Dimeth-oxy-4-methyl-3-[(S)-p-tolyl-sulfin-yl]benzene.

Journal: Acta crystallographica. Section E, Structure reports online 20111101

Title: Application of ethyl chloroformate derivatization for solid-phase microextraction-gas chromatography-mass spectrometric determination of bisphenol-A in water and milk samples.

Journal: Analytical and bioanalytical chemistry 20110901

Title: Quantitative determination of free and total dopamine in human plasma by LC-MS/MS: the importance of sample preparation.

Journal: Bioanalysis 20110901

Title: Ethyl 3-oxo-2,3-dihydro-1,2-benzothia-zole-2-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20110901

Title: Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.

Journal: The Journal of organic chemistry 20110819

Title: Development of miracle medicines from sialic acids.

Journal: Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110610

Title: Microbial community and metabolomic comparison of irritable bowel syndrome faeces.

Journal: Journal of medical microbiology 20110601

Title: Design and characterization of a direct ELISA for the detection and quantification of leucomalachite green.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110601

Title: (S)-2-Benzyl-N-(2,6-diisopropyl-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20110501

Title: 5-tert-Butyl 1-ethyl 3-amino-1,4,5,6-tetra-hydro-pyrrolo-[3,4-c]pyrazole-1,5-dicarboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20110501

Title: Uncovering the structure of human red hair pheomelanin: benzothiazolylthiazinodihydroisoquinolines as key building blocks.

Journal: Journal of natural products 20110425

Title: Determination of trace amino acids in human serum by a selective and sensitive pre-column derivatization method using HPLC-FLD-MS/MS and derivatization optimization by response surface methodology.

Journal: Amino acids 20110401

Title: 1-[(2R,4aR,8R,8aR)-8-Hy-droxy-4a,8-di-methyl-perhydronaphthalen-2-yl]ethan-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20110301

Title: 2-{2-[4-(4-Fluoro-phen-yl)piperazin-1-yl]-2-oxoeth-yl}-6-(morpholin-4-yl)-4-phenyl-pyridazin-3(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20110301

Title: Optimization of in situ derivatization SPME by experimental design for GC-MS multi-residue analysis of pharmaceutical drugs in wastewater.

Journal: Journal of separation science 20110201

Title: High-resolution capillary gas chromatography in combination with mass spectrometry for quantification of three major polyamines in postmortem brain cortex.

Journal: Methods in molecular biology (Clifton, N.J.) 20110101

Title: Correlation of the rates of solvolysis of neopentyl chloroformate-a recommended protecting agent.

Journal: International journal of molecular sciences 20110101

Title: Structural Characteristics and Antioxidative Capability of the Soluble Polysaccharides Present in Dictyophora indusiata (Vent. Ex Pers.) Fish Phallaceae.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: In vitro culture conditions for maintaining a complex population of human gastrointestinal tract microbiota.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Long-term cold acclimation extends survival time at 0°C and modifies the metabolomic profiles of the larvae of the fruit fly Drosophila melanogaster.

Journal: PloS one 20110101

Title: Correlation of the rates of solvolysis of i-butyl fluoroformate and a consideration of leaving-group effects.

Journal: International journal of molecular sciences 20110101

Title: LAP6/POLYKETIDE SYNTHASE A and LAP5/POLYKETIDE SYNTHASE B encode hydroxyalkyl α-pyrone synthases required for pollen development and sporopollenin biosynthesis in Arabidopsis thaliana.

Journal: The Plant cell 20101201

Title: N-Isopropyl-6-methyl-2-phenyl-quinoline-3-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents.

Journal: European journal of medicinal chemistry 20100501

Title: α-Costic anhydride.

Journal: Acta crystallographica. Section E, Structure reports online 20100301

Title: Ethyl N-[3-(N,N-dimethyl-carbamo-yl)pyridin-2-ylsulfon-yl]carbamate.

Journal: Acta crystallographica. Section E, Structure reports online 20100301

Title: Determination of the natural abundance delta15N of nortropane alkaloids by gas chromatography-isotope ratio mass spectrometry of their ethylcarbamate esters.

Journal: Analytical and bioanalytical chemistry 20100201

Title: An improved reagent for determination of aliphatic amines with fluorescence and online atmospheric chemical ionization-mass spectrometry identification.

Journal: Analytica chimica acta 20100118

Title: N-octanoyl dopamine, a non-hemodyanic dopamine derivative, for cell protection during hypothermic organ preservation.

Journal: PloS one 20100101

Title: Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

Journal: PloS one 20100101

Title: Use of empirical correlations to determine solvent effects in the solvolysis of S-methyl chlorothioformate.

Journal: International journal of molecular sciences 20100101

Title: Rapid modification of the insect elicitor N-linolenoyl-glutamate via a lipoxygenase-mediated mechanism on Nicotiana attenuata leaves.

Journal: BMC plant biology 20100101

Title: Analysis of the nucleophilic solvation effects in isopropyl chlorothioformate solvolysis.

Journal: International journal of molecular sciences 20100101

Title: Metabolite analysis of human fecal water by gas chromatography/mass spectrometry with ethyl chloroformate derivatization.

Journal: Analytical biochemistry 20091015

Title: N-{1-[(3-Bromo-prop-yl)amino-carbon-yl]eth-yl}-2-(2-nitro-benzene-sulfonamido)propionamide.

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: tert-Butyl N-[1-diazo-acetyl-3-(methyl-sulfan-yl)prop-yl]carbamate.

Journal: Acta crystallographica. Section E, Structure reports online 20090901

Title: A quantitative GC-MS method for three major polyamines in postmortem brain cortex.

Journal: Journal of mass spectrometry : JMS 20090801

Title: Gas chromatography-mass spectrometry analysis of pheomelanin degradation products.

Journal: Journal of chromatography. A 20090724

Title: Separation and determination of seleno amino acids using gas chromatography hyphenated with inductively coupled plasma mass spectrometry after hollow fiber liquid phase microextraction.

Journal: Journal of mass spectrometry : JMS 20090501

Title: Grunwald-Winstein analysis: isopropyl chloroformate solvolysis revisited.

Journal: International journal of molecular sciences 20090301

Title: Corrrelation of the specific rates of solvolysis of ethyl fluoroformate using the extended Grunwald-Winstein equation.

Journal: International journal of molecular sciences 20090301

Title: Multiresidue screening of endocrine-disrupting chemicals and pharmaceuticals in aqueous samples by multi-stir bar sorptive extraction-single desorption-capillary gas chromatography/mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20090201

Title: N-ethoxycarbonylation combined with (S)-1-phenylethylamidation for enantioseparation of amino acids by achiral gas chromatography and gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20081219

Title: [Effect of jinfu kang to experimental precancerous colon lesions and urinary metabolites in rat].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Extended Grunwald-Winstein analysis - LFER used to gauge solvent effects in p-nitrophenyl chloroformate solvolysis.

Journal: International journal of molecular sciences 20081101

Title: GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia.

Journal: Analytical and bioanalytical chemistry 20080801

Title: 2-[2-(4-Benzyl-piperazin-1-ylcarbon-yl)eth-yl]-5,6-diphenyl-pyridazin-3(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction.

Journal: Analytica chimica acta 20080505

Title: Superhydrophobic surfaces formed using layer-by-layer self-assembly with aminated multiwall carbon nanotubes.

Journal: Langmuir : the ACS journal of surfaces and colloids 20080415

Title: (1R,2R)-N,N'-Dimethyl-cyclo-hexane-1,2-diamine.

Journal: Acta crystallographica. Section E, Structure reports online 20080401

Title: Separation of amino acid enantiomers VIA chiral derivatization and non-chiral gas chromatography.

Journal: Journal of chromatography. A 20080208

Title: Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions.

Journal: Beilstein journal of organic chemistry 20080101

Title: Ethyl chloroformate as a derivatizing reagent for the gas chromatographic determination of isoniazid and hydrazine in pharmaceutical preparations.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080101

Title: Identification of gene markers for formaldehyde exposure in humans.

Journal: Environmental health perspectives 20071001

Title: Determination of thiazolidine-4-carboxylates in urine by chloroformate derivatization and gas chromatography-electron impact mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20070901

Title: Analysis of post-Byzantine icons from the Church of the Assumption in Cephalonia, Ionian Islands, Greece: a multi-method approach.

Journal: Analytica chimica acta 20070813

Title: Regio- and stereoselective anomeric esterification of glucopyranose 1,2-diols and a facile preparation of 2-O-acetylated glucopyranosyl trichloroacetimidates from the corresponding 1,2-diols.

Journal: Carbohydrate research 20070507

Title: Characterization of ethyl chloroformate derivative of beta-methylamino-L-alanine.

Journal: Journal of the American Society for Mass Spectrometry 20070501

Title: Enantiomeric analysis of amino acids by using comprehensive two-dimensional gas chromatography.

Journal: Chirality 20070301

Title: Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization.

Journal: Journal of pharmaceutical and biomedical analysis 20070219

Title: Application of ethyl chloroformate derivatization for gas chromatography-mass spectrometry based metabonomic profiling.

Journal: Analytica chimica acta 20070205

Title: The contribution of gas chromatography to the resynthesis of the post-Byzantine artist's technique.

Journal: Analytical and bioanalytical chemistry 20070201

Title: Development of a GC-MS method for the simultaneous analysis of latent fingerprint components.

Journal: Journal of forensic sciences 20061101

Title: Analysis of phenolic acids as chloroformate derivatives using solid phase microextraction-gas chromatography.

Journal: Analytica chimica acta 20060728

Title: Capillary gas-chromatographic determination of spermidine in hair lotion.

Journal: Journal of separation science 20060601

Title: Characterization of waxes used in pictorial artworks according to their relative amount of fatty acids and hydrocarbons by gas chromatography.

Journal: Journal of chromatography. A 20060106

Title: Rapid determination and confirmation of biogenic amines in tuna loin by gas chromatography/mass spectrometry using ethylchloroformate derivative.

Journal: Journal of AOAC International 20060101

Title: Rapid and simple method for determination of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in urine using gas chromatography/mass spectrometry.

Journal: Biomedical chromatography : BMC 20051101

Title: Neonicotinoid nitroguanidine insecticide metabolites: synthesis and nicotinic receptor potency of guanidines, aminoguanidines, and their derivatives.

Journal: Chemical research in toxicology 20050901

Title: A rapid method of diagnosing pulmonary tuberculosis using stir bar sorptive extraction-thermal desorption-gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20050415

Title: Flux analysis uncovers key role of functional redundancy in formaldehyde metabolism.

Journal: PLoS biology 20050201

Title: Synthesis and cytotoxic evaluation of two novel anthraquinone derivatives.

Journal: Farmaco (Societa chimica italiana : 1989) 20040801

Title: Identification and synthesis of a novel selenium-sulfur amino acid found in selenized yeast: Rapid indirect detection NMR methods for characterizing low-level organoselenium compounds in complex matrices.

Journal: Journal of agricultural and food chemistry 20040616

Title: Chiral discrimination of multiple profens as diastereomeric (R)-(+)-1-phenylethylamides by achiral dual-column gas chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425

Title: Capillary gas chromatographic determination of spermidine in diet integrators.

Journal: Journal of pharmaceutical and biomedical analysis 20040416

Title: Suppression of pigment interference in the gas chromatographic analysis of proteinaceous binding media in paintings with EDTA.

Journal: Journal of chromatography. A 20040206

Title: Analysis of 6-hydroxy-2-aminocaproic acid (HACA) as a specific marker of protein oxidation: the use of N(O,S)-ethoxycarbonyl trifluoroethyl ester derivatives and gas chromatography/mass spectrometry.

Journal: Amino acids 20040201

Title: Identification of diterpenes in canvas painting varnishes by gas chromatography-mass spectrometry with combined derivatisation.

Journal: Journal of chromatography. A 20040123

Title: Novel biodegradable aliphatic poly(butylene succinate-co-cyclic carbonate)s with functional carbonate building blocks. 1. Chemical synthesis and their structural and physical characterization.

Journal: Biomacromolecules 20040101

Title: Research on the connections of isoindole derivatives and ethyl esters of formic, acetic and propionic acids.

Journal: Acta poloniae pharmaceutica 20040101

Title: Palladium-catalyzed cross-coupling reactions of carboxylic anhydrides with organozinc reagents.

Journal: Organic letters 20031127

Title: A novel method for the preparation of alpha,alpha'-difluoroesters and acids using BrF3.

Journal: The Journal of organic chemistry 20031017

Title: Comparison of different chloroformates for the derivatisation of seleno amino acids for gas chromatographic analysis.

Journal: Journal of chromatography. A 20031010

Title: Development and evaluation of a GC/FID method for the analysis of free amino acids in quince fruit and jam.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030901

Title: Simple plasma work-up for a fast chromatographic analysis of homocysteine, cysteine, methionine and aromatic amino acids.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030615

Title: Synthesis and acid-base properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-). Evidence for intramolecular hydrogen-bond formation in aqueous solution between (N-1)H and the phosphonate group.

Journal: Organic & biomolecular chemistry 20030521

Title: Analysis of 3-chlorotyrosine as a specific marker of protein oxidation: the use of N(O,S)-ethoxycarbonyltrifluoroethyl ester derivatives and gas chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase.

Journal: Chemical communications (Cambridge, England) 20020921

Title: Neonicotinoid insecticides: reduction and cleavage of imidacloprid nitroimine substituent by liver microsomal and cytosolic enzymes.

Journal: Chemical research in toxicology 20020901

Title: Direct extract derivatization for determination of amino acids in human urine by gas chromatography and mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020825

Title: Combined cysteine and homocysteine quantitation in plasma by trap and release membrane introduction mass spectrometry.

Journal: The Analyst 20020801

Title: Stir bar sorptive extraction-thermal desorption-capillary GC-MS applied to biological fluids.

Journal: Analytical and bioanalytical chemistry 20020501

Title: Determination of isocyanates, aminoisocyanates and amines in air formed during the thermal degradation of polyurethane.

Journal: Journal of environmental monitoring : JEM 20020401

Title: Rapid screening of urinary proline-hydroxyproline dipeptide in bone turnover studies.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020205

Title: Capillary gas chromatography inductively coupled plasma mass spectrometry (CGC-ICPMS) for the enantiomeric analysis of D,L-selenomethionine in food supplements and urine.

Journal: Journal of pharmaceutical and biomedical analysis 20020115

Title: [Factors contributing to roquefortine yield variability during cultivation of penicillium roquefortii].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20020101

Title: Automated headspace solid-phase microextraction and in-matrix derivatization for the determination of amphetamine-related drugs in human urine by gas chromatography-mass spectrometry.

Journal: Journal of chromatographic science 20020101

Title: Design, synthesis, and evaluation of 9-D-ribityl-1,3,7-trihydro-2,6,8-purinetrione, a potent inhibitor of riboflavin synthase and lumazine synthase.

Journal: The Journal of organic chemistry 20011214

Title: Enantioseparation of chiral amino acids as the N(O,S)-ethoxycarbonylated diastereomeric esters by achiral dual-capillary column gas chromatography.

Journal: The Analyst 20011201

Title: Amino acid quantitation in aqueous matrices via trap and release membrane introduction mass spectrometry: homocysteine in human plasma.

Journal: The Analyst 20010801

Title: Identification by GC-FID and GC-MS of amino acids, fatty and bile acids in binding media used in works of art.

Journal: Fresenius' journal of analytical chemistry 20010401

Title: An efficient process for the synthesis of cyclic HPMPC.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

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Tags:541-41-3 Molecular Formula|541-41-3 MDL|541-41-3 SMILES|541-41-3 Ethyl chloroformate