Home Other Building Blocks 1474110-21-8
1474110-21-8,MFCD29059455
Catalog No.:AA001ESN

1474110-21-8 | Gsk2981278

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$13.00   $9.00
- +
5mg
98+%
in stock  
$29.00   $21.00
- +
25mg
98+%
in stock  
$74.00   $52.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001ESN
Chemical Name:
Gsk2981278
CAS Number:
1474110-21-8
Molecular Formula:
C25H35NO5S
Molecular Weight:
461.6141
MDL Number:
MFCD29059455
SMILES:
OCc1cc(ccc1OCC1CCOCC1)S(=O)(=O)N(c1ccc(cc1)CC)CC(C)C
Properties
Computed Properties
 
Complexity:
635  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
4.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2013/160418,2013,A1

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US2015/80369,2015,A1

[3]Barcan,GreggA.;Conde,JoseJ.;Mokhallalati,MohamedK.;Nilson,MarkG.;Xie,Shiping;Allen,C.Liana;Andemichael,YemaneW.;Calandra,NicholasA.;Leitch,DavidC.;Li,Ling;Morris,MichaelJ.[OrganicProcessResearchandDevelopment,2019,vol.23,#7,p.1396-1406]

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2013/160418,2013,A1

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US2015/80369,2015,A1

[3]Barcan,GreggA.;Conde,JoseJ.;Mokhallalati,MohamedK.;Nilson,MarkG.;Xie,Shiping;Allen,C.Liana;Andemichael,YemaneW.;Calandra,NicholasA.;Leitch,DavidC.;Li,Ling;Morris,MichaelJ.[OrganicProcessResearchandDevelopment,2019,vol.23,#7,p.1396-1406]

[4]Barcan,GreggA.;Conde,JoseJ.;Mokhallalati,MohamedK.;Nilson,MarkG.;Xie,Shiping;Allen,C.Liana;Andemichael,YemaneW.;Calandra,NicholasA.;Leitch,DavidC.;Li,Ling;Morris,MichaelJ.[OrganicProcessResearchandDevelopment,2019,vol.23,#7,p.1396-1406]

[5]Barcan,GreggA.;Conde,JoseJ.;Mokhallalati,MohamedK.;Nilson,MarkG.;Xie,Shiping;Allen,C.Liana;Andemichael,YemaneW.;Calandra,NicholasA.;Leitch,DavidC.;Li,Ling;Morris,MichaelJ.[OrganicProcessResearchandDevelopment,2019,vol.23,#7,p.1396-1406]

[6]Barcan,GreggA.;Conde,JoseJ.;Mokhallalati,MohamedK.;Nilson,MarkG.;Xie,Shiping;Allen,C.Liana;Andemichael,YemaneW.;Calandra,NicholasA.;Leitch,DavidC.;Li,Ling;Morris,MichaelJ.[OrganicProcessResearchandDevelopment,2019,vol.23,#7,p.1396-1406]

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2013/160418,2013,A1

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US2015/80369,2015,A1

[3]Chen,Lei;Su,Mei;Jin,Qiu;Wang,Wei;Wang,Chun-Gu;Assani,Israa;Wang,Mu-Xuan;Zhao,Shi-Feng;Lv,Shen-Min;Wang,Jia-Wei;Sun,Bo;Li,Yan;Liao,Zhi-Xin[JournalofMedicinalChemistry,2021,vol.64,#21,p.16106-16131]

[1]Chen,Lei;Su,Mei;Jin,Qiu;Wang,Wei;Wang,Chun-Gu;Assani,Israa;Wang,Mu-Xuan;Zhao,Shi-Feng;Lv,Shen-Min;Wang,Jia-Wei;Sun,Bo;Li,Yan;Liao,Zhi-Xin[JournalofMedicinalChemistry,2021,vol.64,#21,p.16106-16131]

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2013/160418,2013,A1Locationinpatent:Page/Pagecolumn97

[3]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US2015/80369,2015,A1Locationinpatent:Paragraph0396

[4]Barcan,GreggA.;Conde,JoseJ.;Mokhallalati,MohamedK.;Nilson,MarkG.;Xie,Shiping;Allen,C.Liana;Andemichael,YemaneW.;Calandra,NicholasA.;Leitch,DavidC.;Li,Ling;Morris,MichaelJ.[OrganicProcessResearchandDevelopment,2019,vol.23,#7,p.1396-1406]

[1]Ouvry,Gilles;Bihl,Franck;Bouix-Peter,Claire;Christin,Olivier;Defoin-Platel,Claire;Deret,Sophie;Feret,Christophe;Froude,David;Hacini-Rachinel,Feriel;Harris,CraigS.;Hervouet,Catherine;Lafitte,Guillaume;Luzy,Anne-Pascale;Musicki,Branislav;Orfila,Danielle;Parnet,Veronique;Pascau,Coralie;Pascau,Jonathan;Pierre,Romain;Raffin,Catherine;Rossio,Patricia;Spiesse,Delphine;Taquet,Nathalie;Thoreau,Etienne;Vatinel,Rodolphe;Vial,Emmanuel;Hennequin,LaurentF.[BioorganicandMedicinalChemistryLetters,2018,vol.28,#8,p.1269-1273]

Literature

Title: Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin.

Journal: PloS one 20160101

Title: Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20140315

Title: Smith SH, et al. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin. PLoS One. 2016 Feb 12;11(2):e0147979.

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