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Home Amines 147127-19-3
147127-19-3,MFCD21604708
Catalog No.:AA001EJR

147127-19-3 | (S)-(((1-(6-Amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$44.00   $31.00
- +
1g
95%
in stock  
$53.00   $37.00
- +
5g
95%
in stock  
$208.00   $146.00
- +
10g
95%
in stock  
$377.00   $264.00
- +
25g
95%
in stock  
$941.00   $659.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001EJR
Chemical Name:
(S)-(((1-(6-Amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
CAS Number:
147127-19-3
Molecular Formula:
C9H14N5O4P
Molecular Weight:
287.2123
MDL Number:
MFCD21604708
SMILES:
C[C@@H](Cn1cnc2c1ncnc2N)OCP(=O)(O)O
Properties
Computed Properties
 
Complexity:
354  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
-1.6  

Upstream Synthesis Route

[1]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,#8,p.1390-1409

[2]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,#7,p.1196-1212

[1]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,#7,p.1196-1212

[1]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,#7,p.1196-1212

[1]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,#7,p.1196-1212

Downstream Synthesis Route
147127-19-3   
(S)-9-(2-phosphonomethoxypropyl)hypoxanthine 

[1]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,p.1390-1409

[1]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,p.1390-1409

[2]CollectionofCzechoslovakChemicalCommunications,1995,vol.60,p.1196-1212

[1]CollectionofCzechoslovakChemicalCommunications,1996,vol.61,p.1538-1548

[1]CollectionofCzechoslovakChemicalCommunications,1996,vol.61,p.S52-S54

147127-19-3   
(S)-9-2-(phosphonomethoxy)propyladeninephosphate 

[1]CollectionofCzechoslovakChemicalCommunications,2000,vol.65,p.1653-1668

Literature

Title: A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions.

Journal: Retrovirology 20120101

Title: Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.

Journal: Biochemical and biophysical research communications 19960215

Title: Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.

Journal: Antimicrobial agents and chemotherapy 19930201

Title: Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3).

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SDS
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Tags:147127-19-3 Molecular Formula|147127-19-3 MDL|147127-19-3 SMILES|147127-19-3 (S)-(((1-(6-Amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid